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Q0A6K4 (MURB_ALHEH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase
EC=1.1.1.158
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene names
Name:murB
Ordered Locus Names:Mlg_2191
OrganismAlkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]
Taxonomic identifier187272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00037

Catalytic activity

UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037

Cofactor

FAD By similarity. HAMAP MF_00037

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037

Subcellular location

Cytoplasm By similarity HAMAP MF_00037.

Sequence similarities

Belongs to the MurB family.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP MF_00037
PRO_1000002860

Regions

Domain26 – 190165FAD-binding PCMH-type

Sites

Active site1701 By similarity
Active site2191Proton donor By similarity
Active site2891 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0A6K4 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 1A30F5CCF7A7A364

FASTA29832,214
        10         20         30         40         50         60 
MMAAERRIQP GELRHWEPMA RYTSWRAGGP AERLYRPAGL ADLVAFLRRL PEDEPLFWCG 

        70         80         90        100        110        120 
LGSNLLVREG GLRGTVILTQ GGLDALRVEG EQVHAEAGVA CGRLSRYCIR QGLAGAEFFA 

       130        140        150        160        170        180 
GIPGTLGGAL AMNAGAFGGE TWSRVRRVET VDRHGVLRRR GPEDFRVGYR HVSGPAGEWF 

       190        200        210        220        230        240 
VAAVLDLEPG DAQAMQARVK ALLSQRNRTQ PIGEPSCGSV FRNPPGDHAA RLIEAAGLKG 

       250        260        270        280        290 
LRRGAAQVSE RHANFIINTG GATPADIEAL IEQVRDEVAR RHGVTLVPEV HIVGEAQS

« Hide

References

[1]"Complete sequence of Alkalilimnicola ehrilichei MLHE-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MLHE-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000453 Genomic DNA. Translation: ABI57533.1.
RefSeqYP_743023.1. NC_008340.1.

3D structure databases

ProteinModelPortalQ0A6K4.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0A6K4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4270970.
GenomeReviewsGene locus Mlg_2191 in contig CP000453_GR.
KEGGaeh:Mlg_2191.
NMPDRfig|187272.6.peg.2088.
PATRIC20863639. VBIAlkEhr114327_2188.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0812.
HOGENOMHBG686573.
OMASKKHAGF.
PhylomeDBQ0A6K4.
ProtClustDBPRK13905.

Enzyme and pathway databases

BioCycAEHR187272:MLG_2191-MONOMER.

Family and domain databases

HAMAPMF_00037. MurB.
[Tree]
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.90.78.10. MurB_C. 1 hit.
KOK00075.
PANTHERPTHR21071. MurB. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMSSF56176. FAD-binding_2. 1 hit.
SSF56194. MurB_C. 1 hit.
TIGRFAMsTIGR00179. MurB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMURB_ALHEH
AccessionPrimary (citable) accession number: Q0A6K4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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