ID   MURC_ALHEH              Reviewed;         479 AA.
AC   Q0A6K3;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=UDP-N-acetylmuramate--L-alanine ligase;
DE            EC=6.3.2.8;
DE   AltName: Full=UDP-N-acetylmuramoyl-L-alanine synthetase;
GN   Name=murC; OrderedLocusNames=Mlg_2192;
OS   Alkalilimnicola ehrlichei (strain MLHE-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Alkalilimnicola.
OX   NCBI_TaxID=187272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T.,
RA   King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T.,
RA   Xie G., Stolz J.F., Richardson P.;
RT   "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cell wall formation (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + UDP-N-acetylmuramate + L-alanine = ADP +
CC       phosphate + UDP-N-acetylmuramoyl-L-alanine.
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the murCDEF family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000453; ABI57534.1; -; Genomic_DNA.
DR   RefSeq; YP_743024.1; -.
DR   GeneID; 4270971; -.
DR   GenomeReviews; CP000453_GR; Mlg_2192.
DR   KEGG; aeh:Mlg_2192; -.
DR   NMPDR; fig|187272.6.peg.2089; -.
DR   HOGENOM; Q0A6K3; -.
DR   OMA; Q0A6K3; EWMVVEA.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0008763; F:UDP-N-acetylmuramate-L-alanine ligase activity; IEA:HAMAP.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007047; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   HAMAP; MF_00046; -; 1.
DR   InterPro; IPR004101; Mur_ligase_C.
DR   InterPro; IPR013221; Mur_ligase_cen.
DR   InterPro; IPR000713; Mur_ligase_N.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR005758; UDP-N-AcMur_Ala_ligase.
DR   Gene3D; G3DSA:3.90.190.20; Mur_ligase_C; 1.
DR   Gene3D; G3DSA:3.40.1190.10; Mur_ligase_cen; 1.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01225; Mur_ligase; 1.
DR   Pfam; PF02875; Mur_ligase_C; 1.
DR   Pfam; PF08245; Mur_ligase_M; 1.
DR   TIGRFAMs; TIGR01082; murC; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Cell shape;
KW   Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;
KW   Ligase; Nucleotide-binding; Peptidoglycan synthesis.
FT   CHAIN         1    479       UDP-N-acetylmuramate--L-alanine ligase.
FT                                /FTId=PRO_0000336809.
FT   NP_BIND     126    132       ATP (Potential).
SQ   SEQUENCE   479 AA;  51633 MW;  90902B34CC203F5B CRC64;
     MTDGDTSPAH TRPDAFGRVR HLHFVGIGGA GMGGIAEVLH NLGFTVTGSD LRENAITRRL
     AGLGVQVVFG HEADHVQGAD AVVVSSAVQA DNPEVQAARE YRIPVVRRAE MLAELMRFRY
     GIAVAGTHGK TTTTSLVASV LAEGGLDPTY VIGGRLNSSA SHARLGSGRY LVAEADESDA
     SFLHLKPMMA VVTNIDADHL ETYGGDFDQL RHTFDEFLHH LPFYGLAVLC HDDPVLRDLG
     PEIARQVRSY GFAEDADLRA VDIEQSGRRT RFTVVDGEAT FPVEVNLPGR HNVQNALAAI
     AVARELHVDV AAIQRALQRF QGIGRRFQDH GTLRFGDARV TLVDDYGHHP REIAATLRAV
     RDGWPGRRVL VVFQPHRYSR TRDLFEDFAR VLSEADALLV TEVYAAGEPP VAGATGRGLC
     AAIRARGQVN PVFVETLEEL QQVLPGVARD GDLVLTLGAG SIGGAAAELA RRHGVEDGG
//