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Q0A6K3 (MURC_ALHEH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8
Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase
Gene names
Name:murC
Ordered Locus Names:Mlg_2192
OrganismAlkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]
Taxonomic identifier187272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00046

Catalytic activity

ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046

Subcellular location

Cytoplasm By similarity HAMAP MF_00046.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046
PRO_0000336809

Regions

Nucleotide binding126 – 1327ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q0A6K3 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 90902B34CC203F5B

FASTA47951,633
        10         20         30         40         50         60 
MTDGDTSPAH TRPDAFGRVR HLHFVGIGGA GMGGIAEVLH NLGFTVTGSD LRENAITRRL 

        70         80         90        100        110        120 
AGLGVQVVFG HEADHVQGAD AVVVSSAVQA DNPEVQAARE YRIPVVRRAE MLAELMRFRY 

       130        140        150        160        170        180 
GIAVAGTHGK TTTTSLVASV LAEGGLDPTY VIGGRLNSSA SHARLGSGRY LVAEADESDA 

       190        200        210        220        230        240 
SFLHLKPMMA VVTNIDADHL ETYGGDFDQL RHTFDEFLHH LPFYGLAVLC HDDPVLRDLG 

       250        260        270        280        290        300 
PEIARQVRSY GFAEDADLRA VDIEQSGRRT RFTVVDGEAT FPVEVNLPGR HNVQNALAAI 

       310        320        330        340        350        360 
AVARELHVDV AAIQRALQRF QGIGRRFQDH GTLRFGDARV TLVDDYGHHP REIAATLRAV 

       370        380        390        400        410        420 
RDGWPGRRVL VVFQPHRYSR TRDLFEDFAR VLSEADALLV TEVYAAGEPP VAGATGRGLC 

       430        440        450        460        470 
AAIRARGQVN PVFVETLEEL QQVLPGVARD GDLVLTLGAG SIGGAAAELA RRHGVEDGG

« Hide

References

[1]"Complete sequence of Alkalilimnicola ehrilichei MLHE-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MLHE-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000453 Genomic DNA. Translation: ABI57534.1.
RefSeqYP_743024.1. NC_008340.1.

3D structure databases

ProteinModelPortalQ0A6K3.
SMRQ0A6K3. Positions 16-471.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0A6K3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4270971.
GenomeReviewsGene locus Mlg_2192 in contig CP000453_GR.
KEGGaeh:Mlg_2192.
NMPDRfig|187272.6.peg.2089.
PATRIC20863641. VBIAlkEhr114327_2189.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0773.
HOGENOMHBG476594.
OMAYQPHRYS.
PhylomeDBQ0A6K3.
ProtClustDBPRK00421.

Enzyme and pathway databases

BioCycAEHR187272:MLG_2192-MONOMER.

Family and domain databases

HAMAPMF_00046. MurC.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR016040. NAD(P)-bd_dom.
IPR005758. UDP-N-AcMur_Ala_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01924.
PANTHERPTHR23135:SF5. PTHR23135:SF5. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01082. MurC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURC_ALHEH
AccessionPrimary (citable) accession number: Q0A6K3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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