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Q0A6J9 (MRAY_ALHEH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:Mlg_2196
OrganismAlkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]
Taxonomic identifier187272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000002932

Regions

Transmembrane26 – 4621Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane236 – 25621Helical; Potential
Transmembrane263 – 28321Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane338 – 35821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q0A6J9 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: FA9A04464D5DC2BC

FASTA36038,469
        10         20         30         40         50         60 
MLYHLAMALE GVYSGFNVFQ YLTFRTILGV LTALGIALLV GPAVIQRLVE HQIGQQVRDD 

        70         80         90        100        110        120 
GPQSHLSKAG TPTMGGALIL VAIAVATLLW SDLTNRYVWV VLLTTLAFGV IGGVDDYRKL 

       130        140        150        160        170        180 
ALGNSKGLSA RAKFFWQTVV ALMAAVFLFS TAQSPLETSL IVPLFKDVVL PLGLLFIPLV 

       190        200        210        220        230        240 
WLVVVGSSNA VNLTDGLDGL AILPSVLVAG GLAVFAYATG HAVFADYLGI PFVAGAGEVV 

       250        260        270        280        290        300 
VFCGALIGAG LGFLWFNTYP AQVFMGDVGA LALGAALGIL AVVVRQELVL LIMGGVFVVE 

       310        320        330        340        350        360 
TLSVMLQVAS YKLTGRRIFR MAPLHHHFEL KGWPEPRVIV RFWIITVVLV LVGLAMLKVR

« Hide

References

[1]"Complete sequence of Alkalilimnicola ehrilichei MLHE-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MLHE-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000453 Genomic DNA. Translation: ABI57538.1.
RefSeqYP_743028.1. NC_008340.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ0A6J9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4270975.
GenomeReviewsGene locus Mlg_2196 in contig CP000453_GR.
KEGGaeh:Mlg_2196.
NMPDRfig|187272.6.peg.2093.
PATRIC20863649. VBIAlkEhr114327_2193.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHBG708263.
OMARFWIISM.
PhylomeDBQ0A6J9.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycAEHR187272:MLG_2196-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ALHEH
AccessionPrimary (citable) accession number: Q0A6J9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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