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Q0A5T6

- ACDH_ALKEH

UniProt

Q0A5T6 - ACDH_ALKEH

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Protein

Acetaldehyde dehydrogenase

Gene
Mlg_2461
Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Acyl-thioester intermediate By similarity
Binding sitei271 – 2711NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 134NAD By similarity
Nucleotide bindingi160 – 1689NAD By similarity

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciAEHR187272:GHAX-2513-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene namesi
Ordered Locus Names:Mlg_2461
OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Taxonomic identifieri187272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
ProteomesiUP000001962: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Acetaldehyde dehydrogenaseUniRule annotationPRO_0000387616Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi187272.Mlg_2461.

Structurei

3D structure databases

ProteinModelPortaliQ0A5T6.
SMRiQ0A5T6. Positions 2-293.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q0A5T6-1 [UniParc]FASTAAdd to Basket

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MKIQCAIIGS GNIGTDLMAK LQRSPVLEPA WMVGIDPDSD GLARARAAGL    50
KTTHEGVDGL LPHIEGDGVR IAFDATSAYV HAENDRKLQE KGVMVIDLTP 100
AAIGPFCVPP VNLKDRIGDG ATNVNMVTCG GQATVPIVAA VSQVQPVDYA 150
EIVATISSRS AGPGTRKNID EFTRTTSRAI EQVGGAKQGK AIIILNPAEP 200
PLIMRDTVHC LVQGKPDHKA ITESIERMVA EVQRYVPGYR IKNGPTFDGQ 250
RVSTFLEVEG LGDYLPHYSG NLDIMTAAAA RAAEIFAESL QSASDAPATA 300
Length:300
Mass (Da):31,736
Last modified:October 17, 2006 - v1
Checksum:iEDBB276D78EAEA8A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000453 Genomic DNA. Translation: ABI57801.1.
RefSeqiYP_743291.1. NC_008340.1.

Genome annotation databases

EnsemblBacteriaiABI57801; ABI57801; Mlg_2461.
GeneIDi4270202.
KEGGiaeh:Mlg_2461.
PATRICi20864181. VBIAlkEhr114327_2455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000453 Genomic DNA. Translation: ABI57801.1 .
RefSeqi YP_743291.1. NC_008340.1.

3D structure databases

ProteinModelPortali Q0A5T6.
SMRi Q0A5T6. Positions 2-293.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 187272.Mlg_2461.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABI57801 ; ABI57801 ; Mlg_2461 .
GeneIDi 4270202.
KEGGi aeh:Mlg_2461.
PATRICi 20864181. VBIAlkEhr114327_2455.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci AEHR187272:GHAX-2513-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1101 / DSM 17681 / MLHE-1.

Entry informationi

Entry nameiACDH_ALKEH
AccessioniPrimary (citable) accession number: Q0A5T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: October 17, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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