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Q0A5T6 (ACDH_ALKEH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Ordered Locus Names:Mlg_2461
OrganismAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1) [Complete proteome] [HAMAP]
Taxonomic identifier187272 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 300300Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387616

Regions

Nucleotide binding10 – 134NAD By similarity
Nucleotide binding160 – 1689NAD By similarity

Sites

Active site1291Acyl-thioester intermediate By similarity
Binding site2711NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0A5T6 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: EDBB276D78EAEA8A

FASTA30031,736
        10         20         30         40         50         60 
MKIQCAIIGS GNIGTDLMAK LQRSPVLEPA WMVGIDPDSD GLARARAAGL KTTHEGVDGL 

        70         80         90        100        110        120 
LPHIEGDGVR IAFDATSAYV HAENDRKLQE KGVMVIDLTP AAIGPFCVPP VNLKDRIGDG 

       130        140        150        160        170        180 
ATNVNMVTCG GQATVPIVAA VSQVQPVDYA EIVATISSRS AGPGTRKNID EFTRTTSRAI 

       190        200        210        220        230        240 
EQVGGAKQGK AIIILNPAEP PLIMRDTVHC LVQGKPDHKA ITESIERMVA EVQRYVPGYR 

       250        260        270        280        290        300 
IKNGPTFDGQ RVSTFLEVEG LGDYLPHYSG NLDIMTAAAA RAAEIFAESL QSASDAPATA 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000453 Genomic DNA. Translation: ABI57801.1.
RefSeqYP_743291.1. NC_008340.1.

3D structure databases

ProteinModelPortalQ0A5T6.
SMRQ0A5T6. Positions 2-293.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING187272.Mlg_2461.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABI57801; ABI57801; Mlg_2461.
GeneID4270202.
KEGGaeh:Mlg_2461.
PATRIC20864181. VBIAlkEhr114327_2455.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OMATSAGAHR.
OrthoDBEOG6H1PXH.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycAEHR187272:GHAX-2513-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_ALKEH
AccessionPrimary (citable) accession number: Q0A5T6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: October 17, 2006
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families