Reviewed, UniProtKB/Swiss-Prot Q0A5M7 (GCP_ALHEH)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	Mlg_2520

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc Probable.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_0000303251
Sites
	Metal binding	111	1	Zinc Potential
	Metal binding	115	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	Q0A5M7-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 7A4F1A9DEA37D549	FASTA	339	36,059
	10 20 30 40 50 60 MRVLGVESSC DETGLAIYDS AQGLMAHALH SQVATHAEYG GVVPELASRD HVRRVVPLTR 70 80 90 100 110 120 RVLAEAGCRL RDIDAVAYTR GPGLVGALMV GAGMARSLAW GLGVPALGVH HMEAHLLAPM 130 140 150 160 170 180 LEPNPPAFPF VALLVSGGHT LLVQVAGVGR YRVLGETLDD AAGEAFDKTA KLLGLPYPGG 190 200 210 220 230 240 PELEKLAESG DPGRYRFPRP MTDRPGLDFS FSGLKTRVLQ TVQQSREADR ADIAAAFQSA 250 260 270 280 290 300 VVDTLVIKCR RALRATGSQR LVISGGVGAN GLLREQMRAM ADQAGASLHY PRLALCTDNG 310 320 330 AMVAYTGWCR LSEGQHDDLD FSVTARWPLA DLTPPGQPV

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000453 Genomic DNA. Translation: ABI57860.1.
RefSeq	YP_743350.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0A5M7.
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	4270159.
GenomeReviews	Gene locus Mlg_2520 in contig CP000453_GR.
KEGG	aeh:Mlg_2520.
NMPDR	fig|187272.6.peg.2401.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0A5M7.
OMA	CKRALKQ.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
ProDom	PD002367. Peptidase_M22. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_ALHEH

Accession

Primary (citable) accession number: Q0A5M7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	October 17, 2006
Last modified:	November 3, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)