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Protein

Endonuclease V

Gene

nfi

Organism
Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46MagnesiumUniRule annotation1
Metal bindingi114MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciAEHR187272:G1G7A-2579-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease VUniRule annotation (EC:3.1.21.7UniRule annotation)
Alternative name(s):
Deoxyinosine 3'endonucleaseUniRule annotation
Deoxyribonuclease VUniRule annotation
Short name:
DNase VUniRule annotation
Gene namesi
Name:nfiUniRule annotation
Ordered Locus Names:Mlg_2526
OrganismiAlkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)
Taxonomic identifieri187272 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesEctothiorhodospiraceaeAlkalilimnicola
Proteomesi
  • UP000001962 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000469901 – 227Endonuclease VAdd BLAST227

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei84Interaction with target DNAUniRule annotation1

Protein-protein interaction databases

STRINGi187272.Mlg_2526

Structurei

3D structure databases

ProteinModelPortaliQ0A5M1
SMRiQ0A5M1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endonuclease V family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105Y7X Bacteria
COG1515 LUCA
HOGENOMiHOG000229135
KOiK05982
OMAiCKYRVPE
OrthoDBiPOG091H0CQB

Family and domain databases

CDDicd06559 Endonuclease_V, 1 hit
HAMAPiMF_00801 Endonuclease_5, 1 hit
InterProiView protein in InterPro
IPR007581 Endonuclease-V
PANTHERiPTHR28511 PTHR28511, 1 hit
PfamiView protein in Pfam
PF04493 Endonuclease_5, 1 hit

Sequencei

Sequence statusi: Complete.

Q0A5M1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVSIRALHP WAVDAAEGRR LQQTLREQLC LKTPRGFRPR LVAGVDAGVV
60 70 80 90 100
DGGRTIRAAV VVMSLPDLAV VTQSVARAPA IMPYVPGLLS FRELPGVVRA
110 120 130 140 150
LEQLDVTPEL LLCDGQGIAH PRRLGIAAHL GLITDLPAIG VGKSRLVGTY
160 170 180 190 200
REPRPEKGAT SGLYDGHERI GTVLRSRDHV RPLYVSPGHR ISHEDAVHWV
210 220
LTCCTRYRLP EPQRAADRLA SAKEAPA
Length:227
Mass (Da):24,621
Last modified:October 17, 2006 - v1
Checksum:i15242D4ACD05EF2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000453 Genomic DNA Translation: ABI57866.1
RefSeqiWP_011630259.1, NC_008340.1

Genome annotation databases

EnsemblBacteriaiABI57866; ABI57866; Mlg_2526
KEGGiaeh:Mlg_2526

Similar proteinsi

Entry informationi

Entry nameiNFI_ALKEH
AccessioniPrimary (citable) accession number: Q0A5M1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health