Reviewed, UniProtKB/Swiss-Prot Q0A5K0 (SUCC_ALHEH)

Names and origin

Protein names

Recommended name:
    Succinyl-CoA ligase [ADP-forming] subunit beta
    EC=6.2.1.5
Alternative name(s):
    Succinyl-CoA synthetase subunit beta
      Short name=SCS-beta

Gene names

Name:	sucC
Ordered Locus Names:	Mlg_2547

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP MF_00558
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle. HAMAP MF_00558
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase beta subunit family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 391	391	Succinyl-CoA ligase [ADP-forming] subunit beta HAMAP MF_00558		PRO_1000081995
Regions
	Domain	9 – 246	238	ATP-grasp
	Nucleotide binding	35 – 108	74	ATP By similarity
Sites
	Metal binding	197	1	Magnesium or manganese By similarity
	Metal binding	199	1	Magnesium or manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0A5K0-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: C0C13A9FEF614D55	FASTA	391	41,243
	10 20 30 40 50 60 MNLHEFQAKH LFADYDIPIP QGYVARSSGE AVEAAGRLGG SVWVVKAQVH AGGRGKAGGV 70 80 90 100 110 120 KVLKTKEEVE EFTDSLLGSR LVTHQTDAKG QPIHAVLVEQ GLDIARELYL GALVDRASKR 130 140 150 160 170 180 VTFMGSAAGG MDIEEVAAST PEKILTLAVD PAAGFQAYQG RKMAFALGLE GKQIGQLVKI 190 200 210 220 230 240 MKSLYRIFEE KDLSMIEINP LIVTGDGQLL ALDAKVNVDD NAVEIGRQPQ IADMRDITQE 250 260 270 280 290 300 DEAEVQAAEH NLNYITLDGN IGCMVNGAGL AMATMDVVNL HGGSPANFLD VGGGTTTERV 310 320 330 340 350 360 TAAFKLILSS DTVEGILVNI FGGIVRCDVI AEGIIAAVKE VGVDVPVVVR LEGTNVEQGK 370 380 390 QMLADSGMDL IPADDLTDAA KKVVAAVGKA A

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000453 Genomic DNA. Translation: ABI57887.1.
RefSeq	YP_743377.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4270935.
GenomeReviews	Gene locus Mlg_2547 in contig CP000453_GR.
KEGG	aeh:Mlg_2547.
NMPDR	fig|187272.6.peg.2426.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q0A5K0.
OMA	Q0A5K0. RREFYFA.
Family and domain databases
HAMAP	MF_00558. [Tree]
InterPro	IPR011761. ATP-grasp. IPR013650. ATP-grasp_succ-CoA_synth-type. IPR013816. ATP_grasp_subdomain_2. IPR005811. CoA_ligase. IPR017866. Succ-CoA_synthase_bsu_CS. IPR005809. Succ_CoA_synthase_bsu. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
PANTHER	PTHR11815. CoA_lig_beta. 1 hit.
Pfam	PF08442. ATP-grasp_2. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01016. sucCoAbeta. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. PS01217. SUCCINYL_COA_LIG_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCC_ALHEH

Accession

Primary (citable) accession number: Q0A5K0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	October 17, 2006
Last modified:	June 16, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)