ID   HIS4_ALHEH              Reviewed;         248 AA.
AC   Q0A5D2;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 2.
DT   16-JUN-2009, entry version 16.
DE   RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
DE            EC=5.3.1.16;
DE   AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
GN   Name=hisA; OrderedLocusNames=Mlg_2615;
OS   Alkalilimnicola ehrlichei (strain MLHE-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Alkalilimnicola.
OX   NCBI_TaxID=187272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T.,
RA   King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T.,
RA   Xie G., Stolz J.F., Richardson P.;
RT   "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-5-((5-
CC       phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-
CC       ((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-
CC       phosphoribosyl)imidazole-4-carboxamide.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the hisA/hisF family.
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DR   EMBL; CP000453; ABI57955.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_743445.1; -.
DR   GeneID; 4269524; -.
DR   GenomeReviews; CP000453_GR; Mlg_2615.
DR   KEGG; aeh:Mlg_2615; -.
DR   NMPDR; fig|187272.6.peg.2492; -.
DR   HOGENOM; Q0A5D2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylam...; IEA:HAMAP.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01014; -; 1.
DR   InterPro; IPR006063; His4.
DR   InterPro; IPR006062; His_biosynth.
DR   Pfam; PF00977; His_biosynth; 1.
DR   TIGRFAMs; TIGR00007; His4; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Isomerase.
FT   CHAIN         1    248       1-(5-phosphoribosyl)-5-[(5-
FT                                phosphoribosylamino)methylideneamino]
FT                                imidazole-4-carboxamide isomerase.
FT                                /FTId=PRO_0000290445.
FT   ACT_SITE      8      8       Proton acceptor (By similarity).
FT   ACT_SITE    130    130       Proton donor (By similarity).
SQ   SEQUENCE   248 AA;  26396 MW;  933CD7313CB06AA3 CRC64;
     MQLIPAIDLK DGRCVRLRQG RMDDETVFSD DPVAMAGRWV AAGTRRLHLV DLNGAVAGKP
     VNAEIIHRIA TRYPDLRIQV GGGIRDLDTI RGYREAGVDD LIIGTQAVRR PEFVTEACQA
     FPGHIIVGLD ARDGRVATDG WEQVSEVRAV DLARRFEAAG VNAIVFTDIG RDGMMKGVNI
     EATRELARAI TIPVIASGGV SSLEDVRALC AAAGDGISGA IVGRALYEGS LDLAEAQGLA
     DELCGVKP
//