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Q0A574 (ARLY_ALHEH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:Mlg_2673
OrganismAlkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]
Taxonomic identifier187272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468Argininosuccinate lyase HAMAP MF_00006
PRO_0000321426

Sequences

Sequence LengthMass (Da)Tools
Q0A574 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: E599E2159A52CC45

FASTA46852,551
        10         20         30         40         50         60 
MTDKNTSEQL WTGRFTEATD AFVEQFSASE HFDRRLYRQD IAGSMAHARM LAEVGVLTAE 

        70         80         90        100        110        120 
ERDRIVDGLT RIREEIEHGQ FQWSPKLEDV HMNIEKRLTD LIGEAGKKLH TGRSRNDQVA 

       130        140        150        160        170        180 
TDIRLWLREA IDGILDELLR LQAGLVELAE LEADTIMPGF THMQVAQPVT FGHHLLAWYE 

       190        200        210        220        230        240 
MLVRDQGRLE DCRKRLNQMP LGCAALAGTS FPIDREQTCS ELGFDRPTRN SLDSVSDRDF 

       250        260        270        280        290        300 
AIEFNAAAAL VMTHLSRMAE EVILWASPHF GFIDLPDRFC TGSSIMPQKK NPDVAELVRG 

       310        320        330        340        350        360 
KTARVHGNLN ALLVLMKGQP LAYNRDNQED KEPLFDTADT LRDALTAFAD MLPAMEVQRE 

       370        380        390        400        410        420 
ACYRAARAGF ATATDLADYL VRKGVPFRDA HEIVGRAVRY ASDEGRDLSE LELDELQQFS 

       430        440        450        460 
GTISEDVFEV LTLEGSVAAR NHLGGTAPAQ VRARVAEARD RLRLLMGK

« Hide

References

[1]"Complete sequence of Alkalilimnicola ehrilichei MLHE-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MLHE-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000453 Genomic DNA. Translation: ABI58013.1.
RefSeqYP_743503.1. NC_008340.1.

3D structure databases

ProteinModelPortalQ0A574.
SMRQ0A574. Positions 19-463.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ0A574.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4268806.
GenomeReviewsGene locus Mlg_2673 in contig CP000453_GR.
KEGGaeh:Mlg_2673.
NMPDRfig|187272.6.peg.2550.
PATRIC20864605. VBIAlkEhr114327_2666.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHBG539632.
OMAMAEDLIF.
PhylomeDBQ0A574.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycAEHR187272:MLG_2673-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_ALHEH
AccessionPrimary (citable) accession number: Q0A574
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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