Reviewed, UniProtKB/Swiss-Prot Q0A574 (ARLY_ALHEH)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	Mlg_2673

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Argininosuccinate lyase HAMAP MF_00006		PRO_0000321426

Sequences

	Sequence		Length	Mass (Da)
	Q0A574-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: E599E2159A52CC45	FASTA	468	52,551
	10 20 30 40 50 60 MTDKNTSEQL WTGRFTEATD AFVEQFSASE HFDRRLYRQD IAGSMAHARM LAEVGVLTAE 70 80 90 100 110 120 ERDRIVDGLT RIREEIEHGQ FQWSPKLEDV HMNIEKRLTD LIGEAGKKLH TGRSRNDQVA 130 140 150 160 170 180 TDIRLWLREA IDGILDELLR LQAGLVELAE LEADTIMPGF THMQVAQPVT FGHHLLAWYE 190 200 210 220 230 240 MLVRDQGRLE DCRKRLNQMP LGCAALAGTS FPIDREQTCS ELGFDRPTRN SLDSVSDRDF 250 260 270 280 290 300 AIEFNAAAAL VMTHLSRMAE EVILWASPHF GFIDLPDRFC TGSSIMPQKK NPDVAELVRG 310 320 330 340 350 360 KTARVHGNLN ALLVLMKGQP LAYNRDNQED KEPLFDTADT LRDALTAFAD MLPAMEVQRE 370 380 390 400 410 420 ACYRAARAGF ATATDLADYL VRKGVPFRDA HEIVGRAVRY ASDEGRDLSE LELDELQQFS 430 440 450 460 GTISEDVFEV LTLEGSVAAR NHLGGTAPAQ VRARVAEARD RLRLLMGK

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000453 Genomic DNA. Translation: ABI58013.1.
RefSeq	YP_743503.1.
3D structure databases
SMR	Q0A574. Positions 19-463.
ModBase	Search...
Protein-protein interaction databases
STRING	Q0A574.
Genome annotation databases
GeneID	4268806.
GenomeReviews	Gene locus Mlg_2673 in contig CP000453_GR.
KEGG	aeh:Mlg_2673.
NMPDR	fig|187272.6.peg.2550.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	MAEDLIF.
PhylomeDB	Q0A574.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ALHEH

Accession

Primary (citable) accession number: Q0A574

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 17, 2006
Last modified:	February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)