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Q0A4Y2 (DCUP_ALHEH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:Mlg_2765
OrganismAlkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]
Taxonomic identifier187272 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000023869

Regions

Region27 – 315Substrate binding By similarity

Sites

Binding site771Substrate By similarity
Binding site1541Substrate By similarity
Binding site2091Substrate By similarity
Binding site3271Substrate By similarity
Site771Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q0A4Y2 [UniParc].

Last modified October 17, 2006. Version 1.
Checksum: 55E8719A1674E67C

FASTA36540,238
        10         20         30         40         50         60 
MSVLKNDRLL RALQRQPVDR TPVWMMRQAG RYLPEYRELR AQAGSFMKLA GTPELACEVT 

        70         80         90        100        110        120 
LQPLRRFPLD AAILFSDILT IPDAMGLGLR FLPGEGPVFD HPVRSAADIE HLPVPDPEDE 

       130        140        150        160        170        180 
LRYVTDAVRL IRRELDGEVP LIGFAGSPWT LATYMIEGGS SKDYRRCKAM LYDEPELLHR 

       190        200        210        220        230        240 
LLDKVAQATT AYLNAQIAAG AQAIMIFDSW GGALAHDAYR LFSLAYMERI VRNLTREADG 

       250        260        270        280        290        300 
RHVPVVLFTK GGGQWLEAMA ATGCDGLGLD WTTNLGQARD RVGDRVALQG NLDPCVLYAS 

       310        320        330        340        350        360 
PETIRNEVAR VLADYGPGPG HVFNLGHGIH PAIPPEHAGA MIDAVHQLSP RYHEQQAEAS 


SLTQG

« Hide

References

[1]"Complete sequence of Alkalilimnicola ehrilichei MLHE-1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MLHE-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000453 Genomic DNA. Translation: ABI58105.1.
RefSeqYP_743595.1. NC_008340.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ0A4Y2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4269126.
GenomeReviewsGene locus Mlg_2765 in contig CP000453_GR.
KEGGaeh:Mlg_2765.
NMPDRfig|187272.6.peg.2639.
PATRIC20864795. VBIAlkEhr114327_2758.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAPRIHFGV.
PhylomeDBQ0A4Y2.

Enzyme and pathway databases

BioCycAEHR187272:MLG_2765-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_ALHEH
AccessionPrimary (citable) accession number: Q0A4Y2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 17, 2006
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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