Reviewed, UniProtKB/Swiss-Prot Q0A4Y2 (DCUP_ALHEH)

Names and origin

Protein names

Recommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	Mlg_2765

Organism

Alkalilimnicola ehrlichei (strain MLHE-1) [Complete proteome] [HAMAP]

Taxonomic identifier

187272 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Ectothiorhodospiraceae › Alkalilimnicola

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity. HAMAP MF_00218
Subcellular location	Cytoplasm By similarity HAMAP MF_00218.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_1000023869
Regions
	Region	27 – 31	5	Substrate binding By similarity
Sites
	Binding site	77	1	Substrate By similarity
	Binding site	154	1	Substrate By similarity
	Binding site	209	1	Substrate By similarity
	Binding site	327	1	Substrate By similarity
	Site	77	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q0A4Y2-1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: 55E8719A1674E67C	FASTA	365	40,238
	10 20 30 40 50 60 MSVLKNDRLL RALQRQPVDR TPVWMMRQAG RYLPEYRELR AQAGSFMKLA GTPELACEVT 70 80 90 100 110 120 LQPLRRFPLD AAILFSDILT IPDAMGLGLR FLPGEGPVFD HPVRSAADIE HLPVPDPEDE 130 140 150 160 170 180 LRYVTDAVRL IRRELDGEVP LIGFAGSPWT LATYMIEGGS SKDYRRCKAM LYDEPELLHR 190 200 210 220 230 240 LLDKVAQATT AYLNAQIAAG AQAIMIFDSW GGALAHDAYR LFSLAYMERI VRNLTREADG 250 260 270 280 290 300 RHVPVVLFTK GGGQWLEAMA ATGCDGLGLD WTTNLGQARD RVGDRVALQG NLDPCVLYAS 310 320 330 340 350 360 PETIRNEVAR VLADYGPGPG HVFNLGHGIH PAIPPEHAGA MIDAVHQLSP RYHEQQAEAS SLTQG

References

[1]

"Complete sequence of Alkalilimnicola ehrilichei MLHE-1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000453 Genomic DNA. Translation: ABI58105.1.
RefSeq	YP_743595.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q0A4Y2.
Genome annotation databases
GeneID	4269126.
GenomeReviews	Gene locus Mlg_2765 in contig CP000453_GR.
KEGG	aeh:Mlg_2765.
NMPDR	fig|187272.6.peg.2639.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0407.
HOGENOM	HBG628392.
OMA	QIFDTWG.
PhylomeDB	Q0A4Y2.
Family and domain databases
HAMAP	MF_00218. URO-D. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_ALHEH

Accession

Primary (citable) accession number: Q0A4Y2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 17, 2006
Last modified:	February 9, 2010
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)