ID   AROE_ALHEH              Reviewed;         270 AA.
AC   Q0A4S2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=Mlg_2825;
OS   Alkalilimnicola ehrlichei (strain MLHE-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Alkalilimnicola.
OX   NCBI_TaxID=187272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Mikhailova N., Oremland R.S., Hoeft S.E., Switzer-Blum J., Kulp T.,
RA   King G., Tabita R., Witte B., Santini J.M., Basu P., Hollibaugh J.T.,
RA   Xie G., Stolz J.F., Richardson P.;
RT   "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; CP000453; ABI58165.1; -; Genomic_DNA.
DR   RefSeq; YP_743655.1; -.
DR   GeneID; 4270752; -.
DR   GenomeReviews; CP000453_GR; Mlg_2825.
DR   KEGG; aeh:Mlg_2825; -.
DR   NMPDR; fig|187272.6.peg.2699; -.
DR   HOGENOM; Q0A4S2; -.
DR   OMA; Q0A4S2; YDMMYGR.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    270       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000325097.
FT   NP_BIND     127    131       NADP (By similarity).
FT   ACT_SITE     66     66       Proton acceptor (Potential).
SQ   SEQUENCE   270 AA;  28651 MW;  5274D15E7FF18412 CRC64;
     MTDRYAVMGN PIEHSKSPEI HRMFAEQTGQ AIAYERMRVP LEGFEPAVRA FFASGGKGLN
     ITVPFKEQAW VLVDRRAPRA ERAGAVNTLL AEAGRLVGDN TDGTGLVRDL TVNHGAALQG
     RRVLVIGAGG AVRGVLPALL PEAPGEVVIA NRTVARAEAL VELFADQGRL SAVGFDRLQG
     PFDVVINGTS AGLAGELPPL PDDLLAPGAT CYDMVYGDQP TPFVRWARAH GAAMAVDGLG
     MLVEQAAESF LIWRGVRPES APVIAALRPE
//