Reviewed, UniProtKB/Swiss-Prot Q09XV5 (CHD8_MOUSE)

Names and origin

Protein names

Recommended name:
    Chromodomain-helicase-DNA-binding protein 8
      Short name=CHD-8
    EC=3.6.1.-
Alternative name(s):
    ATP-dependent helicase CHD8
    Axis duplication inhibitor
      Short name=Duplin

Gene names

Name:	Chd8
Synonyms:	Kiaa1564

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	2582 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating to efficient U6 RNA polymerase III transcription. Ref.1 Ref.6
Subunit structure	Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 By similarity. Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of a multiprotein complex of 900 kDa containing WDR5.
Subcellular location	Nucleus. Note: Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites. Ref.1
Developmental stage	Expressed predominantly from early- to mid-stage mouse embryogenesis. Detected throughout embryos from E7.5 to E9.5 but localizes predominantly in the brain, faces, branchial arches, limb buds, and tail buds of embryos at E10.5. Ref.2
Post-translational modification	Sumoylated By similarity.
Disruption phenotype	Death during early embryogenesis due to widespread apoptosis. Embryos manifest growth retardation from E5.5 and developmental arrest accompanied by massive apoptosis at E7.5. They develop into an egg cylinder but do not form a primitive streak or mesoderm. Mice lacking both Tp53 and Chd8 ameliorate this developmental arrest. Ref.6 Ref.2
Sequence similarities	Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily. Contains 2 chromo domains. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.
Sequence caution	The sequence BAC98203.2 differs from that shown. Reason: Miscellaneous discrepancy. Partially unspliced pre-RNA.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Wnt signaling pathway
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Activator Chromatin regulator Helicase Hydrolase Repressor
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Gene Ontology (GO)
Biological process	ATP-dependent chromatin remodeling Inferred from sequence or structural similarity. Source: UniProtKB Wnt receptor signaling pathway through beta-catenin Inferred from sequence or structural similarity. Source: UniProtKB chromatin assembly or disassembly Inferred from electronic annotation. Source: InterPro in utero embryonic development Ref.2 Inferred from mutant phenotype. Source: MGI negative regulation of Wnt receptor signaling pathway Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of apoptosis Ref.2 Ref.6 Inferred from direct assay. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase III promoter Inferred from sequence or structural similarity. Source: UniProtKB transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	MLL1 complex Inferred from sequence or structural similarity. Source: UniProtKB chromatin Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from sequence or structural similarity. Source: UniProtKB DNA binding Ref.6 Inferred from direct assay. Source: UniProtKB DNA helicase activity Inferred from sequence or structural similarity. Source: UniProtKB DNA-dependent ATPase activity Inferred from sequence or structural similarity. Source: UniProtKB beta-catenin binding Inferred from sequence or structural similarity. Source: UniProtKB chromatin binding Inferred from electronic annotation. Source: InterPro methylated histone residue binding Inferred from sequence or structural similarity. Source: UniProtKB p53 binding Ref.6 Inferred from physical interaction. Source: UniProtKB transcription activator activity Inferred from sequence or structural similarity. Source: UniProtKB transcription repressor activity Ref.6 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Ctcf	Q61164	3	EBI-1169080,EBI-932785

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q09XV5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q09XV5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     745-751: PVIYYLV → VSWARRT
     752-2582: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2582	2582	Chromodomain-helicase-DNA-binding protein 8		PRO_0000367310
Regions
	Domain	644 – 711	68	Chromo 1
	Domain	726 – 792	67	Chromo 2
	Domain	825 – 999	175	Helicase ATP-binding
	Domain	1139 – 1290	152	Helicase C-terminal
	Nucleotide binding	838 – 845	8	ATP By similarity
	Motif	950 – 953	4	DEAH box
	Compositional bias	292 – 412	121	Gln-rich
	Compositional bias	1777 – 1781	5	Poly-Arg
	Compositional bias	2070 – 2099	30	Ser-rich
	Compositional bias	2494 – 2509	16	His-rich
	Compositional bias	2539 – 2582	44	Asp-rich
Amino acid modifications
	Modified residue	539	1	Phosphothreonine By similarity
	Modified residue	552	1	Phosphoserine By similarity
	Modified residue	555	1	Phosphoserine By similarity
	Modified residue	564	1	Phosphoserine By similarity
	Modified residue	1400	1	Phosphothreonine By similarity
	Modified residue	1422	1	Phosphoserine Ref.5
	Modified residue	1426	1	Phosphoserine Ref.5
	Modified residue	1978	1	Phosphoserine By similarity
	Modified residue	1995	1	Phosphothreonine By similarity
	Modified residue	1997	1	Phosphoserine By similarity
	Modified residue	2010	1	Phosphoserine By similarity
	Modified residue	2070	1	Phosphoserine By similarity
	Modified residue	2072	1	Phosphoserine By similarity
	Modified residue	2184	1	Phosphoserine By similarity
	Modified residue	2202	1	Phosphoserine By similarity
	Modified residue	2204	1	Phosphoserine By similarity
	Modified residue	2213	1	Phosphoserine By similarity
	Modified residue	2519	1	Phosphoserine By similarity
	Modified residue	2520	1	Phosphoserine By similarity
	Cross-link	611		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Natural variations
	Alternative sequence	745 – 751	7	PVIYYLV → VSWARRT in isoform 2.		VSP_036676
	Alternative sequence	752 – 2582	1831	Missing in isoform 2.		VSP_036677
Experimental info
	Sequence conflict	21	1	T → A in AAW56421. Ref.2
	Sequence conflict	2020	1	N → S in BAC98203. Ref.3
	Sequence conflict	2298	1	L → V in BAC98203. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: D9432500F6A8C329	FASTA	2,582	290,847
	10 20 30 40 50 60 MADPIMDLFD DPNLFGLDSL TDDSFNQVTQ DPIEEALGLP SSLDSLDQMN QDGGGGDVGN 70 80 90 100 110 120 SSASDLVPPP EETASTELPK ESTAPAPESL TLHDYTTQPT SQEQPAQPVL QTSTPTAGLL 130 140 150 160 170 180 QVSKSQEILS QGNPFMGVSA TGVSPSNTGG QPSQSAPKIV ILKAPPNSSV TGTHVAQIQA 190 200 210 220 230 240 QGITSTAQPL VAGTANGGKV TFTKVLTGTP LRPGVSIVSG NTVLATKVPG NQAAVQRIVQ 250 260 270 280 290 300 PSRPVKQLVL QPVKGSAPAG NPGAAGPPLK PAVTLTSTPT QGESKRITLV LQQPQSGGPQ 310 320 330 340 350 360 GHRHVVLGSL PGKIVLQGNQ LAALTQAKNA QGQPAKVVTI QLQVQQPQQK IQIVPQPPSS 370 380 390 400 410 420 QPQPQPQPPP SAQPLTLSSV QQAQIMGPGQ NPGQRLSVPL KMVLQPQAGS SQGASSGLSV 430 440 450 460 470 480 VKVLSASEVA ALSSPASCAP HTAGKTGMEE NRRLEHQKKQ EKANRIVAEA IARARARGEQ 490 500 510 520 530 540 NIPRVLNEDE LPSVRPEEEG EKKRRKKSSG ERLKEEKPKK SKTAAASKTK GKSKLNTITP 550 560 570 580 590 600 VVGKKRKRNT SSDNSDVEVM PAQSPREDEE SSIQKRRSNR QVKRKKYTED LDIKITDDEE 610 620 630 640 650 660 EEEVDVTGPI KPEPILPEPV QEPDGETLPS MQFFVENPSE EDAAIVDKVL SMRVVKKELP 670 680 690 700 710 720 SGQYTEAEEF FVKYKNYSYL HCEWATISQL EKDKRIHQKL KRFKTKMAQM RHFFHEDEEP 730 740 750 760 770 780 FNPDYVEVDR ILDESHSVDK DNGEPVIYYL VKWCSLPYED STWELKEDVD EGKIREFKRI 790 800 810 820 830 840 QSRHPELRRV NRPQANAWKK LELSHEYKNR NQLREYQLEG VNWLLFNWYN RQNCILADEM 850 860 870 880 890 900 GLGKTIQSIA FLQEVYNVGI HGPFLVIAPL STITNWEREF NTWTEMNTIV YHGSLASRQM 910 920 930 940 950 960 IQQYEMYCKD SRGRLIPGAY KFDALITTFE MILSDCPELR EIEWRCVIID EAHRLKNRNC 970 980 990 1000 1010 1020 KLLDSLKHMD LEHKVLLTGT PLQNTVEELF SLLHFLEPSQ FPSESEFLKD FGDLKTEEQV 1030 1040 1050 1060 1070 1080 QKLQAILKPM MLRRLKEDVE KNLAPKQETI IEVELTNIQK KYYRAILEKN FSFLSKGAGH 1090 1100 1110 1120 1130 1140 TNMPNLLNTM MELRKCCNHP YLINGAEEKI LMEFREACHI IPQDFHLQAM VRSAGKLVLI 1150 1160 1170 1180 1190 1200 DKLLPKLKAG GHKVLIFSQM VRCLDILEDY LIQRRYLYER IDGRVRGNLR QAAIDRFSKP 1210 1220 1230 1240 1250 1260 DSDRFVFLLC TRAGGLGINL TAADTCIIFD SDWNPQNDLQ AQARCHRIGQ SKAVKVYRLI 1270 1280 1290 1300 1310 1320 TRNSYEREMF DKASLKLGLD KAVLQSMSGR DGNITGIQQF SKKEIEDLLR KGAYAAIMEE 1330 1340 1350 1360 1370 1380 DDEGSKFCEE DIDQILLRRT TTITIESEGK GSTFAKASFV ASENRTDISL DDPNFWQKWA 1390 1400 1410 1420 1430 1440 KKADLDMDLL NSKNNLVIDT PRVRKQTRHF STLKDDDLVE FSDLESEDDE RPRSRRHDRH 1450 1460 1470 1480 1490 1500 HTYGRTDCFR VEKHLLVYGW GRWRDILSHG RFKRRMTERD VETICRAILV YCLLHYRGDE 1510 1520 1530 1540 1550 1560 NIKSFIWDLI SPAENGKTKE LQNHSGLSIP VPRGRKGKKV KSQSTFDIHK ADWIRKYNPD 1570 1580 1590 1600 1610 1620 TLFQDESYKK HLKHQCNKVL LRVRMLYYLR QEVIGDQAEK VLGGAIASEI DIWFPVVDQL 1630 1640 1650 1660 1670 1680 EVPTTWWDSE ADKSLLIGVF KHGYEKYNTM RADPALCFLE KAGRPDDKAI AAEHRVLDNF 1690 1700 1710 1720 1730 1740 SDLVEGIDFD KDCEDPEYKP LQGPPKDPDD EGDPLMMMDE EISVIDGEEA QVTQQPGHLF 1750 1760 1770 1780 1790 1800 WPPGSALTAR LRRLVTAYQR SYKREQMKME AAERGDRRRR RCEAAFKLKE IARREKQQRW 1810 1820 1830 1840 1850 1860 TRREQTDFYR VVSTFGVEYD PDNMQFHWDR FRTFARLDKK TDESLTKYFH GFVAMCRQVC 1870 1880 1890 1900 1910 1920 RLPPAAGDEP PDPNLFIEPI TEERASRTLY RIELLRRLRE QVLCHPLLED RLALCQPPGL 1930 1940 1950 1960 1970 1980 ELPKWWEPVR HDGELLRGAA RHGVSQTDCN IMQDPDFSFL AARMNYMQNH QAGASAASLS 1990 2000 2010 2020 2030 2040 RCSTPLLHQQ CTSRTASPSP LRPDAPVEKS PEESTVQVPN LESLTLKLED EVVARSRLTS 2050 2060 2070 2080 2090 2100 QDYEVRVGSS DTAPLSRSVP PVKLEDEDDS DSELDLSKLS PSSSSSSSSS SSSSSTDESE 2110 2120 2130 2140 2150 2160 DEKEEKLTAD RSRPKLYDEE SLLSLTMSQD GFPNEDGEQM TPELLLLQER QRASEWPKDR 2170 2180 2190 2200 2210 2220 VLINRIDLVC QAVLSGKWPS NRRSQEVTAG GILGPGNHLL DSPSLTPGED GDSPVPTPRS 2230 2240 2250 2260 2270 2280 GSAASMAEEE ASAVTTAAAQ FTKLRRGMDE KEFTVQIKDE EGLKLTFQKH RLMANGVMGD 2290 2300 2310 2320 2330 2340 GHPLFHKKKG NRKKLVELEV ECMEEPNHLD LDLETRIPVI NKVDGTLLVG DEAPRRAELE 2350 2360 2370 2380 2390 2400 MWLQGHPEFA VDPRFLAYME ERRKQKWQRC KKNNKAELNC LGMEPVQPAN SRNGKKGHYA 2410 2420 2430 2440 2450 2460 ETAFNRVLPG PVAPENSKKR VRRTRPDLSK MMALMQGGST GSLSLHNTFQ HSSSNLQSVS 2470 2480 2490 2500 2510 2520 SLGHSSTTSA SLPFMPFVMG AAAPPHVDSS TMLHHHHHHP HPHHHHHHHP GLRTTGYPSS 2530 2540 2550 2560 2570 2580 PATTTSGTAL RLPTLQPEDD DEEEDEEDDD LSQGYDSSER DFSLIDDPMM PANSDSSEDA DD
	Isoform 2. Checksum: 23F272C1595F2A90	FASTA	751	80,950
	10 20 30 40 50 60 MADPIMDLFD DPNLFGLDSL TDDSFNQVTQ DPIEEALGLP SSLDSLDQMN QDGGGGDVGN 70 80 90 100 110 120 SSASDLVPPP EETASTELPK ESTAPAPESL TLHDYTTQPT SQEQPAQPVL QTSTPTAGLL 130 140 150 160 170 180 QVSKSQEILS QGNPFMGVSA TGVSPSNTGG QPSQSAPKIV ILKAPPNSSV TGTHVAQIQA 190 200 210 220 230 240 QGITSTAQPL VAGTANGGKV TFTKVLTGTP LRPGVSIVSG NTVLATKVPG NQAAVQRIVQ 250 260 270 280 290 300 PSRPVKQLVL QPVKGSAPAG NPGAAGPPLK PAVTLTSTPT QGESKRITLV LQQPQSGGPQ 310 320 330 340 350 360 GHRHVVLGSL PGKIVLQGNQ LAALTQAKNA QGQPAKVVTI QLQVQQPQQK IQIVPQPPSS 370 380 390 400 410 420 QPQPQPQPPP SAQPLTLSSV QQAQIMGPGQ NPGQRLSVPL KMVLQPQAGS SQGASSGLSV 430 440 450 460 470 480 VKVLSASEVA ALSSPASCAP HTAGKTGMEE NRRLEHQKKQ EKANRIVAEA IARARARGEQ 490 500 510 520 530 540 NIPRVLNEDE LPSVRPEEEG EKKRRKKSSG ERLKEEKPKK SKTAAASKTK GKSKLNTITP 550 560 570 580 590 600 VVGKKRKRNT SSDNSDVEVM PAQSPREDEE SSIQKRRSNR QVKRKKYTED LDIKITDDEE 610 620 630 640 650 660 EEEVDVTGPI KPEPILPEPV QEPDGETLPS MQFFVENPSE EDAAIVDKVL SMRVVKKELP 670 680 690 700 710 720 SGQYTEAEEF FVKYKNYSYL HCEWATISQL EKDKRIHQKL KRFKTKMAQM RHFFHEDEEP 730 740 750 FNPDYVEVDR ILDESHSVDK DNGEVSWARR T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CTCF-dependent chromatin insulator is linked to epigenetic remodeling." Ishihara K., Oshimura M., Nakao M. Mol. Cell 23:733-742(2006) [PubMed: 16949368] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CTCF, SUBCELLULAR LOCATION. Tissue: Embryo.
[2]	"Early embryonic death in mice lacking the beta-catenin-binding protein Duplin." Nishiyama M., Nakayama K., Tsunematsu R., Tsukiyama T., Kikuchi A., Nakayama K.I. Mol. Cell. Biol. 24:8386-8394(2004) [PubMed: 15367660] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
[3]	"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H. DNA Res. 10:167-180(2003) [PubMed: 14621295] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1730-2582. Tissue: Brain.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2020-2582. Strain: C57BL/6J. Tissue: Thymus.
[5]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1422 AND SER-1426, MASS SPECTROMETRY.
[6]	"CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis." Nishiyama M., Oshikawa K., Tsukada Y.I., Nakagawa T., Iemura S., Natsume T., Fan Y., Kikuchi A., Skoultchi A.I., Nakayama K.I. Nat. Cell Biol. 11:172-182(2009) [PubMed: 19151705] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH TP53 AND HISTONE H1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ190419 mRNA. Translation: ABB02259.1. AY863219 mRNA. Translation: AAW56421.1. AK129393 Transcribed RNA. Translation: BAC98203.2. Sequence problems. AK160299 mRNA. Translation: BAE35730.1.
IPI	IPI00858099. IPI00923681.
RefSeq	NP_963999.2.
UniGene	Mm.289934
3D structure databases
SMR	Q09XV5. Positions 641-778, 722-781, 811-1312, 1798-1960, 2305-2417.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q09XV5. 1 interaction.
STRING	Q09XV5.
PTM databases
PhosphoSite	Q09XV5.
Proteomic databases
PRIDE	Q09XV5.
Genome annotation databases
Ensembl	ENSMUST00000089752; ENSMUSP00000087184; ENSMUSG00000053754; Mus musculus. [Genome view]
GeneID	67772.
KEGG	mmu:67772.
UCSC	uc007tot.1. mouse.
Organism-specific databases
CTD	67772.
MGI	MGI:1915022. Chd8.
Rouge	Search...
Phylogenomic databases
eggNOG	maNOG22665.
HOGENOM	HBG446013.
HOVERGEN	Q09XV5.
InParanoid	Q09XV5.
OMA	KDQDDEG.
OrthoDB	EOG92JRB5.
PhylomeDB	Q09XV5.
Gene expression databases
ArrayExpress	Q09XV5.
Bgee	Q09XV5.
Genevestigator	Q09XV5.
Family and domain databases
InterPro	IPR006576. BRK_domain. IPR000953. Chromodomain. IPR016197. Chromodomain-like. IPR014001. DEAD-like_N. IPR001650. DNA/RNA_helicase_C. IPR014021. Helicase_SF1/SF2_ATP-bd. IPR000330. SNF2_N. [Graphical view]
Pfam	PF07533. BRK. 2 hits. PF00385. Chromo. 2 hits. PF00271. Helicase_C. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view]
SMART	SM00592. BRK. 2 hits. SM00298. CHROMO. 2 hits. SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
PROSITE	PS00598. CHROMO_1. False negative. PS50013. CHROMO_2. 1 hit. PS00690. DEAH_ATP_HELICASE. False negative. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	325525.
SOURCE	Search...

Entry information

Entry name

CHD8_MOUSE

Accession

Primary (citable) accession number: Q09XV5
Secondary accession number(s): Q3TV89, Q5I1Z2, Q6ZPM8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	October 17, 2006
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)