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Q09XV5

- CHD8_MOUSE

UniProt

Q09XV5 - CHD8_MOUSE

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Protein
Chromodomain-helicase-DNA-binding protein 8
Gene
Chd8, Kiaa1564
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.2 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi838 – 8458ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. DNA binding Source: UniProtKB
  3. DNA helicase activity Source: UniProtKB
  4. DNA-dependent ATPase activity Source: UniProtKB
  5. beta-catenin binding Source: UniProtKB
  6. histone binding Source: UniProtKB
  7. methylated histone binding Source: UniProtKB
  8. p53 binding Source: UniProtKB
  9. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. ATP-dependent chromatin remodeling Source: UniProtKB
  3. canonical Wnt signaling pathway Source: UniProtKB
  4. in utero embryonic development Source: MGI
  5. negative regulation of Wnt signaling pathway Source: UniProtKB
  6. negative regulation of apoptotic process Source: UniProtKB
  7. negative regulation of fibroblast apoptotic process Source: MGI
  8. negative regulation of transcription, DNA-templated Source: UniProtKB
  9. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  10. positive regulation of transcription from RNA polymerase III promoter Source: UniProtKB
  11. positive regulation of transcription, DNA-templated Source: UniProtKB
  12. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Helicase, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 8 (EC:3.6.4.12)
Short name:
CHD-8
Alternative name(s):
ATP-dependent helicase CHD8
Axis duplication inhibitor
Short name:
Duplin
Gene namesi
Name:Chd8
Synonyms:Kiaa1564
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1915022. Chd8.

Subcellular locationi

Nucleus
Note: Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites.1 Publication

GO - Cellular componenti

  1. MLL1 complex Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Death during early embryogenesis due to widespread apoptosis. Embryos manifest growth retardation from E5.5 and developmental arrest accompanied by massive apoptosis at E7.5. They develop into an egg cylinder but do not form a primitive streak or mesoderm. Mice lacking both Tp53 and Chd8 ameliorate this developmental arrest.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25822582Chromodomain-helicase-DNA-binding protein 8
PRO_0000367310Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei555 – 5551Phosphoserine By similarity
Modified residuei564 – 5641Phosphoserine By similarity
Cross-linki611 – 611Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Modified residuei1422 – 14221Phosphoserine By similarity
Modified residuei1426 – 14261Phosphoserine By similarity
Modified residuei1978 – 19781Phosphoserine By similarity
Modified residuei1995 – 19951Phosphothreonine By similarity
Modified residuei2010 – 20101Phosphoserine By similarity
Modified residuei2040 – 20401Phosphoserine1 Publication
Modified residuei2070 – 20701Phosphoserine By similarity
Modified residuei2072 – 20721Phosphoserine By similarity
Modified residuei2184 – 21841Phosphoserine By similarity
Modified residuei2202 – 22021Phosphoserine By similarity
Modified residuei2213 – 22131Phosphoserine By similarity
Modified residuei2520 – 25201Phosphoserine By similarity

Post-translational modificationi

Sumoylated By similarity.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ09XV5.
PRIDEiQ09XV5.

PTM databases

PhosphoSiteiQ09XV5.

Expressioni

Developmental stagei

Expressed predominantly from early- to mid-stage mouse embryogenesis. Detected throughout embryos from E7.5 to E9.5 but localizes predominantly in the brain, faces, branchial arches, limb buds, and tail buds of embryos at E10.5.1 Publication

Gene expression databases

BgeeiQ09XV5.
GenevestigatoriQ09XV5.

Interactioni

Subunit structurei

Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7 By similarity. Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of a multiprotein complex of 900 kDa containing WDR5.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CtcfQ611643EBI-1169080,EBI-932785

Protein-protein interaction databases

BioGridi212432. 4 interactions.
IntActiQ09XV5. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ09XV5.
SMRiQ09XV5. Positions 653-781, 790-1286, 2305-2374.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini644 – 71168Chromo 1
Add
BLAST
Domaini726 – 79267Chromo 2
Add
BLAST
Domaini825 – 999175Helicase ATP-binding
Add
BLAST
Domaini1139 – 1290152Helicase C-terminal
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi950 – 9534DEAH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi292 – 412121Gln-rich
Add
BLAST
Compositional biasi1777 – 17815Poly-Arg
Compositional biasi2070 – 209930Ser-rich
Add
BLAST
Compositional biasi2494 – 250916His-rich
Add
BLAST
Compositional biasi2539 – 258244Asp-rich
Add
BLAST

Sequence similaritiesi

Contains 2 chromo domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00560000077077.
HOGENOMiHOG000246942.
HOVERGENiHBG107676.
InParanoidiQ09XV5.
KOiK04494.
OMAiFLAYMED.
OrthoDBiEOG7NSB1C.
TreeFamiTF313572.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006576. BRK_domain.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF07533. BRK. 2 hits.
PF00385. Chromo. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00592. BRK. 2 hits.
SM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEiPS50013. CHROMO_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q09XV5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADPIMDLFD DPNLFGLDSL TDDSFNQVTQ DPIEEALGLP SSLDSLDQMN     50
QDGGGGDVGN SSASDLVPPP EETASTELPK ESTAPAPESL TLHDYTTQPT 100
SQEQPAQPVL QTSTPTAGLL QVSKSQEILS QGNPFMGVSA TGVSPSNTGG 150
QPSQSAPKIV ILKAPPNSSV TGTHVAQIQA QGITSTAQPL VAGTANGGKV 200
TFTKVLTGTP LRPGVSIVSG NTVLATKVPG NQAAVQRIVQ PSRPVKQLVL 250
QPVKGSAPAG NPGAAGPPLK PAVTLTSTPT QGESKRITLV LQQPQSGGPQ 300
GHRHVVLGSL PGKIVLQGNQ LAALTQAKNA QGQPAKVVTI QLQVQQPQQK 350
IQIVPQPPSS QPQPQPQPPP SAQPLTLSSV QQAQIMGPGQ NPGQRLSVPL 400
KMVLQPQAGS SQGASSGLSV VKVLSASEVA ALSSPASCAP HTAGKTGMEE 450
NRRLEHQKKQ EKANRIVAEA IARARARGEQ NIPRVLNEDE LPSVRPEEEG 500
EKKRRKKSSG ERLKEEKPKK SKTAAASKTK GKSKLNTITP VVGKKRKRNT 550
SSDNSDVEVM PAQSPREDEE SSIQKRRSNR QVKRKKYTED LDIKITDDEE 600
EEEVDVTGPI KPEPILPEPV QEPDGETLPS MQFFVENPSE EDAAIVDKVL 650
SMRVVKKELP SGQYTEAEEF FVKYKNYSYL HCEWATISQL EKDKRIHQKL 700
KRFKTKMAQM RHFFHEDEEP FNPDYVEVDR ILDESHSVDK DNGEPVIYYL 750
VKWCSLPYED STWELKEDVD EGKIREFKRI QSRHPELRRV NRPQANAWKK 800
LELSHEYKNR NQLREYQLEG VNWLLFNWYN RQNCILADEM GLGKTIQSIA 850
FLQEVYNVGI HGPFLVIAPL STITNWEREF NTWTEMNTIV YHGSLASRQM 900
IQQYEMYCKD SRGRLIPGAY KFDALITTFE MILSDCPELR EIEWRCVIID 950
EAHRLKNRNC KLLDSLKHMD LEHKVLLTGT PLQNTVEELF SLLHFLEPSQ 1000
FPSESEFLKD FGDLKTEEQV QKLQAILKPM MLRRLKEDVE KNLAPKQETI 1050
IEVELTNIQK KYYRAILEKN FSFLSKGAGH TNMPNLLNTM MELRKCCNHP 1100
YLINGAEEKI LMEFREACHI IPQDFHLQAM VRSAGKLVLI DKLLPKLKAG 1150
GHKVLIFSQM VRCLDILEDY LIQRRYLYER IDGRVRGNLR QAAIDRFSKP 1200
DSDRFVFLLC TRAGGLGINL TAADTCIIFD SDWNPQNDLQ AQARCHRIGQ 1250
SKAVKVYRLI TRNSYEREMF DKASLKLGLD KAVLQSMSGR DGNITGIQQF 1300
SKKEIEDLLR KGAYAAIMEE DDEGSKFCEE DIDQILLRRT TTITIESEGK 1350
GSTFAKASFV ASENRTDISL DDPNFWQKWA KKADLDMDLL NSKNNLVIDT 1400
PRVRKQTRHF STLKDDDLVE FSDLESEDDE RPRSRRHDRH HTYGRTDCFR 1450
VEKHLLVYGW GRWRDILSHG RFKRRMTERD VETICRAILV YCLLHYRGDE 1500
NIKSFIWDLI SPAENGKTKE LQNHSGLSIP VPRGRKGKKV KSQSTFDIHK 1550
ADWIRKYNPD TLFQDESYKK HLKHQCNKVL LRVRMLYYLR QEVIGDQAEK 1600
VLGGAIASEI DIWFPVVDQL EVPTTWWDSE ADKSLLIGVF KHGYEKYNTM 1650
RADPALCFLE KAGRPDDKAI AAEHRVLDNF SDLVEGIDFD KDCEDPEYKP 1700
LQGPPKDPDD EGDPLMMMDE EISVIDGEEA QVTQQPGHLF WPPGSALTAR 1750
LRRLVTAYQR SYKREQMKME AAERGDRRRR RCEAAFKLKE IARREKQQRW 1800
TRREQTDFYR VVSTFGVEYD PDNMQFHWDR FRTFARLDKK TDESLTKYFH 1850
GFVAMCRQVC RLPPAAGDEP PDPNLFIEPI TEERASRTLY RIELLRRLRE 1900
QVLCHPLLED RLALCQPPGL ELPKWWEPVR HDGELLRGAA RHGVSQTDCN 1950
IMQDPDFSFL AARMNYMQNH QAGASAASLS RCSTPLLHQQ CTSRTASPSP 2000
LRPDAPVEKS PEESTVQVPN LESLTLKLED EVVARSRLTS QDYEVRVGSS 2050
DTAPLSRSVP PVKLEDEDDS DSELDLSKLS PSSSSSSSSS SSSSSTDESE 2100
DEKEEKLTAD RSRPKLYDEE SLLSLTMSQD GFPNEDGEQM TPELLLLQER 2150
QRASEWPKDR VLINRIDLVC QAVLSGKWPS NRRSQEVTAG GILGPGNHLL 2200
DSPSLTPGED GDSPVPTPRS GSAASMAEEE ASAVTTAAAQ FTKLRRGMDE 2250
KEFTVQIKDE EGLKLTFQKH RLMANGVMGD GHPLFHKKKG NRKKLVELEV 2300
ECMEEPNHLD LDLETRIPVI NKVDGTLLVG DEAPRRAELE MWLQGHPEFA 2350
VDPRFLAYME ERRKQKWQRC KKNNKAELNC LGMEPVQPAN SRNGKKGHYA 2400
ETAFNRVLPG PVAPENSKKR VRRTRPDLSK MMALMQGGST GSLSLHNTFQ 2450
HSSSNLQSVS SLGHSSTTSA SLPFMPFVMG AAAPPHVDSS TMLHHHHHHP 2500
HPHHHHHHHP GLRTTGYPSS PATTTSGTAL RLPTLQPEDD DEEEDEEDDD 2550
LSQGYDSSER DFSLIDDPMM PANSDSSEDA DD 2582
Length:2,582
Mass (Da):290,847
Last modified:October 17, 2006 - v1
Checksum:iD9432500F6A8C329
GO
Isoform 2 (identifier: Q09XV5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     745-751: PVIYYLV → VSWARRT
     752-2582: Missing.

Show »
Length:751
Mass (Da):80,950
Checksum:i23F272C1595F2A90
GO

Sequence cautioni

The sequence BAC98203.2 differs from that shown. Reason: Partially unspliced pre-RNA.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei745 – 7517PVIYYLV → VSWARRT in isoform 2.
VSP_036676
Alternative sequencei752 – 25821831Missing in isoform 2.
VSP_036677Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211T → A in AAW56421. 1 Publication
Sequence conflicti2020 – 20201N → S in BAC98203. 1 Publication
Sequence conflicti2298 – 22981L → V in BAC98203. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ190419 mRNA. Translation: ABB02259.1.
AY863219 mRNA. Translation: AAW56421.1.
AK129393 Transcribed RNA. Translation: BAC98203.2. Sequence problems.
AK160299 mRNA. Translation: BAE35730.1.
CCDSiCCDS36919.1. [Q09XV5-1]
RefSeqiNP_963999.2. NM_201637.2. [Q09XV5-1]
XP_006519539.1. XM_006519476.1. [Q09XV5-1]
UniGeneiMm.289934.

Genome annotation databases

EnsembliENSMUST00000089752; ENSMUSP00000087184; ENSMUSG00000053754. [Q09XV5-1]
GeneIDi67772.
KEGGimmu:67772.
UCSCiuc007tot.1. mouse. [Q09XV5-1]
uc007tov.1. mouse. [Q09XV5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ190419 mRNA. Translation: ABB02259.1 .
AY863219 mRNA. Translation: AAW56421.1 .
AK129393 Transcribed RNA. Translation: BAC98203.2 . Sequence problems.
AK160299 mRNA. Translation: BAE35730.1 .
CCDSi CCDS36919.1. [Q09XV5-1 ]
RefSeqi NP_963999.2. NM_201637.2. [Q09XV5-1 ]
XP_006519539.1. XM_006519476.1. [Q09XV5-1 ]
UniGenei Mm.289934.

3D structure databases

ProteinModelPortali Q09XV5.
SMRi Q09XV5. Positions 653-781, 790-1286, 2305-2374.
ModBasei Search...

Protein-protein interaction databases

BioGridi 212432. 4 interactions.
IntActi Q09XV5. 1 interaction.

PTM databases

PhosphoSitei Q09XV5.

Proteomic databases

PaxDbi Q09XV5.
PRIDEi Q09XV5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000089752 ; ENSMUSP00000087184 ; ENSMUSG00000053754 . [Q09XV5-1 ]
GeneIDi 67772.
KEGGi mmu:67772.
UCSCi uc007tot.1. mouse. [Q09XV5-1 ]
uc007tov.1. mouse. [Q09XV5-2 ]

Organism-specific databases

CTDi 57680.
MGIi MGI:1915022. Chd8.
Rougei Search...

Phylogenomic databases

eggNOGi COG0553.
GeneTreei ENSGT00560000077077.
HOGENOMi HOG000246942.
HOVERGENi HBG107676.
InParanoidi Q09XV5.
KOi K04494.
OMAi FLAYMED.
OrthoDBi EOG7NSB1C.
TreeFami TF313572.

Miscellaneous databases

ChiTaRSi CHD8. mouse.
NextBioi 325525.
PROi Q09XV5.
SOURCEi Search...

Gene expression databases

Bgeei Q09XV5.
Genevestigatori Q09XV5.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR006576. BRK_domain.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view ]
Pfami PF07533. BRK. 2 hits.
PF00385. Chromo. 2 hits.
PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
SMARTi SM00592. BRK. 2 hits.
SM00298. CHROMO. 2 hits.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF54160. SSF54160. 2 hits.
PROSITEi PS50013. CHROMO_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CTCF-dependent chromatin insulator is linked to epigenetic remodeling."
    Ishihara K., Oshimura M., Nakao M.
    Mol. Cell 23:733-742(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CTCF, SUBCELLULAR LOCATION.
    Tissue: Embryo.
  2. "Early embryonic death in mice lacking the beta-catenin-binding protein Duplin."
    Nishiyama M., Nakayama K., Tsunematsu R., Tsukiyama T., Kikuchi A., Nakayama K.I.
    Mol. Cell. Biol. 24:8386-8394(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1730-2582.
    Tissue: Brain.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2020-2582.
    Strain: C57BL/6J.
    Tissue: Thymus.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2040, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis."
    Nishiyama M., Oshikawa K., Tsukada Y.I., Nakagawa T., Iemura S., Natsume T., Fan Y., Kikuchi A., Skoultchi A.I., Nakayama K.I.
    Nat. Cell Biol. 11:172-182(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH TP53 AND HISTONE H1.

Entry informationi

Entry nameiCHD8_MOUSE
AccessioniPrimary (citable) accession number: Q09XV5
Secondary accession number(s): Q3TV89, Q5I1Z2, Q6ZPM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi