Q09GT4 (Q09GT4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Tyrosinase-related protein 2 EMBL ABI73976.1

Submitted name:
Uncharacterized protein Ensembl ENSP00000392762

Gene names

Name:

DCT Ensembl ENSP00000392762

Organism

Homo sapiens (Human) EMBL ABI73976.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	552 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Ligand	Metal-binding SAAS SAAS002227
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q09GT4 [UniParc]. Last modified October 17, 2006. Version 1. Checksum: F2B047A524167DD3	FASTA	552	62,929
	10 20 30 40 50 60 MSPLWWGFLL SCLGCKILPG AQGQFPRVCM TVDSLVNKEC CPRLGAESAN VCGSQQGRGQ 70 80 90 100 110 120 CTEVRADTRP WSGPYILRNQ DDRELWPRKF FHRTCKCTGN FAGYNCGDCK FGWTGPNCER 130 140 150 160 170 180 KKPPVIRQNI HSLSPQEREQ FLGALDLAKK RVHPDYVITT QHWLGLLGPN GTQPQFANCS 190 200 210 220 230 240 VYDFFVWLHY YSVRDTLLGP GRPYRAIDFS HQGPAFVTWH RYHLLCLERD LQRLIGNESF 250 260 270 280 290 300 ALPYWNFATG RNECDVCTDQ LFGAARPDDP TLISRNSRFS SWETVCDSLD DYNHLVTLCN 310 320 330 340 350 360 GTYEGLLRRN QMGRNSMKLP TLKDIRDCLS LQKFDNPPFF QNSTFSFRNA LEGFDKADGT 370 380 390 400 410 420 LDSQVMSLHN LVHSFLNGTN ALPHSAANDP IFVVISNRLL YNATTNILEH VRKEKATKEL 430 440 450 460 470 480 PSLHVLVLHS FTDAIFDEWM KRFNPPADAW PQELAPIGHN RMYNMVPFFP PVTNEELFLT 490 500 510 520 530 540 SDQLGYSYAI DLPVSVEETP GWPTTLLVVM GTLVALVGLF VLLAFLQYRR LRKGYTPLME 550 THLSSKRYTE EA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy." Khong H.T., Rosenberg S.A. J. Immunol. 168:951-956(2002) [PubMed: 11777994] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Melanoma EMBL ABI73976.1.
[2]	"Molecular and functional analysis of tyrosinase-related protein (TRP)-2 as a cytotoxic T lymphocyte target in patients with malignant glioma." Liu G., Khong H.T., Wheeler C.J., Yu J.S., Black K.L., Ying H. J. Immunother. 26:301-312(2003) [PubMed: 12843792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Melanoma EMBL ABI73976.1.
[3]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
[5]	Khong H.T. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Melanoma EMBL ABI73976.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL139318 Genomic DNA. No translation available. DQ902581 mRNA. Translation: ABI73976.1.
IPI	IPI00798153.
RefSeq	NP_001123361.1. NM_001129889.1.
UniGene	Hs.301865.
3D structure databases
ProteinModelPortal	Q09GT4.
SMR	Q09GT4. Positions 125-490.
ModBase	Search...
Protein-protein interaction databases
STRING	Q09GT4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000446125; ENSP00000392762; ENSG00000080166.
GeneID	1638.
KEGG	hsa:1638.
UCSC	uc010afh.1. human.
Organism-specific databases
CTD	1638.
HGNC	HGNC:2709. DCT.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG447182.
HOVERGEN	HBG003553.
OMA	WPRKFFN.
OrthoDB	EOG4B5P4T.
Gene expression databases
ArrayExpress	Q09GT4.
Bgee	Q09GT4.
Family and domain databases
InterPro	IPR002227. Tyrosinase. IPR008922. Unchr_di-copper_centre. [Graphical view]
Gene3D	G3DSA:1.10.1280.10. Di-copper_centre. 2 hits.
KO	K01827.
Pfam	PF00264. Tyrosinase. 1 hit. [Graphical view]
PRINTS	PR00092. TYROSINASE.
SUPFAM	SSF48056. Di-copper_centre. 2 hits.
PROSITE	PS00497. TYROSINASE_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	6730.

Entry information

Entry name

Q09GT4_HUMAN

Accession

Primary (citable) accession number: Q09GT4

Entry history

Integrated into UniProtKB/TrEMBL:	October 17, 2006
Last sequence update:	October 17, 2006
Last modified:	November 16, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.