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Q09996 (SYLC_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:lrs-1
ORF Names:R74.1
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1186 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11861186Leucine--tRNA ligase
PRO_0000152152

Regions

Motif50 – 6011"HIGH" region
Motif718 – 7225"KMSKS" region

Sites

Binding site7211ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09996 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 7CC479B71AB53979

FASTA1,186134,520
        10         20         30         40         50         60 
MSKINKERKK VAQLQEIEKS IQELWESKKA FEADARDDGK PKYLVTFPFP YMNGRLHLGH 

        70         80         90        100        110        120 
TFSASKCEFA AGFQRLQGKE VLFPFGFHCT GMPIKACADK LKREMQDFGY PPNFPEDVVE 

       130        140        150        160        170        180 
EVKEEVSAVD EIIKDKSKGK KSKLVAKTGN AKYQWQIMKS LGLCDEEIKE FSDPNHWLYY 

       190        200        210        220        230        240 
FPPHCIADLK KMGLKADWRR SFITTDVNPY FDSFVRWQFN LLRAAKKIDF GKRYTIYSPK 

       250        260        270        280        290        300 
DGQPCMDHDR ASGEGVGPQE YTLIKLKVLD PKPQALSHIK EDIYLVAATL RPETMYGQTN 

       310        320        330        340        350        360 
CYLHPDIQYS VFYATENEKQ VFVATARSAR IMSYQGLTKE NGKVNYVLGL EKIAGSKILG 

       370        380        390        400        410        420 
APLSAPLAKY ERVYALPMLT IKDDKGTGVV TSVPSDSPDD FAALSDLKKK KPLREKYGLT 

       430        440        450        460        470        480 
DEMVLPFEPV PIIKIEGLGD LAAVEMCSRL KIESQNEKDK LEEAKKEVYL KGFYDGVMLV 

       490        500        510        520        530        540 
GKYAGKKTAD VKKVIQDDLT AEGLATKYVE PEKKVMSRSG DECVVALCDQ WYLNYGEAEW 

       550        560        570        580        590        600 
KAAAKKVLEP LRTFNDETRR GLETTVDWLH EYACSRSYGL GTKLPWDTQY LIESLSDSTI 

       610        620        630        640        650        660 
YNAYYTVAHL LQQGAFDGSV VGPAGIKADQ MTDASWSYVF LGEIYDSKTM PVEEEKLKSL 

       670        680        690        700        710        720 
RKEFMYWYPI DMRASGKDLI GNHLTYLLFN HAAIWPTDTS KWPKGIRANG HLLLNNEKMS 

       730        740        750        760        770        780 
KSTGNFMTLE EAIEKFSADG MRLSLADAGD GLEDANFVYA MADAAILRLF TMIEWIKEMI 

       790        800        810        820        830        840 
EQRDAGLLRK DAKKFADRVF ANEMNSLIAA TEQNYEATNF KDALKTGFFE YQAIRDTYRE 

       850        860        870        880        890        900 
LCAGIDEPMS ESLVFRFIET QMLILSPICP HIAEYIWQLL GKDGLIVNAP WPTVDPVDEK 

       910        920        930        940        950        960 
LAIGARFITE SLAEFRARLK TYMTPKKKAL KEIPEVPTEA VIYVAKEYPP WQKTILDILE 

       970        980        990       1000       1010       1020 
KQAKANNGAL PDNKAISQLI GKEESLKKFA KKAMPFVQMI KERFEQKGVS ALASSSPVDQ 

      1030       1040       1050       1060       1070       1080 
TSILNENIDF IMNALDLDRV TIRHTDEEGI DANIVETTVP LVPMLNFTPN RPTIKLVARN 

      1090       1100       1110       1120       1130       1140 
VQICNAMFDV DVPIVNGDSV SMVIRKMRRI SKAIKPKFEV SLWRYKNAVW GDRQMISYRN 

      1150       1160       1170       1180 
PFEENIQLSD ADIFNFEADN KISVTSGSEK FDLGRTIVYK ANVPEN 

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z36238, Z46787 Genomic DNA. Translation: CAA85280.1.
PIRT19334.
RefSeqNP_497837.1. NM_065436.5.
UniGeneCel.34027.

3D structure databases

ProteinModelPortalQ09996.
SMRQ09996. Positions 14-944.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid40775. 2 interactions.
IntActQ09996. 1 interaction.
STRING6239.R74.1.1.

Proteomic databases

PaxDbQ09996.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaR74.1.1; R74.1.1; WBGene00003073.
R74.1.2; R74.1.2; WBGene00003073.
GeneID175538.
KEGGcel:CELE_R74.1.
UCSCR74.1.1. c. elegans.

Organism-specific databases

CTD175538.
WormBaseR74.1; CE16317; WBGene00003073; lars-1.

Phylogenomic databases

eggNOGCOG0495.
GeneTreeENSGT00390000012163.
HOGENOMHOG000216621.
InParanoidQ09996.
KOK01869.
OMAFDENVAN.
PhylomeDBQ09996.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsTIGR00395. leuS_arch. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio888576.

Entry information

Entry nameSYLC_CAEEL
AccessionPrimary (citable) accession number: Q09996
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: June 11, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries