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Q09996

- SYLC_CAEEL

UniProt

Q09996 - SYLC_CAEEL

Protein

Leucine--tRNA ligase

Gene

lrs-1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei721 – 7211ATPBy similarity

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. leucine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligase (EC:6.1.1.4)
    Alternative name(s):
    Leucyl-tRNA synthetase
    Short name:
    LeuRS
    Gene namesi
    Name:lrs-1
    ORF Names:R74.1
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome III

    Organism-specific databases

    WormBaseiR74.1; CE16317; WBGene00003073; lars-1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11861186Leucine--tRNA ligasePRO_0000152152Add
    BLAST

    Proteomic databases

    PaxDbiQ09996.

    Interactioni

    Protein-protein interaction databases

    BioGridi40775. 2 interactions.
    IntActiQ09996. 1 interaction.
    STRINGi6239.R74.1.1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09996.
    SMRiQ09996. Positions 14-944.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi50 – 6011"HIGH" regionAdd
    BLAST
    Motifi718 – 7225"KMSKS" region

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0495.
    GeneTreeiENSGT00390000012163.
    HOGENOMiHOG000216621.
    InParanoidiQ09996.
    KOiK01869.
    OMAiFDENVAN.
    PhylomeDBiQ09996.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09996-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKINKERKK VAQLQEIEKS IQELWESKKA FEADARDDGK PKYLVTFPFP     50
    YMNGRLHLGH TFSASKCEFA AGFQRLQGKE VLFPFGFHCT GMPIKACADK 100
    LKREMQDFGY PPNFPEDVVE EVKEEVSAVD EIIKDKSKGK KSKLVAKTGN 150
    AKYQWQIMKS LGLCDEEIKE FSDPNHWLYY FPPHCIADLK KMGLKADWRR 200
    SFITTDVNPY FDSFVRWQFN LLRAAKKIDF GKRYTIYSPK DGQPCMDHDR 250
    ASGEGVGPQE YTLIKLKVLD PKPQALSHIK EDIYLVAATL RPETMYGQTN 300
    CYLHPDIQYS VFYATENEKQ VFVATARSAR IMSYQGLTKE NGKVNYVLGL 350
    EKIAGSKILG APLSAPLAKY ERVYALPMLT IKDDKGTGVV TSVPSDSPDD 400
    FAALSDLKKK KPLREKYGLT DEMVLPFEPV PIIKIEGLGD LAAVEMCSRL 450
    KIESQNEKDK LEEAKKEVYL KGFYDGVMLV GKYAGKKTAD VKKVIQDDLT 500
    AEGLATKYVE PEKKVMSRSG DECVVALCDQ WYLNYGEAEW KAAAKKVLEP 550
    LRTFNDETRR GLETTVDWLH EYACSRSYGL GTKLPWDTQY LIESLSDSTI 600
    YNAYYTVAHL LQQGAFDGSV VGPAGIKADQ MTDASWSYVF LGEIYDSKTM 650
    PVEEEKLKSL RKEFMYWYPI DMRASGKDLI GNHLTYLLFN HAAIWPTDTS 700
    KWPKGIRANG HLLLNNEKMS KSTGNFMTLE EAIEKFSADG MRLSLADAGD 750
    GLEDANFVYA MADAAILRLF TMIEWIKEMI EQRDAGLLRK DAKKFADRVF 800
    ANEMNSLIAA TEQNYEATNF KDALKTGFFE YQAIRDTYRE LCAGIDEPMS 850
    ESLVFRFIET QMLILSPICP HIAEYIWQLL GKDGLIVNAP WPTVDPVDEK 900
    LAIGARFITE SLAEFRARLK TYMTPKKKAL KEIPEVPTEA VIYVAKEYPP 950
    WQKTILDILE KQAKANNGAL PDNKAISQLI GKEESLKKFA KKAMPFVQMI 1000
    KERFEQKGVS ALASSSPVDQ TSILNENIDF IMNALDLDRV TIRHTDEEGI 1050
    DANIVETTVP LVPMLNFTPN RPTIKLVARN VQICNAMFDV DVPIVNGDSV 1100
    SMVIRKMRRI SKAIKPKFEV SLWRYKNAVW GDRQMISYRN PFEENIQLSD 1150
    ADIFNFEADN KISVTSGSEK FDLGRTIVYK ANVPEN 1186
    Length:1,186
    Mass (Da):134,520
    Last modified:May 30, 2000 - v2
    Checksum:i7CC479B71AB53979
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36238, Z46787 Genomic DNA. Translation: CAA85280.1.
    PIRiT19334.
    RefSeqiNP_497837.1. NM_065436.5.
    UniGeneiCel.34027.

    Genome annotation databases

    EnsemblMetazoaiR74.1.1; R74.1.1; WBGene00003073.
    R74.1.2; R74.1.2; WBGene00003073.
    GeneIDi175538.
    KEGGicel:CELE_R74.1.
    UCSCiR74.1.1. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36238 , Z46787 Genomic DNA. Translation: CAA85280.1 .
    PIRi T19334.
    RefSeqi NP_497837.1. NM_065436.5.
    UniGenei Cel.34027.

    3D structure databases

    ProteinModelPortali Q09996.
    SMRi Q09996. Positions 14-944.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 40775. 2 interactions.
    IntActi Q09996. 1 interaction.
    STRINGi 6239.R74.1.1.

    Proteomic databases

    PaxDbi Q09996.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai R74.1.1 ; R74.1.1 ; WBGene00003073 .
    R74.1.2 ; R74.1.2 ; WBGene00003073 .
    GeneIDi 175538.
    KEGGi cel:CELE_R74.1.
    UCSCi R74.1.1. c. elegans.

    Organism-specific databases

    CTDi 175538.
    WormBasei R74.1 ; CE16317 ; WBGene00003073 ; lars-1.

    Phylogenomic databases

    eggNOGi COG0495.
    GeneTreei ENSGT00390000012163.
    HOGENOMi HOG000216621.
    InParanoidi Q09996.
    KOi K01869.
    OMAi FDENVAN.
    PhylomeDBi Q09996.

    Miscellaneous databases

    NextBioi 888576.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiSYLC_CAEEL
    AccessioniPrimary (citable) accession number: Q09996
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3