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Q09996

- SYLC_CAEEL

UniProt

Q09996 - SYLC_CAEEL

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Protein

Leucine--tRNA ligase

Gene
lrs-1, R74.1
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei721 – 7211ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. leucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:lrs-1
ORF Names:R74.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome III

Organism-specific databases

WormBaseiR74.1; CE16317; WBGene00003073; lars-1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11861186Leucine--tRNA ligasePRO_0000152152Add
BLAST

Proteomic databases

PaxDbiQ09996.

Interactioni

Protein-protein interaction databases

BioGridi40775. 2 interactions.
IntActiQ09996. 1 interaction.
STRINGi6239.R74.1.1.

Structurei

3D structure databases

ProteinModelPortaliQ09996.
SMRiQ09996. Positions 14-944.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 6011"HIGH" regionAdd
BLAST
Motifi718 – 7225"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
GeneTreeiENSGT00390000012163.
HOGENOMiHOG000216621.
InParanoidiQ09996.
KOiK01869.
OMAiFDENVAN.
PhylomeDBiQ09996.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09996-1 [UniParc]FASTAAdd to Basket

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MSKINKERKK VAQLQEIEKS IQELWESKKA FEADARDDGK PKYLVTFPFP     50
YMNGRLHLGH TFSASKCEFA AGFQRLQGKE VLFPFGFHCT GMPIKACADK 100
LKREMQDFGY PPNFPEDVVE EVKEEVSAVD EIIKDKSKGK KSKLVAKTGN 150
AKYQWQIMKS LGLCDEEIKE FSDPNHWLYY FPPHCIADLK KMGLKADWRR 200
SFITTDVNPY FDSFVRWQFN LLRAAKKIDF GKRYTIYSPK DGQPCMDHDR 250
ASGEGVGPQE YTLIKLKVLD PKPQALSHIK EDIYLVAATL RPETMYGQTN 300
CYLHPDIQYS VFYATENEKQ VFVATARSAR IMSYQGLTKE NGKVNYVLGL 350
EKIAGSKILG APLSAPLAKY ERVYALPMLT IKDDKGTGVV TSVPSDSPDD 400
FAALSDLKKK KPLREKYGLT DEMVLPFEPV PIIKIEGLGD LAAVEMCSRL 450
KIESQNEKDK LEEAKKEVYL KGFYDGVMLV GKYAGKKTAD VKKVIQDDLT 500
AEGLATKYVE PEKKVMSRSG DECVVALCDQ WYLNYGEAEW KAAAKKVLEP 550
LRTFNDETRR GLETTVDWLH EYACSRSYGL GTKLPWDTQY LIESLSDSTI 600
YNAYYTVAHL LQQGAFDGSV VGPAGIKADQ MTDASWSYVF LGEIYDSKTM 650
PVEEEKLKSL RKEFMYWYPI DMRASGKDLI GNHLTYLLFN HAAIWPTDTS 700
KWPKGIRANG HLLLNNEKMS KSTGNFMTLE EAIEKFSADG MRLSLADAGD 750
GLEDANFVYA MADAAILRLF TMIEWIKEMI EQRDAGLLRK DAKKFADRVF 800
ANEMNSLIAA TEQNYEATNF KDALKTGFFE YQAIRDTYRE LCAGIDEPMS 850
ESLVFRFIET QMLILSPICP HIAEYIWQLL GKDGLIVNAP WPTVDPVDEK 900
LAIGARFITE SLAEFRARLK TYMTPKKKAL KEIPEVPTEA VIYVAKEYPP 950
WQKTILDILE KQAKANNGAL PDNKAISQLI GKEESLKKFA KKAMPFVQMI 1000
KERFEQKGVS ALASSSPVDQ TSILNENIDF IMNALDLDRV TIRHTDEEGI 1050
DANIVETTVP LVPMLNFTPN RPTIKLVARN VQICNAMFDV DVPIVNGDSV 1100
SMVIRKMRRI SKAIKPKFEV SLWRYKNAVW GDRQMISYRN PFEENIQLSD 1150
ADIFNFEADN KISVTSGSEK FDLGRTIVYK ANVPEN 1186
Length:1,186
Mass (Da):134,520
Last modified:May 30, 2000 - v2
Checksum:i7CC479B71AB53979
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36238, Z46787 Genomic DNA. Translation: CAA85280.1.
PIRiT19334.
RefSeqiNP_497837.1. NM_065436.5.
UniGeneiCel.34027.

Genome annotation databases

EnsemblMetazoaiR74.1.1; R74.1.1; WBGene00003073.
R74.1.2; R74.1.2; WBGene00003073.
GeneIDi175538.
KEGGicel:CELE_R74.1.
UCSCiR74.1.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36238 , Z46787 Genomic DNA. Translation: CAA85280.1 .
PIRi T19334.
RefSeqi NP_497837.1. NM_065436.5.
UniGenei Cel.34027.

3D structure databases

ProteinModelPortali Q09996.
SMRi Q09996. Positions 14-944.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 40775. 2 interactions.
IntActi Q09996. 1 interaction.
STRINGi 6239.R74.1.1.

Proteomic databases

PaxDbi Q09996.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai R74.1.1 ; R74.1.1 ; WBGene00003073 .
R74.1.2 ; R74.1.2 ; WBGene00003073 .
GeneIDi 175538.
KEGGi cel:CELE_R74.1.
UCSCi R74.1.1. c. elegans.

Organism-specific databases

CTDi 175538.
WormBasei R74.1 ; CE16317 ; WBGene00003073 ; lars-1.

Phylogenomic databases

eggNOGi COG0495.
GeneTreei ENSGT00390000012163.
HOGENOMi HOG000216621.
InParanoidi Q09996.
KOi K01869.
OMAi FDENVAN.
PhylomeDBi Q09996.

Miscellaneous databases

NextBioi 888576.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiSYLC_CAEEL
AccessioniPrimary (citable) accession number: Q09996
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 30, 2000
Last modified: June 11, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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