Reviewed, UniProtKB/Swiss-Prot Q09994 (ANI2_CAEEL)

Names and origin

Protein names

Recommended name:
    Anillin-like protein 2

Gene names

Name:	ani-2
ORF Names:	K10B2.5

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	1009 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Required to maintain the structure of the rachis, the central cytoplasmic core of the syncytial adult gonad. Failure to maintain the rachis leads to premature dissociation of oocytes and thereby impedes oogenesis. Ref.2
Tissue specificity	Localizes to the surface of the rachis. Ref.2
Developmental stage	Enriched in adults. Ref.2
Sequence similarities	Contains 1 PH domain.

Ontologies

Keywords
Biological process	Differentiation Oogenesis
Domain	Coiled coil
Molecular function	Developmental protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	body morphogenesis Inferred from mutant phenotype. Source: WormBase cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW embryonic development ending in birth or egg hatching Inferred from mutant phenotype. Source: WormBase negative regulation of multicellular organism growth Inferred from mutant phenotype. Source: WormBase oogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1009	1009	Anillin-like protein 2		PRO_0000227970
Regions
	Domain	892 – 1005	114	PH
	Coiled coil	626 – 657	32	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q09994-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 6B2D842697E7FAE3	FASTA	1,009	115,020
	10 20 30 40 50 60 MYRRENINFS HPPQLKSPPP MSSPLDSNRS YRWTSLTAAN NSKFADTPVK ETPQKPDMSW 70 80 90 100 110 120 WSPSRGDTWR LNAPRGRTLD LVAAFDQCSR QDQLDSPRYA NLGRYRRNSE PMQDNEKEVV 130 140 150 160 170 180 TTNFIDDSMI EDHEEYEEHD IELGTDFYDP HMIRHHRSSE RFEQSLGTGQ QIETIHISTR 190 200 210 220 230 240 LVPQLKRVPN SDYANDGRGD MKEYGSISKK NETPILDGTP KRPSPLTTRN IHKVDINRMD 250 260 270 280 290 300 HLMKTENTVA GFITLTPQVS KVTHKSDFSK HFGQEESVRA SPMSRRNRRG TQTIVLPSFD 310 320 330 340 350 360 SPASVRKSIP SPGLPTKTDI RSPSSLVKSI ANDFEKADFG FHRKIDAAEE IAQLRKRADN 370 380 390 400 410 420 STFDENQNMV SDSAEDNVSN DFVPRISHLE MHPSVHMGIS GYAKKNHVPY GESNEEVLYS 430 440 450 460 470 480 LPIKKQSRNV DREGMDQTDE ILLTPRAITM RQSLPFSDIP EERTCDKIDE MFDFVEVPTG 490 500 510 520 530 540 DYDDKTTLER TVDGYAEVKS QKSPNKMIRN RLDLSTNTYQ EIEFEKDTTP YMQEFEEDGT 550 560 570 580 590 600 GYSASSSGPQ FTRSPTLVTP HAGQSVAEYR VSDKEGCAKT EKVVVQKMSQ PSALATSTPK 610 620 630 640 650 660 GTFAWRNKNQ SNAADDSFVS SISNFSAADK INDSKRQISK LIETIEKTRK HIQLAEISLI 670 680 690 700 710 720 DAKRAQMVVQ ELASQRVLLI CRERLKLQLD EVRRLQALSV VRHPPPPINR HFKSAMVISN 730 740 750 760 770 780 IAIHLNKNFN CRGSFAFIVA LKCRTEIEAT GVVTLLAHYQ TRMHVIHFGE HMHFSNLPVD 790 800 810 820 830 840 FVIAMEVYMM RVPEYKAPEK TCAAVLAAKF RNLLVPNSAH RRARNNSVLS NRTVLSMPGY 850 860 870 880 890 900 QAPDCDFRFC GKLTLDRDSA GDRQFYLDDV TYPLEGTVKL QSHCSSLPEA IDVEYRGFLY 910 920 930 940 950 960 LFDERSPNGE AAWDRYWAML HRGIIFFWKN PIDEKNQKVP LSQIDLTKCT NQSVEETRNG 970 980 990 1000 RDHEFHIELL IDQTPSLLEK RRVVLAAESS DHLASWLNAI NDTLFVLRS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"Distinct roles for two C. elegans anillins in the gonad and early embryo." Maddox A.S., Habermann B., Desai A., Oegema K. Development 132:2837-2848(2005) [PubMed: 15930113] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U28730 Genomic DNA. Translation: AAA68262.1.
PIR	T16604.
RefSeq	NP_495282.1.
UniGene	Cel.23022
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	K10B2.5; K10B2.5; K10B2.5; Caenorhabditis elegans. [Genome view]
GeneID	174055.
KEGG	cel:K10B2.5.
NMPDR	fig|6239.3.peg.5876.
UCSC	K10B2.5. c. elegans.
Organism-specific databases
CTD	174055.
WormBase	WBGene00019608. ani-2.
WormPep	K10B2.5. CE02012. [WorfDB]
Phylogenomic databases
OMA	HEEYEEH
Gene expression databases
ArrayExpress	Q09994.
Family and domain databases
InterPro	IPR011993. PH_type. IPR001849. Pleckstrin_homology. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit.
Pfam	PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	882311.

Entry information

Entry name

ANI2_CAEEL

Accession

Primary (citable) accession number: Q09994

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	November 1, 1996
Last modified:	November 24, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Caenorhabditis annotation project