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Protein

F-box/WD repeat-containing protein lin-23

Gene

lin-23

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity).By similarity1 Publication

GO - Molecular functioni

  • beta-catenin binding Source: WormBase
  • phosphatase binding Source: WormBase
  • protein dimerization activity Source: InterPro

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of centrosome duplication Source: UniProtKB
  • neuron projection morphogenesis Source: WormBase
  • regulation of protein stability Source: UniProtKB
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: WormBase

Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle, Cell division, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-195253 Degradation of beta-catenin by the destruction complex
R-CEL-3769402 Deactivation of the beta-catenin transactivating complex
R-CEL-8951664 Neddylation
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation
SignaLinkiQ09990

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein lin-23
Alternative name(s):
Abnormal cell lineage protein 23
Gene namesi
Name:lin-23
ORF Names:K10B2.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiK10B2.1a ; CE28600 ; WBGene00003009 ; lin-23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi441G → R in Lin-32(RH293). 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510581 – 665F-box/WD repeat-containing protein lin-23Add BLAST665

Proteomic databases

EPDiQ09990
PaxDbiQ09990
PeptideAtlasiQ09990
PRIDEiQ09990

Expressioni

Developmental stagei

Highest levels in embryos and adults, lowest levels in larvae. Maternal expression results in high zygotic levels.1 Publication

Gene expression databases

BgeeiWBGene00003009
ExpressionAtlasiQ09990 baseline and differential

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

GO - Molecular functioni

  • beta-catenin binding Source: WormBase
  • phosphatase binding Source: WormBase
  • protein dimerization activity Source: InterPro

Protein-protein interaction databases

BioGridi39398, 5 interactors
STRINGi6239.K10B2.1

Structurei

3D structure databases

ProteinModelPortaliQ09990
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 127F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati220 – 257WD 1Add BLAST38
Repeati260 – 299WD 2Add BLAST40
Repeati301 – 337WD 3Add BLAST37
Repeati343 – 380WD 4Add BLAST38
Repeati383 – 420WD 5Add BLAST38
Repeati423 – 460WD 6Add BLAST38
Repeati472 – 509WD 7Add BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi525 – 582Ala-richAdd BLAST58

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0281 Eukaryota
ENOG410XTA8 LUCA
GeneTreeiENSGT00760000119106
HOGENOMiHOG000006638
InParanoidiQ09990
OrthoDBiEOG091G0437
PhylomeDBiQ09990

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR021977 Beta-TrCP_D
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12125 Beta-TrCP_D, 1 hit
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM01028 Beta-TrCP_D, 1 hit
SM00256 FBOX, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS00678 WD_REPEATS_1, 5 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q09990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPHRASTT QQLADLSLTE GEHDEGKPLS IDYLQGHEGL IEEVLKWSEH
60 70 80 90 100
EQLDFMDKIV HRLSHYQLGK VDNFIRPMLQ RDFISNLPAH LVELILFNVN
110 120 130 140 150
SDSLKSCEEV STSWRCALAR GQHWKKLIEK NVRSDSLWWG LSEKRQWDKF
160 170 180 190 200
LNISRDMSVR RICEKFNYDV NIKRDKLDQL ILMHVFYSKL YPKIIRDIHN
210 220 230 240 250
IDNNWKRGNY KMTRINCQSE NSKGVYCLQY DDDKIVSGLR DNTIKIWDRK
260 270 280 290 300
DYSCSRILSG HTGSVLCLQY DNRVIISGSS DATVRVWDVE TGECIKTLIH
310 320 330 340 350
HCEAVLHLRF ANGIMVTCSK DRSIAVWDMV SPRDITIRRV LVGHRAAVNV
360 370 380 390 400
VDFDDRYIVS ASGDRTIKVW SMDTLEFVRT LAGHRRGIAC LQYRGRLVVS
410 420 430 440 450
GSSDNTIRLW DIHSGVCLRV LEGHEELVRC IRFDEKRIVS GAYDGKIKVW
460 470 480 490 500
DLQAALDPRA LSSEICLCSL VQHTGRVFRL QFDDFQIVSS SHDDTILIWD
510 520 530 540 550
FLDAPPSGLP SSTNRATLPE LPNQAAVARA QMLFEMAARR EIERRDREVV
560 570 580 590 600
EEPALRPRAN AARRHNADIA AAAAAAEAAR GAGDNDESSS EEDLDRVDQV
610 620 630 640 650
NNPNVAGPAP PQPHNQNHRR RQPRPELPVR LMQEMAAFDN MRRQQNNMDH
660
LGGGDVDEEM PDGGP
Length:665
Mass (Da):75,917
Last modified:January 31, 2002 - v2
Checksum:iBF3E9AF51F12ECCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275253 mRNA Translation: AAG28037.1
FO080748 Genomic DNA Translation: CCD66391.1
PIRiT16607
RefSeqiNP_495285.1, NM_062884.5
UniGeneiCel.17632

Genome annotation databases

EnsemblMetazoaiK10B2.1a.1; K10B2.1a.1; WBGene00003009
K10B2.1a.2; K10B2.1a.2; WBGene00003009
GeneIDi174058
UCSCiK10B2.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiLIN23_CAEEL
AccessioniPrimary (citable) accession number: Q09990
Secondary accession number(s): Q9GNN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 31, 2002
Last modified: May 23, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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