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Protein

F-box/WD repeat-containing protein lin-23

Gene

lin-23

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity).By similarity1 Publication

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of centrosome duplication Source: UniProtKB
  • neuron projection morphogenesis Source: WormBase
  • regulation of protein stability Source: UniProtKB
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell cycle, Cell division, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-CEL-3769402. Deactivation of the beta-catenin transactivating complex.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ09990.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein lin-23
Alternative name(s):
Abnormal cell lineage protein 23
Gene namesi
Name:lin-23
ORF Names:K10B2.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiK10B2.1a; CE28600; WBGene00003009; lin-23.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
  • nucleus Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi441G → R in Lin-32(RH293). 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510581 – 665F-box/WD repeat-containing protein lin-23Add BLAST665

Proteomic databases

EPDiQ09990.
PaxDbiQ09990.
PeptideAtlasiQ09990.
PRIDEiQ09990.

Expressioni

Developmental stagei

Highest levels in embryos and adults, lowest levels in larvae. Maternal expression results in high zygotic levels.1 Publication

Gene expression databases

BgeeiWBGene00003009.
ExpressionAtlasiQ09990. differential.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Protein-protein interaction databases

BioGridi39398. 5 interactors.
STRINGi6239.K10B2.1.

Structurei

3D structure databases

ProteinModelPortaliQ09990.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 127F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati220 – 257WD 1Add BLAST38
Repeati260 – 299WD 2Add BLAST40
Repeati301 – 337WD 3Add BLAST37
Repeati343 – 380WD 4Add BLAST38
Repeati383 – 420WD 5Add BLAST38
Repeati423 – 460WD 6Add BLAST38
Repeati472 – 509WD 7Add BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi525 – 582Ala-richAdd BLAST58

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0281. Eukaryota.
ENOG410XTA8. LUCA.
GeneTreeiENSGT00760000119106.
HOGENOMiHOG000006638.
InParanoidiQ09990.
OMAiHLRFQNG.
OrthoDBiEOG091G0437.
PhylomeDBiQ09990.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR021977. Beta-TrCP_D.
IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12125. Beta-TrCP_D. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM01028. Beta-TrCP_D. 1 hit.
SM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPHRASTT QQLADLSLTE GEHDEGKPLS IDYLQGHEGL IEEVLKWSEH
60 70 80 90 100
EQLDFMDKIV HRLSHYQLGK VDNFIRPMLQ RDFISNLPAH LVELILFNVN
110 120 130 140 150
SDSLKSCEEV STSWRCALAR GQHWKKLIEK NVRSDSLWWG LSEKRQWDKF
160 170 180 190 200
LNISRDMSVR RICEKFNYDV NIKRDKLDQL ILMHVFYSKL YPKIIRDIHN
210 220 230 240 250
IDNNWKRGNY KMTRINCQSE NSKGVYCLQY DDDKIVSGLR DNTIKIWDRK
260 270 280 290 300
DYSCSRILSG HTGSVLCLQY DNRVIISGSS DATVRVWDVE TGECIKTLIH
310 320 330 340 350
HCEAVLHLRF ANGIMVTCSK DRSIAVWDMV SPRDITIRRV LVGHRAAVNV
360 370 380 390 400
VDFDDRYIVS ASGDRTIKVW SMDTLEFVRT LAGHRRGIAC LQYRGRLVVS
410 420 430 440 450
GSSDNTIRLW DIHSGVCLRV LEGHEELVRC IRFDEKRIVS GAYDGKIKVW
460 470 480 490 500
DLQAALDPRA LSSEICLCSL VQHTGRVFRL QFDDFQIVSS SHDDTILIWD
510 520 530 540 550
FLDAPPSGLP SSTNRATLPE LPNQAAVARA QMLFEMAARR EIERRDREVV
560 570 580 590 600
EEPALRPRAN AARRHNADIA AAAAAAEAAR GAGDNDESSS EEDLDRVDQV
610 620 630 640 650
NNPNVAGPAP PQPHNQNHRR RQPRPELPVR LMQEMAAFDN MRRQQNNMDH
660
LGGGDVDEEM PDGGP
Length:665
Mass (Da):75,917
Last modified:January 31, 2002 - v2
Checksum:iBF3E9AF51F12ECCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275253 mRNA. Translation: AAG28037.1.
FO080748 Genomic DNA. Translation: CCD66391.1.
PIRiT16607.
RefSeqiNP_495285.1. NM_062884.5.
UniGeneiCel.17632.

Genome annotation databases

EnsemblMetazoaiK10B2.1a; K10B2.1a; WBGene00003009.
GeneIDi174058.
UCSCiK10B2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275253 mRNA. Translation: AAG28037.1.
FO080748 Genomic DNA. Translation: CCD66391.1.
PIRiT16607.
RefSeqiNP_495285.1. NM_062884.5.
UniGeneiCel.17632.

3D structure databases

ProteinModelPortaliQ09990.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39398. 5 interactors.
STRINGi6239.K10B2.1.

Proteomic databases

EPDiQ09990.
PaxDbiQ09990.
PeptideAtlasiQ09990.
PRIDEiQ09990.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK10B2.1a; K10B2.1a; WBGene00003009.
GeneIDi174058.
UCSCiK10B2.1. c. elegans.

Organism-specific databases

CTDi174058.
WormBaseiK10B2.1a; CE28600; WBGene00003009; lin-23.

Phylogenomic databases

eggNOGiKOG0281. Eukaryota.
ENOG410XTA8. LUCA.
GeneTreeiENSGT00760000119106.
HOGENOMiHOG000006638.
InParanoidiQ09990.
OMAiHLRFQNG.
OrthoDBiEOG091G0437.
PhylomeDBiQ09990.

Enzyme and pathway databases

ReactomeiR-CEL-3769402. Deactivation of the beta-catenin transactivating complex.
R-CEL-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SignaLinkiQ09990.

Miscellaneous databases

PROiQ09990.

Gene expression databases

BgeeiWBGene00003009.
ExpressionAtlasiQ09990. differential.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR021977. Beta-TrCP_D.
IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12125. Beta-TrCP_D. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM01028. Beta-TrCP_D. 1 hit.
SM00256. FBOX. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIN23_CAEEL
AccessioniPrimary (citable) accession number: Q09990
Secondary accession number(s): Q9GNN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 31, 2002
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.