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Protein

Chromatin structure-remodeling complex subunit rsc4

Gene

rsc4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.1 Publication

GO - Biological processi

  • chromatin remodeling Source: PomBase
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin structure-remodeling complex subunit rsc4
Alternative name(s):
Bromodomain-containing protein brd1
RSC complex subunit rsc4
Gene namesi
Name:rsc4
Synonyms:brd1
ORF Names:SPBC1734.15
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.15
PomBaseiSPBC1734.15 rsc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002111781 – 542Chromatin structure-remodeling complex subunit rsc4Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei257Phosphoserine1 Publication1
Modified residuei271Phosphoserine1 Publication1
Modified residuei287Phosphoserine1 Publication1
Modified residuei313Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09948
PaxDbiQ09948
PRIDEiQ09948

PTM databases

iPTMnetiQ09948

Interactioni

Subunit structurei

Component of the RSC complex composed of at least arp9, arp42, rsc1, rsc4, rsc7, rsc9, rsc58, sfh1, snf21, ssr1, ssr2, ssr3 and ssr4. The complex interacts with histone and histone variant components of centromeric chromatin (By similarity).By similarity

Protein-protein interaction databases

BioGridi276543, 137 interactors
DIPiDIP-48391N
IntActiQ09948, 6 interactors
STRINGi4896.SPBC1734.15.1

Structurei

3D structure databases

ProteinModelPortaliQ09948
SMRiQ09948
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 99Bromo 1PROSITE-ProRule annotationAdd BLAST71
Domaini162 – 232Bromo 2PROSITE-ProRule annotationAdd BLAST71

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

InParanoidiQ09948
OrthoDBiEOG092C2J71

Family and domain databases

Gene3Di1.20.920.10, 2 hits
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR037382 Rsc/polybromo
PANTHERiPTHR16062 PTHR16062, 1 hit
PfamiView protein in Pfam
PF00439 Bromodomain, 2 hits
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 2 hits
SUPFAMiSSF47370 SSF47370, 2 hits
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q09948-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDDSHNAPF DKTKFDEVLE ALVGLKDNEG NPFDDIFEEL PSKRYFPDYY
60 70 80 90 100
QIIQKPICYK MMRNKAKTGK YLSMGDFYDD IRLMVSNAQT YNMPGSLVYE
110 120 130 140 150
CSVLIANTAN SLESKDGTLN EEENEEMESS INEEHKPGTN EIDVPKVIQN
160 170 180 190 200
ILDALHEEKD EQGRFLIDIF IDLPSKRLYP DYYEIIKSPM TIKMLEKRFK
210 220 230 240 250
KGEYTTLESF VKDLNQMFIN AKTYNAPGSF VYEDAEKLSQ LSSSLISSFS
260 270 280 290 300
EQPKEHSPAT SKHEPEETPA SPTPSVSAST SRERSTSVAP SFITSDQAAT
310 320 330 340 350
PDVLKSEEAH VESFSKESEK DQTPIPEDVP SPMDTLSQAN YGAFALIKSF
360 370 380 390 400
PSTPVPDFLN FSHKSVMGRS TFNMPNFPEP KFFEDIPNTE RCILSAFICS
410 420 430 440 450
PPQLPLPNPL RMYLPCPSLN STEVSVITLA PQHSFLNIVI NLNPALALKS
460 470 480 490 500
YTIITLLNGK RLGAGVSTPP STLYALEGIK HTEEPIRTVY EAKLSVGLNC
510 520 530 540
LEFVLGSTEP VEPPSIEPGL PASAYSRTVE RERFVLMAYV QP
Length:542
Mass (Da):60,667
Last modified:November 1, 1996 - v1
Checksum:iB900D1F77327C2A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86764 Genomic DNA Translation: CAA60444.1
CU329671 Genomic DNA Translation: CAA21309.1
PIRiS58680 S54260
RefSeqiNP_595432.1, NM_001021340.2

Genome annotation databases

EnsemblFungiiSPBC1734.15.1; SPBC1734.15.1:pep; SPBC1734.15
GeneIDi2539999
KEGGispo:SPBC1734.15

Entry informationi

Entry nameiRSC4_SCHPO
AccessioniPrimary (citable) accession number: Q09948
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

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