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Protein

Chromatin structure-remodeling complex subunit rsc4

Gene

rsc4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin structure-remodeling complex subunit rsc4
Alternative name(s):
Bromodomain-containing protein brd1
RSC complex subunit rsc4
Gene namesi
Name:rsc4
Synonyms:brd1
ORF Names:SPBC1734.15
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.15.
PomBaseiSPBC1734.15. rsc4.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nuclear chromatin Source: PomBase
  • nucleus Source: PomBase
  • RSC complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Chromatin structure-remodeling complex subunit rsc4PRO_0000211178Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei257 – 2571Phosphoserine1 Publication
Modified residuei271 – 2711Phosphoserine1 Publication
Modified residuei287 – 2871Phosphoserine1 Publication
Modified residuei313 – 3131Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09948.

PTM databases

iPTMnetiQ09948.

Interactioni

Subunit structurei

Component of the RSC complex composed of at least arp9, arp42, rsc1, rsc4, rsc7, rsc9, rsc58, sfh1, snf21, ssr1, ssr2, ssr3 and ssr4. The complex interacts with histone and histone variant components of centromeric chromatin (By similarity).By similarity

Protein-protein interaction databases

BioGridi276543. 136 interactions.
DIPiDIP-48391N.
MINTiMINT-4696544.

Structurei

3D structure databases

ProteinModelPortaliQ09948.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 9971Bromo 1PROSITE-ProRule annotationAdd
BLAST
Domaini162 – 23271Bromo 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 bromo domains.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Repeat

Phylogenomic databases

InParanoidiQ09948.
OrthoDBiEOG75TMNJ.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
InterProiIPR001487. Bromodomain.
[Graphical view]
PfamiPF00439. Bromodomain. 2 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
PROSITEiPS50014. BROMODOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09948-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDDSHNAPF DKTKFDEVLE ALVGLKDNEG NPFDDIFEEL PSKRYFPDYY
60 70 80 90 100
QIIQKPICYK MMRNKAKTGK YLSMGDFYDD IRLMVSNAQT YNMPGSLVYE
110 120 130 140 150
CSVLIANTAN SLESKDGTLN EEENEEMESS INEEHKPGTN EIDVPKVIQN
160 170 180 190 200
ILDALHEEKD EQGRFLIDIF IDLPSKRLYP DYYEIIKSPM TIKMLEKRFK
210 220 230 240 250
KGEYTTLESF VKDLNQMFIN AKTYNAPGSF VYEDAEKLSQ LSSSLISSFS
260 270 280 290 300
EQPKEHSPAT SKHEPEETPA SPTPSVSAST SRERSTSVAP SFITSDQAAT
310 320 330 340 350
PDVLKSEEAH VESFSKESEK DQTPIPEDVP SPMDTLSQAN YGAFALIKSF
360 370 380 390 400
PSTPVPDFLN FSHKSVMGRS TFNMPNFPEP KFFEDIPNTE RCILSAFICS
410 420 430 440 450
PPQLPLPNPL RMYLPCPSLN STEVSVITLA PQHSFLNIVI NLNPALALKS
460 470 480 490 500
YTIITLLNGK RLGAGVSTPP STLYALEGIK HTEEPIRTVY EAKLSVGLNC
510 520 530 540
LEFVLGSTEP VEPPSIEPGL PASAYSRTVE RERFVLMAYV QP
Length:542
Mass (Da):60,667
Last modified:November 1, 1996 - v1
Checksum:iB900D1F77327C2A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86764 Genomic DNA. Translation: CAA60444.1.
CU329671 Genomic DNA. Translation: CAA21309.1.
PIRiS58680. S54260.
RefSeqiNP_595432.1. NM_001021340.2.

Genome annotation databases

EnsemblFungiiSPBC1734.15.1; SPBC1734.15.1:pep; SPBC1734.15.
GeneIDi2539999.
KEGGispo:SPBC1734.15.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86764 Genomic DNA. Translation: CAA60444.1.
CU329671 Genomic DNA. Translation: CAA21309.1.
PIRiS58680. S54260.
RefSeqiNP_595432.1. NM_001021340.2.

3D structure databases

ProteinModelPortaliQ09948.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276543. 136 interactions.
DIPiDIP-48391N.
MINTiMINT-4696544.

PTM databases

iPTMnetiQ09948.

Proteomic databases

MaxQBiQ09948.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1734.15.1; SPBC1734.15.1:pep; SPBC1734.15.
GeneIDi2539999.
KEGGispo:SPBC1734.15.

Organism-specific databases

EuPathDBiFungiDB:SPBC1734.15.
PomBaseiSPBC1734.15. rsc4.

Phylogenomic databases

InParanoidiQ09948.
OrthoDBiEOG75TMNJ.

Miscellaneous databases

NextBioi20801142.
PROiQ09948.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
InterProiIPR001487. Bromodomain.
[Graphical view]
PfamiPF00439. Bromodomain. 2 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
PROSITEiPS50014. BROMODOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A fission yeast gene mapping close to suc1 encodes a protein containing two bromodomains."
    Aves S.J., Hindley J., Phear G.A., Tongue N.
    Mol. Gen. Genet. 248:491-498(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-257; SER-271; SER-287 AND SER-313, IDENTIFICATION BY MASS SPECTROMETRY.
  4. "Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast."
    Monahan B.J., Villen J., Marguerat S., Baehler J., Gygi S.P., Winston F.
    Nat. Struct. Mol. Biol. 15:873-880(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE RSC COMPLEX, FUNCTION OF THE RSC COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiRSC4_SCHPO
AccessioniPrimary (citable) accession number: Q09948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: February 17, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.