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Protein

Probable ubiquitin carboxyl-terminal hydrolase K02C4.3

Gene

K02C4.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei177 – 1771NucleophilePROSITE-ProRule annotation
Active sitei707 – 7071Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.A34.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase K02C4.3 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme
Ubiquitin thioesterase
Ubiquitin-specific-processing protease
Gene namesi
ORF Names:K02C4.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiK02C4.3; CE46932; WBGene00010502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12761276Probable ubiquitin carboxyl-terminal hydrolase K02C4.3PRO_0000080685Add
BLAST

Proteomic databases

PaxDbiQ09931.

Interactioni

Protein-protein interaction databases

STRINGi6239.K02C4.3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 762595USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiNOG275561.
GeneTreeiENSGT00390000016082.
HOGENOMiHOG000016047.
InParanoidiQ09931.
KOiK11849.
OMAiHKYELHA.
OrthoDBiEOG761BSZ.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09931-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVEENETGTP GTSRTVTFHD GRKLTDAEHF VFFKVKEVIA DKVAEAEILE
60 70 80 90 100
SIRKRSECKP TDEQFISDII NELFYSGEPP KGRKSERFIG PLFDPEKAST
110 120 130 140 150
ASGPMDCTDV VSYDSTHPNI SEISKKEEVE MQSAIQQSLA SSASQNISRP
160 170 180 190 200
TMLMSNLEDM VRNPNFSTGL YNSGNTCWLN CLSQVLYSIP KFRSILYHCA
210 220 230 240 250
PLSWHEQPIT NVKIENQQHA ELLMLFRGLF AELQFSEMKY IEVGPLINMV
260 270 280 290 300
DKLSKSSKGP STIGTQQDAT EMLTLIFDWL QRAFDAALHA QLNPEFSNVS
310 320 330 340 350
DEENLVISDS TTTAPNSDII GAPPGYNAAN LSLPSSSHVD PKSTLNPMYV
360 370 380 390 400
NEKEPSSTPT SLFGTRSKTI EVNESMDTEA ATSSNLPGNS VENHPNPAAP
410 420 430 440 450
EVDDNKKAFC DKLKESFNNI FSSVCYTESV AEDGTVSVKS NVRNCPQFFQ
460 470 480 490 500
LQVTYGNLHD ALEAATFDHG LGNTASHVRN LYDPLPAVIF FGLSRFSFNS
510 520 530 540 550
NIESKLHDKF TFPKIIFMDR YLKCNKEQLV QLRSHRELCR DSLSEVRAKL
560 570 580 590 600
SGLRRYPQGN GEVRLEDSFQ TVWQAVSNFR EFVTFYLKVS QKTFFSREDA
610 620 630 640 650
HENTAFVGPL TPSTYQSSSD NCSSKFVKDG GKLFPTFTEG FFPGKAAFIE
660 670 680 690 700
TLQNMLEALK TEERDCLAEE ARLQEVIDQT YEVPELQQHK YELHAIIVHS
710 720 730 740 750
GEANRGHYWT YKLKKSIDGL EEWEKLNDQN ADRVDWPKVE SDSFGTGSRD
760 770 780 790 800
APSAYMLMYV RSDAEWLVSA DKLTALEAFE TIPPDLQEKV LQKRDEFKEK
810 820 830 840 850
LQRFRENKEF NYQQFSVDSP TVQSTEETPS SFSWYRDELE DIDIGDENAN
860 870 880 890 900
PTKNDYLLNA RLDSYSVPIA PDVETSEMKR MVSQMWNQIT KIAPRKYTDS
910 920 930 940 950
QDLLDSNLRS VMEGESGGIN FINSRLGYDI HELRSDADND VEGVYNAFIN
960 970 980 990 1000
EYLGLVKDLH ELQNSKFVVF VGFQLQRIHV PVLRYLLVRA MAVSELGIIS
1010 1020 1030 1040 1050
QRANNELSGM SSNSHDKGTA MLQIALLLSH FFELGVMSAW GCRSSLENIH
1060 1070 1080 1090 1100
VILNDFKKKN SRGSEQIEVT YCAMIGARNA RICNGLLREM AYFLESYSIF
1110 1120 1130 1140 1150
FVSQKHIEAC TVFSTITMIK LIMQHMASKT LQLIDMEFHL SKNERRVRFE
1160 1170 1180 1190 1200
DIIREVVSSV CIIHHWSKSY SKEFQNEINL KELMGLLHLK VEFMVSLTSF
1210 1220 1230 1240 1250
EVADPKYECL QAFKAMVVNT VMDLERASNE LDYDVLDGAV ELRELKKYFK
1260 1270
ELQLTDVKVN NIITSYDPII ESLVKI
Length:1,276
Mass (Da):144,893
Last modified:October 3, 2012 - v3
Checksum:iEB5293F0045028D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47811 Genomic DNA. Translation: CAA87786.3.
PIRiT23236.
RefSeqiNP_495696.3. NM_063295.4.
UniGeneiCel.14832.

Genome annotation databases

EnsemblMetazoaiK02C4.3; K02C4.3; WBGene00010502.
GeneIDi174300.
KEGGicel:CELE_K02C4.3.
UCSCiK02C4.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47811 Genomic DNA. Translation: CAA87786.3.
PIRiT23236.
RefSeqiNP_495696.3. NM_063295.4.
UniGeneiCel.14832.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K02C4.3.

Protein family/group databases

MEROPSiC19.A34.

Proteomic databases

PaxDbiQ09931.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK02C4.3; K02C4.3; WBGene00010502.
GeneIDi174300.
KEGGicel:CELE_K02C4.3.
UCSCiK02C4.3. c. elegans.

Organism-specific databases

CTDi174300.
WormBaseiK02C4.3; CE46932; WBGene00010502.

Phylogenomic databases

eggNOGiNOG275561.
GeneTreeiENSGT00390000016082.
HOGENOMiHOG000016047.
InParanoidiQ09931.
KOiK11849.
OMAiHKYELHA.
OrthoDBiEOG761BSZ.

Miscellaneous databases

NextBioi883426.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiUBPY_CAEEL
AccessioniPrimary (citable) accession number: Q09931
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: January 7, 2015
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.