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Q09931 (UBPY_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ubiquitin carboxyl-terminal hydrolase K02C4.3

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme
Ubiquitin thioesterase
Ubiquitin-specific-processing protease
Gene names
ORF Names:K02C4.3
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length1276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12761276Probable ubiquitin carboxyl-terminal hydrolase K02C4.3
PRO_0000080685

Regions

Domain168 – 762595USP

Sites

Active site1771Nucleophile By similarity
Active site7071Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09931 [UniParc].

Last modified October 3, 2012. Version 3.
Checksum: EB5293F0045028D4

FASTA1,276144,893
        10         20         30         40         50         60 
MVEENETGTP GTSRTVTFHD GRKLTDAEHF VFFKVKEVIA DKVAEAEILE SIRKRSECKP 

        70         80         90        100        110        120 
TDEQFISDII NELFYSGEPP KGRKSERFIG PLFDPEKAST ASGPMDCTDV VSYDSTHPNI 

       130        140        150        160        170        180 
SEISKKEEVE MQSAIQQSLA SSASQNISRP TMLMSNLEDM VRNPNFSTGL YNSGNTCWLN 

       190        200        210        220        230        240 
CLSQVLYSIP KFRSILYHCA PLSWHEQPIT NVKIENQQHA ELLMLFRGLF AELQFSEMKY 

       250        260        270        280        290        300 
IEVGPLINMV DKLSKSSKGP STIGTQQDAT EMLTLIFDWL QRAFDAALHA QLNPEFSNVS 

       310        320        330        340        350        360 
DEENLVISDS TTTAPNSDII GAPPGYNAAN LSLPSSSHVD PKSTLNPMYV NEKEPSSTPT 

       370        380        390        400        410        420 
SLFGTRSKTI EVNESMDTEA ATSSNLPGNS VENHPNPAAP EVDDNKKAFC DKLKESFNNI 

       430        440        450        460        470        480 
FSSVCYTESV AEDGTVSVKS NVRNCPQFFQ LQVTYGNLHD ALEAATFDHG LGNTASHVRN 

       490        500        510        520        530        540 
LYDPLPAVIF FGLSRFSFNS NIESKLHDKF TFPKIIFMDR YLKCNKEQLV QLRSHRELCR 

       550        560        570        580        590        600 
DSLSEVRAKL SGLRRYPQGN GEVRLEDSFQ TVWQAVSNFR EFVTFYLKVS QKTFFSREDA 

       610        620        630        640        650        660 
HENTAFVGPL TPSTYQSSSD NCSSKFVKDG GKLFPTFTEG FFPGKAAFIE TLQNMLEALK 

       670        680        690        700        710        720 
TEERDCLAEE ARLQEVIDQT YEVPELQQHK YELHAIIVHS GEANRGHYWT YKLKKSIDGL 

       730        740        750        760        770        780 
EEWEKLNDQN ADRVDWPKVE SDSFGTGSRD APSAYMLMYV RSDAEWLVSA DKLTALEAFE 

       790        800        810        820        830        840 
TIPPDLQEKV LQKRDEFKEK LQRFRENKEF NYQQFSVDSP TVQSTEETPS SFSWYRDELE 

       850        860        870        880        890        900 
DIDIGDENAN PTKNDYLLNA RLDSYSVPIA PDVETSEMKR MVSQMWNQIT KIAPRKYTDS 

       910        920        930        940        950        960 
QDLLDSNLRS VMEGESGGIN FINSRLGYDI HELRSDADND VEGVYNAFIN EYLGLVKDLH 

       970        980        990       1000       1010       1020 
ELQNSKFVVF VGFQLQRIHV PVLRYLLVRA MAVSELGIIS QRANNELSGM SSNSHDKGTA 

      1030       1040       1050       1060       1070       1080 
MLQIALLLSH FFELGVMSAW GCRSSLENIH VILNDFKKKN SRGSEQIEVT YCAMIGARNA 

      1090       1100       1110       1120       1130       1140 
RICNGLLREM AYFLESYSIF FVSQKHIEAC TVFSTITMIK LIMQHMASKT LQLIDMEFHL 

      1150       1160       1170       1180       1190       1200 
SKNERRVRFE DIIREVVSSV CIIHHWSKSY SKEFQNEINL KELMGLLHLK VEFMVSLTSF 

      1210       1220       1230       1240       1250       1260 
EVADPKYECL QAFKAMVVNT VMDLERASNE LDYDVLDGAV ELRELKKYFK ELQLTDVKVN 

      1270 
NIITSYDPII ESLVKI 

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References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z47811 Genomic DNA. Translation: CAA87786.3.
PIRT23236.
RefSeqNP_495696.3. NM_063295.4.
UniGeneCel.14832.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6239.K02C4.3.

Protein family/group databases

MEROPSC19.A34.

Proteomic databases

PaxDbQ09931.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaK02C4.3; K02C4.3; WBGene00010502.
GeneID174300.
KEGGcel:CELE_K02C4.3.
UCSCK02C4.3. c. elegans.

Organism-specific databases

CTD174300.
WormBaseK02C4.3; CE46932; WBGene00010502.

Phylogenomic databases

eggNOGNOG275561.
GeneTreeENSGT00390000016082.
HOGENOMHOG000016047.
InParanoidQ09931.
KOK11849.
OMAHKYELHA.
OrthoDBEOG761BSZ.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio883426.

Entry information

Entry nameUBPY_CAEEL
AccessionPrimary (citable) accession number: Q09931
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: June 11, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase