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Q09931

- UBPY_CAEEL

UniProt

Q09931 - UBPY_CAEEL

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Protein

Probable ubiquitin carboxyl-terminal hydrolase K02C4.3

Gene
K02C4.3
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei177 – 1771Nucleophile By similarity
Active sitei707 – 7071Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.A34.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase K02C4.3 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme
Ubiquitin thioesterase
Ubiquitin-specific-processing protease
Gene namesi
ORF Names:K02C4.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome II

Organism-specific databases

WormBaseiK02C4.3; CE46932; WBGene00010502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12761276Probable ubiquitin carboxyl-terminal hydrolase K02C4.3PRO_0000080685Add
BLAST

Proteomic databases

PaxDbiQ09931.

Interactioni

Protein-protein interaction databases

STRINGi6239.K02C4.3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 762595USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiNOG275561.
GeneTreeiENSGT00390000016082.
HOGENOMiHOG000016047.
InParanoidiQ09931.
KOiK11849.
OMAiHKYELHA.
OrthoDBiEOG761BSZ.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09931-1 [UniParc]FASTAAdd to Basket

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MVEENETGTP GTSRTVTFHD GRKLTDAEHF VFFKVKEVIA DKVAEAEILE     50
SIRKRSECKP TDEQFISDII NELFYSGEPP KGRKSERFIG PLFDPEKAST 100
ASGPMDCTDV VSYDSTHPNI SEISKKEEVE MQSAIQQSLA SSASQNISRP 150
TMLMSNLEDM VRNPNFSTGL YNSGNTCWLN CLSQVLYSIP KFRSILYHCA 200
PLSWHEQPIT NVKIENQQHA ELLMLFRGLF AELQFSEMKY IEVGPLINMV 250
DKLSKSSKGP STIGTQQDAT EMLTLIFDWL QRAFDAALHA QLNPEFSNVS 300
DEENLVISDS TTTAPNSDII GAPPGYNAAN LSLPSSSHVD PKSTLNPMYV 350
NEKEPSSTPT SLFGTRSKTI EVNESMDTEA ATSSNLPGNS VENHPNPAAP 400
EVDDNKKAFC DKLKESFNNI FSSVCYTESV AEDGTVSVKS NVRNCPQFFQ 450
LQVTYGNLHD ALEAATFDHG LGNTASHVRN LYDPLPAVIF FGLSRFSFNS 500
NIESKLHDKF TFPKIIFMDR YLKCNKEQLV QLRSHRELCR DSLSEVRAKL 550
SGLRRYPQGN GEVRLEDSFQ TVWQAVSNFR EFVTFYLKVS QKTFFSREDA 600
HENTAFVGPL TPSTYQSSSD NCSSKFVKDG GKLFPTFTEG FFPGKAAFIE 650
TLQNMLEALK TEERDCLAEE ARLQEVIDQT YEVPELQQHK YELHAIIVHS 700
GEANRGHYWT YKLKKSIDGL EEWEKLNDQN ADRVDWPKVE SDSFGTGSRD 750
APSAYMLMYV RSDAEWLVSA DKLTALEAFE TIPPDLQEKV LQKRDEFKEK 800
LQRFRENKEF NYQQFSVDSP TVQSTEETPS SFSWYRDELE DIDIGDENAN 850
PTKNDYLLNA RLDSYSVPIA PDVETSEMKR MVSQMWNQIT KIAPRKYTDS 900
QDLLDSNLRS VMEGESGGIN FINSRLGYDI HELRSDADND VEGVYNAFIN 950
EYLGLVKDLH ELQNSKFVVF VGFQLQRIHV PVLRYLLVRA MAVSELGIIS 1000
QRANNELSGM SSNSHDKGTA MLQIALLLSH FFELGVMSAW GCRSSLENIH 1050
VILNDFKKKN SRGSEQIEVT YCAMIGARNA RICNGLLREM AYFLESYSIF 1100
FVSQKHIEAC TVFSTITMIK LIMQHMASKT LQLIDMEFHL SKNERRVRFE 1150
DIIREVVSSV CIIHHWSKSY SKEFQNEINL KELMGLLHLK VEFMVSLTSF 1200
EVADPKYECL QAFKAMVVNT VMDLERASNE LDYDVLDGAV ELRELKKYFK 1250
ELQLTDVKVN NIITSYDPII ESLVKI 1276
Length:1,276
Mass (Da):144,893
Last modified:October 3, 2012 - v3
Checksum:iEB5293F0045028D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z47811 Genomic DNA. Translation: CAA87786.3.
PIRiT23236.
RefSeqiNP_495696.3. NM_063295.4.
UniGeneiCel.14832.

Genome annotation databases

EnsemblMetazoaiK02C4.3; K02C4.3; WBGene00010502.
GeneIDi174300.
KEGGicel:CELE_K02C4.3.
UCSCiK02C4.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z47811 Genomic DNA. Translation: CAA87786.3 .
PIRi T23236.
RefSeqi NP_495696.3. NM_063295.4.
UniGenei Cel.14832.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6239.K02C4.3.

Protein family/group databases

MEROPSi C19.A34.

Proteomic databases

PaxDbi Q09931.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai K02C4.3 ; K02C4.3 ; WBGene00010502 .
GeneIDi 174300.
KEGGi cel:CELE_K02C4.3.
UCSCi K02C4.3. c. elegans.

Organism-specific databases

CTDi 174300.
WormBasei K02C4.3 ; CE46932 ; WBGene00010502 .

Phylogenomic databases

eggNOGi NOG275561.
GeneTreei ENSGT00390000016082.
HOGENOMi HOG000016047.
InParanoidi Q09931.
KOi K11849.
OMAi HKYELHA.
OrthoDBi EOG761BSZ.

Miscellaneous databases

NextBioi 883426.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiUBPY_CAEEL
AccessioniPrimary (citable) accession number: Q09931
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3