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Q09931

- UBPY_CAEEL

UniProt

Q09931 - UBPY_CAEEL

Protein

Probable ubiquitin carboxyl-terminal hydrolase K02C4.3

Gene

K02C4.3

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 3 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei177 – 1771NucleophilePROSITE-ProRule annotation
    Active sitei707 – 7071Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.A34.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase K02C4.3 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme
    Ubiquitin thioesterase
    Ubiquitin-specific-processing protease
    Gene namesi
    ORF Names:K02C4.3
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome II

    Organism-specific databases

    WormBaseiK02C4.3; CE46932; WBGene00010502.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12761276Probable ubiquitin carboxyl-terminal hydrolase K02C4.3PRO_0000080685Add
    BLAST

    Proteomic databases

    PaxDbiQ09931.

    Interactioni

    Protein-protein interaction databases

    STRINGi6239.K02C4.3.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini168 – 762595USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiNOG275561.
    GeneTreeiENSGT00390000016082.
    HOGENOMiHOG000016047.
    InParanoidiQ09931.
    KOiK11849.
    OMAiHKYELHA.
    OrthoDBiEOG761BSZ.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09931-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVEENETGTP GTSRTVTFHD GRKLTDAEHF VFFKVKEVIA DKVAEAEILE     50
    SIRKRSECKP TDEQFISDII NELFYSGEPP KGRKSERFIG PLFDPEKAST 100
    ASGPMDCTDV VSYDSTHPNI SEISKKEEVE MQSAIQQSLA SSASQNISRP 150
    TMLMSNLEDM VRNPNFSTGL YNSGNTCWLN CLSQVLYSIP KFRSILYHCA 200
    PLSWHEQPIT NVKIENQQHA ELLMLFRGLF AELQFSEMKY IEVGPLINMV 250
    DKLSKSSKGP STIGTQQDAT EMLTLIFDWL QRAFDAALHA QLNPEFSNVS 300
    DEENLVISDS TTTAPNSDII GAPPGYNAAN LSLPSSSHVD PKSTLNPMYV 350
    NEKEPSSTPT SLFGTRSKTI EVNESMDTEA ATSSNLPGNS VENHPNPAAP 400
    EVDDNKKAFC DKLKESFNNI FSSVCYTESV AEDGTVSVKS NVRNCPQFFQ 450
    LQVTYGNLHD ALEAATFDHG LGNTASHVRN LYDPLPAVIF FGLSRFSFNS 500
    NIESKLHDKF TFPKIIFMDR YLKCNKEQLV QLRSHRELCR DSLSEVRAKL 550
    SGLRRYPQGN GEVRLEDSFQ TVWQAVSNFR EFVTFYLKVS QKTFFSREDA 600
    HENTAFVGPL TPSTYQSSSD NCSSKFVKDG GKLFPTFTEG FFPGKAAFIE 650
    TLQNMLEALK TEERDCLAEE ARLQEVIDQT YEVPELQQHK YELHAIIVHS 700
    GEANRGHYWT YKLKKSIDGL EEWEKLNDQN ADRVDWPKVE SDSFGTGSRD 750
    APSAYMLMYV RSDAEWLVSA DKLTALEAFE TIPPDLQEKV LQKRDEFKEK 800
    LQRFRENKEF NYQQFSVDSP TVQSTEETPS SFSWYRDELE DIDIGDENAN 850
    PTKNDYLLNA RLDSYSVPIA PDVETSEMKR MVSQMWNQIT KIAPRKYTDS 900
    QDLLDSNLRS VMEGESGGIN FINSRLGYDI HELRSDADND VEGVYNAFIN 950
    EYLGLVKDLH ELQNSKFVVF VGFQLQRIHV PVLRYLLVRA MAVSELGIIS 1000
    QRANNELSGM SSNSHDKGTA MLQIALLLSH FFELGVMSAW GCRSSLENIH 1050
    VILNDFKKKN SRGSEQIEVT YCAMIGARNA RICNGLLREM AYFLESYSIF 1100
    FVSQKHIEAC TVFSTITMIK LIMQHMASKT LQLIDMEFHL SKNERRVRFE 1150
    DIIREVVSSV CIIHHWSKSY SKEFQNEINL KELMGLLHLK VEFMVSLTSF 1200
    EVADPKYECL QAFKAMVVNT VMDLERASNE LDYDVLDGAV ELRELKKYFK 1250
    ELQLTDVKVN NIITSYDPII ESLVKI 1276
    Length:1,276
    Mass (Da):144,893
    Last modified:October 3, 2012 - v3
    Checksum:iEB5293F0045028D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47811 Genomic DNA. Translation: CAA87786.3.
    PIRiT23236.
    RefSeqiNP_495696.3. NM_063295.4.
    UniGeneiCel.14832.

    Genome annotation databases

    EnsemblMetazoaiK02C4.3; K02C4.3; WBGene00010502.
    GeneIDi174300.
    KEGGicel:CELE_K02C4.3.
    UCSCiK02C4.3. c. elegans.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47811 Genomic DNA. Translation: CAA87786.3 .
    PIRi T23236.
    RefSeqi NP_495696.3. NM_063295.4.
    UniGenei Cel.14832.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6239.K02C4.3.

    Protein family/group databases

    MEROPSi C19.A34.

    Proteomic databases

    PaxDbi Q09931.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai K02C4.3 ; K02C4.3 ; WBGene00010502 .
    GeneIDi 174300.
    KEGGi cel:CELE_K02C4.3.
    UCSCi K02C4.3. c. elegans.

    Organism-specific databases

    CTDi 174300.
    WormBasei K02C4.3 ; CE46932 ; WBGene00010502 .

    Phylogenomic databases

    eggNOGi NOG275561.
    GeneTreei ENSGT00390000016082.
    HOGENOMi HOG000016047.
    InParanoidi Q09931.
    KOi K11849.
    OMAi HKYELHA.
    OrthoDBi EOG761BSZ.

    Miscellaneous databases

    NextBioi 883426.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.

    Entry informationi

    Entry nameiUBPY_CAEEL
    AccessioniPrimary (citable) accession number: Q09931
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 98 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3