Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP-binding protein drn-1

Gene

drn-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Displays low GTPase activity and exists predominantly in the GTP-bound form (By similarity). Together with epac-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1 (PubMed:22897658).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 44GTPBy similarity8
Nucleotide bindingi56 – 62GTPBy similarity7
Nucleotide bindingi85 – 89GTPBy similarity5
Nucleotide bindingi146 – 149GTPBy similarity4
Nucleotide bindingi177 – 178GTPBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein drn-1Curated
Alternative name(s):
Di-Ras/Rig/Noey2 Ras-like protein homolog1 Publication
Gene namesi
Name:drn-1Imported
ORF Names:C54A12.4Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC54A12.4; CE39342; WBGene00016911; drn-1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Viable and fertile. Resistant to paralysis induced by treatment with acetylcholinesterase inhibitor aldicarb (but not with acetylcholine agonist levamisole). Hypersensitivity to aldicarb treatment is partially reduced in an egl-30(js126), goa-1(n1134) or gsa-1(ce94) mutant background.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi40G → V: Probably constitutively active. Does not reduce paralysis induced by aldicarb treatment. 1 Publication1
Mutagenesisi45S → N: Probably nucleotide-free or GDP-bound. Reduces paralysis induced by aldicarb treatment. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000438305‹1 – 219GTP-binding protein drn-1CuratedAdd BLAST›219
PropeptideiPRO_0000438306217 – 219Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216Cysteine methyl esterSequence analysis1
Lipidationi216S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ09930.

Expressioni

Tissue specificityi

Expressed specifically in neurons including the nerve ring, ventral and dorsal nerve cord motor neurons and tail ganglia.1 Publication

Gene expression databases

BgeeiWBGene00016911.

Interactioni

Subunit structurei

Interacts with epac-1 (via C-terminus).1 Publication

Protein-protein interaction databases

STRINGi6239.C54A12.4.2.

Structurei

3D structure databases

ProteinModelPortaliQ09930.
SMRiQ09930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi59 – 67Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Di-Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000135293.
HOGENOMiHOG000233973.
InParanoidiQ09930.
KOiK07841.
OMAiEKASKEW.
OrthoDBiEOG091G0SBH.
PhylomeDBiQ09930.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LLDTDFSIEA TAATTTAGSG SKVAEASTSD YRVAVFGAGG VGKSSITQRF
60 70 80 90 100
VKGTFNENYV PTIEDTYRQV ISCNQKNVCT LQITDTTGSH QFPAMQRLSI
110 120 130 140 150
SKGNAFILIY SVTNKQSFAE LVPIIEMMKE VKGNAIAETP IMLVGNKKDE
160 170 180 190 200
ESKREVSSNS GQKVATNMEC GFIETSAKNN ENITELFQQL LALEKKRQLA
210
LTMDDPDGKN GKKKGCHIM
Length:219
Mass (Da):23,834
Last modified:November 30, 2016 - v3
Checksum:iCC593752DC3951DF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD68002.2.
PIRiT15833.
RefSeqiNP_494989.2. NM_062588.3.
UniGeneiCel.15612.

Genome annotation databases

EnsemblMetazoaiC54A12.4.1; C54A12.4.1; WBGene00016911.
C54A12.4.2; C54A12.4.2; WBGene00016911.
GeneIDi183765.
KEGGicel:CELE_C54A12.4.
UCSCiC54A12.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CCD68002.2.
PIRiT15833.
RefSeqiNP_494989.2. NM_062588.3.
UniGeneiCel.15612.

3D structure databases

ProteinModelPortaliQ09930.
SMRiQ09930.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.C54A12.4.2.

Proteomic databases

PaxDbiQ09930.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC54A12.4.1; C54A12.4.1; WBGene00016911.
C54A12.4.2; C54A12.4.2; WBGene00016911.
GeneIDi183765.
KEGGicel:CELE_C54A12.4.
UCSCiC54A12.4. c. elegans.

Organism-specific databases

CTDi183765.
WormBaseiC54A12.4; CE39342; WBGene00016911; drn-1.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000135293.
HOGENOMiHOG000233973.
InParanoidiQ09930.
KOiK07841.
OMAiEKASKEW.
OrthoDBiEOG091G0SBH.
PhylomeDBiQ09930.

Miscellaneous databases

PROiQ09930.

Gene expression databases

BgeeiWBGene00016911.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDIRA_CAEEL
AccessioniPrimary (citable) accession number: Q09930
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2016
Last sequence update: November 30, 2016
Last modified: November 30, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.