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Protein

Probable translation initiation factor eIF-2B subunit delta

Gene

tif224

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.By similarity

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: PomBase
  • translation initiation factor activity Source: PomBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-SPO-72731. Recycling of eIF2:GDP.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable translation initiation factor eIF-2B subunit delta
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit delta
Gene namesi
Name:tif224
ORF Names:SPAC21E11.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC21E11.06.
PomBaseiSPAC21E11.06. tif224.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • eukaryotic translation initiation factor 2B complex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001560711 – 467Probable translation initiation factor eIF-2B subunit deltaAdd BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16Phosphoserine1 Publication1
Modified residuei19Phosphoserine1 Publication1
Modified residuei21Phosphoserine1 Publication1
Modified residuei23Phosphoserine1 Publication1
Modified residuei27Phosphothreonine1 Publication1
Modified residuei28Phosphoserine1 Publication1
Modified residuei37Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09924.
PRIDEiQ09924.

PTM databases

iPTMnetiQ09924.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.By similarity

Protein-protein interaction databases

BioGridi278541. 2 interactors.
DIPiDIP-61961N.
MINTiMINT-4696455.

Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni122 – 125Combined sources4
Helixi143 – 154Combined sources12
Helixi160 – 177Combined sources18
Helixi186 – 204Combined sources19
Helixi209 – 224Combined sources16
Helixi231 – 248Combined sources18
Helixi251 – 262Combined sources12
Beta strandi269 – 275Combined sources7
Helixi278 – 289Combined sources12
Beta strandi294 – 300Combined sources7
Beta strandi302 – 304Combined sources3
Helixi306 – 316Combined sources11
Beta strandi320 – 325Combined sources6
Helixi326 – 328Combined sources3
Helixi329 – 333Combined sources5
Beta strandi337 – 342Combined sources6
Beta strandi344 – 346Combined sources3
Beta strandi352 – 355Combined sources4
Helixi358 – 367Combined sources10
Beta strandi372 – 375Combined sources4
Helixi378 – 380Combined sources3
Beta strandi387 – 392Combined sources6
Helixi398 – 401Combined sources4
Beta strandi405 – 410Combined sources6
Turni415 – 421Combined sources7
Beta strandi425 – 430Combined sources6
Beta strandi432 – 435Combined sources4
Helixi437 – 439Combined sources3
Beta strandi442 – 445Combined sources4
Beta strandi448 – 450Combined sources3
Helixi452 – 454Combined sources3
Helixi455 – 461Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5B04X-ray2.99G/H1-467[»]
ProteinModelPortaliQ09924.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000176924.
InParanoidiQ09924.
KOiK03680.
OMAiTTHINSQ.
OrthoDBiEOG092C2LM0.
PhylomeDBiQ09924.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFSAEQAKK DGKDQSPVSE SSSVGGTSPA TASSVVSPNE PKLSGKEAKA
60 70 80 90 100
LKKARKQASR RAKAEAAAAN NPPGVSEEKK VAIPNKNSNQ QKKASKQNPQ
110 120 130 140 150
NSPETDANLQ EKKIFEEKQV SIFSHLDWRR RRTTENIPKD IHPAVIRLGL
160 170 180 190 200
KLANYKIFGS NQRCIDLLKT FKIVIQDYQT PYGTTLSRHL TTHINSQIAY
210 220 230 240 250
LVSTRPLSIS MGNAIRFLKL EISVLDIDLT DDEGKELLLE KIDSYIRDRI
260 270 280 290 300
IIAGQVIVQA ATEKIQDGDV ILTYLHSSTV NDVLIHAKNV GKKFRVVVVD
310 320 330 340 350
SRPEFEGRVC LKLLTEHGIE CTYVMISALS YIMQEVTKIF LGGHAMLSNG
360 370 380 390 400
ALYSRAGTSL ISLLGHESNV PVIACCESYK FTERIQLDSL VYNELAPGDQ
410 420 430 440 450
LVNMGVDDFE EKPGVLANWK SVKNLKLLSL KYDVTPPRLI TVCVCEMGLL
460
PSTSVPAIIN EFKQVYA
Length:467
Mass (Da):51,583
Last modified:February 1, 1996 - v1
Checksum:i3C7029EBDFEF6EAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91965.1.
PIRiT38138. S62591.
RefSeqiNP_594503.1. NM_001019932.2.

Genome annotation databases

EnsemblFungiiSPAC21E11.06.1; SPAC21E11.06.1:pep; SPAC21E11.06.
GeneIDi2542064.
KEGGispo:SPAC21E11.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91965.1.
PIRiT38138. S62591.
RefSeqiNP_594503.1. NM_001019932.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5B04X-ray2.99G/H1-467[»]
ProteinModelPortaliQ09924.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278541. 2 interactors.
DIPiDIP-61961N.
MINTiMINT-4696455.

PTM databases

iPTMnetiQ09924.

Proteomic databases

MaxQBiQ09924.
PRIDEiQ09924.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC21E11.06.1; SPAC21E11.06.1:pep; SPAC21E11.06.
GeneIDi2542064.
KEGGispo:SPAC21E11.06.

Organism-specific databases

EuPathDBiFungiDB:SPAC21E11.06.
PomBaseiSPAC21E11.06. tif224.

Phylogenomic databases

HOGENOMiHOG000176924.
InParanoidiQ09924.
KOiK03680.
OMAiTTHINSQ.
OrthoDBiEOG092C2LM0.
PhylomeDBiQ09924.

Enzyme and pathway databases

ReactomeiR-SPO-72731. Recycling of eIF2:GDP.

Miscellaneous databases

PROiQ09924.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEI2BD_SCHPO
AccessioniPrimary (citable) accession number: Q09924
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 5, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.