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Protein

Probable translation initiation factor eIF-2B subunit delta

Gene

tif224

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

ReactomeiR-SPO-72731. Recycling of eIF2:GDP.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable translation initiation factor eIF-2B subunit delta
Alternative name(s):
eIF-2B GDP-GTP exchange factor subunit delta
Gene namesi
Name:tif224
ORF Names:SPAC21E11.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC21E11.06.
PomBaseiSPAC21E11.06. tif224.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • eukaryotic translation initiation factor 2B complex Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Probable translation initiation factor eIF-2B subunit deltaPRO_0000156071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine1 Publication
Modified residuei19 – 191Phosphoserine1 Publication
Modified residuei21 – 211Phosphoserine1 Publication
Modified residuei23 – 231Phosphoserine1 Publication
Modified residuei27 – 271Phosphothreonine1 Publication
Modified residuei28 – 281Phosphoserine1 Publication
Modified residuei37 – 371Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09924.

PTM databases

iPTMnetiQ09924.

Interactioni

Subunit structurei

Complex of five different subunits; alpha, beta, gamma, delta and epsilon.By similarity

Protein-protein interaction databases

BioGridi278541. 2 interactions.
MINTiMINT-4696455.

Structurei

Secondary structure

1
467
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni122 – 1254Combined sources
Helixi143 – 15412Combined sources
Helixi160 – 17718Combined sources
Helixi186 – 20419Combined sources
Helixi209 – 22416Combined sources
Helixi231 – 24818Combined sources
Helixi251 – 26212Combined sources
Beta strandi269 – 2757Combined sources
Helixi278 – 28912Combined sources
Beta strandi294 – 3007Combined sources
Beta strandi302 – 3043Combined sources
Helixi306 – 31611Combined sources
Beta strandi320 – 3256Combined sources
Helixi326 – 3283Combined sources
Helixi329 – 3335Combined sources
Beta strandi337 – 3426Combined sources
Beta strandi344 – 3463Combined sources
Beta strandi352 – 3554Combined sources
Helixi358 – 36710Combined sources
Beta strandi372 – 3754Combined sources
Helixi378 – 3803Combined sources
Beta strandi387 – 3926Combined sources
Helixi398 – 4014Combined sources
Beta strandi405 – 4106Combined sources
Turni415 – 4217Combined sources
Beta strandi425 – 4306Combined sources
Beta strandi432 – 4354Combined sources
Helixi437 – 4393Combined sources
Beta strandi442 – 4454Combined sources
Beta strandi448 – 4503Combined sources
Helixi452 – 4543Combined sources
Helixi455 – 4617Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5B04X-ray2.99G/H1-467[»]
ProteinModelPortaliQ09924.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000176924.
InParanoidiQ09924.
KOiK03680.
OMAiHTESEAK.
OrthoDBiEOG7KSXK1.
PhylomeDBiQ09924.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFSAEQAKK DGKDQSPVSE SSSVGGTSPA TASSVVSPNE PKLSGKEAKA
60 70 80 90 100
LKKARKQASR RAKAEAAAAN NPPGVSEEKK VAIPNKNSNQ QKKASKQNPQ
110 120 130 140 150
NSPETDANLQ EKKIFEEKQV SIFSHLDWRR RRTTENIPKD IHPAVIRLGL
160 170 180 190 200
KLANYKIFGS NQRCIDLLKT FKIVIQDYQT PYGTTLSRHL TTHINSQIAY
210 220 230 240 250
LVSTRPLSIS MGNAIRFLKL EISVLDIDLT DDEGKELLLE KIDSYIRDRI
260 270 280 290 300
IIAGQVIVQA ATEKIQDGDV ILTYLHSSTV NDVLIHAKNV GKKFRVVVVD
310 320 330 340 350
SRPEFEGRVC LKLLTEHGIE CTYVMISALS YIMQEVTKIF LGGHAMLSNG
360 370 380 390 400
ALYSRAGTSL ISLLGHESNV PVIACCESYK FTERIQLDSL VYNELAPGDQ
410 420 430 440 450
LVNMGVDDFE EKPGVLANWK SVKNLKLLSL KYDVTPPRLI TVCVCEMGLL
460
PSTSVPAIIN EFKQVYA
Length:467
Mass (Da):51,583
Last modified:February 1, 1996 - v1
Checksum:i3C7029EBDFEF6EAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91965.1.
PIRiT38138. S62591.
RefSeqiNP_594503.1. NM_001019932.2.

Genome annotation databases

EnsemblFungiiSPAC21E11.06.1; SPAC21E11.06.1:pep; SPAC21E11.06.
GeneIDi2542064.
KEGGispo:SPAC21E11.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91965.1.
PIRiT38138. S62591.
RefSeqiNP_594503.1. NM_001019932.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5B04X-ray2.99G/H1-467[»]
ProteinModelPortaliQ09924.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278541. 2 interactions.
MINTiMINT-4696455.

PTM databases

iPTMnetiQ09924.

Proteomic databases

MaxQBiQ09924.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC21E11.06.1; SPAC21E11.06.1:pep; SPAC21E11.06.
GeneIDi2542064.
KEGGispo:SPAC21E11.06.

Organism-specific databases

EuPathDBiFungiDB:SPAC21E11.06.
PomBaseiSPAC21E11.06. tif224.

Phylogenomic databases

HOGENOMiHOG000176924.
InParanoidiQ09924.
KOiK03680.
OMAiHTESEAK.
OrthoDBiEOG7KSXK1.
PhylomeDBiQ09924.

Enzyme and pathway databases

ReactomeiR-SPO-72731. Recycling of eIF2:GDP.

Miscellaneous databases

PROiQ09924.

Family and domain databases

InterProiIPR000649. IF-2B-related.
[Graphical view]
PfamiPF01008. IF-2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-16; SER-19; SER-21; SER-23; THR-27; SER-28 AND SER-37, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiEI2BD_SCHPO
AccessioniPrimary (citable) accession number: Q09924
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.