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Protein

GTP-binding protein rho1

Gene

rho1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the regulation of cell wall growth and actin cytoskeleton organization. Activates (1,3)-beta-D-glucan synthase.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20GTPBy similarity8
Nucleotide bindingi60 – 64GTPBy similarity5
Nucleotide bindingi118 – 121GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: PomBase
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • establishment or maintenance of actin cytoskeleton polarity Source: PomBase
  • positive regulation of (1->3)-beta-D-glucan biosynthetic process Source: PomBase
  • regulation of actin cortical patch localization Source: PomBase
  • regulation of actin cytoskeleton organization Source: PomBase
  • regulation of alpha-glucan biosynthetic process Source: PomBase
  • regulation of cell wall (1->3)-beta-D-glucan biosynthetic process Source: PomBase
  • regulation of division septum assembly Source: PomBase
  • regulation of endocytosis Source: PomBase
  • regulation of establishment or maintenance of cell polarity regulating cell shape Source: PomBase
  • regulation of fungal-type cell wall biogenesis Source: PomBase
  • Rho protein signal transduction Source: PomBase

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-194840 Rho GTPase cycle
R-SPO-198203 PI3K/AKT activation
R-SPO-392451 G beta:gamma signalling through PI3Kgamma
R-SPO-416482 G alpha (12/13) signalling events
R-SPO-5625740 RHO GTPases activate PKNs
R-SPO-5663220 RHO GTPases Activate Formins
R-SPO-5666185 RHO GTPases Activate Rhotekin and Rhophilins
R-SPO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein rho1
Gene namesi
Name:rho1
ORF Names:SPAC1F7.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1F7.04
PomBaseiSPAC1F7.04 rho1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001989401 – 199GTP-binding protein rho1Add BLAST199
PropeptideiPRO_0000281270200 – 202Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei199Cysteine methyl esterBy similarity1
Lipidationi199S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ09914
PaxDbiQ09914
PRIDEiQ09914

Interactioni

Protein-protein interaction databases

BioGridi27810926 interactors.
IntActiQ09914 1 interactor.
STRINGi4896.SPAC1F7.04.1

Structurei

3D structure databases

ProteinModelPortaliQ09914
SMRiQ09914
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

HOGENOMiHOG000233974
InParanoidiQ09914
KOiK04513
OMAiQKIGARH
OrthoDBiEOG092C4TDG
PhylomeDBiQ09914

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09914-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATELRRKLV IVGDGACGKT CLLIVFSKGT FPEVYVPTVF ENYVADVEVD
60 70 80 90 100
GRHVELALWD TAGQEDYDRL RPLSYPDSHV ILICFAVDSP DSLDNVQEKW
110 120 130 140 150
ISEVLHFCSS LPILLVACKA DLRNDPKIIE ELSKTNQHPV TTEEGQAVAQ
160 170 180 190 200
KIGAYKYLEC SAKTNEGVRE VFESATRAAM LKHKPKVKPS SGTKKKKRCI

LL
Length:202
Mass (Da):22,523
Last modified:February 1, 1996 - v1
Checksum:i21B625E0B9098CB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38180 mRNA Translation: BAA07377.1
CU329670 Genomic DNA Translation: CAA91951.1
PIRiJC4044
RefSeqiNP_594490.1, NM_001019919.2

Genome annotation databases

EnsemblFungiiSPAC1F7.04.1; SPAC1F7.04.1:pep; SPAC1F7.04
GeneIDi2541612
KEGGispo:SPAC1F7.04

Similar proteinsi

Entry informationi

Entry nameiRHO1_SCHPO
AccessioniPrimary (citable) accession number: Q09914
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 28, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome