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Protein

GTP-binding protein rho1

Gene

rho1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the regulation of cell wall growth and actin cytoskeleton organization. Activates (1,3)-beta-D-glucan synthase.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208GTPBy similarity
Nucleotide bindingi60 – 645GTPBy similarity
Nucleotide bindingi118 – 1214GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: PomBase
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • establishment or maintenance of actin cytoskeleton polarity Source: PomBase
  • positive regulation of (1->3)-beta-D-glucan biosynthetic process Source: PomBase
  • regulation of actin cortical patch localization Source: PomBase
  • regulation of actin cytoskeleton organization Source: PomBase
  • regulation of alpha-glucan biosynthetic process Source: PomBase
  • regulation of barrier septum assembly Source: PomBase
  • regulation of cell wall (1->3)-beta-D-glucan biosynthetic process Source: PomBase
  • regulation of endocytosis Source: PomBase
  • regulation of establishment or maintenance of cell polarity regulating cell shape Source: PomBase
  • regulation of fungal-type cell wall biogenesis Source: PomBase
  • Rho protein signal transduction Source: PomBase
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-193634. Axonal growth inhibition (RHOA activation).
R-SPO-194840. Rho GTPase cycle.
R-SPO-198203. PI3K/AKT activation.
R-SPO-392451. G beta:gamma signalling through PI3Kgamma.
R-SPO-416482. G alpha (12/13) signalling events.
R-SPO-5625740. RHO GTPases activate PKNs.
R-SPO-5663220. RHO GTPases Activate Formins.
R-SPO-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein rho1
Gene namesi
Name:rho1
ORF Names:SPAC1F7.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1F7.04.
PomBaseiSPAC1F7.04. rho1.

Subcellular locationi

  • Cell membrane 1 Publication; Lipid-anchor 1 Publication

  • Note: Found at the growing tips of interphase cells and at the septum prior to cytokinesis.

GO - Cellular componenti

  • barrier septum Source: PomBase
  • cell tip Source: PomBase
  • cytosol Source: PomBase
  • extrinsic component of cytoplasmic side of plasma membrane Source: PomBase
  • nucleus Source: PomBase
  • site of polarized growth Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199GTP-binding protein rho1PRO_0000198940Add
BLAST
Propeptidei200 – 2023Removed in mature formBy similarityPRO_0000281270

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei199 – 1991Cysteine methyl esterBy similarity
Lipidationi199 – 1991S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ09914.
PRIDEiQ09914.

Interactioni

Protein-protein interaction databases

BioGridi278109. 25 interactions.
IntActiQ09914. 1 interaction.
MINTiMINT-4696327.

Structurei

3D structure databases

ProteinModelPortaliQ09914.
SMRiQ09914. Positions 5-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 439Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

HOGENOMiHOG000233974.
InParanoidiQ09914.
KOiK04513.
OMAiNILEKWH.
OrthoDBiEOG7SN8QP.
PhylomeDBiQ09914.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09914-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATELRRKLV IVGDGACGKT CLLIVFSKGT FPEVYVPTVF ENYVADVEVD
60 70 80 90 100
GRHVELALWD TAGQEDYDRL RPLSYPDSHV ILICFAVDSP DSLDNVQEKW
110 120 130 140 150
ISEVLHFCSS LPILLVACKA DLRNDPKIIE ELSKTNQHPV TTEEGQAVAQ
160 170 180 190 200
KIGAYKYLEC SAKTNEGVRE VFESATRAAM LKHKPKVKPS SGTKKKKRCI

LL
Length:202
Mass (Da):22,523
Last modified:February 1, 1996 - v1
Checksum:i21B625E0B9098CB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38180 mRNA. Translation: BAA07377.1.
CU329670 Genomic DNA. Translation: CAA91951.1.
PIRiJC4044.
RefSeqiNP_594490.1. NM_001019919.2.

Genome annotation databases

EnsemblFungiiSPAC1F7.04.1; SPAC1F7.04.1:pep; SPAC1F7.04.
GeneIDi2541612.
KEGGispo:SPAC1F7.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38180 mRNA. Translation: BAA07377.1.
CU329670 Genomic DNA. Translation: CAA91951.1.
PIRiJC4044.
RefSeqiNP_594490.1. NM_001019919.2.

3D structure databases

ProteinModelPortaliQ09914.
SMRiQ09914. Positions 5-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278109. 25 interactions.
IntActiQ09914. 1 interaction.
MINTiMINT-4696327.

Proteomic databases

MaxQBiQ09914.
PRIDEiQ09914.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1F7.04.1; SPAC1F7.04.1:pep; SPAC1F7.04.
GeneIDi2541612.
KEGGispo:SPAC1F7.04.

Organism-specific databases

EuPathDBiFungiDB:SPAC1F7.04.
PomBaseiSPAC1F7.04. rho1.

Phylogenomic databases

HOGENOMiHOG000233974.
InParanoidiQ09914.
KOiK04513.
OMAiNILEKWH.
OrthoDBiEOG7SN8QP.
PhylomeDBiQ09914.

Enzyme and pathway databases

ReactomeiR-SPO-193634. Axonal growth inhibition (RHOA activation).
R-SPO-194840. Rho GTPase cycle.
R-SPO-198203. PI3K/AKT activation.
R-SPO-392451. G beta:gamma signalling through PI3Kgamma.
R-SPO-416482. G alpha (12/13) signalling events.
R-SPO-5625740. RHO GTPases activate PKNs.
R-SPO-5663220. RHO GTPases Activate Formins.
R-SPO-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Miscellaneous databases

NextBioi20802706.
PROiQ09914.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51420. RHO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and sequencing of two cDNA clones encoding Rho proteins from the fission yeast Schizosaccharomyces pombe."
    Nakano K., Mabuchi I.
    Gene 155:119-122(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: JY450.
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. "Localisation of the Schizosaccharomyces pombe rho1p GTPase and its involvement in the organisation of the actin cytoskeleton."
    Arellano M., Duran A., Perez P.
    J. Cell Sci. 110:2547-2555(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRHO1_SCHPO
AccessioniPrimary (citable) accession number: Q09914
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.