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Q09909

- CWF19_SCHPO

UniProt

Q09909 - CWF19_SCHPO

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Protein

Pre-mRNA-splicing factor cwf19

Gene
cwf19, SPAC30D11.09
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.
Involved in mRNA splicing.

GO - Molecular functioni

  1. catalytic activity Source: InterPro

GO - Biological processi

  1. mRNA cis splicing, via spliceosome Source: PomBase
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor cwf19
Alternative name(s):
Complexed with cdc5 protein 19
Gene namesi
Name:cwf19
ORF Names:SPAC30D11.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC30D11.09.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. spliceosomal complex Source: PomBase
  2. U2-type spliceosomal complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639Pre-mRNA-splicing factor cwf19PRO_0000079614Add
BLAST

Proteomic databases

MaxQBiQ09909.

Interactioni

Subunit structurei

Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2.1 Publication

Protein-protein interaction databases

BioGridi279618. 95 interactions.
IntActiQ09909. 4 interactions.
STRINGi4896.SPAC30D11.09-1.

Structurei

3D structure databases

ProteinModelPortaliQ09909.

Family & Domainsi

Sequence similaritiesi

Belongs to the CWF19 family.

Phylogenomic databases

eggNOGiNOG248199.
HOGENOMiHOG000191634.
OMAiNANTINR.
OrthoDBiEOG77M8XR.
PhylomeDBiQ09909.

Family and domain databases

InterProiIPR006768. Cwf19-like_C_dom-1.
IPR006767. Cwf19-like_C_dom-2.
IPR011146. HIT-like.
[Graphical view]
PfamiPF04677. CwfJ_C_1. 1 hit.
PF04676. CwfJ_C_2. 1 hit.
[Graphical view]
SUPFAMiSSF54197. SSF54197. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09909-1 [UniParc]FASTAAdd to Basket

« Hide

MEKEKLTNRT STHKFNETDR ETNHSRRHRH HHSRHRESKH GRHDRSERPS    50
SREAGDRSRH ERFSKEPLEV KKLPVENEYF DSKFASASSM PSSKDNPQNN 100
DFTNSLQGLD FGTFGSRIQR EPIDRKSNKP GEIFVGATLQ NESSTSTEHK 150
DIEQLETEIN ESGINYKIGD NGSRWRMMKL KRVFDMAQDQ RRPVEEVALE 200
RYGSLKEFDF ALEERDELEL RKRTRKVQKE VPTGELYEKR CADEFKTRKD 250
SGNGATYYKV IPDPSVNKDT PTESDLNRLK ADLLRAQLKK DPNYESLERE 300
YQKACDDFEN SLHPSENSNS QATIPSKKRN FDDPTIDEMV QEEKLLNKQR 350
KYGQNYEYAK QIAKDKTYSN NLDYLDENAG KLSNRMKRGD VSLAQISSGG 400
DLKKINHVLD TCPLCLNYET QPLAPVISLS HRAYVSLPTQ PELAKYHCLI 450
VPTGHRINTL SCDEDEWDEI RNFMKCIALM FDSMNLGVIF YENAPSPQRY 500
MHTAIECIPV SKRILSLAPA YFREALSTSD EEWSQHRKII DTLEGSKKYG 550
KWAFRKMMVK ELGYFHVWFS IDGGYGHVVE DEKAWGRHDQ VPRQVFASML 600
NLPPEVIRRK GSWTGKKDPR EDMFRSRFEK FDWTKGLID 639
Length:639
Mass (Da):74,420
Last modified:February 1, 1996 - v1
Checksum:i95F79E570802DA1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA91895.1.
PIRiT38590. S62567.
RefSeqiNP_593208.1. NM_001018604.2.

Genome annotation databases

EnsemblFungiiSPAC30D11.09.1; SPAC30D11.09.1:pep; SPAC30D11.09.
GeneIDi2543189.
KEGGispo:SPAC30D11.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA91895.1 .
PIRi T38590. S62567.
RefSeqi NP_593208.1. NM_001018604.2.

3D structure databases

ProteinModelPortali Q09909.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279618. 95 interactions.
IntActi Q09909. 4 interactions.
STRINGi 4896.SPAC30D11.09-1.

Proteomic databases

MaxQBi Q09909.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC30D11.09.1 ; SPAC30D11.09.1:pep ; SPAC30D11.09 .
GeneIDi 2543189.
KEGGi spo:SPAC30D11.09.

Organism-specific databases

PomBasei SPAC30D11.09.

Phylogenomic databases

eggNOGi NOG248199.
HOGENOMi HOG000191634.
OMAi NANTINR.
OrthoDBi EOG77M8XR.
PhylomeDBi Q09909.

Miscellaneous databases

NextBioi 20804212.
PROi Q09909.

Family and domain databases

InterProi IPR006768. Cwf19-like_C_dom-1.
IPR006767. Cwf19-like_C_dom-2.
IPR011146. HIT-like.
[Graphical view ]
Pfami PF04677. CwfJ_C_1. 1 hit.
PF04676. CwfJ_C_2. 1 hit.
[Graphical view ]
SUPFAMi SSF54197. SSF54197. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs."
    Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., Gould K.L.
    Mol. Cell. Biol. 22:2011-2024(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CWF COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCWF19_SCHPO
AccessioniPrimary (citable) accession number: Q09909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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