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Q09909 (CWF19_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pre-mRNA-splicing factor cwf19
Alternative name(s):
Complexed with cdc5 protein 19
Gene names
Name:cwf19
ORF Names:SPAC30D11.09
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length639 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.

Involved in mRNA splicing.

Subunit structure

Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2. Ref.2

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the CWF19 family.

Ontologies

Keywords
   Biological processmRNA processing
mRNA splicing
   Cellular componentNucleus
Spliceosome
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmRNA cis splicing, via spliceosome

Traceable author statement Ref.2. Source: PomBase

   Cellular_componentU2-type spliceosomal complex

Inferred from direct assay PubMed 21386897. Source: PomBase

spliceosomal complex

Inferred from direct assay Ref.2. Source: PomBase

   Molecular_functioncatalytic activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 639639Pre-mRNA-splicing factor cwf19
PRO_0000079614

Sequences

Sequence LengthMass (Da)Tools
Q09909 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 95F79E570802DA1B

FASTA63974,420
        10         20         30         40         50         60 
MEKEKLTNRT STHKFNETDR ETNHSRRHRH HHSRHRESKH GRHDRSERPS SREAGDRSRH 

        70         80         90        100        110        120 
ERFSKEPLEV KKLPVENEYF DSKFASASSM PSSKDNPQNN DFTNSLQGLD FGTFGSRIQR 

       130        140        150        160        170        180 
EPIDRKSNKP GEIFVGATLQ NESSTSTEHK DIEQLETEIN ESGINYKIGD NGSRWRMMKL 

       190        200        210        220        230        240 
KRVFDMAQDQ RRPVEEVALE RYGSLKEFDF ALEERDELEL RKRTRKVQKE VPTGELYEKR 

       250        260        270        280        290        300 
CADEFKTRKD SGNGATYYKV IPDPSVNKDT PTESDLNRLK ADLLRAQLKK DPNYESLERE 

       310        320        330        340        350        360 
YQKACDDFEN SLHPSENSNS QATIPSKKRN FDDPTIDEMV QEEKLLNKQR KYGQNYEYAK 

       370        380        390        400        410        420 
QIAKDKTYSN NLDYLDENAG KLSNRMKRGD VSLAQISSGG DLKKINHVLD TCPLCLNYET 

       430        440        450        460        470        480 
QPLAPVISLS HRAYVSLPTQ PELAKYHCLI VPTGHRINTL SCDEDEWDEI RNFMKCIALM 

       490        500        510        520        530        540 
FDSMNLGVIF YENAPSPQRY MHTAIECIPV SKRILSLAPA YFREALSTSD EEWSQHRKII 

       550        560        570        580        590        600 
DTLEGSKKYG KWAFRKMMVK ELGYFHVWFS IDGGYGHVVE DEKAWGRHDQ VPRQVFASML 

       610        620        630 
NLPPEVIRRK GSWTGKKDPR EDMFRSRFEK FDWTKGLID 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs."
Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., Gould K.L.
Mol. Cell. Biol. 22:2011-2024(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE CWF COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAA91895.1.
PIRS62567. T38590.
RefSeqNP_593208.1. NM_001018604.2.

3D structure databases

ProteinModelPortalQ09909.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279618. 94 interactions.
IntActQ09909. 4 interactions.
STRING4896.SPAC30D11.09-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC30D11.09.1; SPAC30D11.09.1:pep; SPAC30D11.09.
GeneID2543189.
KEGGspo:SPAC30D11.09.

Organism-specific databases

PomBaseSPAC30D11.09.

Phylogenomic databases

eggNOGNOG248199.
HOGENOMHOG000191634.
OMANANTINR.
OrthoDBEOG77M8XR.
PhylomeDBQ09909.

Family and domain databases

InterProIPR006768. Cwf19-like_C_dom-1.
IPR006767. Cwf19-like_C_dom-2.
IPR011146. HIT-like.
[Graphical view]
PfamPF04677. CwfJ_C_1. 1 hit.
PF04676. CwfJ_C_2. 1 hit.
[Graphical view]
SUPFAMSSF54197. SSF54197. 1 hit.
ProtoNetSearch...

Other

NextBio20804212.
PROQ09909.

Entry information

Entry nameCWF19_SCHPO
AccessionPrimary (citable) accession number: Q09909
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names