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Protein

Pre-mRNA-splicing factor cwf19

Gene

cwf19

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.
Involved in mRNA splicing.

GO - Biological processi

  • mRNA cis splicing, via spliceosome Source: PomBase

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor cwf19
Alternative name(s):
Complexed with cdc5 protein 19
Gene namesi
Name:cwf19
ORF Names:SPAC30D11.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC30D11.09
PomBaseiSPAC30D11.09 cwf19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000796141 – 639Pre-mRNA-splicing factor cwf19Add BLAST639

Proteomic databases

MaxQBiQ09909
PaxDbiQ09909
PRIDEiQ09909

PTM databases

iPTMnetiQ09909

Interactioni

Subunit structurei

Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2.1 Publication

Protein-protein interaction databases

BioGridi279618, 96 interactors
IntActiQ09909, 4 interactors
STRINGi4896.SPAC30D11.09.1

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JB9electron microscopy3.60c1-639[»]
ProteinModelPortaliQ09909
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CWF19 family.Curated

Phylogenomic databases

HOGENOMiHOG000191634
InParanoidiQ09909
OMAiQMFEREK
OrthoDBiEOG092C2DM0
PhylomeDBiQ09909

Family and domain databases

Gene3Di3.30.428.10, 1 hit
InterProiView protein in InterPro
IPR006768 Cwf19-like_C_dom-1
IPR006767 Cwf19-like_C_dom-2
IPR036265 HIT-like_sf
PfamiView protein in Pfam
PF04677 CwfJ_C_1, 1 hit
PF04676 CwfJ_C_2, 1 hit
SUPFAMiSSF54197 SSF54197, 1 hit

Sequencei

Sequence statusi: Complete.

Q09909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKEKLTNRT STHKFNETDR ETNHSRRHRH HHSRHRESKH GRHDRSERPS
60 70 80 90 100
SREAGDRSRH ERFSKEPLEV KKLPVENEYF DSKFASASSM PSSKDNPQNN
110 120 130 140 150
DFTNSLQGLD FGTFGSRIQR EPIDRKSNKP GEIFVGATLQ NESSTSTEHK
160 170 180 190 200
DIEQLETEIN ESGINYKIGD NGSRWRMMKL KRVFDMAQDQ RRPVEEVALE
210 220 230 240 250
RYGSLKEFDF ALEERDELEL RKRTRKVQKE VPTGELYEKR CADEFKTRKD
260 270 280 290 300
SGNGATYYKV IPDPSVNKDT PTESDLNRLK ADLLRAQLKK DPNYESLERE
310 320 330 340 350
YQKACDDFEN SLHPSENSNS QATIPSKKRN FDDPTIDEMV QEEKLLNKQR
360 370 380 390 400
KYGQNYEYAK QIAKDKTYSN NLDYLDENAG KLSNRMKRGD VSLAQISSGG
410 420 430 440 450
DLKKINHVLD TCPLCLNYET QPLAPVISLS HRAYVSLPTQ PELAKYHCLI
460 470 480 490 500
VPTGHRINTL SCDEDEWDEI RNFMKCIALM FDSMNLGVIF YENAPSPQRY
510 520 530 540 550
MHTAIECIPV SKRILSLAPA YFREALSTSD EEWSQHRKII DTLEGSKKYG
560 570 580 590 600
KWAFRKMMVK ELGYFHVWFS IDGGYGHVVE DEKAWGRHDQ VPRQVFASML
610 620 630
NLPPEVIRRK GSWTGKKDPR EDMFRSRFEK FDWTKGLID
Length:639
Mass (Da):74,420
Last modified:February 1, 1996 - v1
Checksum:i95F79E570802DA1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA91895.1
PIRiT38590 S62567
RefSeqiNP_593208.1, NM_001018604.2

Genome annotation databases

EnsemblFungiiSPAC30D11.09.1; SPAC30D11.09.1:pep; SPAC30D11.09
GeneIDi2543189
KEGGispo:SPAC30D11.09

Similar proteinsi

Entry informationi

Entry nameiCWF19_SCHPO
AccessioniPrimary (citable) accession number: Q09909
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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