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Q09909

- CWF19_SCHPO

UniProt

Q09909 - CWF19_SCHPO

Protein

Pre-mRNA-splicing factor cwf19

Gene

cwf19

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.
    Involved in mRNA splicing.

    GO - Molecular functioni

    1. catalytic activity Source: InterPro

    GO - Biological processi

    1. mRNA cis splicing, via spliceosome Source: PomBase

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-mRNA-splicing factor cwf19
    Alternative name(s):
    Complexed with cdc5 protein 19
    Gene namesi
    Name:cwf19
    ORF Names:SPAC30D11.09
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC30D11.09.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. spliceosomal complex Source: PomBase
    2. U2-type spliceosomal complex Source: PomBase

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 639639Pre-mRNA-splicing factor cwf19PRO_0000079614Add
    BLAST

    Proteomic databases

    MaxQBiQ09909.

    Interactioni

    Subunit structurei

    Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2.1 Publication

    Protein-protein interaction databases

    BioGridi279618. 95 interactions.
    IntActiQ09909. 4 interactions.
    STRINGi4896.SPAC30D11.09-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09909.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CWF19 family.Curated

    Phylogenomic databases

    eggNOGiNOG248199.
    HOGENOMiHOG000191634.
    OMAiNANTINR.
    OrthoDBiEOG77M8XR.
    PhylomeDBiQ09909.

    Family and domain databases

    InterProiIPR006768. Cwf19-like_C_dom-1.
    IPR006767. Cwf19-like_C_dom-2.
    IPR011146. HIT-like.
    [Graphical view]
    PfamiPF04677. CwfJ_C_1. 1 hit.
    PF04676. CwfJ_C_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF54197. SSF54197. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q09909-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKEKLTNRT STHKFNETDR ETNHSRRHRH HHSRHRESKH GRHDRSERPS    50
    SREAGDRSRH ERFSKEPLEV KKLPVENEYF DSKFASASSM PSSKDNPQNN 100
    DFTNSLQGLD FGTFGSRIQR EPIDRKSNKP GEIFVGATLQ NESSTSTEHK 150
    DIEQLETEIN ESGINYKIGD NGSRWRMMKL KRVFDMAQDQ RRPVEEVALE 200
    RYGSLKEFDF ALEERDELEL RKRTRKVQKE VPTGELYEKR CADEFKTRKD 250
    SGNGATYYKV IPDPSVNKDT PTESDLNRLK ADLLRAQLKK DPNYESLERE 300
    YQKACDDFEN SLHPSENSNS QATIPSKKRN FDDPTIDEMV QEEKLLNKQR 350
    KYGQNYEYAK QIAKDKTYSN NLDYLDENAG KLSNRMKRGD VSLAQISSGG 400
    DLKKINHVLD TCPLCLNYET QPLAPVISLS HRAYVSLPTQ PELAKYHCLI 450
    VPTGHRINTL SCDEDEWDEI RNFMKCIALM FDSMNLGVIF YENAPSPQRY 500
    MHTAIECIPV SKRILSLAPA YFREALSTSD EEWSQHRKII DTLEGSKKYG 550
    KWAFRKMMVK ELGYFHVWFS IDGGYGHVVE DEKAWGRHDQ VPRQVFASML 600
    NLPPEVIRRK GSWTGKKDPR EDMFRSRFEK FDWTKGLID 639
    Length:639
    Mass (Da):74,420
    Last modified:February 1, 1996 - v1
    Checksum:i95F79E570802DA1B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA91895.1.
    PIRiT38590. S62567.
    RefSeqiNP_593208.1. NM_001018604.2.

    Genome annotation databases

    EnsemblFungiiSPAC30D11.09.1; SPAC30D11.09.1:pep; SPAC30D11.09.
    GeneIDi2543189.
    KEGGispo:SPAC30D11.09.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA91895.1 .
    PIRi T38590. S62567.
    RefSeqi NP_593208.1. NM_001018604.2.

    3D structure databases

    ProteinModelPortali Q09909.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279618. 95 interactions.
    IntActi Q09909. 4 interactions.
    STRINGi 4896.SPAC30D11.09-1.

    Proteomic databases

    MaxQBi Q09909.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC30D11.09.1 ; SPAC30D11.09.1:pep ; SPAC30D11.09 .
    GeneIDi 2543189.
    KEGGi spo:SPAC30D11.09.

    Organism-specific databases

    PomBasei SPAC30D11.09.

    Phylogenomic databases

    eggNOGi NOG248199.
    HOGENOMi HOG000191634.
    OMAi NANTINR.
    OrthoDBi EOG77M8XR.
    PhylomeDBi Q09909.

    Miscellaneous databases

    NextBioi 20804212.
    PROi Q09909.

    Family and domain databases

    InterProi IPR006768. Cwf19-like_C_dom-1.
    IPR006767. Cwf19-like_C_dom-2.
    IPR011146. HIT-like.
    [Graphical view ]
    Pfami PF04677. CwfJ_C_1. 1 hit.
    PF04676. CwfJ_C_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54197. SSF54197. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs."
      Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., Gould K.L.
      Mol. Cell. Biol. 22:2011-2024(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE CWF COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiCWF19_SCHPO
    AccessioniPrimary (citable) accession number: Q09909
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3