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Protein

Pre-mRNA-splicing factor cwf19

Gene

cwf19

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.
Involved in mRNA splicing.

GO - Molecular functioni

  1. catalytic activity Source: InterPro

GO - Biological processi

  1. mRNA cis splicing, via spliceosome Source: PomBase
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor cwf19
Alternative name(s):
Complexed with cdc5 protein 19
Gene namesi
Name:cwf19
ORF Names:SPAC30D11.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC30D11.09.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. U2-type spliceosomal complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639Pre-mRNA-splicing factor cwf19PRO_0000079614Add
BLAST

Proteomic databases

MaxQBiQ09909.

Interactioni

Subunit structurei

Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2.1 Publication

Protein-protein interaction databases

BioGridi279618. 96 interactions.
IntActiQ09909. 4 interactions.
STRINGi4896.SPAC30D11.09-1.

Structurei

3D structure databases

ProteinModelPortaliQ09909.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CWF19 family.Curated

Phylogenomic databases

eggNOGiNOG248199.
HOGENOMiHOG000191634.
InParanoidiQ09909.
OMAiNANTINR.
OrthoDBiEOG77M8XR.
PhylomeDBiQ09909.

Family and domain databases

InterProiIPR006768. Cwf19-like_C_dom-1.
IPR006767. Cwf19-like_C_dom-2.
IPR011146. HIT-like.
[Graphical view]
PfamiPF04677. CwfJ_C_1. 1 hit.
PF04676. CwfJ_C_2. 1 hit.
[Graphical view]
SUPFAMiSSF54197. SSF54197. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09909-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKEKLTNRT STHKFNETDR ETNHSRRHRH HHSRHRESKH GRHDRSERPS
60 70 80 90 100
SREAGDRSRH ERFSKEPLEV KKLPVENEYF DSKFASASSM PSSKDNPQNN
110 120 130 140 150
DFTNSLQGLD FGTFGSRIQR EPIDRKSNKP GEIFVGATLQ NESSTSTEHK
160 170 180 190 200
DIEQLETEIN ESGINYKIGD NGSRWRMMKL KRVFDMAQDQ RRPVEEVALE
210 220 230 240 250
RYGSLKEFDF ALEERDELEL RKRTRKVQKE VPTGELYEKR CADEFKTRKD
260 270 280 290 300
SGNGATYYKV IPDPSVNKDT PTESDLNRLK ADLLRAQLKK DPNYESLERE
310 320 330 340 350
YQKACDDFEN SLHPSENSNS QATIPSKKRN FDDPTIDEMV QEEKLLNKQR
360 370 380 390 400
KYGQNYEYAK QIAKDKTYSN NLDYLDENAG KLSNRMKRGD VSLAQISSGG
410 420 430 440 450
DLKKINHVLD TCPLCLNYET QPLAPVISLS HRAYVSLPTQ PELAKYHCLI
460 470 480 490 500
VPTGHRINTL SCDEDEWDEI RNFMKCIALM FDSMNLGVIF YENAPSPQRY
510 520 530 540 550
MHTAIECIPV SKRILSLAPA YFREALSTSD EEWSQHRKII DTLEGSKKYG
560 570 580 590 600
KWAFRKMMVK ELGYFHVWFS IDGGYGHVVE DEKAWGRHDQ VPRQVFASML
610 620 630
NLPPEVIRRK GSWTGKKDPR EDMFRSRFEK FDWTKGLID
Length:639
Mass (Da):74,420
Last modified:February 1, 1996 - v1
Checksum:i95F79E570802DA1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91895.1.
PIRiT38590. S62567.
RefSeqiNP_593208.1. NM_001018604.2.

Genome annotation databases

EnsemblFungiiSPAC30D11.09.1; SPAC30D11.09.1:pep; SPAC30D11.09.
GeneIDi2543189.
KEGGispo:SPAC30D11.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91895.1.
PIRiT38590. S62567.
RefSeqiNP_593208.1. NM_001018604.2.

3D structure databases

ProteinModelPortaliQ09909.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279618. 96 interactions.
IntActiQ09909. 4 interactions.
STRINGi4896.SPAC30D11.09-1.

Proteomic databases

MaxQBiQ09909.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC30D11.09.1; SPAC30D11.09.1:pep; SPAC30D11.09.
GeneIDi2543189.
KEGGispo:SPAC30D11.09.

Organism-specific databases

PomBaseiSPAC30D11.09.

Phylogenomic databases

eggNOGiNOG248199.
HOGENOMiHOG000191634.
InParanoidiQ09909.
OMAiNANTINR.
OrthoDBiEOG77M8XR.
PhylomeDBiQ09909.

Miscellaneous databases

NextBioi20804212.
PROiQ09909.

Family and domain databases

InterProiIPR006768. Cwf19-like_C_dom-1.
IPR006767. Cwf19-like_C_dom-2.
IPR011146. HIT-like.
[Graphical view]
PfamiPF04677. CwfJ_C_1. 1 hit.
PF04676. CwfJ_C_2. 1 hit.
[Graphical view]
SUPFAMiSSF54197. SSF54197. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs."
    Ohi M.D., Link A.J., Ren L., Jennings J.L., McDonald W.H., Gould K.L.
    Mol. Cell. Biol. 22:2011-2024(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE CWF COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCWF19_SCHPO
AccessioniPrimary (citable) accession number: Q09909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.