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Protein

AP-3 complex subunit sigma

Gene

aps3

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit sigma
Alternative name(s):
AP-3 complex sigma3A subunit
Adaptor-related protein complex 3 subunit sigma
Clathrin-associated/assembly/adaptor protein, small 3
Sigma-adaptin 3A
Sigma3-adaptin
Gene namesi
Name:aps3
ORF Names:SPAC30D11.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC30D11.05.
PomBaseiSPAC30D11.05. aps3.

Subcellular locationi

  • Golgi apparatus By similarity
  • Cytoplasmic vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

  • Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.By similarity

GO - Cellular componenti

  • AP-3 adaptor complex Source: PomBase
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • cytosol Source: PomBase
  • Golgi apparatus Source: UniProtKB-SubCell
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938231 – 165AP-3 complex subunit sigmaAdd BLAST165

Proteomic databases

MaxQBiQ09905.
PRIDEiQ09905.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (apl5 and apl6), a medium adaptin (apm3) and a small adaptin (aps3).By similarity

Protein-protein interaction databases

BioGridi278590. 2 interactors.
MINTiMINT-4696247.

Structurei

3D structure databases

ProteinModelPortaliQ09905.
SMRiQ09905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000185228.
InParanoidiQ09905.
KOiK12399.
OMAiEMIIGGV.
OrthoDBiEOG092C59LG.
PhylomeDBiQ09905.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR027155. APS3.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PTHR11753:SF2. PTHR11753:SF2. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09905-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYAVFIFNN KGKPRLTKFY TPIDESIQQK LIGDIYAAVS TRPPTACNFL
60 70 80 90 100
ESNLIAGKNR IIYRQYATLY FVFVVDEGES ELGILDLIQV FVEALDRCFN
110 120 130 140 150
NVCELDLVFK FQEIHAILAE VVSGGLVLET NLNEIVLAAQ NQMPKTKRSN
160
AMPFSNTLSS FATRF
Length:165
Mass (Da):18,643
Last modified:February 1, 1996 - v1
Checksum:i9EA796AD34C40FF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91891.1.
PIRiT38594. S62563.
RefSeqiNP_593212.1. NM_001018608.2.

Genome annotation databases

EnsemblFungiiSPAC30D11.05.1; SPAC30D11.05.1:pep; SPAC30D11.05.
GeneIDi2542114.
KEGGispo:SPAC30D11.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91891.1.
PIRiT38594. S62563.
RefSeqiNP_593212.1. NM_001018608.2.

3D structure databases

ProteinModelPortaliQ09905.
SMRiQ09905.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278590. 2 interactors.
MINTiMINT-4696247.

Proteomic databases

MaxQBiQ09905.
PRIDEiQ09905.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC30D11.05.1; SPAC30D11.05.1:pep; SPAC30D11.05.
GeneIDi2542114.
KEGGispo:SPAC30D11.05.

Organism-specific databases

EuPathDBiFungiDB:SPAC30D11.05.
PomBaseiSPAC30D11.05. aps3.

Phylogenomic databases

HOGENOMiHOG000185228.
InParanoidiQ09905.
KOiK12399.
OMAiEMIIGGV.
OrthoDBiEOG092C59LG.
PhylomeDBiQ09905.

Miscellaneous databases

PROiQ09905.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR027155. APS3.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PTHR11753:SF2. PTHR11753:SF2. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP3S_SCHPO
AccessioniPrimary (citable) accession number: Q09905
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.