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Q09892

- HOG1_SCHPO

UniProt

Q09892 - HOG1_SCHPO

Protein

Mitogen-activated protein kinase sty1

Gene

sty1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that affect cell physiology. Phosphorylates atf1 and mkp1. In conjunction with hal4, has a role in the cellular resistance to toxic cations such as Na+, Li+ and Ca2+. Involved in resistance to arsenite, methylglyoxal and hydrogen peroxide. Involved in induction of thermotolerance in mRNA export, as well as in vacuolar fission.16 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by the MAPK kinase wisl, and negatively regulated by pypl and pyp2 tyrosine phosphatases.6 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491ATPPROSITE-ProRule annotation
    Active sitei141 – 1411Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: PomBase
    3. MAP kinase activity involved in osmosensory signaling pathway Source: PomBase
    4. protein binding Source: IntAct

    GO - Biological processi

    1. activation of bipolar cell growth Source: PomBase
    2. cell cycle arrest in response to nitrogen starvation Source: PomBase
    3. cellular response to arsenic-containing substance Source: PomBase
    4. cellular response to cation stress Source: PomBase
    5. cellular response to nitrogen starvation Source: PomBase
    6. G1 cell cycle arrest in response to nitrogen starvation Source: PomBase
    7. G1 to G0 transition Source: PomBase
    8. MAPK cascade in response to starvation Source: PomBase
    9. MAPK cascade involved in osmosensory signaling pathway Source: PomBase
    10. mRNA export from nucleus in response to heat stress Source: PomBase
    11. positive regulation of G2/M transition of mitotic cell cycle Source: PomBase
    12. positive regulation of transcription factor import into nucleus in response to oxidative stress Source: PomBase
    13. positive regulation of transcription from RNA polymerase II promoter Source: PomBase
    14. positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: PomBase
    15. regulation of cAMP-mediated signaling Source: PomBase
    16. regulation of cAMP-mediated signaling by regulation of transcription from RNA polymerase II promoter Source: PomBase
    17. regulation of cell shape involved in G1 to G0 transition Source: PomBase
    18. regulation of chromatin assembly Source: PomBase
    19. regulation of chromatin disassembly Source: PomBase
    20. regulation of DNA binding Source: PomBase
    21. regulation of histone acetylation Source: PomBase
    22. regulation of meiotic cell cycle Source: PomBase
    23. regulation of mRNA stability involved in cellular response to UV Source: PomBase
    24. regulation of reciprocal meiotic recombination Source: PomBase
    25. regulation of translation in response to nitrogen starvation Source: PomBase
    26. regulation of translation in response to osmotic stress Source: PomBase
    27. regulation of translation in response to oxidative stress Source: PomBase
    28. response to methylglyoxal Source: PomBase
    29. stress-activated MAPK cascade Source: PomBase
    30. stress granule assembly Source: PomBase
    31. stress granule disassembly Source: PomBase
    32. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.24. 5615.
    ReactomeiREACT_109535. Activation of the AP-1 family of transcription factors.
    REACT_188356. NOD1/2 Signaling Pathway.
    REACT_199400. Oxidative Stress Induced Senescence.
    REACT_218310. p38MAPK events.
    REACT_93683. activated TAK1 mediates p38 MAPK activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase sty1 (EC:2.7.11.24)
    Short name:
    MAP kinase sty1
    Alternative name(s):
    MAP kinase spc1
    Gene namesi
    Name:sty1
    Synonyms:hog1, phh1, spc1
    ORF Names:SPAC24B11.06c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC24B11.06c.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Predominantly cytoplasmic in unstressed cells but rapidly concentrates within the nucleus in response to hyperosmotic conditions and phosphorylation.

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 349349Mitogen-activated protein kinase sty1PRO_0000186342Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei171 – 1711Phosphothreonine1 Publication
    Modified residuei173 – 1731Phosphotyrosine1 Publication
    Modified residuei175 – 1751Phosphoserine1 Publication
    Modified residuei176 – 1761Phosphothreonine1 Publication

    Post-translational modificationi

    Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme By similarity. Phosphorylated by wis1 in response to osmotic stress, nutrient limitation, hydrogen peroxide and arsenite. Dephosphorylated by pyp1 and pyp2.By similarity9 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ09892.
    PaxDbiQ09892.

    Interactioni

    Subunit structurei

    Interacts with cdc37, cmk2, hal4, sin1 and srk1.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ptc4O141564EBI-3648525,EBI-7593590
    srk1O945473EBI-3648525,EBI-3648527

    Protein-protein interaction databases

    BioGridi278148. 297 interactions.
    IntActiQ09892. 5 interactions.
    MINTiMINT-4696085.
    STRINGi4896.SPAC24B11.06c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09892.
    SMRiQ09892. Positions 3-342.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 299280Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi171 – 1733TXY
    Motifi176 – 1783TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    KOiK04441.
    OMAiPDDVIHT.
    OrthoDBiEOG7K3TWD.
    PhylomeDBiQ09892.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008352. MAPK_p38.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR01773. P38MAPKINASE.
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09892-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEFIRTQIF GTCFEITTRY SDLQPIGMGA FGLVCSAKDQ LTGMNVAVKK    50
    IMKPFSTPVL AKRTYRELKL LKHLRHENII SLSDIFISPF EDIYFVTELL 100
    GTDLHRLLTS RPLETQFIQY FLYQILRGLK FVHSAGVIHR DLKPSNILIN 150
    ENCDLKICDF GLARIQDPQM TGYVSTRYYR APEIMLTWQK YNVEVDIWSA 200
    GCIFAEMIEG KPLFPGRDHV NQFSIITELL GTPPMEVIET ICSKNTLRFV 250
    QSLPQKEKVP FAEKFKNADP DAIDLLEKML VFDPRKRISA ADALAHNYLA 300
    PYHDPTDEPV ADEVFDWSFQ DNDLPVETWK VMMYSEVLSF HNMDNELQS 349
    Length:349
    Mass (Da):40,222
    Last modified:February 1, 1996 - v1
    Checksum:i9A10835FFD381AC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89262 Genomic DNA. Translation: CAA61537.1.
    U26739 mRNA. Translation: AAA91020.1.
    CU329670 Genomic DNA. Translation: CAA91771.1.
    PIRiS68675.
    RefSeqiNP_592843.1. NM_001018244.2.

    Genome annotation databases

    EnsemblFungiiSPAC24B11.06c.1; SPAC24B11.06c.1:pep; SPAC24B11.06c.
    GeneIDi2541652.
    KEGGispo:SPAC24B11.06c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89262 Genomic DNA. Translation: CAA61537.1 .
    U26739 mRNA. Translation: AAA91020.1 .
    CU329670 Genomic DNA. Translation: CAA91771.1 .
    PIRi S68675.
    RefSeqi NP_592843.1. NM_001018244.2.

    3D structure databases

    ProteinModelPortali Q09892.
    SMRi Q09892. Positions 3-342.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278148. 297 interactions.
    IntActi Q09892. 5 interactions.
    MINTi MINT-4696085.
    STRINGi 4896.SPAC24B11.06c-1.

    Proteomic databases

    MaxQBi Q09892.
    PaxDbi Q09892.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC24B11.06c.1 ; SPAC24B11.06c.1:pep ; SPAC24B11.06c .
    GeneIDi 2541652.
    KEGGi spo:SPAC24B11.06c.

    Organism-specific databases

    PomBasei SPAC24B11.06c.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    KOi K04441.
    OMAi PDDVIHT.
    OrthoDBi EOG7K3TWD.
    PhylomeDBi Q09892.

    Enzyme and pathway databases

    BRENDAi 2.7.11.24. 5615.
    Reactomei REACT_109535. Activation of the AP-1 family of transcription factors.
    REACT_188356. NOD1/2 Signaling Pathway.
    REACT_199400. Oxidative Stress Induced Senescence.
    REACT_218310. p38MAPK events.
    REACT_93683. activated TAK1 mediates p38 MAPK activation.

    Miscellaneous databases

    NextBioi 20802745.
    PROi Q09892.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR003527. MAP_kinase_CS.
    IPR008352. MAPK_p38.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR01773. P38MAPKINASE.
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS01351. MAPK. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast."
      Millar J.B.A., Buck V., Wilkinson M.G.
      Genes Dev. 9:2117-2130(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    2. "Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast."
      Shiozaki K., Russell P.
      Nature 378:739-743(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PHOSPHORYLATION, ENZYME REGULATION.
    3. "Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast."
      Kato T. Jr., Okazaki K., Murakami H., Stettler S., Fantes P.A., Okayama H.
      FEBS Lett. 378:207-212(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    4. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    5. "Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast."
      Shiozaki K., Russell P.
      Genes Dev. 10:2276-2288(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: 972 / ATCC 24843.
    6. "Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe."
      Degols G., Shiozaki K., Russell P.
      Mol. Cell. Biol. 16:2870-2877(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, PHOSPHORYLATION.
    7. "Stress-activated protein kinase pathway in cell cycle control of fission yeast."
      Shiozaki K., Russell P.
      Methods Enzymol. 283:506-520(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    8. "Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade."
      Shiozaki K., Shiozaki M., Russell P.
      Mol. Biol. Cell 8:409-419(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, PHOSPHORYLATION.
    9. "Regulated vacuole fusion and fission in Schizosaccharomyces pombe: an osmotic response dependent on MAP kinases."
      Bone N., Millar J.B.A., Toda T., Armstrong J.
      Curr. Biol. 8:135-144(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION.
    10. "Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1."
      Toone W.M., Kuge S., Samuels M., Morgan B.A., Toda T., Jones N.
      Genes Dev. 12:1453-1463(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast."
      Gaits F., Degols G., Shiozaki K., Russell P.
      Genes Dev. 12:1464-1473(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    12. "The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast."
      Smith D.A., Toone W.M., Chen D., Baehler J., Jones N., Morgan B.A., Quinn J.
      J. Biol. Chem. 277:33411-33421(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH SRK1.
    13. "Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast."
      Nguyen A.N., Ikner A.D., Shiozaki M., Warren S.M., Shiozaki K.
      Mol. Biol. Cell 13:2651-2663(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: ENZYME REGULATION, SUBCELLULAR LOCATION.
    14. "Identification of cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase."
      Tatebe H., Shiozaki K.
      Mol. Cell. Biol. 23:5132-5142(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CDC37, ENZYME REGULATION.
    15. "Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1."
      Asp E., Sunnerhagen P.
      Mol. Genet. Genomics 268:585-597(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CMK2 AND SRK1.
    16. "Hsp16p is required for thermotolerance in nuclear mRNA export in fission yeast Schizosaccharomyces pombe."
      Yoshida J., Tani T.
      Cell Struct. Funct. 29:125-138(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    17. "Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe."
      Rodriguez-Gabriel M.A., Russell P.
      Eukaryot. Cell 4:1396-1402(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION.
    18. "Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeast."
      Dunand-Sauthier I., Walker C.A., Narasimhan J., Pearce A.K., Wek R.C., Humphrey T.C.
      Eukaryot. Cell 4:1785-1793(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    19. "The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe."
      Zuin A., Vivancos A.P., Sanso M., Takatsume Y., Ayte J., Inoue Y., Hidalgo E.
      J. Biol. Chem. 280:36708-36713(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.
    20. "Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase."
      Wang L.-Y., Shimada K., Morishita M., Shiozaki K.
      Mol. Cell. Biol. 25:3945-3955(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH HAL4.
    21. "The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein."
      Wang L.-Y., Shiozaki K.
      FEBS Lett. 580:2409-2413(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    22. "Methylglyoxal as a signal initiator for activation of the stress-activated protein kinase cascade in the fission yeast Schizosaccharomyces pombe."
      Takatsume Y., Izawa S., Inoue Y.
      J. Biol. Chem. 281:9086-9092(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION, ENZYME REGULATION.
    23. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
      Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
      Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    24. "Regulation of Schizosaccharomyces pombe Atf1 protein levels by Sty1-mediated phosphorylation and heterodimerization with Pcr1."
      Lawrence C.L., Maekawa H., Worthington J.L., Reiter W., Wilkinson C.R.M., Jones N.
      J. Biol. Chem. 282:5160-5170(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    25. "Rad4TopBP1 associates with Srr2, an Spc1 MAPK-regulated protein, in response to environmental stress."
      Taricani L., Wang T.S.F.
      J. Biol. Chem. 282:8793-8800(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    26. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-171; TYR-173; SER-175 AND THR-176, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiHOG1_SCHPO
    AccessioniPrimary (citable) accession number: Q09892
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3