SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q09892

- HOG1_SCHPO

UniProt

Q09892 - HOG1_SCHPO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Mitogen-activated protein kinase sty1
Gene
sty1, hog1, phh1, spc1, SPAC24B11.06c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that affect cell physiology. Phosphorylates atf1 and mkp1. In conjunction with hal4, has a role in the cellular resistance to toxic cations such as Na+, Li+ and Ca2+. Involved in resistance to arsenite, methylglyoxal and hydrogen peroxide. Involved in induction of thermotolerance in mRNA export, as well as in vacuolar fission.16 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.

Enzyme regulationi

Activated by the MAPK kinase wisl, and negatively regulated by pypl and pyp2 tyrosine phosphatases.6 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATP By similarity
Active sitei141 – 1411Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: PomBase
  3. MAP kinase activity involved in osmosensory signaling pathway Source: PomBase
  4. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. G1 cell cycle arrest in response to nitrogen starvation Source: PomBase
  2. G1 to G0 transition Source: PomBase
  3. MAPK cascade in response to starvation Source: PomBase
  4. MAPK cascade involved in osmosensory signaling pathway Source: PomBase
  5. activation of bipolar cell growth Source: PomBase
  6. cell cycle arrest in response to nitrogen starvation Source: PomBase
  7. cellular response to arsenic-containing substance Source: PomBase
  8. cellular response to cation stress Source: PomBase
  9. cellular response to nitrogen starvation Source: PomBase
  10. mRNA export from nucleus in response to heat stress Source: PomBase
  11. positive regulation of G2/M transition of mitotic cell cycle Source: PomBase
  12. positive regulation of transcription factor import into nucleus in response to oxidative stress Source: PomBase
  13. positive regulation of transcription from RNA polymerase II promoter Source: PomBase
  14. positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: PomBase
  15. protein phosphorylation Source: PomBase
  16. regulation of DNA binding Source: PomBase
  17. regulation of cAMP-mediated signaling Source: PomBase
  18. regulation of cAMP-mediated signaling by regulation of transcription from RNA polymerase II promoter Source: PomBase
  19. regulation of cell shape involved in G1 to G0 transition Source: PomBase
  20. regulation of chromatin assembly Source: PomBase
  21. regulation of chromatin disassembly Source: PomBase
  22. regulation of histone acetylation Source: PomBase
  23. regulation of mRNA stability involved in cellular response to UV Source: PomBase
  24. regulation of meiotic cell cycle Source: PomBase
  25. regulation of reciprocal meiotic recombination Source: PomBase
  26. regulation of translation in response to nitrogen starvation Source: PomBase
  27. regulation of translation in response to osmotic stress Source: PomBase
  28. regulation of translation in response to oxidative stress Source: PomBase
  29. response to methylglyoxal Source: PomBase
  30. stress granule assembly Source: PomBase
  31. stress granule disassembly Source: PomBase
  32. stress-activated MAPK cascade Source: PomBase
  33. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.24. 5615.
ReactomeiREACT_109535. Activation of the AP-1 family of transcription factors.
REACT_188356. NOD1/2 Signaling Pathway.
REACT_199400. Oxidative Stress Induced Senescence.
REACT_218310. p38MAPK events.
REACT_93683. activated TAK1 mediates p38 MAPK activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase sty1 (EC:2.7.11.24)
Short name:
MAP kinase sty1
Alternative name(s):
MAP kinase spc1
Gene namesi
Name:sty1
Synonyms:hog1, phh1, spc1
ORF Names:SPAC24B11.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC24B11.06c.

Subcellular locationi

Cytoplasm. Nucleus
Note: Predominantly cytoplasmic in unstressed cells but rapidly concentrates within the nucleus in response to hyperosmotic conditions and phosphorylation.6 Publications

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Mitogen-activated protein kinase sty1
PRO_0000186342Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei171 – 1711Phosphothreonine1 Publication
Modified residuei173 – 1731Phosphotyrosine1 Publication
Modified residuei175 – 1751Phosphoserine1 Publication
Modified residuei176 – 1761Phosphothreonine1 Publication

Post-translational modificationi

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme By similarity. Phosphorylated by wis1 in response to osmotic stress, nutrient limitation, hydrogen peroxide and arsenite. Dephosphorylated by pyp1 and pyp2.8 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09892.
PaxDbiQ09892.

Interactioni

Subunit structurei

Interacts with cdc37, cmk2, hal4, sin1 and srk1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ptc4O141564EBI-3648525,EBI-7593590
srk1O945473EBI-3648525,EBI-3648527

Protein-protein interaction databases

BioGridi278148. 297 interactions.
IntActiQ09892. 5 interactions.
MINTiMINT-4696085.
STRINGi4896.SPAC24B11.06c-1.

Structurei

3D structure databases

ProteinModelPortaliQ09892.
SMRiQ09892. Positions 3-342.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 299280Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi171 – 1733TXY
Motifi176 – 1783TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK04441.
OMAiPDDVIHT.
OrthoDBiEOG7K3TWD.
PhylomeDBiQ09892.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09892-1 [UniParc]FASTAAdd to Basket

« Hide

MAEFIRTQIF GTCFEITTRY SDLQPIGMGA FGLVCSAKDQ LTGMNVAVKK    50
IMKPFSTPVL AKRTYRELKL LKHLRHENII SLSDIFISPF EDIYFVTELL 100
GTDLHRLLTS RPLETQFIQY FLYQILRGLK FVHSAGVIHR DLKPSNILIN 150
ENCDLKICDF GLARIQDPQM TGYVSTRYYR APEIMLTWQK YNVEVDIWSA 200
GCIFAEMIEG KPLFPGRDHV NQFSIITELL GTPPMEVIET ICSKNTLRFV 250
QSLPQKEKVP FAEKFKNADP DAIDLLEKML VFDPRKRISA ADALAHNYLA 300
PYHDPTDEPV ADEVFDWSFQ DNDLPVETWK VMMYSEVLSF HNMDNELQS 349
Length:349
Mass (Da):40,222
Last modified:February 1, 1996 - v1
Checksum:i9A10835FFD381AC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89262 Genomic DNA. Translation: CAA61537.1.
U26739 mRNA. Translation: AAA91020.1.
CU329670 Genomic DNA. Translation: CAA91771.1.
PIRiS68675.
RefSeqiNP_592843.1. NM_001018244.2.

Genome annotation databases

EnsemblFungiiSPAC24B11.06c.1; SPAC24B11.06c.1:pep; SPAC24B11.06c.
GeneIDi2541652.
KEGGispo:SPAC24B11.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89262 Genomic DNA. Translation: CAA61537.1 .
U26739 mRNA. Translation: AAA91020.1 .
CU329670 Genomic DNA. Translation: CAA91771.1 .
PIRi S68675.
RefSeqi NP_592843.1. NM_001018244.2.

3D structure databases

ProteinModelPortali Q09892.
SMRi Q09892. Positions 3-342.
ModBasei Search...

Protein-protein interaction databases

BioGridi 278148. 297 interactions.
IntActi Q09892. 5 interactions.
MINTi MINT-4696085.
STRINGi 4896.SPAC24B11.06c-1.

Proteomic databases

MaxQBi Q09892.
PaxDbi Q09892.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC24B11.06c.1 ; SPAC24B11.06c.1:pep ; SPAC24B11.06c .
GeneIDi 2541652.
KEGGi spo:SPAC24B11.06c.

Organism-specific databases

PomBasei SPAC24B11.06c.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
KOi K04441.
OMAi PDDVIHT.
OrthoDBi EOG7K3TWD.
PhylomeDBi Q09892.

Enzyme and pathway databases

BRENDAi 2.7.11.24. 5615.
Reactomei REACT_109535. Activation of the AP-1 family of transcription factors.
REACT_188356. NOD1/2 Signaling Pathway.
REACT_199400. Oxidative Stress Induced Senescence.
REACT_218310. p38MAPK events.
REACT_93683. activated TAK1 mediates p38 MAPK activation.

Miscellaneous databases

NextBioi 20802745.
PROi Q09892.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR01773. P38MAPKINASE.
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast."
    Millar J.B.A., Buck V., Wilkinson M.G.
    Genes Dev. 9:2117-2130(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast."
    Shiozaki K., Russell P.
    Nature 378:739-743(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PHOSPHORYLATION, ENZYME REGULATION.
  3. "Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast."
    Kato T. Jr., Okazaki K., Murakami H., Stettler S., Fantes P.A., Okayama H.
    FEBS Lett. 378:207-212(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  4. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  5. "Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast."
    Shiozaki K., Russell P.
    Genes Dev. 10:2276-2288(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: 972 / ATCC 24843.
  6. "Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe."
    Degols G., Shiozaki K., Russell P.
    Mol. Cell. Biol. 16:2870-2877(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, PHOSPHORYLATION.
  7. "Stress-activated protein kinase pathway in cell cycle control of fission yeast."
    Shiozaki K., Russell P.
    Methods Enzymol. 283:506-520(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade."
    Shiozaki K., Shiozaki M., Russell P.
    Mol. Biol. Cell 8:409-419(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, PHOSPHORYLATION.
  9. "Regulated vacuole fusion and fission in Schizosaccharomyces pombe: an osmotic response dependent on MAP kinases."
    Bone N., Millar J.B.A., Toda T., Armstrong J.
    Curr. Biol. 8:135-144(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION.
  10. "Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1."
    Toone W.M., Kuge S., Samuels M., Morgan B.A., Toda T., Jones N.
    Genes Dev. 12:1453-1463(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast."
    Gaits F., Degols G., Shiozaki K., Russell P.
    Genes Dev. 12:1464-1473(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  12. "The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast."
    Smith D.A., Toone W.M., Chen D., Baehler J., Jones N., Morgan B.A., Quinn J.
    J. Biol. Chem. 277:33411-33421(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH SRK1.
  13. "Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast."
    Nguyen A.N., Ikner A.D., Shiozaki M., Warren S.M., Shiozaki K.
    Mol. Biol. Cell 13:2651-2663(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, SUBCELLULAR LOCATION.
  14. "Identification of cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase."
    Tatebe H., Shiozaki K.
    Mol. Cell. Biol. 23:5132-5142(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDC37, ENZYME REGULATION.
  15. "Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1."
    Asp E., Sunnerhagen P.
    Mol. Genet. Genomics 268:585-597(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CMK2 AND SRK1.
  16. "Hsp16p is required for thermotolerance in nuclear mRNA export in fission yeast Schizosaccharomyces pombe."
    Yoshida J., Tani T.
    Cell Struct. Funct. 29:125-138(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe."
    Rodriguez-Gabriel M.A., Russell P.
    Eukaryot. Cell 4:1396-1402(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION.
  18. "Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeast."
    Dunand-Sauthier I., Walker C.A., Narasimhan J., Pearce A.K., Wek R.C., Humphrey T.C.
    Eukaryot. Cell 4:1785-1793(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  19. "The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe."
    Zuin A., Vivancos A.P., Sanso M., Takatsume Y., Ayte J., Inoue Y., Hidalgo E.
    J. Biol. Chem. 280:36708-36713(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.
  20. "Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase."
    Wang L.-Y., Shimada K., Morishita M., Shiozaki K.
    Mol. Cell. Biol. 25:3945-3955(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HAL4.
  21. "The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein."
    Wang L.-Y., Shiozaki K.
    FEBS Lett. 580:2409-2413(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  22. "Methylglyoxal as a signal initiator for activation of the stress-activated protein kinase cascade in the fission yeast Schizosaccharomyces pombe."
    Takatsume Y., Izawa S., Inoue Y.
    J. Biol. Chem. 281:9086-9092(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, ENZYME REGULATION.
  23. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  24. "Regulation of Schizosaccharomyces pombe Atf1 protein levels by Sty1-mediated phosphorylation and heterodimerization with Pcr1."
    Lawrence C.L., Maekawa H., Worthington J.L., Reiter W., Wilkinson C.R.M., Jones N.
    J. Biol. Chem. 282:5160-5170(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  25. "Rad4TopBP1 associates with Srr2, an Spc1 MAPK-regulated protein, in response to environmental stress."
    Taricani L., Wang T.S.F.
    J. Biol. Chem. 282:8793-8800(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  26. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-171; TYR-173; SER-175 AND THR-176, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiHOG1_SCHPO
AccessioniPrimary (citable) accession number: Q09892
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi