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Protein

Mitogen-activated protein kinase sty1

Gene

sty1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that affect cell physiology. Phosphorylates atf1 and mkp1. In conjunction with hal4, has a role in the cellular resistance to toxic cations such as Na+, Li+ and Ca2+. Involved in resistance to arsenite, methylglyoxal and hydrogen peroxide. Involved in induction of thermotolerance in mRNA export, as well as in vacuolar fission.16 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by the MAPK kinase wisl, and negatively regulated by pypl and pyp2 tyrosine phosphatases.6 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATPPROSITE-ProRule annotation
Active sitei141 – 1411Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase activity Source: PomBase
  • MAP kinase activity involved in osmosensory signaling pathway Source: PomBase

GO - Biological processi

  • cellular response to cation stress Source: PomBase
  • MAPK cascade in response to starvation Source: PomBase
  • MAPK cascade involved in osmosensory signaling pathway Source: PomBase
  • mitotic cell cycle arrest in response to nitrogen starvation Source: PomBase
  • mRNA export from nucleus in response to heat stress Source: PomBase
  • positive regulation of G2/M transition of mitotic cell cycle Source: PomBase
  • positive regulation of protein kinase activity Source: PomBase
  • positive regulation of recombination hotspot binding Source: PomBase
  • positive regulation of transcription factor import into nucleus in response to oxidative stress Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: PomBase
  • protein phosphorylation Source: PomBase
  • regulation of aerobic respiration Source: PomBase
  • regulation of cAMP-mediated signaling Source: PomBase
  • regulation of cAMP-mediated signaling by regulation of transcription from RNA polymerase II promoter Source: PomBase
  • regulation of chromatin assembly Source: PomBase
  • regulation of chromatin disassembly Source: PomBase
  • regulation of cytoplasmic translation in response to stress Source: PomBase
  • regulation of DNA binding Source: PomBase
  • regulation of histone acetylation Source: PomBase
  • regulation of meiotic cell cycle Source: PomBase
  • regulation of mRNA stability involved in cellular response to UV Source: PomBase
  • regulation of reciprocal meiotic recombination Source: PomBase
  • stress-activated MAPK cascade Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.24. 5613.
ReactomeiREACT_272850. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_273674. Activation of the AP-1 family of transcription factors.
REACT_285646. NRAGE signals death through JNK.
REACT_299806. Oxidative Stress Induced Senescence.
REACT_309457. NOD1/2 Signaling Pathway.
REACT_311045. CDO in myogenesis.
REACT_315418. Ca2+ pathway.
REACT_321804. FCERI mediated MAPK activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase sty1 (EC:2.7.11.24)
Short name:
MAP kinase sty1
Alternative name(s):
MAP kinase spc1
Gene namesi
Name:sty1
Synonyms:hog1, phh1, spc1
ORF Names:SPAC24B11.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC24B11.06c.
PomBaseiSPAC24B11.06c.

Subcellular locationi

  • Cytoplasm
  • Nucleus

  • Note: Predominantly cytoplasmic in unstressed cells but rapidly concentrates within the nucleus in response to hyperosmotic conditions and phosphorylation.

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • mitochondrial inner membrane Source: PomBase
  • mitochondrial intermembrane space Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Mitogen-activated protein kinase sty1PRO_0000186342Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei171 – 1711Phosphothreonine1 Publication
Modified residuei173 – 1731Phosphotyrosine1 Publication
Modified residuei175 – 1751Phosphoserine1 Publication
Modified residuei176 – 1761Phosphothreonine1 Publication

Post-translational modificationi

Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme (By similarity). Phosphorylated by wis1 in response to osmotic stress, nutrient limitation, hydrogen peroxide and arsenite. Dephosphorylated by pyp1 and pyp2.By similarity9 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09892.
PaxDbiQ09892.

Interactioni

Subunit structurei

Interacts with cdc37, cmk2, hal4, sin1 and srk1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ptc4O141564EBI-3648525,EBI-7593590
srk1O945473EBI-3648525,EBI-3648527

Protein-protein interaction databases

BioGridi278148. 297 interactions.
IntActiQ09892. 5 interactions.
MINTiMINT-4696085.
STRINGi4896.SPAC24B11.06c-1.

Structurei

3D structure databases

ProteinModelPortaliQ09892.
SMRiQ09892. Positions 3-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 299280Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi171 – 1733TXY
Motifi176 – 1783TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ09892.
KOiK04441.
OMAiQPLRNKF.
OrthoDBiEOG7K3TWD.
PhylomeDBiQ09892.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09892-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFIRTQIF GTCFEITTRY SDLQPIGMGA FGLVCSAKDQ LTGMNVAVKK
60 70 80 90 100
IMKPFSTPVL AKRTYRELKL LKHLRHENII SLSDIFISPF EDIYFVTELL
110 120 130 140 150
GTDLHRLLTS RPLETQFIQY FLYQILRGLK FVHSAGVIHR DLKPSNILIN
160 170 180 190 200
ENCDLKICDF GLARIQDPQM TGYVSTRYYR APEIMLTWQK YNVEVDIWSA
210 220 230 240 250
GCIFAEMIEG KPLFPGRDHV NQFSIITELL GTPPMEVIET ICSKNTLRFV
260 270 280 290 300
QSLPQKEKVP FAEKFKNADP DAIDLLEKML VFDPRKRISA ADALAHNYLA
310 320 330 340
PYHDPTDEPV ADEVFDWSFQ DNDLPVETWK VMMYSEVLSF HNMDNELQS
Length:349
Mass (Da):40,222
Last modified:February 1, 1996 - v1
Checksum:i9A10835FFD381AC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89262 Genomic DNA. Translation: CAA61537.1.
U26739 mRNA. Translation: AAA91020.1.
CU329670 Genomic DNA. Translation: CAA91771.1.
PIRiS68675.
RefSeqiNP_592843.1. NM_001018244.2.

Genome annotation databases

EnsemblFungiiSPAC24B11.06c.1; SPAC24B11.06c.1:pep; SPAC24B11.06c.
GeneIDi2541652.
KEGGispo:SPAC24B11.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89262 Genomic DNA. Translation: CAA61537.1.
U26739 mRNA. Translation: AAA91020.1.
CU329670 Genomic DNA. Translation: CAA91771.1.
PIRiS68675.
RefSeqiNP_592843.1. NM_001018244.2.

3D structure databases

ProteinModelPortaliQ09892.
SMRiQ09892. Positions 3-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278148. 297 interactions.
IntActiQ09892. 5 interactions.
MINTiMINT-4696085.
STRINGi4896.SPAC24B11.06c-1.

Proteomic databases

MaxQBiQ09892.
PaxDbiQ09892.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC24B11.06c.1; SPAC24B11.06c.1:pep; SPAC24B11.06c.
GeneIDi2541652.
KEGGispo:SPAC24B11.06c.

Organism-specific databases

EuPathDBiFungiDB:SPAC24B11.06c.
PomBaseiSPAC24B11.06c.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ09892.
KOiK04441.
OMAiQPLRNKF.
OrthoDBiEOG7K3TWD.
PhylomeDBiQ09892.

Enzyme and pathway databases

BRENDAi2.7.11.24. 5613.
ReactomeiREACT_272850. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
REACT_273674. Activation of the AP-1 family of transcription factors.
REACT_285646. NRAGE signals death through JNK.
REACT_299806. Oxidative Stress Induced Senescence.
REACT_309457. NOD1/2 Signaling Pathway.
REACT_311045. CDO in myogenesis.
REACT_315418. Ca2+ pathway.
REACT_321804. FCERI mediated MAPK activation.

Miscellaneous databases

NextBioi20802745.
PROiQ09892.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast."
    Millar J.B.A., Buck V., Wilkinson M.G.
    Genes Dev. 9:2117-2130(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. "Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast."
    Shiozaki K., Russell P.
    Nature 378:739-743(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PHOSPHORYLATION, ENZYME REGULATION.
  3. "Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast."
    Kato T. Jr., Okazaki K., Murakami H., Stettler S., Fantes P.A., Okayama H.
    FEBS Lett. 378:207-212(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  4. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  5. "Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast."
    Shiozaki K., Russell P.
    Genes Dev. 10:2276-2288(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: 972 / ATCC 24843.
  6. "Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe."
    Degols G., Shiozaki K., Russell P.
    Mol. Cell. Biol. 16:2870-2877(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, PHOSPHORYLATION.
  7. "Stress-activated protein kinase pathway in cell cycle control of fission yeast."
    Shiozaki K., Russell P.
    Methods Enzymol. 283:506-520(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade."
    Shiozaki K., Shiozaki M., Russell P.
    Mol. Biol. Cell 8:409-419(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, PHOSPHORYLATION.
  9. "Regulated vacuole fusion and fission in Schizosaccharomyces pombe: an osmotic response dependent on MAP kinases."
    Bone N., Millar J.B.A., Toda T., Armstrong J.
    Curr. Biol. 8:135-144(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION.
  10. "Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1."
    Toone W.M., Kuge S., Samuels M., Morgan B.A., Toda T., Jones N.
    Genes Dev. 12:1453-1463(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast."
    Gaits F., Degols G., Shiozaki K., Russell P.
    Genes Dev. 12:1464-1473(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  12. "The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast."
    Smith D.A., Toone W.M., Chen D., Baehler J., Jones N., Morgan B.A., Quinn J.
    J. Biol. Chem. 277:33411-33421(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION, INTERACTION WITH SRK1.
  13. "Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast."
    Nguyen A.N., Ikner A.D., Shiozaki M., Warren S.M., Shiozaki K.
    Mol. Biol. Cell 13:2651-2663(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: ENZYME REGULATION, SUBCELLULAR LOCATION.
  14. "Identification of cdc37 as a novel regulator of the stress-responsive mitogen-activated protein kinase."
    Tatebe H., Shiozaki K.
    Mol. Cell. Biol. 23:5132-5142(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CDC37, ENZYME REGULATION.
  15. "Mkp1 and Mkp2, two MAPKAP-kinase homologues in Schizosaccharomyces pombe, interact with the MAP kinase Sty1."
    Asp E., Sunnerhagen P.
    Mol. Genet. Genomics 268:585-597(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CMK2 AND SRK1.
  16. "Hsp16p is required for thermotolerance in nuclear mRNA export in fission yeast Schizosaccharomyces pombe."
    Yoshida J., Tani T.
    Cell Struct. Funct. 29:125-138(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Distinct signaling pathways respond to arsenite and reactive oxygen species in Schizosaccharomyces pombe."
    Rodriguez-Gabriel M.A., Russell P.
    Eukaryot. Cell 4:1396-1402(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION.
  18. "Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeast."
    Dunand-Sauthier I., Walker C.A., Narasimhan J., Pearce A.K., Wek R.C., Humphrey T.C.
    Eukaryot. Cell 4:1785-1793(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  19. "The glycolytic metabolite methylglyoxal activates Pap1 and Sty1 stress responses in Schizosaccharomyces pombe."
    Zuin A., Vivancos A.P., Sanso M., Takatsume Y., Ayte J., Inoue Y., Hidalgo E.
    J. Biol. Chem. 280:36708-36713(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.
  20. "Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase."
    Wang L.-Y., Shimada K., Morishita M., Shiozaki K.
    Mol. Cell. Biol. 25:3945-3955(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HAL4.
  21. "The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein."
    Wang L.-Y., Shiozaki K.
    FEBS Lett. 580:2409-2413(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  22. "Methylglyoxal as a signal initiator for activation of the stress-activated protein kinase cascade in the fission yeast Schizosaccharomyces pombe."
    Takatsume Y., Izawa S., Inoue Y.
    J. Biol. Chem. 281:9086-9092(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION, ENZYME REGULATION.
  23. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  24. "Regulation of Schizosaccharomyces pombe Atf1 protein levels by Sty1-mediated phosphorylation and heterodimerization with Pcr1."
    Lawrence C.L., Maekawa H., Worthington J.L., Reiter W., Wilkinson C.R.M., Jones N.
    J. Biol. Chem. 282:5160-5170(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  25. "Rad4TopBP1 associates with Srr2, an Spc1 MAPK-regulated protein, in response to environmental stress."
    Taricani L., Wang T.S.F.
    J. Biol. Chem. 282:8793-8800(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  26. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-171; TYR-173; SER-175 AND THR-176, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiHOG1_SCHPO
AccessioniPrimary (citable) accession number: Q09892
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 27, 2015
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.