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Q09879

- UBP5_SCHPO

UniProt

Q09879 - UBP5_SCHPO

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Protein

Probable ubiquitin carboxyl-terminal hydrolase 5

Gene

ubp5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei222 – 2221NucleophilePROSITE-ProRule annotation
Active sitei464 – 4641Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: PomBase

GO - Biological processi

  1. endocytosis Source: PomBase
  2. protein deubiquitination Source: PomBase
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.A59.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 5 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 5
Ubiquitin thioesterase 5
Ubiquitin-specific-processing protease 5
Gene namesi
Name:ubp5
ORF Names:SPCC188.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC188.08c.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. Golgi apparatus Source: PomBase
  3. nucleus Source: PomBase
  4. transport vesicle Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11081108Probable ubiquitin carboxyl-terminal hydrolase 5PRO_0000080606Add
BLAST

Proteomic databases

MaxQBiQ09879.

Interactioni

Protein-protein interaction databases

BioGridi275950. 3 interactions.
MINTiMINT-4695964.
STRINGi4896.SPCC188.08c-1.

Structurei

3D structure databases

ProteinModelPortaliQ09879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 187133MATHPROSITE-ProRule annotationAdd
BLAST
Domaini213 – 528316USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 MATH domain.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5077.
HOGENOMiHOG000160240.
InParanoidiQ09879.
KOiK11838.
OMAiGLGHIFV.
OrthoDBiEOG7C2R8P.
PhylomeDBiQ09879.

Family and domain databases

InterProiIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view]
PfamiPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTiSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMiSSF49599. SSF49599. 1 hit.
PROSITEiPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09879-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTGETLVDS QKSLINNDTL LNEKLKEDFE ENVSIDVKIH EELRRALPDY
60 70 80 90 100
EESGFQRFTW HIKSWHELDR RAVSPQFAVG SRQFKITYFP QGTLQSAGFT
110 120 130 140 150
SIFLEYIPSE EEKLSNKYGC CCQFAFVISN PRKPSLSVAN SAHCRFSPEI
160 170 180 190 200
VDWGFTQFAE LKKLLCRQAP DVPPIVEDGA LLLTAYVRIL KDPTGVLWHS
210 220 230 240 250
FNDYDSKIAT GYVGLKNQGA TCYMNSLLQS LYIIHAFRRI VYQIPTDSPQ
260 270 280 290 300
GKDSIAYALQ RCFYNLQFMN EPVSTTELTK SFGWDSLDSF MQHDVQEFNR
310 320 330 340 350
VLQDNLERSM RDTKVENALT NLFVGKMKSY IACVNVNFES ARSEDYWDIQ
360 370 380 390 400
LNVKGMKNLE DSFRSYIQVE TLEGDNCYFA DTYGFQEAKK GVIFESFPPI
410 420 430 440 450
LHLQLKRFEY DFERDMMIKI NDRYEFPLEF DAKAFLSPEA DQSQNCEYVL
460 470 480 490 500
YGVLVHSGDL HNGHYYALLK TEKDGPWYKY DDTRVTRATL REVLEENYGG
510 520 530 540 550
DYIMHPPFRS PVKLKRFMSA YMLLYLRKDK LDELMNPVSA DEIPEHLKEA
560 570 580 590 600
LNPSIQLAEL RRKERLESHL YTKVQLITPE FYSEHHEFDI ADFGNAYKEE
610 620 630 640 650
TIPQFRIKKE AKFSEFIPIV AEKLGYPQEC MRFWYVVKRH NCTVRVESPV
660 670 680 690 700
NELNSTMEEV KNVWNSQGEI LRLYLEITPE NELSSSLTHQ NTGEWNAFIF
710 720 730 740 750
VKYFDRKSQE ISGCGTLHVN KSDEIRSICP LLCERANLPK NTPLNIYEEI
760 770 780 790 800
KPGMVDFLRL EKTFTQSELS TGDIICFEPC RPSALEDDIV NSGFDSALKL
810 820 830 840 850
YDFLSNKVLV LFRPRFIDQD SIIEFEMLLD RRIKYDDLCI ELGQKLGIGA
860 870 880 890 900
DHIRLTTCNP LTYSAGMVVP NDSNITLYEI LYSSEEEMPS NVIFYETMDV
910 920 930 940 950
SLSDLDRKRL VRLRWLVDGL ANIELVEAYI NKSGDINDLF GAVCERFPDS
960 970 980 990 1000
DLRKKKVRVY EVFESRYHRD LSLRTLIRTI NPAATLVGEV VPLDQLQLYP
1010 1020 1030 1040 1050
EEKIVQVHHF HKDIARIHGI PFSFVIKPQE KFIDTKLRLA ARTQYPESIF
1060 1070 1080 1090 1100
SVIKFCVVDF DNNRVVYLND EDITYDVVEK LNGTLALDRA KKDSKKPNIL

DRAIQMKN
Length:1,108
Mass (Da):128,668
Last modified:February 21, 2001 - v3
Checksum:i5C5A57058E3839C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB41228.1.
PIRiT41188.
RefSeqiNP_588211.1. NM_001023201.2.

Genome annotation databases

EnsemblFungiiSPCC188.08c.1; SPCC188.08c.1:pep; SPCC188.08c.
GeneIDi2539385.
KEGGispo:SPCC188.08c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329672 Genomic DNA. Translation: CAB41228.1 .
PIRi T41188.
RefSeqi NP_588211.1. NM_001023201.2.

3D structure databases

ProteinModelPortali Q09879.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275950. 3 interactions.
MINTi MINT-4695964.
STRINGi 4896.SPCC188.08c-1.

Protein family/group databases

MEROPSi C19.A59.

Proteomic databases

MaxQBi Q09879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC188.08c.1 ; SPCC188.08c.1:pep ; SPCC188.08c .
GeneIDi 2539385.
KEGGi spo:SPCC188.08c.

Organism-specific databases

PomBasei SPCC188.08c.

Phylogenomic databases

eggNOGi COG5077.
HOGENOMi HOG000160240.
InParanoidi Q09879.
KOi K11838.
OMAi GLGHIFV.
OrthoDBi EOG7C2R8P.
PhylomeDBi Q09879.

Miscellaneous databases

NextBioi 20800549.

Family and domain databases

InterProi IPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view ]
Pfami PF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view ]
SMARTi SM00061. MATH. 1 hit.
[Graphical view ]
SUPFAMi SSF49599. SSF49599. 1 hit.
PROSITEi PS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiUBP5_SCHPO
AccessioniPrimary (citable) accession number: Q09879
Secondary accession number(s): Q10433, Q9Y7P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 21, 2001
Last modified: October 29, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3