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Q09879 (UBP5_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ubiquitin carboxyl-terminal hydrolase 5

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 5
Ubiquitin thioesterase 5
Ubiquitin-specific-processing protease 5
Gene names
Name:ubp5
ORF Names:SPCC188.08c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length1108 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 MATH domain.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11081108Probable ubiquitin carboxyl-terminal hydrolase 5
PRO_0000080606

Regions

Domain55 – 187133MATH
Domain213 – 528316USP

Sites

Active site2221Nucleophile By similarity
Active site4641Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09879 [UniParc].

Last modified February 21, 2001. Version 3.
Checksum: 5C5A57058E3839C7

FASTA1,108128,668
        10         20         30         40         50         60 
MVTGETLVDS QKSLINNDTL LNEKLKEDFE ENVSIDVKIH EELRRALPDY EESGFQRFTW 

        70         80         90        100        110        120 
HIKSWHELDR RAVSPQFAVG SRQFKITYFP QGTLQSAGFT SIFLEYIPSE EEKLSNKYGC 

       130        140        150        160        170        180 
CCQFAFVISN PRKPSLSVAN SAHCRFSPEI VDWGFTQFAE LKKLLCRQAP DVPPIVEDGA 

       190        200        210        220        230        240 
LLLTAYVRIL KDPTGVLWHS FNDYDSKIAT GYVGLKNQGA TCYMNSLLQS LYIIHAFRRI 

       250        260        270        280        290        300 
VYQIPTDSPQ GKDSIAYALQ RCFYNLQFMN EPVSTTELTK SFGWDSLDSF MQHDVQEFNR 

       310        320        330        340        350        360 
VLQDNLERSM RDTKVENALT NLFVGKMKSY IACVNVNFES ARSEDYWDIQ LNVKGMKNLE 

       370        380        390        400        410        420 
DSFRSYIQVE TLEGDNCYFA DTYGFQEAKK GVIFESFPPI LHLQLKRFEY DFERDMMIKI 

       430        440        450        460        470        480 
NDRYEFPLEF DAKAFLSPEA DQSQNCEYVL YGVLVHSGDL HNGHYYALLK TEKDGPWYKY 

       490        500        510        520        530        540 
DDTRVTRATL REVLEENYGG DYIMHPPFRS PVKLKRFMSA YMLLYLRKDK LDELMNPVSA 

       550        560        570        580        590        600 
DEIPEHLKEA LNPSIQLAEL RRKERLESHL YTKVQLITPE FYSEHHEFDI ADFGNAYKEE 

       610        620        630        640        650        660 
TIPQFRIKKE AKFSEFIPIV AEKLGYPQEC MRFWYVVKRH NCTVRVESPV NELNSTMEEV 

       670        680        690        700        710        720 
KNVWNSQGEI LRLYLEITPE NELSSSLTHQ NTGEWNAFIF VKYFDRKSQE ISGCGTLHVN 

       730        740        750        760        770        780 
KSDEIRSICP LLCERANLPK NTPLNIYEEI KPGMVDFLRL EKTFTQSELS TGDIICFEPC 

       790        800        810        820        830        840 
RPSALEDDIV NSGFDSALKL YDFLSNKVLV LFRPRFIDQD SIIEFEMLLD RRIKYDDLCI 

       850        860        870        880        890        900 
ELGQKLGIGA DHIRLTTCNP LTYSAGMVVP NDSNITLYEI LYSSEEEMPS NVIFYETMDV 

       910        920        930        940        950        960 
SLSDLDRKRL VRLRWLVDGL ANIELVEAYI NKSGDINDLF GAVCERFPDS DLRKKKVRVY 

       970        980        990       1000       1010       1020 
EVFESRYHRD LSLRTLIRTI NPAATLVGEV VPLDQLQLYP EEKIVQVHHF HKDIARIHGI 

      1030       1040       1050       1060       1070       1080 
PFSFVIKPQE KFIDTKLRLA ARTQYPESIF SVIKFCVVDF DNNRVVYLND EDITYDVVEK 

      1090       1100 
LNGTLALDRA KKDSKKPNIL DRAIQMKN 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329672 Genomic DNA. Translation: CAB41228.1.
PIRT41188.
RefSeqNP_588211.1. NM_001023201.2.

3D structure databases

ProteinModelPortalQ09879.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275950. 3 interactions.
MINTMINT-4695964.
STRING4896.SPCC188.08c-1.

Protein family/group databases

MEROPSC19.A59.

Proteomic databases

MaxQBQ09879.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC188.08c.1; SPCC188.08c.1:pep; SPCC188.08c.
GeneID2539385.
KEGGspo:SPCC188.08c.

Organism-specific databases

PomBaseSPCC188.08c.

Phylogenomic databases

eggNOGCOG5077.
HOGENOMHOG000160240.
KOK11838.
OMAGLGHIFV.
OrthoDBEOG7C2R8P.
PhylomeDBQ09879.

Family and domain databases

InterProIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view]
PfamPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMSSF49599. SSF49599. 1 hit.
PROSITEPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800549.

Entry information

Entry nameUBP5_SCHPO
AccessionPrimary (citable) accession number: Q09879
Secondary accession number(s): Q10433, Q9Y7P5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 21, 2001
Last modified: June 11, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

Peptidase families

Classification of peptidase families and list of entries