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Q09879

- UBP5_SCHPO

UniProt

Q09879 - UBP5_SCHPO

Protein

Probable ubiquitin carboxyl-terminal hydrolase 5

Gene

ubp5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (21 Feb 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei222 – 2221NucleophilePROSITE-ProRule annotation
    Active sitei464 – 4641Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein binding Source: PomBase
    2. ubiquitin-specific protease activity Source: PomBase

    GO - Biological processi

    1. endocytosis Source: PomBase
    2. protein deubiquitination Source: PomBase
    3. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.A59.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase 5 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 5
    Ubiquitin thioesterase 5
    Ubiquitin-specific-processing protease 5
    Gene namesi
    Name:ubp5
    ORF Names:SPCC188.08c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC188.08c.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. Golgi apparatus Source: PomBase
    3. nucleus Source: PomBase
    4. transport vesicle Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11081108Probable ubiquitin carboxyl-terminal hydrolase 5PRO_0000080606Add
    BLAST

    Proteomic databases

    MaxQBiQ09879.

    Interactioni

    Protein-protein interaction databases

    BioGridi275950. 3 interactions.
    MINTiMINT-4695964.
    STRINGi4896.SPCC188.08c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09879.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 187133MATHPROSITE-ProRule annotationAdd
    BLAST
    Domaini213 – 528316USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 MATH domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    HOGENOMiHOG000160240.
    KOiK11838.
    OMAiGLGHIFV.
    OrthoDBiEOG7C2R8P.
    PhylomeDBiQ09879.

    Family and domain databases

    InterProiIPR002083. MATH.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR008974. TRAF-like.
    IPR028889. UCH/PAN2.
    IPR024729. USP7_ICP0-binding_dom.
    IPR029346. USP_C.
    [Graphical view]
    PfamiPF00917. MATH. 1 hit.
    PF00443. UCH. 1 hit.
    PF14533. USP7_C2. 1 hit.
    PF12436. USP7_ICP0_bdg. 1 hit.
    [Graphical view]
    SMARTiSM00061. MATH. 1 hit.
    [Graphical view]
    SUPFAMiSSF49599. SSF49599. 1 hit.
    PROSITEiPS50144. MATH. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09879-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTGETLVDS QKSLINNDTL LNEKLKEDFE ENVSIDVKIH EELRRALPDY     50
    EESGFQRFTW HIKSWHELDR RAVSPQFAVG SRQFKITYFP QGTLQSAGFT 100
    SIFLEYIPSE EEKLSNKYGC CCQFAFVISN PRKPSLSVAN SAHCRFSPEI 150
    VDWGFTQFAE LKKLLCRQAP DVPPIVEDGA LLLTAYVRIL KDPTGVLWHS 200
    FNDYDSKIAT GYVGLKNQGA TCYMNSLLQS LYIIHAFRRI VYQIPTDSPQ 250
    GKDSIAYALQ RCFYNLQFMN EPVSTTELTK SFGWDSLDSF MQHDVQEFNR 300
    VLQDNLERSM RDTKVENALT NLFVGKMKSY IACVNVNFES ARSEDYWDIQ 350
    LNVKGMKNLE DSFRSYIQVE TLEGDNCYFA DTYGFQEAKK GVIFESFPPI 400
    LHLQLKRFEY DFERDMMIKI NDRYEFPLEF DAKAFLSPEA DQSQNCEYVL 450
    YGVLVHSGDL HNGHYYALLK TEKDGPWYKY DDTRVTRATL REVLEENYGG 500
    DYIMHPPFRS PVKLKRFMSA YMLLYLRKDK LDELMNPVSA DEIPEHLKEA 550
    LNPSIQLAEL RRKERLESHL YTKVQLITPE FYSEHHEFDI ADFGNAYKEE 600
    TIPQFRIKKE AKFSEFIPIV AEKLGYPQEC MRFWYVVKRH NCTVRVESPV 650
    NELNSTMEEV KNVWNSQGEI LRLYLEITPE NELSSSLTHQ NTGEWNAFIF 700
    VKYFDRKSQE ISGCGTLHVN KSDEIRSICP LLCERANLPK NTPLNIYEEI 750
    KPGMVDFLRL EKTFTQSELS TGDIICFEPC RPSALEDDIV NSGFDSALKL 800
    YDFLSNKVLV LFRPRFIDQD SIIEFEMLLD RRIKYDDLCI ELGQKLGIGA 850
    DHIRLTTCNP LTYSAGMVVP NDSNITLYEI LYSSEEEMPS NVIFYETMDV 900
    SLSDLDRKRL VRLRWLVDGL ANIELVEAYI NKSGDINDLF GAVCERFPDS 950
    DLRKKKVRVY EVFESRYHRD LSLRTLIRTI NPAATLVGEV VPLDQLQLYP 1000
    EEKIVQVHHF HKDIARIHGI PFSFVIKPQE KFIDTKLRLA ARTQYPESIF 1050
    SVIKFCVVDF DNNRVVYLND EDITYDVVEK LNGTLALDRA KKDSKKPNIL 1100
    DRAIQMKN 1108
    Length:1,108
    Mass (Da):128,668
    Last modified:February 21, 2001 - v3
    Checksum:i5C5A57058E3839C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB41228.1.
    PIRiT41188.
    RefSeqiNP_588211.1. NM_001023201.2.

    Genome annotation databases

    EnsemblFungiiSPCC188.08c.1; SPCC188.08c.1:pep; SPCC188.08c.
    GeneIDi2539385.
    KEGGispo:SPCC188.08c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329672 Genomic DNA. Translation: CAB41228.1 .
    PIRi T41188.
    RefSeqi NP_588211.1. NM_001023201.2.

    3D structure databases

    ProteinModelPortali Q09879.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275950. 3 interactions.
    MINTi MINT-4695964.
    STRINGi 4896.SPCC188.08c-1.

    Protein family/group databases

    MEROPSi C19.A59.

    Proteomic databases

    MaxQBi Q09879.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC188.08c.1 ; SPCC188.08c.1:pep ; SPCC188.08c .
    GeneIDi 2539385.
    KEGGi spo:SPCC188.08c.

    Organism-specific databases

    PomBasei SPCC188.08c.

    Phylogenomic databases

    eggNOGi COG5077.
    HOGENOMi HOG000160240.
    KOi K11838.
    OMAi GLGHIFV.
    OrthoDBi EOG7C2R8P.
    PhylomeDBi Q09879.

    Miscellaneous databases

    NextBioi 20800549.

    Family and domain databases

    InterProi IPR002083. MATH.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR008974. TRAF-like.
    IPR028889. UCH/PAN2.
    IPR024729. USP7_ICP0-binding_dom.
    IPR029346. USP_C.
    [Graphical view ]
    Pfami PF00917. MATH. 1 hit.
    PF00443. UCH. 1 hit.
    PF14533. USP7_C2. 1 hit.
    PF12436. USP7_ICP0_bdg. 1 hit.
    [Graphical view ]
    SMARTi SM00061. MATH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49599. SSF49599. 1 hit.
    PROSITEi PS50144. MATH. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiUBP5_SCHPO
    AccessioniPrimary (citable) accession number: Q09879
    Secondary accession number(s): Q10433, Q9Y7P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 21, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3