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Protein

Probable ubiquitin carboxyl-terminal hydrolase 5

Gene

ubp5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei222NucleophilePROSITE-ProRule annotation1
Active sitei464Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • endopeptidase activity Source: PomBase
  • thiol-dependent ubiquitin-specific protease activity Source: PomBase
  • thiol-dependent ubiquitinyl hydrolase activity Source: PomBase

GO - Biological processi

  • protein deubiquitination Source: PomBase
  • protein K11-linked deubiquitination Source: PomBase
  • protein K63-linked deubiquitination Source: PomBase
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-SPO-6781823 Formation of TC-NER Pre-Incision Complex
R-SPO-6782135 Dual incision in TC-NER
R-SPO-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Protein family/group databases

MEROPSiC19.A59

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 5 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 5
Ubiquitin thioesterase 5
Ubiquitin-specific-processing protease 5
Gene namesi
Name:ubp5
ORF Names:SPCC188.08c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC188.08c
PomBaseiSPCC188.08c ubp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806061 – 1108Probable ubiquitin carboxyl-terminal hydrolase 5Add BLAST1108

Proteomic databases

MaxQBiQ09879
PaxDbiQ09879
PRIDEiQ09879

PTM databases

iPTMnetiQ09879
SwissPalmiQ09879

Interactioni

Protein-protein interaction databases

BioGridi275950, 2 interactors
STRINGi4896.SPCC188.08c.1

Structurei

3D structure databases

ProteinModelPortaliQ09879
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 187MATHPROSITE-ProRule annotationAdd BLAST133
Domaini213 – 528USPAdd BLAST316

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

HOGENOMiHOG000160240
InParanoidiQ09879
KOiK11838
OMAiQIEDPPI
OrthoDBiEOG092C06CQ
PhylomeDBiQ09879

Family and domain databases

Gene3Di2.60.210.10, 1 hit
InterProiView protein in InterPro
IPR002083 MATH/TRAF_dom
IPR001394 Peptidase_C19_UCH
IPR008974 TRAF-like
IPR024729 USP7_ICP0-binding_dom
IPR029346 USP_C
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF14533 USP7_C2, 1 hit
PF12436 USP7_ICP0_bdg, 1 hit
SMARTiView protein in SMART
SM00061 MATH, 1 hit
SUPFAMiSSF49599 SSF49599, 1 hit
PROSITEiView protein in PROSITE
PS50144 MATH, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q09879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTGETLVDS QKSLINNDTL LNEKLKEDFE ENVSIDVKIH EELRRALPDY
60 70 80 90 100
EESGFQRFTW HIKSWHELDR RAVSPQFAVG SRQFKITYFP QGTLQSAGFT
110 120 130 140 150
SIFLEYIPSE EEKLSNKYGC CCQFAFVISN PRKPSLSVAN SAHCRFSPEI
160 170 180 190 200
VDWGFTQFAE LKKLLCRQAP DVPPIVEDGA LLLTAYVRIL KDPTGVLWHS
210 220 230 240 250
FNDYDSKIAT GYVGLKNQGA TCYMNSLLQS LYIIHAFRRI VYQIPTDSPQ
260 270 280 290 300
GKDSIAYALQ RCFYNLQFMN EPVSTTELTK SFGWDSLDSF MQHDVQEFNR
310 320 330 340 350
VLQDNLERSM RDTKVENALT NLFVGKMKSY IACVNVNFES ARSEDYWDIQ
360 370 380 390 400
LNVKGMKNLE DSFRSYIQVE TLEGDNCYFA DTYGFQEAKK GVIFESFPPI
410 420 430 440 450
LHLQLKRFEY DFERDMMIKI NDRYEFPLEF DAKAFLSPEA DQSQNCEYVL
460 470 480 490 500
YGVLVHSGDL HNGHYYALLK TEKDGPWYKY DDTRVTRATL REVLEENYGG
510 520 530 540 550
DYIMHPPFRS PVKLKRFMSA YMLLYLRKDK LDELMNPVSA DEIPEHLKEA
560 570 580 590 600
LNPSIQLAEL RRKERLESHL YTKVQLITPE FYSEHHEFDI ADFGNAYKEE
610 620 630 640 650
TIPQFRIKKE AKFSEFIPIV AEKLGYPQEC MRFWYVVKRH NCTVRVESPV
660 670 680 690 700
NELNSTMEEV KNVWNSQGEI LRLYLEITPE NELSSSLTHQ NTGEWNAFIF
710 720 730 740 750
VKYFDRKSQE ISGCGTLHVN KSDEIRSICP LLCERANLPK NTPLNIYEEI
760 770 780 790 800
KPGMVDFLRL EKTFTQSELS TGDIICFEPC RPSALEDDIV NSGFDSALKL
810 820 830 840 850
YDFLSNKVLV LFRPRFIDQD SIIEFEMLLD RRIKYDDLCI ELGQKLGIGA
860 870 880 890 900
DHIRLTTCNP LTYSAGMVVP NDSNITLYEI LYSSEEEMPS NVIFYETMDV
910 920 930 940 950
SLSDLDRKRL VRLRWLVDGL ANIELVEAYI NKSGDINDLF GAVCERFPDS
960 970 980 990 1000
DLRKKKVRVY EVFESRYHRD LSLRTLIRTI NPAATLVGEV VPLDQLQLYP
1010 1020 1030 1040 1050
EEKIVQVHHF HKDIARIHGI PFSFVIKPQE KFIDTKLRLA ARTQYPESIF
1060 1070 1080 1090 1100
SVIKFCVVDF DNNRVVYLND EDITYDVVEK LNGTLALDRA KKDSKKPNIL

DRAIQMKN
Length:1,108
Mass (Da):128,668
Last modified:February 21, 2001 - v3
Checksum:i5C5A57058E3839C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329672 Genomic DNA Translation: CAB41228.1
PIRiT41188
RefSeqiNP_588211.1, NM_001023201.2

Genome annotation databases

EnsemblFungiiSPCC188.08c.1; SPCC188.08c.1:pep; SPCC188.08c
GeneIDi2539385
KEGGispo:SPCC188.08c

Similar proteinsi

Entry informationi

Entry nameiUBP5_SCHPO
AccessioniPrimary (citable) accession number: Q09879
Secondary accession number(s): Q10433, Q9Y7P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 21, 2001
Last modified: May 23, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health