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Protein

Heat shock protein 60, mitochondrial

Gene

hsp60

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 60, mitochondrial
Short name:
HSP60
Gene namesi
Name:hsp60
Synonyms:mcp60
ORF Names:SPAC12G12.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC12G12.04.
PomBaseiSPAC12G12.04.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial intermembrane space Source: PomBase
  • mitochondrial matrix Source: PomBase
  • mitochondrial membrane Source: PomBase
  • mitochondrial nucleoid Source: PomBase
  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionSequence analysisAdd BLAST35
ChainiPRO_000000504336 – 582Heat shock protein 60, mitochondrialAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77Phosphoserine1 Publication1
Modified residuei92Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09864.
PRIDEiQ09864.

PTM databases

iPTMnetiQ09864.

Interactioni

Protein-protein interaction databases

BioGridi279563. 8 interactors.
IntActiQ09864. 2 interactors.
MINTiMINT-4695833.

Structurei

3D structure databases

ProteinModelPortaliQ09864.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076290.
InParanoidiQ09864.
KOiK04077.
OMAiSEYDRTK.
OrthoDBiEOG092C1JWK.
PhylomeDBiQ09864.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSFLSSSVS RLPLRIAGRR IPGRFAVPQV RTYAKDLKFG VDARASLLTG
60 70 80 90 100
VDTLARAVSV TLGPKGRNVL IDQPFGSPKI TKDGVTVARS VSLKDKFENL
110 120 130 140 150
GARLVQDVAS KTNEVAGDGT TTATVLTRAI FSETVRNVAA GCNPMDLRRG
160 170 180 190 200
IQLAVDNVVE FLQANKRDIT TSEEISQVAT ISANGDTHIG ELLAKAMERV
210 220 230 240 250
GKEGVITVKE GRTISDELEV TEGMKFDRGY ISPYFITDVK SQKVEFENPL
260 270 280 290 300
ILLSEKKVSA VQDILPSLEL AAQQRRPLVI IAEDVDGEAL AACILNKLRG
310 320 330 340 350
QLQVVAIKAP GFGDNRRNML GDLAVLTDSA VFNDEIDVSI EKAQPHHLGS
360 370 380 390 400
CGSVTVTKED TIIMKGAGDH VKVNDRCEQI RGVMADPNLT EYEKEKLQER
410 420 430 440 450
LAKLSGGIAV IKVGGSSEVE VNEKKDRIVD ALNAVKAAVS EGVLPGAGTS
460 470 480 490 500
FVKASLRLGD IPTNNFDQKL GVEIVRKAIT RPAQTILENA GLEGNLIVGK
510 520 530 540 550
LKELYGKEFN IGYDIAKDRF VDLNEIGVLD PLKVVRTGLV DASGVASLMG
560 570 580
TTECAIVDAP EESKAPAGPP GMGGMGGMPG MM
Length:582
Mass (Da):62,167
Last modified:February 1, 1996 - v1
Checksum:iE5434436A98AFDC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti392Y → S in BAA09171 (PubMed:8566770).Curated1
Sequence conflicti415G → A in BAA09171 (PubMed:8566770).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91499.1.
D50609 Genomic DNA. Translation: BAA09171.1.
PIRiS62535.
T43369.
RefSeqiNP_592894.1. NM_001018294.2.

Genome annotation databases

EnsemblFungiiSPAC12G12.04.1; SPAC12G12.04.1:pep; SPAC12G12.04.
GeneIDi2543131.
KEGGispo:SPAC12G12.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91499.1.
D50609 Genomic DNA. Translation: BAA09171.1.
PIRiS62535.
T43369.
RefSeqiNP_592894.1. NM_001018294.2.

3D structure databases

ProteinModelPortaliQ09864.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279563. 8 interactors.
IntActiQ09864. 2 interactors.
MINTiMINT-4695833.

PTM databases

iPTMnetiQ09864.

Proteomic databases

MaxQBiQ09864.
PRIDEiQ09864.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC12G12.04.1; SPAC12G12.04.1:pep; SPAC12G12.04.
GeneIDi2543131.
KEGGispo:SPAC12G12.04.

Organism-specific databases

EuPathDBiFungiDB:SPAC12G12.04.
PomBaseiSPAC12G12.04.

Phylogenomic databases

HOGENOMiHOG000076290.
InParanoidiQ09864.
KOiK04077.
OMAiSEYDRTK.
OrthoDBiEOG092C1JWK.
PhylomeDBiQ09864.

Miscellaneous databases

PROiQ09864.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHSP60_SCHPO
AccessioniPrimary (citable) accession number: Q09864
Secondary accession number(s): Q10285
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.