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Protein

Heat shock protein 60, mitochondrial

Gene

hsp60

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-1268020 Mitochondrial protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 60, mitochondrial
Short name:
HSP60
Gene namesi
Name:hsp60
Synonyms:mcp60
ORF Names:SPAC12G12.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC12G12.04
PomBaseiSPAC12G12.04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionSequence analysisAdd BLAST35
ChainiPRO_000000504336 – 582Heat shock protein 60, mitochondrialAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77Phosphoserine1 Publication1
Modified residuei92Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09864
PaxDbiQ09864
PRIDEiQ09864

PTM databases

iPTMnetiQ09864

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi279563, 8 interactors
IntActiQ09864, 2 interactors
MINTiQ09864
STRINGi4896.SPAC12G12.04.1

Structurei

3D structure databases

ProteinModelPortaliQ09864
SMRiQ09864
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000076290
InParanoidiQ09864
KOiK04077
OMAiTDTDKME
OrthoDBiEOG092C1JWK
PhylomeDBiQ09864

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSFLSSSVS RLPLRIAGRR IPGRFAVPQV RTYAKDLKFG VDARASLLTG
60 70 80 90 100
VDTLARAVSV TLGPKGRNVL IDQPFGSPKI TKDGVTVARS VSLKDKFENL
110 120 130 140 150
GARLVQDVAS KTNEVAGDGT TTATVLTRAI FSETVRNVAA GCNPMDLRRG
160 170 180 190 200
IQLAVDNVVE FLQANKRDIT TSEEISQVAT ISANGDTHIG ELLAKAMERV
210 220 230 240 250
GKEGVITVKE GRTISDELEV TEGMKFDRGY ISPYFITDVK SQKVEFENPL
260 270 280 290 300
ILLSEKKVSA VQDILPSLEL AAQQRRPLVI IAEDVDGEAL AACILNKLRG
310 320 330 340 350
QLQVVAIKAP GFGDNRRNML GDLAVLTDSA VFNDEIDVSI EKAQPHHLGS
360 370 380 390 400
CGSVTVTKED TIIMKGAGDH VKVNDRCEQI RGVMADPNLT EYEKEKLQER
410 420 430 440 450
LAKLSGGIAV IKVGGSSEVE VNEKKDRIVD ALNAVKAAVS EGVLPGAGTS
460 470 480 490 500
FVKASLRLGD IPTNNFDQKL GVEIVRKAIT RPAQTILENA GLEGNLIVGK
510 520 530 540 550
LKELYGKEFN IGYDIAKDRF VDLNEIGVLD PLKVVRTGLV DASGVASLMG
560 570 580
TTECAIVDAP EESKAPAGPP GMGGMGGMPG MM
Length:582
Mass (Da):62,167
Last modified:February 1, 1996 - v1
Checksum:iE5434436A98AFDC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti392Y → S in BAA09171 (PubMed:8566770).Curated1
Sequence conflicti415G → A in BAA09171 (PubMed:8566770).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA91499.1
D50609 Genomic DNA Translation: BAA09171.1
PIRiS62535
T43369
RefSeqiNP_592894.1, NM_001018294.2

Genome annotation databases

EnsemblFungiiSPAC12G12.04.1; SPAC12G12.04.1:pep; SPAC12G12.04
GeneIDi2543131
KEGGispo:SPAC12G12.04

Similar proteinsi

Entry informationi

Entry nameiHSP60_SCHPO
AccessioniPrimary (citable) accession number: Q09864
Secondary accession number(s): Q10285
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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