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Protein

NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

Gene

ayr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively. Required for the biosynthesis of phosphatidic acid via the DHAP pathway, where it reduces 1-acyl DHAP to lysophosphatidic acid (LPA). Required for spore germination (By similarity).By similarity

Catalytic activityi

1-palmitoylglycerol 3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351SubstrateBy similarity
Active sitei148 – 1481Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 3326NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase (EC:1.1.1.101)
Short name:
ADR
Alternative name(s):
1-acyl DHAP reductase
Acyl/alkyl DHAP reductase
Acylglycerone-phosphate reductase
Gene namesi
Name:ayr1
ORF Names:SPAC23D3.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23D3.11.
PomBaseiSPAC23D3.11. ayr1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • endoplasmic reticulum Source: PomBase
  • fungal-type vacuole membrane Source: PomBase
  • Golgi apparatus Source: PomBase
  • mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296NADPH-dependent 1-acyldihydroxyacetone phosphate reductasePRO_0000054874Add
BLAST

Proteomic databases

MaxQBiQ09851.

Interactioni

Protein-protein interaction databases

BioGridi277991. 7 interactions.
MINTiMINT-4695709.

Structurei

3D structure databases

ProteinModelPortaliQ09851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ09851.
KOiK06123.
OMAiQQMLNIN.
OrthoDBiEOG092C4WZU.
PhylomeDBiQ09851.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAEKFVLIT GCSEGGIGNA LALKFHQEGF QVLATARQVE RMDNLTKAGL
60 70 80 90 100
QTLKLDVTDE DSVREVEQEV RKFTNGSLHY LINNAGAPCS APAIDLDIED
110 120 130 140 150
VSKVMDVNFY GVIRMNKAFQ HQLIRAKGTI VNVNSLVSYV PFAFNAAYNA
160 170 180 190 200
SKAALLAYSN TLRIELAPFG VQVTSIMTGG VQTKIQSKPL GTMTEAAIPE
210 220 230 240 250
NSIYYPYRKL ILENRNPVEK FVTIEEFADA AYPQLVGRGR WYQLFKPGVR
260 270 280 290
PAQIWAGYMS SAGRVGSMLP VEVFSMSVRL IVKLPSTAVW RDHTVD
Length:296
Mass (Da):32,731
Last modified:May 30, 2000 - v2
Checksum:i91E33D2575F141FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91246.1.
PIRiS62502.
RefSeqiNP_594548.1. NM_001019977.2.

Genome annotation databases

EnsemblFungiiSPAC23D3.11.1; SPAC23D3.11.1:pep; SPAC23D3.11.
GeneIDi2541489.
KEGGispo:SPAC23D3.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91246.1.
PIRiS62502.
RefSeqiNP_594548.1. NM_001019977.2.

3D structure databases

ProteinModelPortaliQ09851.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277991. 7 interactions.
MINTiMINT-4695709.

Proteomic databases

MaxQBiQ09851.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23D3.11.1; SPAC23D3.11.1:pep; SPAC23D3.11.
GeneIDi2541489.
KEGGispo:SPAC23D3.11.

Organism-specific databases

EuPathDBiFungiDB:SPAC23D3.11.
PomBaseiSPAC23D3.11. ayr1.

Phylogenomic databases

InParanoidiQ09851.
KOiK06123.
OMAiQQMLNIN.
OrthoDBiEOG092C4WZU.
PhylomeDBiQ09851.

Miscellaneous databases

PROiQ09851.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAYR1_SCHPO
AccessioniPrimary (citable) accession number: Q09851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2000
Last modified: September 7, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.