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Protein

NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

Gene

ayr1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively. Required for the biosynthesis of phosphatidic acid via the DHAP pathway, where it reduces 1-acyl DHAP to lysophosphatidic acid (LPA). Required for spore germination (By similarity).By similarity

Catalytic activityi

1-palmitoylglycerol 3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei135SubstrateBy similarity1
Active sitei148Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 33NAD or NADPBy similarityAdd BLAST26

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase (EC:1.1.1.101)
Short name:
ADR
Alternative name(s):
1-acyl DHAP reductase
Acyl/alkyl DHAP reductase
Acylglycerone-phosphate reductase
Gene namesi
Name:ayr1
ORF Names:SPAC23D3.11
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23D3.11
PomBaseiSPAC23D3.11 ayr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000548741 – 296NADPH-dependent 1-acyldihydroxyacetone phosphate reductaseAdd BLAST296

Proteomic databases

MaxQBiQ09851
PaxDbiQ09851
PRIDEiQ09851

PTM databases

iPTMnetiQ09851

Interactioni

Protein-protein interaction databases

BioGridi277991, 7 interactors
STRINGi4896.SPAC23D3.11.1

Structurei

3D structure databases

ProteinModelPortaliQ09851
SMRiQ09851
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ09851
KOiK06123
OMAiWQGYYNA
OrthoDBiEOG092C4WZU
PhylomeDBiQ09851

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q09851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAEKFVLIT GCSEGGIGNA LALKFHQEGF QVLATARQVE RMDNLTKAGL
60 70 80 90 100
QTLKLDVTDE DSVREVEQEV RKFTNGSLHY LINNAGAPCS APAIDLDIED
110 120 130 140 150
VSKVMDVNFY GVIRMNKAFQ HQLIRAKGTI VNVNSLVSYV PFAFNAAYNA
160 170 180 190 200
SKAALLAYSN TLRIELAPFG VQVTSIMTGG VQTKIQSKPL GTMTEAAIPE
210 220 230 240 250
NSIYYPYRKL ILENRNPVEK FVTIEEFADA AYPQLVGRGR WYQLFKPGVR
260 270 280 290
PAQIWAGYMS SAGRVGSMLP VEVFSMSVRL IVKLPSTAVW RDHTVD
Length:296
Mass (Da):32,731
Last modified:May 30, 2000 - v2
Checksum:i91E33D2575F141FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA91246.1
PIRiS62502
RefSeqiNP_594548.1, NM_001019977.2

Genome annotation databases

EnsemblFungiiSPAC23D3.11.1; SPAC23D3.11.1:pep; SPAC23D3.11
GeneIDi2541489
KEGGispo:SPAC23D3.11

Similar proteinsi

Entry informationi

Entry nameiAYR1_SCHPO
AccessioniPrimary (citable) accession number: Q09851
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health