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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)] 2

Gene

gpd2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123NADBy similarity1
Binding sitei146NAD; via amide nitrogenBy similarity1
Binding sitei146SubstrateBy similarity1
Binding sitei179NAD; via amide nitrogenBy similarity1
Active sitei236Proton acceptorBy similarity1
Binding sitei300NADBy similarity1
Binding sitei329NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 36NADBy similarity6

GO - Molecular functioni

GO - Biological processi

  • glycerol-3-phosphate catabolic process Source: InterPro
  • glycerol biosynthetic process Source: PomBase
  • NADH oxidation Source: PomBase

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-SPO-1483166. Synthesis of PA.
R-SPO-75109. Triglyceride Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2 (EC:1.1.1.8)
Gene namesi
Name:gpd2
ORF Names:SPAC23D3.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23D3.04c.
PomBaseiSPAC23D3.04c. gpd2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • glycerol-3-phosphate dehydrogenase complex Source: InterPro

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001380961 – 373Glycerol-3-phosphate dehydrogenase [NAD(+)] 2Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09845.
PRIDEiQ09845.

PTM databases

iPTMnetiQ09845.

Interactioni

Protein-protein interaction databases

BioGridi278004. 12 interactors.
MINTiMINT-4695674.

Structurei

3D structure databases

ProteinModelPortaliQ09845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni300 – 301Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000246855.
InParanoidiQ09845.
KOiK00006.
OMAiLFSEWIG.
OrthoDBiEOG092701T6.
PhylomeDBiQ09845.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiView protein in PROSITE
PS00957. NAD_G3PDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVAALNKLS ALSGSIQKSF SPKLISVGII GSGNWGTAIA KICGENAKAH
60 70 80 90 100
PDIFHPQVHM WMYEEKIQHE GKECNLTEVF NTTHENVKYL KGIKCPSNVF
110 120 130 140 150
ANPDIRDVGS RSDILVWVLP HQFVVRICNQ LKGCLKKDAV AISCIKGVSV
160 170 180 190 200
TKDRVRLFSD IIEENTGMYC GVLSGANIAS EVAQEKFCET TIGYLPNSSV
210 220 230 240 250
NPRYTPKTIQ ALFNRPYFRV NIVEDVPGVA LGGALKNIVA VAAGIIDGLE
260 270 280 290 300
LGDNTKSAVM RIGLLEMQKF GRMFFDCKPL TMSEESCGIA DLITTCLGGR
310 320 330 340 350
NHKCAVAFVK TGKPMHVVEQ ELLDGQKLQG AATAKEVYEF LDNQNKVSEF
360 370
PLFTAVYRIV YEGLPPNKLL EAI
Length:373
Mass (Da):40,874
Last modified:February 1, 1996 - v1
Checksum:i7C3AFBC3DFFB470E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50797 Genomic DNA. Translation: BAA09425.1.
CU329670 Genomic DNA. Translation: CAA91239.1.
PIRiJC6053.
RefSeqiNP_594542.1. NM_001019971.2.

Genome annotation databases

EnsemblFungiiSPAC23D3.04c.1; SPAC23D3.04c.1:pep; SPAC23D3.04c.
GeneIDi2541502.
KEGGispo:SPAC23D3.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50797 Genomic DNA. Translation: BAA09425.1.
CU329670 Genomic DNA. Translation: CAA91239.1.
PIRiJC6053.
RefSeqiNP_594542.1. NM_001019971.2.

3D structure databases

ProteinModelPortaliQ09845.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278004. 12 interactors.
MINTiMINT-4695674.

PTM databases

iPTMnetiQ09845.

Proteomic databases

MaxQBiQ09845.
PRIDEiQ09845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC23D3.04c.1; SPAC23D3.04c.1:pep; SPAC23D3.04c.
GeneIDi2541502.
KEGGispo:SPAC23D3.04c.

Organism-specific databases

EuPathDBiFungiDB:SPAC23D3.04c.
PomBaseiSPAC23D3.04c. gpd2.

Phylogenomic databases

HOGENOMiHOG000246855.
InParanoidiQ09845.
KOiK00006.
OMAiLFSEWIG.
OrthoDBiEOG092701T6.
PhylomeDBiQ09845.

Enzyme and pathway databases

ReactomeiR-SPO-1483166. Synthesis of PA.
R-SPO-75109. Triglyceride Biosynthesis.

Miscellaneous databases

PROiQ09845.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiView protein in PROSITE
PS00957. NAD_G3PDH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGPD2_SCHPO
AccessioniPrimary (citable) accession number: Q09845
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 15, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.