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Q09845

- GPD2_SCHPO

UniProt

Q09845 - GPD2_SCHPO

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Protein
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2
Gene
gpd2, SPAC23D3.04c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231NAD By similarity
Binding sitei146 – 1461NAD; via amide nitrogen By similarity
Binding sitei146 – 1461Substrate By similarity
Binding sitei179 – 1791NAD; via amide nitrogen By similarity
Active sitei236 – 2361Proton acceptor By similarity
Binding sitei300 – 3001NAD By similarity
Binding sitei329 – 3291NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 366NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC

GO - Biological processi

  1. NADH oxidation Source: PomBase
  2. glycerol biosynthetic process Source: PomBase
  3. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_201900. Synthesis of PA.
REACT_224904. Triglyceride Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2 (EC:1.1.1.8)
Gene namesi
Name:gpd2
ORF Names:SPAC23D3.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC23D3.04c.

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Glycerol-3-phosphate dehydrogenase [NAD(+)] 2
PRO_0000138096Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09845.
PaxDbiQ09845.

Interactioni

Protein-protein interaction databases

BioGridi278004. 15 interactions.
MINTiMINT-4695674.
STRINGi4896.SPAC23D3.04c-1.

Structurei

3D structure databases

ProteinModelPortaliQ09845.
SMRiQ09845. Positions 26-372.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni300 – 3012Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
HOGENOMiHOG000246855.
KOiK00006.
OMAiPVGEFIH.
OrthoDBiEOG7V76H7.
PhylomeDBiQ09845.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09845-1 [UniParc]FASTAAdd to Basket

« Hide

MTVAALNKLS ALSGSIQKSF SPKLISVGII GSGNWGTAIA KICGENAKAH    50
PDIFHPQVHM WMYEEKIQHE GKECNLTEVF NTTHENVKYL KGIKCPSNVF 100
ANPDIRDVGS RSDILVWVLP HQFVVRICNQ LKGCLKKDAV AISCIKGVSV 150
TKDRVRLFSD IIEENTGMYC GVLSGANIAS EVAQEKFCET TIGYLPNSSV 200
NPRYTPKTIQ ALFNRPYFRV NIVEDVPGVA LGGALKNIVA VAAGIIDGLE 250
LGDNTKSAVM RIGLLEMQKF GRMFFDCKPL TMSEESCGIA DLITTCLGGR 300
NHKCAVAFVK TGKPMHVVEQ ELLDGQKLQG AATAKEVYEF LDNQNKVSEF 350
PLFTAVYRIV YEGLPPNKLL EAI 373
Length:373
Mass (Da):40,874
Last modified:February 1, 1996 - v1
Checksum:i7C3AFBC3DFFB470E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50797 Genomic DNA. Translation: BAA09425.1.
CU329670 Genomic DNA. Translation: CAA91239.1.
PIRiJC6053.
RefSeqiNP_594542.1. NM_001019971.2.

Genome annotation databases

EnsemblFungiiSPAC23D3.04c.1; SPAC23D3.04c.1:pep; SPAC23D3.04c.
GeneIDi2541502.
KEGGispo:SPAC23D3.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50797 Genomic DNA. Translation: BAA09425.1 .
CU329670 Genomic DNA. Translation: CAA91239.1 .
PIRi JC6053.
RefSeqi NP_594542.1. NM_001019971.2.

3D structure databases

ProteinModelPortali Q09845.
SMRi Q09845. Positions 26-372.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278004. 15 interactions.
MINTi MINT-4695674.
STRINGi 4896.SPAC23D3.04c-1.

Proteomic databases

MaxQBi Q09845.
PaxDbi Q09845.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC23D3.04c.1 ; SPAC23D3.04c.1:pep ; SPAC23D3.04c .
GeneIDi 2541502.
KEGGi spo:SPAC23D3.04c.

Organism-specific databases

PomBasei SPAC23D3.04c.

Phylogenomic databases

eggNOGi COG0240.
HOGENOMi HOG000246855.
KOi K00006.
OMAi PVGEFIH.
OrthoDBi EOG7V76H7.
PhylomeDBi Q09845.

Enzyme and pathway databases

Reactomei REACT_201900. Synthesis of PA.
REACT_224904. Triglyceride Biosynthesis.

Miscellaneous databases

NextBioi 20802601.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
PROSITEi PS00957. NAD_G3PDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Osmoregulation of fission yeast: cloning of two distinct genes encoding glycerol-3-phosphate dehydrogenase, one of which is responsible for osmotolerance for growth."
    Ohmiya R., Yamada H., Nakashima K., Aiba H., Mizuno T.
    Mol. Microbiol. 18:963-973(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiGPD2_SCHPO
AccessioniPrimary (citable) accession number: Q09845
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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