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Q09845 (GPD2_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2
EC=1.1.1.8
Gene names
Name:gpd2
ORF Names:SPAC23D3.04c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 373373Glycerol-3-phosphate dehydrogenase [NAD(+)] 2
PRO_0000138096

Regions

Nucleotide binding31 – 366NAD By similarity
Region300 – 3012Substrate binding By similarity

Sites

Active site2361Proton acceptor By similarity
Binding site1231NAD By similarity
Binding site1461NAD; via amide nitrogen By similarity
Binding site1461Substrate By similarity
Binding site1791NAD; via amide nitrogen By similarity
Binding site3001NAD By similarity
Binding site3291NAD By similarity

Amino acid modifications

Modified residue151Phosphoserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q09845 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 7C3AFBC3DFFB470E

FASTA37340,874
        10         20         30         40         50         60 
MTVAALNKLS ALSGSIQKSF SPKLISVGII GSGNWGTAIA KICGENAKAH PDIFHPQVHM 

        70         80         90        100        110        120 
WMYEEKIQHE GKECNLTEVF NTTHENVKYL KGIKCPSNVF ANPDIRDVGS RSDILVWVLP 

       130        140        150        160        170        180 
HQFVVRICNQ LKGCLKKDAV AISCIKGVSV TKDRVRLFSD IIEENTGMYC GVLSGANIAS 

       190        200        210        220        230        240 
EVAQEKFCET TIGYLPNSSV NPRYTPKTIQ ALFNRPYFRV NIVEDVPGVA LGGALKNIVA 

       250        260        270        280        290        300 
VAAGIIDGLE LGDNTKSAVM RIGLLEMQKF GRMFFDCKPL TMSEESCGIA DLITTCLGGR 

       310        320        330        340        350        360 
NHKCAVAFVK TGKPMHVVEQ ELLDGQKLQG AATAKEVYEF LDNQNKVSEF PLFTAVYRIV 

       370 
YEGLPPNKLL EAI

« Hide

References

« Hide 'large scale' references
[1]"Osmoregulation of fission yeast: cloning of two distinct genes encoding glycerol-3-phosphate dehydrogenase, one of which is responsible for osmotolerance for growth."
Ohmiya R., Yamada H., Nakashima K., Aiba H., Mizuno T.
Mol. Microbiol. 18:963-973(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[3]"Phosphoproteome analysis of fission yeast."
Wilson-Grady J.T., Villen J., Gygi S.P.
J. Proteome Res. 7:1088-1097(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D50797 Genomic DNA. Translation: BAA09425.1.
CU329670 Genomic DNA. Translation: CAA91239.1.
PIRJC6053.
RefSeqNP_594542.1. NM_001019971.2.

3D structure databases

ProteinModelPortalQ09845.
SMRQ09845. Positions 26-372.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4695674.
STRING4896.SPAC23D3.04c-1.

Proteomic databases

PaxDbQ09845.
PRIDEQ09845.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC23D3.04c.1; SPAC23D3.04c.1:pep; SPAC23D3.04c.
GeneID2541502.
KEGGspo:SPAC23D3.04c.

Organism-specific databases

PomBaseSPAC23D3.04c.

Phylogenomic databases

eggNOGCOG0240.
HOGENOMHOG000246855.
KOK00006.
OMAAFAKMFC.
OrthoDBEOG4FBN2Q.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11728. PTHR11728. 1 hit.
PfamPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSPR00077. GPDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR03376. glycerol3P_DH. 1 hit.
PROSITEPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20802601.

Entry information

Entry nameGPD2_SCHPO
AccessionPrimary (citable) accession number: Q09845
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 29, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents