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Protein

Probable proteasome subunit beta type-2

Gene

pup1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (Potential).Curated

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei36NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SPO-382556 ABC-family proteins mediated transport
R-SPO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-SPO-5689603 UCH proteinases
R-SPO-5689880 Ub-specific processing proteases
R-SPO-6798695 Neutrophil degranulation
R-SPO-68949 Orc1 removal from chromatin
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.011

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit beta type-2 (EC:3.4.25.1)
Gene namesi
Name:pup1
ORF Names:SPAC23D3.07
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC23D3.07
PomBaseiSPAC23D3.07 pup1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000266551 – 35Removed in mature formBy similarityAdd BLAST35
ChainiPRO_000002665636 – 267Probable proteasome subunit beta type-2Add BLAST232

Keywords - PTMi

Zymogen

Proteomic databases

MaxQBiQ09841
PaxDbiQ09841
PRIDEiQ09841

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi278296, 2 interactors
STRINGi4896.SPAC23D3.07.1

Structurei

3D structure databases

ProteinModelPortaliQ09841
SMRiQ09841
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000182856
InParanoidiQ09841
KOiK02739
OMAiDLCVIRK
OrthoDBiEOG092C44RU
PhylomeDBiQ09841

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR035216 Proteasome_beta7
IPR024689 Proteasome_bsu_C
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF44 PTHR11599:SF44, 1 hit
PfamiView protein in Pfam
PF12465 Pr_beta_C, 1 hit
PF00227 Proteasome, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGINERKGF DFEYYQRNLL LQEKGFPTPK ATSTGTTIVG VIAKDCIVLG
60 70 80 90 100
ADTRATAGPI IADKNCKKLH LISPNIWCAG AGTAADTEFV TSMISSNIEL
110 120 130 140 150
HSLYTNRKPR VVTALTMLKQ HLFRYQGHIG AYLVLGGYDC KGPHLFTIAA
160 170 180 190 200
HGSSDKLPYV ALGSGSLAAI SVLETKYQPD LERHEAMELV KEAIEAGIFN
210 220 230 240 250
DLGSGSNCDL VVIDEEKATP YRGYSKPNER ATKQSKYTYD RGTTAVLKED
260
IYKFVTVQDL DEMQVDV
Length:267
Mass (Da):29,337
Last modified:February 1, 1996 - v1
Checksum:i646764EBE1E3CFBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA91242.1
AB000540 mRNA Translation: BAA19146.1
PIRiT38282 S62498
RefSeqiNP_594544.1, NM_001019973.2

Genome annotation databases

EnsemblFungiiSPAC23D3.07.1; SPAC23D3.07.1:pep; SPAC23D3.07
GeneIDi2541805
KEGGispo:SPAC23D3.07

Similar proteinsi

Entry informationi

Entry nameiPSB2_SCHPO
AccessioniPrimary (citable) accession number: Q09841
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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