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Protein

Transcriptional regulator prz1

Gene

prz1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of calcium ion homeostasis. Binds to the calcineurin-dependent response element. Transcriptionally regulates pmc1.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri570 – 59425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri600 – 62223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri628 – 65023C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • calcineurin-NFAT signaling cascade Source: PomBase
  • calcium-mediated signaling Source: PomBase
  • cellular calcium ion homeostasis Source: PomBase
  • positive regulation of transcription from RNA polymerase II promoter Source: GOC
  • regulation of transcription from RNA polymerase II promoter Source: PomBase
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-SPO-2426168. Activation of gene expression by SREBF (SREBP).
R-SPO-3232118. SUMOylation of transcription factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator prz1
Alternative name(s):
Pbp1-responsive zinc finger protein 1
Gene namesi
Name:prz1
ORF Names:SPAC4G8.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC4G8.13c.
PomBaseiSPAC4G8.13c. prz1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 681681Transcriptional regulator prz1PRO_0000046814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei543 – 5431Phosphoserine1 Publication
Modified residuei546 – 5461Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated. Dephosphorylated by calcineurin which leads to rapid translocation from the cytoplasm to the nucleus.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09838.

PTM databases

iPTMnetiQ09838.

Interactioni

GO - Molecular functioni

  • 14-3-3 protein binding Source: PomBase

Protein-protein interaction databases

BioGridi278297. 364 interactions.
MINTiMINT-4695607.

Structurei

3D structure databases

ProteinModelPortaliQ09838.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri570 – 59425C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri600 – 62223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri628 – 65023C2H2-type 3; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

InParanoidiQ09838.
OrthoDBiEOG7CZKH9.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09838-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERQRSEEAN RRFKDLNPSS LYDNLSKPDL GGSSELHTYM NDTSLADIPL
60 70 80 90 100
FEDTLASEVS SSLISNPSKN NIQHLHPNTS EPFKTSSKSD EYDSYPRTGN
110 120 130 140 150
VPTFSFTELN DTSVSGFGSQ AVFENSVSPL SNPSNSPQAF DLTQGSSSTH
160 170 180 190 200
NANDFTVNNV GSRRQSIYEF NIGIPSSNID SSQFLPVSRA IAASEISPSS
210 220 230 240 250
SPQLLTSFLP SGSVSNPSSP YLQGSVGALY EADAFNFVDV MSQASGTEVD
260 270 280 290 300
SERFPSVDFE DPSLLMENQQ NITGTGSFAD YLQPPSSGSL GAFTNASPGE
310 320 330 340 350
SNTGIDFDTD NTNLNPSVDL LSNHSTPSFI FENSPSAEFS HQSSPYLVPN
360 370 380 390 400
SGRTLNSENA RESTIRSVNS PFSEDHADAS LTTHVFDPIS PTALSNSVLN
410 420 430 440 450
YDSNNFSGTP QINVVPSSPS KSQSGPSLPA NPLLQTDISI TYSQSASPVS
460 470 480 490 500
GQPAMNENSY DLQNANLCAP EMSPTYTARH RSNSAGSRFD AYEPIPQLYT
510 520 530 540 550
HFSHSSECLS VNQDTELLGK IENDNSKSND YLSVRNTRPR SRSLNSLVGN
560 570 580 590 600
KSENSSSSKA KSESKSQGNY VCTFAGCNKR FTRAYNLKSH MNTHTNYRPF
610 620 630 640 650
QCSICKKSFA RQHDKRRHEQ LHTGIKAFAC VTCNQRFARM DALNRHYKSE
660 670 680
VGQNCLRTAT ERGIQVPPSR KTAVASTSKQ K
Length:681
Mass (Da):74,190
Last modified:February 1, 1996 - v1
Checksum:iBB912939969503C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91214.1.
PIRiT38858. S62490.
RefSeqiNP_593073.1. NM_001018471.2.

Genome annotation databases

EnsemblFungiiSPAC4G8.13c.1; SPAC4G8.13c.1:pep; SPAC4G8.13c.
GeneIDi2541806.
KEGGispo:SPAC4G8.13c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91214.1.
PIRiT38858. S62490.
RefSeqiNP_593073.1. NM_001018471.2.

3D structure databases

ProteinModelPortaliQ09838.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278297. 364 interactions.
MINTiMINT-4695607.

PTM databases

iPTMnetiQ09838.

Proteomic databases

MaxQBiQ09838.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4G8.13c.1; SPAC4G8.13c.1:pep; SPAC4G8.13c.
GeneIDi2541806.
KEGGispo:SPAC4G8.13c.

Organism-specific databases

EuPathDBiFungiDB:SPAC4G8.13c.
PomBaseiSPAC4G8.13c. prz1.

Phylogenomic databases

InParanoidiQ09838.
OrthoDBiEOG7CZKH9.

Enzyme and pathway databases

ReactomeiR-SPO-2426168. Activation of gene expression by SREBF (SREBP).
R-SPO-3232118. SUMOylation of transcription factors.

Miscellaneous databases

NextBioi20802894.
PROiQ09838.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Zinc finger protein Prz1 regulates Ca2+ but not Cl- homeostasis in fission yeast. Identification of distinct branches of calcineurin signaling pathway in fission yeast."
    Hirayama S., Sugiura R., Lu Y., Maeda T., Kawagishi K., Yokoyama M., Tohda H., Giga-Hama Y., Shuntoh H., Kuno T.
    J. Biol. Chem. 278:18078-18084(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-543 AND SER-546, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPRZ1_SCHPO
AccessioniPrimary (citable) accession number: Q09838
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 17, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.