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Protein

Serine/threonine-protein kinase ppk14

Gene

ppk14

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei224 – 2241ATPPROSITE-ProRule annotation
Active sitei320 – 3201Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi201 – 2099ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to pheromone Source: PomBase
  2. signal transduction Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ppk14 (EC:2.7.11.1)
Gene namesi
Name:ppk14
ORF Names:SPAC4G8.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

PomBaseiSPAC4G8.05.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Serine/threonine-protein kinase ppk14PRO_0000086043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei379 – 3791Phosphothreonine1 Publication
Modified residuei381 – 3811Phosphoserine1 Publication
Modified residuei385 – 3851Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09831.

Interactioni

Protein-protein interaction databases

BioGridi279852. 111 interactions.
MINTiMINT-4695541.
STRINGi4896.SPAC4G8.05-1.

Structurei

3D structure databases

ProteinModelPortaliQ09831.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini195 – 485291Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. KIN82 subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ09831.
KOiK08286.
OMAiRINVEDH.
OrthoDBiEOG7R2BT5.
PhylomeDBiQ09831.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09831-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNELHDGESS EEGRINVEDH LEEAKKDDTG HWKHSGTAKP SKFRAFIRLH
60 70 80 90 100
FKDSRKFAFS RKKEKELTSE DSDAANQSPS GAPESQTEEE SDRKIDGTGS
110 120 130 140 150
SAEGGDGSGT DSISVIKKSF FKSGRKKKDV PKSRNVSRSN GADTSVQREK
160 170 180 190 200
LKDIFSPHGK EKELAHIKKT VATRARTYSS NSIKICDVEV GPSSFEKVFL
210 220 230 240 250
LGKGDVGRVY LVREKKSGKF YAMKVLSKQE MIKRNKSKRA FAEQHILATS
260 270 280 290 300
NHPFIVTLYH SFQSDEYLYL CMEYCMGGEF FRALQRRPGR CLSENEAKFY
310 320 330 340 350
IAEVTAALEY LHLMGFIYRD LKPENILLHE SGHIMLSDFD LSKQSNSAGA
360 370 380 390 400
PTVIQARNAP SAQNAYALDT KSCIADFRTN SFVGTEEYIA PEVIKGCGHT
410 420 430 440 450
SAVDWWTLGI LFYEMLYATT PFKGKNRNMT FSNILHKDVI FPEYADAPSI
460 470 480 490 500
SSLCKNLIRK LLVKDENDRL GSQAGAADVK LHPFFKNVQW ALLRHTEPPI
510 520 530 540 550
IPKLAPIDEK GNPNISHLKE SKSLDITHSP QNTQTVEVPL SNLSGADHGD
560
DPFESFNSVT VHHEWD
Length:566
Mass (Da):63,482
Last modified:January 31, 1996 - v1
Checksum:i3D18B4F84E10AA13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91206.1.
PIRiS62482.
RefSeqiNP_593065.1. NM_001018463.2.

Genome annotation databases

EnsemblFungiiSPAC4G8.05.1; SPAC4G8.05.1:pep; SPAC4G8.05.
GeneIDi2543432.
KEGGispo:SPAC4G8.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91206.1.
PIRiS62482.
RefSeqiNP_593065.1. NM_001018463.2.

3D structure databases

ProteinModelPortaliQ09831.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279852. 111 interactions.
MINTiMINT-4695541.
STRINGi4896.SPAC4G8.05-1.

Proteomic databases

MaxQBiQ09831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC4G8.05.1; SPAC4G8.05.1:pep; SPAC4G8.05.
GeneIDi2543432.
KEGGispo:SPAC4G8.05.

Organism-specific databases

PomBaseiSPAC4G8.05.

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ09831.
KOiK08286.
OMAiRINVEDH.
OrthoDBiEOG7R2BT5.
PhylomeDBiQ09831.

Miscellaneous databases

NextBioi20804445.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. Cited for: IDENTIFICATION.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-379; SER-381 AND THR-385, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiPPK14_SCHPO
AccessioniPrimary (citable) accession number: Q09831
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 1996
Last sequence update: January 31, 1996
Last modified: January 6, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.