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Q09831

- PPK14_SCHPO

UniProt

Q09831 - PPK14_SCHPO

Protein

Serine/threonine-protein kinase ppk14

Gene

ppk14

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei224 – 2241ATPPROSITE-ProRule annotation
    Active sitei320 – 3201Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi201 – 2099ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. activation of bipolar cell growth Source: PomBase
    2. cellular response to pheromone Source: PomBase
    3. protein phosphorylation Source: PomBase
    4. signal transduction Source: PomBase

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase ppk14 (EC:2.7.11.1)
    Gene namesi
    Name:ppk14
    ORF Names:SPAC4G8.05
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC4G8.05.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566Serine/threonine-protein kinase ppk14PRO_0000086043Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei379 – 3791Phosphothreonine1 Publication
    Modified residuei381 – 3811Phosphoserine1 Publication
    Modified residuei385 – 3851Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ09831.

    Interactioni

    Protein-protein interaction databases

    BioGridi279852. 111 interactions.
    MINTiMINT-4695541.
    STRINGi4896.SPAC4G8.05-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09831.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini195 – 485291Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. KIN82 subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    KOiK08286.
    OMAiRVHANEA.
    OrthoDBiEOG7R2BT5.
    PhylomeDBiQ09831.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09831-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNELHDGESS EEGRINVEDH LEEAKKDDTG HWKHSGTAKP SKFRAFIRLH    50
    FKDSRKFAFS RKKEKELTSE DSDAANQSPS GAPESQTEEE SDRKIDGTGS 100
    SAEGGDGSGT DSISVIKKSF FKSGRKKKDV PKSRNVSRSN GADTSVQREK 150
    LKDIFSPHGK EKELAHIKKT VATRARTYSS NSIKICDVEV GPSSFEKVFL 200
    LGKGDVGRVY LVREKKSGKF YAMKVLSKQE MIKRNKSKRA FAEQHILATS 250
    NHPFIVTLYH SFQSDEYLYL CMEYCMGGEF FRALQRRPGR CLSENEAKFY 300
    IAEVTAALEY LHLMGFIYRD LKPENILLHE SGHIMLSDFD LSKQSNSAGA 350
    PTVIQARNAP SAQNAYALDT KSCIADFRTN SFVGTEEYIA PEVIKGCGHT 400
    SAVDWWTLGI LFYEMLYATT PFKGKNRNMT FSNILHKDVI FPEYADAPSI 450
    SSLCKNLIRK LLVKDENDRL GSQAGAADVK LHPFFKNVQW ALLRHTEPPI 500
    IPKLAPIDEK GNPNISHLKE SKSLDITHSP QNTQTVEVPL SNLSGADHGD 550
    DPFESFNSVT VHHEWD 566
    Length:566
    Mass (Da):63,482
    Last modified:February 1, 1996 - v1
    Checksum:i3D18B4F84E10AA13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA91206.1.
    PIRiS62482.
    RefSeqiNP_593065.1. NM_001018463.2.

    Genome annotation databases

    EnsemblFungiiSPAC4G8.05.1; SPAC4G8.05.1:pep; SPAC4G8.05.
    GeneIDi2543432.
    KEGGispo:SPAC4G8.05.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA91206.1 .
    PIRi S62482.
    RefSeqi NP_593065.1. NM_001018463.2.

    3D structure databases

    ProteinModelPortali Q09831.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279852. 111 interactions.
    MINTi MINT-4695541.
    STRINGi 4896.SPAC4G8.05-1.

    Proteomic databases

    MaxQBi Q09831.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC4G8.05.1 ; SPAC4G8.05.1:pep ; SPAC4G8.05 .
    GeneIDi 2543432.
    KEGGi spo:SPAC4G8.05.

    Organism-specific databases

    PomBasei SPAC4G8.05.

    Phylogenomic databases

    eggNOGi COG0515.
    KOi K08286.
    OMAi RVHANEA.
    OrthoDBi EOG7R2BT5.
    PhylomeDBi Q09831.

    Miscellaneous databases

    NextBioi 20804445.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. Cited for: IDENTIFICATION.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-379; SER-381 AND THR-385, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiPPK14_SCHPO
    AccessioniPrimary (citable) accession number: Q09831
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3