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Q09828

- SYLM_SCHPO

UniProt

Q09828 - SYLM_SCHPO

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Protein

Putative leucine--tRNA ligase, mitochondrial

Gene

SPAC4G8.09

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei631 – 6311ATPBy similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. leucine-tRNA ligase activity Source: PomBase
  4. mRNA binding Source: PomBase

GO - Biological processi

  1. Group I intron splicing Source: PomBase
  2. leucyl-tRNA aminoacylation Source: PomBase
  3. mitochondrial translation Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative leucine--tRNA ligase, mitochondrial (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
ORF Names:SPAC4G8.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC4G8.09.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121MitochondrionBy similarityAdd
BLAST
Chaini22 – 874853Putative leucine--tRNA ligase, mitochondrialPRO_0000035811Add
BLAST

Proteomic databases

MaxQBiQ09828.

Interactioni

Protein-protein interaction databases

BioGridi279896. 2 interactions.
MINTiMINT-4695515.
STRINGi4896.SPAC4G8.09-1.

Structurei

3D structure databases

ProteinModelPortaliQ09828.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi67 – 7711"HIGH" regionAdd
BLAST
Motifi628 – 6325"KMSKS" region

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
InParanoidiQ09828.
KOiK01869.
OMAiMAFAGPP.
OrthoDBiEOG7Q8CWM.
PhylomeDBiQ09828.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09828-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKSVGTNGR KVPKIASLCN FLKFNKNIHS NPDFLAIAEN WKSYWKSHYP
60 70 80 90 100
FVKNDKGKKK YILSMFPYPS GLLHIGHVRV YTISDILSRY YRMKGYKVIH
110 120 130 140 150
PMGWDAFGLP AENAAIENGI SASSWTYENI KKMKEQTYHM NIYFDWDREI
160 170 180 190 200
STCNPDYYKW SQYLFLQMFH KGLAYQAEAT VNWDPVDCTV LANEQVDSHG
210 220 230 240 250
RSWRSGAIVE KKNLRQWFLK ISDYSDQLLD DLETLPKWPD KVKKMQRNWI
260 270 280 290 300
GRTTGFEISF PLLNDKETLT VFTTKPETII DVSFIALSKN HKLVLLESQK
310 320 330 340 350
DPSLAEHLRN ESLLDKGYQL PCFAKNPVTG KALPIFYAPY VLDCYGTGAV
360 370 380 390 400
MGAPIHDRRD FEFAKRNNII FSKESCIGSY FTNEGKELLN HHDSSNLMDI
410 420 430 440 450
KQKMLQQKIV SYLEEKKLAK RVKNYRLKDW LISRQRFWGT PIPMVHCETC
460 470 480 490 500
GAVPVPESEL PVKLPDLDKI YEKGTSPLSN LETWMKTTCP KCHGPATRET
510 520 530 540 550
DTMDTFVDSS WYYFRFLDSK NSELPVGLAS ASSLMPVDIY IGGVEHSILH
560 570 580 590 600
LLYSRFFSKF MKDIGLWNGD KYLNEPFTQL ITQGMVHGLT YTTMSDERIL
610 620 630 640 650
NPKEVQKIGD EYFLISNPKE KVQLSYQKMS KSKHNGVDPI RTIQKYGSDI
660 670 680 690 700
IRAYIIFSAP VEGVLLWNEN AIMGTKRWLT KIWNCVHQLL EREKKMSDAM
710 720 730 740 750
RQTKLTIVDD HNSRKLESQY NEFISQCSAH YENVFSLNLV ISDAMKLTNN
760 770 780 790 800
IADALKNNKV NIGTIKASLE VLVKCIAPII PCFSSECWLL LGHNSSVYSN
810 820 830 840 850
WPISKNKKEN MEEPVTIPVQ INGKVRFKIE MPKLNDENEI LNFVLETNDG
860 870
KRWLSNKKVL KSFVKQKIIS LVTD
Length:874
Mass (Da):100,886
Last modified:February 1, 1996 - v1
Checksum:i0F9550E7E720AFC6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA91210.1.
PIRiT38854. S62486.
RefSeqiNP_593069.1. NM_001018467.2.

Genome annotation databases

EnsemblFungiiSPAC4G8.09.1; SPAC4G8.09.1:pep; SPAC4G8.09.
GeneIDi2543476.
KEGGispo:SPAC4G8.09.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA91210.1 .
PIRi T38854. S62486.
RefSeqi NP_593069.1. NM_001018467.2.

3D structure databases

ProteinModelPortali Q09828.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279896. 2 interactions.
MINTi MINT-4695515.
STRINGi 4896.SPAC4G8.09-1.

Proteomic databases

MaxQBi Q09828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC4G8.09.1 ; SPAC4G8.09.1:pep ; SPAC4G8.09 .
GeneIDi 2543476.
KEGGi spo:SPAC4G8.09.

Organism-specific databases

PomBasei SPAC4G8.09.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
InParanoidi Q09828.
KOi K01869.
OMAi MAFAGPP.
OrthoDBi EOG7Q8CWM.
PhylomeDBi Q09828.

Miscellaneous databases

NextBioi 20804488.
PROi Q09828.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiSYLM_SCHPO
AccessioniPrimary (citable) accession number: Q09828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3