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Q09828

- SYLM_SCHPO

UniProt

Q09828 - SYLM_SCHPO

Protein

Putative leucine--tRNA ligase, mitochondrial

Gene

SPAC4G8.09

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei631 – 6311ATPBy similarity

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. leucine-tRNA ligase activity Source: PomBase
    4. mRNA binding Source: PomBase

    GO - Biological processi

    1. Group I intron splicing Source: PomBase
    2. leucyl-tRNA aminoacylation Source: PomBase
    3. mitochondrial translation Source: PomBase

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative leucine--tRNA ligase, mitochondrial (EC:6.1.1.4)
    Alternative name(s):
    Leucyl-tRNA synthetase
    Short name:
    LeuRS
    Gene namesi
    ORF Names:SPAC4G8.09
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC4G8.09.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: PomBase

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2121MitochondrionBy similarityAdd
    BLAST
    Chaini22 – 874853Putative leucine--tRNA ligase, mitochondrialPRO_0000035811Add
    BLAST

    Proteomic databases

    MaxQBiQ09828.

    Interactioni

    Protein-protein interaction databases

    BioGridi279896. 2 interactions.
    MINTiMINT-4695515.
    STRINGi4896.SPAC4G8.09-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09828.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi67 – 7711"HIGH" regionAdd
    BLAST
    Motifi628 – 6325"KMSKS" region

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiMAFAGPP.
    OrthoDBiEOG7Q8CWM.
    PhylomeDBiQ09828.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q09828-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKSVGTNGR KVPKIASLCN FLKFNKNIHS NPDFLAIAEN WKSYWKSHYP    50
    FVKNDKGKKK YILSMFPYPS GLLHIGHVRV YTISDILSRY YRMKGYKVIH 100
    PMGWDAFGLP AENAAIENGI SASSWTYENI KKMKEQTYHM NIYFDWDREI 150
    STCNPDYYKW SQYLFLQMFH KGLAYQAEAT VNWDPVDCTV LANEQVDSHG 200
    RSWRSGAIVE KKNLRQWFLK ISDYSDQLLD DLETLPKWPD KVKKMQRNWI 250
    GRTTGFEISF PLLNDKETLT VFTTKPETII DVSFIALSKN HKLVLLESQK 300
    DPSLAEHLRN ESLLDKGYQL PCFAKNPVTG KALPIFYAPY VLDCYGTGAV 350
    MGAPIHDRRD FEFAKRNNII FSKESCIGSY FTNEGKELLN HHDSSNLMDI 400
    KQKMLQQKIV SYLEEKKLAK RVKNYRLKDW LISRQRFWGT PIPMVHCETC 450
    GAVPVPESEL PVKLPDLDKI YEKGTSPLSN LETWMKTTCP KCHGPATRET 500
    DTMDTFVDSS WYYFRFLDSK NSELPVGLAS ASSLMPVDIY IGGVEHSILH 550
    LLYSRFFSKF MKDIGLWNGD KYLNEPFTQL ITQGMVHGLT YTTMSDERIL 600
    NPKEVQKIGD EYFLISNPKE KVQLSYQKMS KSKHNGVDPI RTIQKYGSDI 650
    IRAYIIFSAP VEGVLLWNEN AIMGTKRWLT KIWNCVHQLL EREKKMSDAM 700
    RQTKLTIVDD HNSRKLESQY NEFISQCSAH YENVFSLNLV ISDAMKLTNN 750
    IADALKNNKV NIGTIKASLE VLVKCIAPII PCFSSECWLL LGHNSSVYSN 800
    WPISKNKKEN MEEPVTIPVQ INGKVRFKIE MPKLNDENEI LNFVLETNDG 850
    KRWLSNKKVL KSFVKQKIIS LVTD 874
    Length:874
    Mass (Da):100,886
    Last modified:February 1, 1996 - v1
    Checksum:i0F9550E7E720AFC6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA91210.1.
    PIRiT38854. S62486.
    RefSeqiNP_593069.1. NM_001018467.2.

    Genome annotation databases

    EnsemblFungiiSPAC4G8.09.1; SPAC4G8.09.1:pep; SPAC4G8.09.
    GeneIDi2543476.
    KEGGispo:SPAC4G8.09.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA91210.1 .
    PIRi T38854. S62486.
    RefSeqi NP_593069.1. NM_001018467.2.

    3D structure databases

    ProteinModelPortali Q09828.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279896. 2 interactions.
    MINTi MINT-4695515.
    STRINGi 4896.SPAC4G8.09-1.

    Proteomic databases

    MaxQBi Q09828.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC4G8.09.1 ; SPAC4G8.09.1:pep ; SPAC4G8.09 .
    GeneIDi 2543476.
    KEGGi spo:SPAC4G8.09.

    Organism-specific databases

    PomBasei SPAC4G8.09.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi MAFAGPP.
    OrthoDBi EOG7Q8CWM.
    PhylomeDBi Q09828.

    Miscellaneous databases

    NextBioi 20804488.
    PROi Q09828.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiSYLM_SCHPO
    AccessioniPrimary (citable) accession number: Q09828
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3