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Q09828 (SYLM_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative leucine--tRNA ligase, mitochondrial

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
ORF Names:SPAC4G8.09
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length874 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049_B

Subcellular location

Mitochondrion matrix HAMAP-Rule MF_00049_B.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2121Mitochondrion By similarity
Chain22 – 874853Putative leucine--tRNA ligase, mitochondrial HAMAP-Rule MF_00049_B
PRO_0000035811

Regions

Motif67 – 7711"HIGH" region HAMAP-Rule MF_00049_B
Motif628 – 6325"KMSKS" region HAMAP-Rule MF_00049_B

Sites

Binding site6311ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09828 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 0F9550E7E720AFC6

FASTA874100,886
        10         20         30         40         50         60 
MLKSVGTNGR KVPKIASLCN FLKFNKNIHS NPDFLAIAEN WKSYWKSHYP FVKNDKGKKK 

        70         80         90        100        110        120 
YILSMFPYPS GLLHIGHVRV YTISDILSRY YRMKGYKVIH PMGWDAFGLP AENAAIENGI 

       130        140        150        160        170        180 
SASSWTYENI KKMKEQTYHM NIYFDWDREI STCNPDYYKW SQYLFLQMFH KGLAYQAEAT 

       190        200        210        220        230        240 
VNWDPVDCTV LANEQVDSHG RSWRSGAIVE KKNLRQWFLK ISDYSDQLLD DLETLPKWPD 

       250        260        270        280        290        300 
KVKKMQRNWI GRTTGFEISF PLLNDKETLT VFTTKPETII DVSFIALSKN HKLVLLESQK 

       310        320        330        340        350        360 
DPSLAEHLRN ESLLDKGYQL PCFAKNPVTG KALPIFYAPY VLDCYGTGAV MGAPIHDRRD 

       370        380        390        400        410        420 
FEFAKRNNII FSKESCIGSY FTNEGKELLN HHDSSNLMDI KQKMLQQKIV SYLEEKKLAK 

       430        440        450        460        470        480 
RVKNYRLKDW LISRQRFWGT PIPMVHCETC GAVPVPESEL PVKLPDLDKI YEKGTSPLSN 

       490        500        510        520        530        540 
LETWMKTTCP KCHGPATRET DTMDTFVDSS WYYFRFLDSK NSELPVGLAS ASSLMPVDIY 

       550        560        570        580        590        600 
IGGVEHSILH LLYSRFFSKF MKDIGLWNGD KYLNEPFTQL ITQGMVHGLT YTTMSDERIL 

       610        620        630        640        650        660 
NPKEVQKIGD EYFLISNPKE KVQLSYQKMS KSKHNGVDPI RTIQKYGSDI IRAYIIFSAP 

       670        680        690        700        710        720 
VEGVLLWNEN AIMGTKRWLT KIWNCVHQLL EREKKMSDAM RQTKLTIVDD HNSRKLESQY 

       730        740        750        760        770        780 
NEFISQCSAH YENVFSLNLV ISDAMKLTNN IADALKNNKV NIGTIKASLE VLVKCIAPII 

       790        800        810        820        830        840 
PCFSSECWLL LGHNSSVYSN WPISKNKKEN MEEPVTIPVQ INGKVRFKIE MPKLNDENEI 

       850        860        870 
LNFVLETNDG KRWLSNKKVL KSFVKQKIIS LVTD 

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAA91210.1.
PIRS62486. T38854.
RefSeqNP_593069.1. NM_001018467.2.

3D structure databases

ProteinModelPortalQ09828.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279896. 2 interactions.
MINTMINT-4695515.
STRING4896.SPAC4G8.09-1.

Proteomic databases

MaxQBQ09828.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC4G8.09.1; SPAC4G8.09.1:pep; SPAC4G8.09.
GeneID2543476.
KEGGspo:SPAC4G8.09.

Organism-specific databases

PomBaseSPAC4G8.09.

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAMAFAGPP.
OrthoDBEOG7Q8CWM.
PhylomeDBQ09828.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20804488.
PROQ09828.

Entry information

Entry nameSYLM_SCHPO
AccessionPrimary (citable) accession number: Q09828
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 14, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries