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Q09822

- CDC15_SCHPO

UniProt

Q09822 - CDC15_SCHPO

Protein

Cell division control protein 15

Gene

cdc15

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.

    GO - Molecular functioni

    1. protein anchor Source: PomBase
    2. protein binding Source: IntAct

    GO - Biological processi

    1. actin cytoskeleton organization Source: PomBase
    2. actomyosin contractile ring assembly Source: PomBase
    3. cortical actin cytoskeleton organization Source: PomBase
    4. establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site Source: PomBase
    5. mitotic actomyosin contractile ring localization Source: PomBase
    6. mitotic nuclear division Source: UniProtKB-KW
    7. protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly Source: PomBase
    8. regulation of actin nucleation Source: PomBase
    9. regulation of mitotic cell cycle Source: PomBase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division control protein 15
    Gene namesi
    Name:cdc15
    ORF Names:SPAC20G8.05c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC20G8.05c.

    Subcellular locationi

    GO - Cellular componenti

    1. cell division site Source: PomBase
    2. cell tip Source: PomBase
    3. cytoplasm Source: PomBase
    4. cytoskeleton Source: UniProtKB-SubCell
    5. medial membrane band Source: PomBase

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 927927Cell division control protein 15PRO_0000089443Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei331 – 3311Phosphoserine1 Publication
    Modified residuei332 – 3321Phosphoserine1 Publication
    Modified residuei529 – 5291Phosphothreonine1 Publication
    Modified residuei636 – 6361Phosphoserine1 Publication
    Modified residuei639 – 6391Phosphoserine1 Publication
    Modified residuei700 – 7001Phosphoserine1 Publication
    Modified residuei774 – 7741Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ09822.

    Expressioni

    Developmental stagei

    Peaks in early mitosis before septation.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    cdc12Q100594EBI-1148185,EBI-1148281
    myo1Q9Y7Z84EBI-1148185,EBI-1148082

    Protein-protein interaction databases

    BioGridi278460. 44 interactions.
    DIPiDIP-35649N.
    IntActiQ09822. 3 interactions.
    MINTiMINT-4695421.
    STRINGi4896.SPAC20G8.05c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09822.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 10182FCHPROSITE-ProRule annotationAdd
    BLAST
    Domaini866 – 92762SH3PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili108 – 207100Sequence AnalysisAdd
    BLAST

    Domaini

    The N-terminal region is in a coiled coil structure.

    Sequence similaritiesi

    Contains 1 FCH domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    eggNOGiNOG303711.
    OMAiTARWNRE.
    OrthoDBiEOG7F7WKS.
    PhylomeDBiQ09822.

    Family and domain databases

    InterProiIPR001060. FCH_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00611. FCH. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00055. FCH. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50133. FCH. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09822-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVNGVSQSE AAPYVTKSSV KFRDNFWGSE DAGMDALMSR TKSSLSVLES    50
    IDEFYAKRAS IEREYASKLQ ELAASSADIP EVGSTLNNIL SMRTETGSMA 100
    KAHEEVSQQI NTELRNKIRE YIDQTEQQKV VAANAIEELY QKKTALEIDL 150
    SEKKDAYEYS CNKLNSYMRQ TKKMTGRELD KYNLKIRQAA LAVKKMDAEY 200
    RETNELLLTV TREWIDRWTE VCDAFQHIEE YRLEFLKTNM WAYANIISTA 250
    CVKDDESCEK IRLTLENTNI DEDITQMIQN EGTGTTIPPL PEFNDYFKEN 300
    GLNYDIDQLI SKAPSYPYSS SRPSASASLA SSPTRSAFRP KTSETVSSEV 350
    VSSPPTSPLH SPVKPVSNEQ VEQVTEVELS IPVPSIQEAE SQKPVLTGSS 400
    MRRPSVTSPT FEVAARPLTS MDVRSSHNAE TEVQAIPAAT DISPEVKEGK 450
    NSENAITKDN DDIILSSQLQ PTATGSRSSR LSFSRHGHGS QTSLGSIKRK 500
    SIMERMGRPT SPFMGSSFSN MGSRSTSPTK EGFASNQHAT GASVQSDELE 550
    DIDPRANVVL NVGPNMLSVG EAPVESTSKE EDKDVPDPIA NAMAELSSSM 600
    RRRQSTSVDD EAPVSLSKTS SSTRLNGLGY HSRNTSIASD IDGVPKKSTL 650
    GAPPAAHTSA QMQRMSNSFA SQTKQVFGEQ RTENSARESL RHSRSNMSRS 700
    PSPMLSRRSS TLRPSFERSA SSLSVRQSDV VSPAPSTRAR GQSVSGQQRP 750
    SSSMSLYGEY NKSQPQLSMQ RSVSPNPLGP NRRSSSVLQS QKSTSSNTSN 800
    RNNGGYSGSR PSSEMGHRYG SMSGRSMRQV SQRSTSRARS PEPTNRNSVQ 850
    SKNVDPRATF TAEGEPILGY VIALYDYQAQ IPEEISFQKG DTLMVLRTQE 900
    DGWWDGEIIN VPNSKRGLFP SNFVQTV 927
    Length:927
    Mass (Da):102,119
    Last modified:May 30, 2000 - v2
    Checksum:iFDCE7E0AAA3D247D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86179 Genomic DNA. Translation: CAA60115.1.
    CU329670 Genomic DNA. Translation: CAB08599.2.
    AB027810 Genomic DNA. Translation: BAA87114.1.
    PIRiT38127.
    RefSeqiNP_593322.1. NM_001018753.2.

    Genome annotation databases

    EnsemblFungiiSPAC20G8.05c.1; SPAC20G8.05c.1:pep; SPAC20G8.05c.
    GeneIDi2541975.
    KEGGispo:SPAC20G8.05c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X86179 Genomic DNA. Translation: CAA60115.1 .
    CU329670 Genomic DNA. Translation: CAB08599.2 .
    AB027810 Genomic DNA. Translation: BAA87114.1 .
    PIRi T38127.
    RefSeqi NP_593322.1. NM_001018753.2.

    3D structure databases

    ProteinModelPortali Q09822.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278460. 44 interactions.
    DIPi DIP-35649N.
    IntActi Q09822. 3 interactions.
    MINTi MINT-4695421.
    STRINGi 4896.SPAC20G8.05c-1.

    Proteomic databases

    MaxQBi Q09822.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC20G8.05c.1 ; SPAC20G8.05c.1:pep ; SPAC20G8.05c .
    GeneIDi 2541975.
    KEGGi spo:SPAC20G8.05c.

    Organism-specific databases

    PomBasei SPAC20G8.05c.

    Phylogenomic databases

    eggNOGi NOG303711.
    OMAi TARWNRE.
    OrthoDBi EOG7F7WKS.
    PhylomeDBi Q09822.

    Miscellaneous databases

    NextBioi 20803057.

    Family and domain databases

    InterProi IPR001060. FCH_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00611. FCH. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00055. FCH. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50133. FCH. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis."
      Fankhauser C., Reymond A., Cerutti L., Utzig S., Hofmann K., Simanis V.
      Cell 82:435-444(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    2. Fankhauser C., Reymond A., Cerutti L., Utzig S., Hofmann K., Simanis V.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO N-TERMINUS.
    3. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.
    4. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
      Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
      Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 286-425.
      Strain: ATCC 38364 / 968.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331; SER-332; THR-529; SER-636; SER-639; SER-700 AND SER-774, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiCDC15_SCHPO
    AccessioniPrimary (citable) accession number: Q09822
    Secondary accession number(s): O14365, Q9UU50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3