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Protein

Cell division control protein 15

Gene

cdc15

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.

GO - Molecular functioni

  • protein membrane anchor Source: PomBase

GO - Biological processi

  • anchoring of the mitotic actomyosin contractile ring to the plasma membrane Source: PomBase
  • clathrin-dependent endocytosis Source: PomBase
  • establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site Source: PomBase
  • mitotic actomyosin contractile ring assembly Source: PomBase
  • positive regulation of division septum assembly Source: PomBase
  • protein localization to cell division site involved in mitotic actomyosin contractile ring assembly Source: PomBase

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 15
Gene namesi
Name:cdc15
ORF Names:SPAC20G8.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC20G8.05c
PomBaseiSPAC20G8.05c cdc15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894431 – 927Cell division control protein 15Add BLAST927

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei331Phosphoserine1 Publication1
Modified residuei332Phosphoserine1 Publication1
Modified residuei529Phosphothreonine1 Publication1
Modified residuei636Phosphoserine1 Publication1
Modified residuei639Phosphoserine1 Publication1
Modified residuei700Phosphoserine1 Publication1
Modified residuei774Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09822
PaxDbiQ09822
PRIDEiQ09822

PTM databases

iPTMnetiQ09822

Expressioni

Developmental stagei

Peaks in early mitosis before septation.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein membrane anchor Source: PomBase

Protein-protein interaction databases

BioGridi278460, 47 interactors
DIPiDIP-35649N
IntActiQ09822, 4 interactors
STRINGi4896.SPAC20G8.05c.1

Structurei

3D structure databases

ProteinModelPortaliQ09822
SMRiQ09822
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 273F-BARPROSITE-ProRule annotationAdd BLAST254
Domaini866 – 927SH3PROSITE-ProRule annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili108 – 207Sequence analysisAdd BLAST100

Domaini

The N-terminal region is in a coiled coil structure.

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

InParanoidiQ09822
OMAiYINFCRG
OrthoDBiEOG092C3EOZ
PhylomeDBiQ09822

Family and domain databases

Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR031160 F_BAR
IPR001060 FCH_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00611 FCH, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00055 FCH, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51741 F_BAR, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q09822-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVNGVSQSE AAPYVTKSSV KFRDNFWGSE DAGMDALMSR TKSSLSVLES
60 70 80 90 100
IDEFYAKRAS IEREYASKLQ ELAASSADIP EVGSTLNNIL SMRTETGSMA
110 120 130 140 150
KAHEEVSQQI NTELRNKIRE YIDQTEQQKV VAANAIEELY QKKTALEIDL
160 170 180 190 200
SEKKDAYEYS CNKLNSYMRQ TKKMTGRELD KYNLKIRQAA LAVKKMDAEY
210 220 230 240 250
RETNELLLTV TREWIDRWTE VCDAFQHIEE YRLEFLKTNM WAYANIISTA
260 270 280 290 300
CVKDDESCEK IRLTLENTNI DEDITQMIQN EGTGTTIPPL PEFNDYFKEN
310 320 330 340 350
GLNYDIDQLI SKAPSYPYSS SRPSASASLA SSPTRSAFRP KTSETVSSEV
360 370 380 390 400
VSSPPTSPLH SPVKPVSNEQ VEQVTEVELS IPVPSIQEAE SQKPVLTGSS
410 420 430 440 450
MRRPSVTSPT FEVAARPLTS MDVRSSHNAE TEVQAIPAAT DISPEVKEGK
460 470 480 490 500
NSENAITKDN DDIILSSQLQ PTATGSRSSR LSFSRHGHGS QTSLGSIKRK
510 520 530 540 550
SIMERMGRPT SPFMGSSFSN MGSRSTSPTK EGFASNQHAT GASVQSDELE
560 570 580 590 600
DIDPRANVVL NVGPNMLSVG EAPVESTSKE EDKDVPDPIA NAMAELSSSM
610 620 630 640 650
RRRQSTSVDD EAPVSLSKTS SSTRLNGLGY HSRNTSIASD IDGVPKKSTL
660 670 680 690 700
GAPPAAHTSA QMQRMSNSFA SQTKQVFGEQ RTENSARESL RHSRSNMSRS
710 720 730 740 750
PSPMLSRRSS TLRPSFERSA SSLSVRQSDV VSPAPSTRAR GQSVSGQQRP
760 770 780 790 800
SSSMSLYGEY NKSQPQLSMQ RSVSPNPLGP NRRSSSVLQS QKSTSSNTSN
810 820 830 840 850
RNNGGYSGSR PSSEMGHRYG SMSGRSMRQV SQRSTSRARS PEPTNRNSVQ
860 870 880 890 900
SKNVDPRATF TAEGEPILGY VIALYDYQAQ IPEEISFQKG DTLMVLRTQE
910 920
DGWWDGEIIN VPNSKRGLFP SNFVQTV
Length:927
Mass (Da):102,119
Last modified:May 30, 2000 - v2
Checksum:iFDCE7E0AAA3D247D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86179 Genomic DNA Translation: CAA60115.1
CU329670 Genomic DNA Translation: CAB08599.2
AB027810 Genomic DNA Translation: BAA87114.1
PIRiT38127
RefSeqiNP_593322.1, NM_001018753.2

Genome annotation databases

EnsemblFungiiSPAC20G8.05c.1; SPAC20G8.05c.1:pep; SPAC20G8.05c
GeneIDi2541975
KEGGispo:SPAC20G8.05c

Similar proteinsi

Entry informationi

Entry nameiCDC15_SCHPO
AccessioniPrimary (citable) accession number: Q09822
Secondary accession number(s): O14365, Q9UU50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health