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Q09822

- CDC15_SCHPO

UniProt

Q09822 - CDC15_SCHPO

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Protein

Cell division control protein 15

Gene
cdc15, SPAC20G8.05c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.

GO - Molecular functioni

  1. protein anchor Source: PomBase
  2. protein binding Source: IntAct

GO - Biological processi

  1. actin cytoskeleton organization Source: PomBase
  2. actomyosin contractile ring assembly Source: PomBase
  3. contractile ring localization Source: PomBase
  4. cortical actin cytoskeleton organization Source: PomBase
  5. establishment of endoplasmic reticulum localization involved in endoplasmic reticulum polarization at cell division site Source: PomBase
  6. mitotic nuclear division Source: UniProtKB-KW
  7. protein localization to cell division site involved in cytokinesis, actomyosin contractile ring assembly Source: PomBase
  8. regulation of actin nucleation Source: PomBase
  9. regulation of mitotic cell cycle Source: PomBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 15
Gene namesi
Name:cdc15
ORF Names:SPAC20G8.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC20G8.05c.

Subcellular locationi

GO - Cellular componenti

  1. cell division site Source: PomBase
  2. cell tip Source: PomBase
  3. cytoplasm Source: PomBase
  4. cytoskeleton Source: UniProtKB-SubCell
  5. medial membrane band Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 927927Cell division control protein 15PRO_0000089443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei331 – 3311Phosphoserine1 Publication
Modified residuei332 – 3321Phosphoserine1 Publication
Modified residuei529 – 5291Phosphothreonine1 Publication
Modified residuei636 – 6361Phosphoserine1 Publication
Modified residuei639 – 6391Phosphoserine1 Publication
Modified residuei700 – 7001Phosphoserine1 Publication
Modified residuei774 – 7741Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09822.

Expressioni

Developmental stagei

Peaks in early mitosis before septation.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
cdc12Q100594EBI-1148185,EBI-1148281
myo1Q9Y7Z84EBI-1148185,EBI-1148082

Protein-protein interaction databases

BioGridi278460. 44 interactions.
DIPiDIP-35649N.
IntActiQ09822. 3 interactions.
MINTiMINT-4695421.
STRINGi4896.SPAC20G8.05c-1.

Structurei

3D structure databases

ProteinModelPortaliQ09822.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 10182FCHAdd
BLAST
Domaini866 – 92762SH3Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili108 – 207100 Reviewed predictionAdd
BLAST

Domaini

The N-terminal region is in a coiled coil structure.

Sequence similaritiesi

Contains 1 FCH domain.
Contains 1 SH3 domain.

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiNOG303711.
OMAiTARWNRE.
OrthoDBiEOG7F7WKS.
PhylomeDBiQ09822.

Family and domain databases

InterProiIPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09822-1 [UniParc]FASTAAdd to Basket

« Hide

MEVNGVSQSE AAPYVTKSSV KFRDNFWGSE DAGMDALMSR TKSSLSVLES    50
IDEFYAKRAS IEREYASKLQ ELAASSADIP EVGSTLNNIL SMRTETGSMA 100
KAHEEVSQQI NTELRNKIRE YIDQTEQQKV VAANAIEELY QKKTALEIDL 150
SEKKDAYEYS CNKLNSYMRQ TKKMTGRELD KYNLKIRQAA LAVKKMDAEY 200
RETNELLLTV TREWIDRWTE VCDAFQHIEE YRLEFLKTNM WAYANIISTA 250
CVKDDESCEK IRLTLENTNI DEDITQMIQN EGTGTTIPPL PEFNDYFKEN 300
GLNYDIDQLI SKAPSYPYSS SRPSASASLA SSPTRSAFRP KTSETVSSEV 350
VSSPPTSPLH SPVKPVSNEQ VEQVTEVELS IPVPSIQEAE SQKPVLTGSS 400
MRRPSVTSPT FEVAARPLTS MDVRSSHNAE TEVQAIPAAT DISPEVKEGK 450
NSENAITKDN DDIILSSQLQ PTATGSRSSR LSFSRHGHGS QTSLGSIKRK 500
SIMERMGRPT SPFMGSSFSN MGSRSTSPTK EGFASNQHAT GASVQSDELE 550
DIDPRANVVL NVGPNMLSVG EAPVESTSKE EDKDVPDPIA NAMAELSSSM 600
RRRQSTSVDD EAPVSLSKTS SSTRLNGLGY HSRNTSIASD IDGVPKKSTL 650
GAPPAAHTSA QMQRMSNSFA SQTKQVFGEQ RTENSARESL RHSRSNMSRS 700
PSPMLSRRSS TLRPSFERSA SSLSVRQSDV VSPAPSTRAR GQSVSGQQRP 750
SSSMSLYGEY NKSQPQLSMQ RSVSPNPLGP NRRSSSVLQS QKSTSSNTSN 800
RNNGGYSGSR PSSEMGHRYG SMSGRSMRQV SQRSTSRARS PEPTNRNSVQ 850
SKNVDPRATF TAEGEPILGY VIALYDYQAQ IPEEISFQKG DTLMVLRTQE 900
DGWWDGEIIN VPNSKRGLFP SNFVQTV 927
Length:927
Mass (Da):102,119
Last modified:May 30, 2000 - v2
Checksum:iFDCE7E0AAA3D247D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86179 Genomic DNA. Translation: CAA60115.1.
CU329670 Genomic DNA. Translation: CAB08599.2.
AB027810 Genomic DNA. Translation: BAA87114.1.
PIRiT38127.
RefSeqiNP_593322.1. NM_001018753.2.

Genome annotation databases

EnsemblFungiiSPAC20G8.05c.1; SPAC20G8.05c.1:pep; SPAC20G8.05c.
GeneIDi2541975.
KEGGispo:SPAC20G8.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86179 Genomic DNA. Translation: CAA60115.1 .
CU329670 Genomic DNA. Translation: CAB08599.2 .
AB027810 Genomic DNA. Translation: BAA87114.1 .
PIRi T38127.
RefSeqi NP_593322.1. NM_001018753.2.

3D structure databases

ProteinModelPortali Q09822.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278460. 44 interactions.
DIPi DIP-35649N.
IntActi Q09822. 3 interactions.
MINTi MINT-4695421.
STRINGi 4896.SPAC20G8.05c-1.

Proteomic databases

MaxQBi Q09822.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC20G8.05c.1 ; SPAC20G8.05c.1:pep ; SPAC20G8.05c .
GeneIDi 2541975.
KEGGi spo:SPAC20G8.05c.

Organism-specific databases

PomBasei SPAC20G8.05c.

Phylogenomic databases

eggNOGi NOG303711.
OMAi TARWNRE.
OrthoDBi EOG7F7WKS.
PhylomeDBi Q09822.

Miscellaneous databases

NextBioi 20803057.

Family and domain databases

InterProi IPR001060. FCH_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00055. FCH. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50133. FCH. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis."
    Fankhauser C., Reymond A., Cerutti L., Utzig S., Hofmann K., Simanis V.
    Cell 82:435-444(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. Fankhauser C., Reymond A., Cerutti L., Utzig S., Hofmann K., Simanis V.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO N-TERMINUS.
  3. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  4. "Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library."
    Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T., Hiraoka Y.
    Genes Cells 5:169-190(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 286-425.
    Strain: ATCC 38364 / 968.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331; SER-332; THR-529; SER-636; SER-639; SER-700 AND SER-774, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCDC15_SCHPO
AccessioniPrimary (citable) accession number: Q09822
Secondary accession number(s): O14365, Q9UU50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2000
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3