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Q09803

- VPS4_SCHPO

UniProt

Q09803 - VPS4_SCHPO

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Protein

Suppressor protein of bem1/bed5 double mutants

Gene
vps4, SPAC2G11.06
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Involved in multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex By similarity.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi169 – 1768ATP Reviewed prediction

GO - Molecular functioni

  1. ATPase activity Source: PomBase
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. late endosome to vacuole transport Source: PomBase
  3. protein retention in Golgi apparatus Source: PomBase
  4. protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor protein of bem1/bed5 double mutants (EC:3.6.4.6)
Gene namesi
Name:vps4
ORF Names:SPAC2G11.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC2G11.06.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: PomBase
  2. cytosol Source: PomBase
  3. endosome membrane Source: UniProtKB-SubCell
  4. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 432432Suppressor protein of bem1/bed5 double mutantsPRO_0000084769Add
BLAST

Proteomic databases

MaxQBiQ09803.

Interactioni

Protein-protein interaction databases

BioGridi278533. 1 interaction.
MINTiMINT-4695267.
STRINGi4896.SPAC2G11.06-1.

Structurei

3D structure databases

ProteinModelPortaliQ09803.
SMRiQ09803. Positions 1-78, 118-432.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8078MITAdd
BLAST

Sequence similaritiesi

Belongs to the AAA ATPase family.
Contains 1 MIT domain.

Phylogenomic databases

eggNOGiCOG0464.
HOGENOMiHOG000225146.
KOiK12196.
OMAiFRLYQHA.
OrthoDBiEOG72JWRT.
PhylomeDBiQ09803.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR007330. MIT.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF04212. MIT. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00745. MIT. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09803-1 [UniParc]FASTAAdd to Basket

« Hide

MSNPDCLSKA ISLVKTAIDN DNAEQYPDAY KYYQSALDYF MMALKYEKNE    50
KSKEIIRSKV IEYLDRAEKL KVYLQEKNNQ ISSKSRVSNG NVEGSNSPTA 100
NEALDSDAKK LRSALTSAIL VEKPNVRWDD IAGLENAKEA LKETVLLPIK 150
LPQLFSHGRK PWSGILLYGP PGTGKSYLAK AVATEAGSTF FSISSSDLVS 200
KWMGESERLV RQLFEMAREQ KPSIIFIDEI DSLCGSRSEG ESESSRRIKT 250
EFLVQMNGVG KDESGVLVLG ATNIPWTLDS AIRRRFEKRI YIPLPNAHAR 300
ARMFELNVGK IPSELTSQDF KELAKMTDGY SGSDISIVVR DAIMEPVRRI 350
HTATHFKEVY DNKSNRTLVT PCSPGDPDAF ESSWLEVNPE DIMEPKLTVR 400
DFYSAVRKVK PTLNAGDIEK HTQFTKDFGA EG 432
Length:432
Mass (Da):48,402
Last modified:November 1, 1995 - v1
Checksum:i65E6948AB9360D1E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33456 Genomic DNA. Translation: AAA35347.1.
CU329670 Genomic DNA. Translation: CAA91171.1.
PIRiT38572. S62461.
RefSeqiNP_593086.1. NM_001018484.2.

Genome annotation databases

EnsemblFungiiSPAC2G11.06.1; SPAC2G11.06.1:pep; SPAC2G11.06.
GeneIDi2542054.
KEGGispo:SPAC2G11.06.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L33456 Genomic DNA. Translation: AAA35347.1 .
CU329670 Genomic DNA. Translation: CAA91171.1 .
PIRi T38572. S62461.
RefSeqi NP_593086.1. NM_001018484.2.

3D structure databases

ProteinModelPortali Q09803.
SMRi Q09803. Positions 1-78, 118-432.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278533. 1 interaction.
MINTi MINT-4695267.
STRINGi 4896.SPAC2G11.06-1.

Proteomic databases

MaxQBi Q09803.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC2G11.06.1 ; SPAC2G11.06.1:pep ; SPAC2G11.06 .
GeneIDi 2542054.
KEGGi spo:SPAC2G11.06.

Organism-specific databases

PomBasei SPAC2G11.06.

Phylogenomic databases

eggNOGi COG0464.
HOGENOMi HOG000225146.
KOi K12196.
OMAi FRLYQHA.
OrthoDBi EOG72JWRT.
PhylomeDBi Q09803.

Miscellaneous databases

NextBioi 20803129.

Family and domain databases

Gene3Di 1.20.58.280. 1 hit.
3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR007330. MIT.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF04212. MIT. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00745. MIT. 1 hit.
[Graphical view ]
SUPFAMi SSF116846. SSF116846. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00674. AAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Valencik M.L., Pringle J.R.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiVPS4_SCHPO
AccessioniPrimary (citable) accession number: Q09803
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi