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Protein

Suppressor protein of bem1/bed5 double mutants

Gene

vps4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Involved in multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi169 – 176ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • endoplasmic reticulum tubular network membrane organization Source: ARUK-UCL
  • late endosome to vacuole transport Source: PomBase
  • negative regulation of nuclear envelope permeability Source: ARUK-UCL
  • nuclear division Source: ARUK-UCL
  • nuclear envelope organization Source: ARUK-UCL
  • positive regulation of cell growth Source: ARUK-UCL
  • protein retention in Golgi apparatus Source: PomBase
  • protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: PomBase
  • spindle pole body separation Source: ARUK-UCL
  • sporulation Source: ARUK-UCL

Keywordsi

Molecular functionHydrolase
Biological processProtein transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor protein of bem1/bed5 double mutants (EC:3.6.4.6)
Gene namesi
Name:vps4
ORF Names:SPAC2G11.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC2G11.06.
PomBaseiSPAC2G11.06. vps4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • endosome membrane Source: UniProtKB-SubCell
  • nucleus Source: PomBase

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847691 – 432Suppressor protein of bem1/bed5 double mutantsAdd BLAST432

Proteomic databases

MaxQBiQ09803.
PRIDEiQ09803.

PTM databases

SwissPalmiQ09803.

Interactioni

Protein-protein interaction databases

MINTiMINT-4695267.
STRINGi4896.SPAC2G11.06.1.

Structurei

3D structure databases

ProteinModelPortaliQ09803.
SMRiQ09803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 80MITAdd BLAST78

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

HOGENOMiHOG000225146.
InParanoidiQ09803.
KOiK12196.
OMAiVRWNDVA.
OrthoDBiEOG092C2QJ3.
PhylomeDBiQ09803.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR007330. MIT.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF04212. MIT. 1 hit.
PF09336. Vps4_C. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00745. MIT. 1 hit.
SUPFAMiSSF116846. SSF116846. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00674. AAA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPDCLSKA ISLVKTAIDN DNAEQYPDAY KYYQSALDYF MMALKYEKNE
60 70 80 90 100
KSKEIIRSKV IEYLDRAEKL KVYLQEKNNQ ISSKSRVSNG NVEGSNSPTA
110 120 130 140 150
NEALDSDAKK LRSALTSAIL VEKPNVRWDD IAGLENAKEA LKETVLLPIK
160 170 180 190 200
LPQLFSHGRK PWSGILLYGP PGTGKSYLAK AVATEAGSTF FSISSSDLVS
210 220 230 240 250
KWMGESERLV RQLFEMAREQ KPSIIFIDEI DSLCGSRSEG ESESSRRIKT
260 270 280 290 300
EFLVQMNGVG KDESGVLVLG ATNIPWTLDS AIRRRFEKRI YIPLPNAHAR
310 320 330 340 350
ARMFELNVGK IPSELTSQDF KELAKMTDGY SGSDISIVVR DAIMEPVRRI
360 370 380 390 400
HTATHFKEVY DNKSNRTLVT PCSPGDPDAF ESSWLEVNPE DIMEPKLTVR
410 420 430
DFYSAVRKVK PTLNAGDIEK HTQFTKDFGA EG
Length:432
Mass (Da):48,402
Last modified:November 1, 1995 - v1
Checksum:i65E6948AB9360D1E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33456 Genomic DNA. Translation: AAA35347.1.
CU329670 Genomic DNA. Translation: CAA91171.1.
PIRiT38572. S62461.
RefSeqiNP_593086.1. NM_001018484.2.

Genome annotation databases

EnsemblFungiiSPAC2G11.06.1; SPAC2G11.06.1:pep; SPAC2G11.06.
GeneIDi2542054.
KEGGispo:SPAC2G11.06.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiVPS4_SCHPO
AccessioniPrimary (citable) accession number: Q09803
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 5, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families