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Q09803 (VPS4_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Suppressor protein of bem1/bed5 double mutants

EC=3.6.4.6
Gene names
Name:vps4
ORF Names:SPAC2G11.06
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Involved in multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subcellular location

Endosome membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the AAA ATPase family.

Contains 1 MIT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Suppressor protein of bem1/bed5 double mutants
PRO_0000084769

Regions

Domain3 – 8078MIT
Nucleotide binding169 – 1768ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q09803 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 65E6948AB9360D1E

FASTA43248,402
        10         20         30         40         50         60 
MSNPDCLSKA ISLVKTAIDN DNAEQYPDAY KYYQSALDYF MMALKYEKNE KSKEIIRSKV 

        70         80         90        100        110        120 
IEYLDRAEKL KVYLQEKNNQ ISSKSRVSNG NVEGSNSPTA NEALDSDAKK LRSALTSAIL 

       130        140        150        160        170        180 
VEKPNVRWDD IAGLENAKEA LKETVLLPIK LPQLFSHGRK PWSGILLYGP PGTGKSYLAK 

       190        200        210        220        230        240 
AVATEAGSTF FSISSSDLVS KWMGESERLV RQLFEMAREQ KPSIIFIDEI DSLCGSRSEG 

       250        260        270        280        290        300 
ESESSRRIKT EFLVQMNGVG KDESGVLVLG ATNIPWTLDS AIRRRFEKRI YIPLPNAHAR 

       310        320        330        340        350        360 
ARMFELNVGK IPSELTSQDF KELAKMTDGY SGSDISIVVR DAIMEPVRRI HTATHFKEVY 

       370        380        390        400        410        420 
DNKSNRTLVT PCSPGDPDAF ESSWLEVNPE DIMEPKLTVR DFYSAVRKVK PTLNAGDIEK 

       430 
HTQFTKDFGA EG 

« Hide

References

« Hide 'large scale' references
[1]Valencik M.L., Pringle J.R.
Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L33456 Genomic DNA. Translation: AAA35347.1.
CU329670 Genomic DNA. Translation: CAA91171.1.
PIRS62461. T38572.
RefSeqNP_593086.1. NM_001018484.2.

3D structure databases

ProteinModelPortalQ09803.
SMRQ09803. Positions 1-78, 118-432.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid278533. 1 interaction.
MINTMINT-4695267.
STRING4896.SPAC2G11.06-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC2G11.06.1; SPAC2G11.06.1:pep; SPAC2G11.06.
GeneID2542054.
KEGGspo:SPAC2G11.06.

Organism-specific databases

PomBaseSPAC2G11.06.

Phylogenomic databases

eggNOGCOG0464.
HOGENOMHOG000225146.
KOK12196.
OMAIQARRRM.
OrthoDBEOG72JWRT.
PhylomeDBQ09803.

Family and domain databases

Gene3D1.20.58.280. 1 hit.
3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR007330. MIT.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamPF00004. AAA. 1 hit.
PF04212. MIT. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM00745. MIT. 1 hit.
[Graphical view]
SUPFAMSSF116846. SSF116846. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20803129.

Entry information

Entry nameVPS4_SCHPO
AccessionPrimary (citable) accession number: Q09803
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names