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Q09803

- VPS4_SCHPO

UniProt

Q09803 - VPS4_SCHPO

Protein

Suppressor protein of bem1/bed5 double mutants

Gene

vps4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Involved in multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi169 – 1768ATPSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: PomBase
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. late endosome to vacuole transport Source: PomBase
    3. protein retention in Golgi apparatus Source: PomBase
    4. protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: PomBase

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Suppressor protein of bem1/bed5 double mutants (EC:3.6.4.6)
    Gene namesi
    Name:vps4
    ORF Names:SPAC2G11.06
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC2G11.06.

    Subcellular locationi

    Endosome membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. cytoplasm Source: PomBase
    2. cytosol Source: PomBase
    3. endosome membrane Source: UniProtKB-SubCell
    4. nucleus Source: PomBase

    Keywords - Cellular componenti

    Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432Suppressor protein of bem1/bed5 double mutantsPRO_0000084769Add
    BLAST

    Proteomic databases

    MaxQBiQ09803.

    Interactioni

    Protein-protein interaction databases

    BioGridi278533. 1 interaction.
    MINTiMINT-4695267.
    STRINGi4896.SPAC2G11.06-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09803.
    SMRiQ09803. Positions 1-78, 118-432.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 8078MITAdd
    BLAST

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated
    Contains 1 MIT domain.Curated

    Phylogenomic databases

    eggNOGiCOG0464.
    HOGENOMiHOG000225146.
    KOiK12196.
    OMAiFRLYQHA.
    OrthoDBiEOG72JWRT.
    PhylomeDBiQ09803.

    Family and domain databases

    Gene3Di1.20.58.280. 1 hit.
    3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR007330. MIT.
    IPR027417. P-loop_NTPase.
    IPR015415. Vps4_C.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    PF04212. MIT. 1 hit.
    PF09336. Vps4_C. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM00745. MIT. 1 hit.
    [Graphical view]
    SUPFAMiSSF116846. SSF116846. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09803-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNPDCLSKA ISLVKTAIDN DNAEQYPDAY KYYQSALDYF MMALKYEKNE    50
    KSKEIIRSKV IEYLDRAEKL KVYLQEKNNQ ISSKSRVSNG NVEGSNSPTA 100
    NEALDSDAKK LRSALTSAIL VEKPNVRWDD IAGLENAKEA LKETVLLPIK 150
    LPQLFSHGRK PWSGILLYGP PGTGKSYLAK AVATEAGSTF FSISSSDLVS 200
    KWMGESERLV RQLFEMAREQ KPSIIFIDEI DSLCGSRSEG ESESSRRIKT 250
    EFLVQMNGVG KDESGVLVLG ATNIPWTLDS AIRRRFEKRI YIPLPNAHAR 300
    ARMFELNVGK IPSELTSQDF KELAKMTDGY SGSDISIVVR DAIMEPVRRI 350
    HTATHFKEVY DNKSNRTLVT PCSPGDPDAF ESSWLEVNPE DIMEPKLTVR 400
    DFYSAVRKVK PTLNAGDIEK HTQFTKDFGA EG 432
    Length:432
    Mass (Da):48,402
    Last modified:November 1, 1995 - v1
    Checksum:i65E6948AB9360D1E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33456 Genomic DNA. Translation: AAA35347.1.
    CU329670 Genomic DNA. Translation: CAA91171.1.
    PIRiT38572. S62461.
    RefSeqiNP_593086.1. NM_001018484.2.

    Genome annotation databases

    EnsemblFungiiSPAC2G11.06.1; SPAC2G11.06.1:pep; SPAC2G11.06.
    GeneIDi2542054.
    KEGGispo:SPAC2G11.06.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33456 Genomic DNA. Translation: AAA35347.1 .
    CU329670 Genomic DNA. Translation: CAA91171.1 .
    PIRi T38572. S62461.
    RefSeqi NP_593086.1. NM_001018484.2.

    3D structure databases

    ProteinModelPortali Q09803.
    SMRi Q09803. Positions 1-78, 118-432.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278533. 1 interaction.
    MINTi MINT-4695267.
    STRINGi 4896.SPAC2G11.06-1.

    Proteomic databases

    MaxQBi Q09803.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC2G11.06.1 ; SPAC2G11.06.1:pep ; SPAC2G11.06 .
    GeneIDi 2542054.
    KEGGi spo:SPAC2G11.06.

    Organism-specific databases

    PomBasei SPAC2G11.06.

    Phylogenomic databases

    eggNOGi COG0464.
    HOGENOMi HOG000225146.
    KOi K12196.
    OMAi FRLYQHA.
    OrthoDBi EOG72JWRT.
    PhylomeDBi Q09803.

    Miscellaneous databases

    NextBioi 20803129.

    Family and domain databases

    Gene3Di 1.20.58.280. 1 hit.
    3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR007330. MIT.
    IPR027417. P-loop_NTPase.
    IPR015415. Vps4_C.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    PF04212. MIT. 1 hit.
    PF09336. Vps4_C. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM00745. MIT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF116846. SSF116846. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Valencik M.L., Pringle J.R.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiVPS4_SCHPO
    AccessioniPrimary (citable) accession number: Q09803
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3