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Q09785

- GCSP_SCHPO

UniProt

Q09785 - GCSP_SCHPO

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Protein

Putative glycine dehydrogenase (decarboxylating), mitochondrial

Gene
gcv2, SPAC13G6.06c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

Cofactori

Pyridoxal phosphate By similarity.

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcv2
ORF Names:SPAC13G6.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC13G6.06c.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. glycine cleavage complex Source: PomBase
  2. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4949Mitochondrion Reviewed predictionAdd
BLAST
Chaini50 – 1031982Putative glycine dehydrogenase (decarboxylating), mitochondrialPRO_0000010751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei783 – 7831N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

MaxQBiQ09785.

Interactioni

Protein-protein interaction databases

MINTiMINT-4695084.
STRINGi4896.SPAC13G6.06c-1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OrthoDBiEOG7KWSS4.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09785-1 [UniParc]FASTAAdd to Basket

« Hide

MFDSFMKRNQ LALIMFRACS KLQYHGVNTS LSRHLFLAKR NLSISSACLE     50
AKNSQKFPAL DTFEPRHIGP SKTDQQYQLE SLGYKDFDSF LKDVIPDSVR 100
TPESQLMAFG SVNPNEKNPP VNYSESEFTT LANNVANQNK LIKSFIGMGY 150
YNVKLPAAIQ RNVLENPEWY TQYTPYQAEI SQGRLESMMN YQTMIADLTG 200
LSISNASLLD EGTAAGEAMV MLMANDKKKR KTFLVDKNIY PNTLSVLRTR 250
ASGFGIKIEL DNITPELITK SAKHVFGIFV QYPAADGSIF DYGHLAATAR 300
SFNMHVVAAT DLLALTILKS PGEWGADVAV GSTQRFGLPM GYGGPHAGFF 350
ACSEEFKRKI PGRLIGLSKD RLENPAYRLA LQTREQHIRR EKATSNICTA 400
QALLANMSAF YAIYHGPNGL QEIANRIYAS TSFLKSALES SGYKIVNKSH 450
FFDTLTIEVE SADKVLAKAL DHGYNLRKVD DSHVGLSLDE TVCDKDIQAL 500
FSIFNINKSV DQYYMEIATS EPNGNSASTV DNLSICSLPE NFRRTTLYLQ 550
HPVFNRYHSE TELMRYIHHL QSKDLSLAHA MTPLGSCTMK LNAVTEMMPI 600
TNPLFANIHP YVPEEQAKGY RHVIEDLQLM LTTITGFDAA CFQPNSGAAG 650
EYTGLSVIRA YQRSIGQGHR NICLIPVSAH GTNPASAAMA GFTVIPVKCL 700
NNGYLDMQDL KEKASKHADK LAAFMVTYPS TFGIFEPDVK EALEVIHEHG 750
GQVYFDGANM NAMVGLCKAG DIGADVCHLN LHKTFCIPHG GGGPGVGPIC 800
VKKHLADFLP SHPVVSCGGK NGITSVSSSP FGSAGILPIS WAYMRMMGLA 850
GLRDASKAAL LNANYMAKRL SSHYKLVYTN KNNLCAHEFI LDAREFKATA 900
GVDATDIAKR LQDYSFHAPT LSWPIANTLM IEPTESESMY EMDRFCDALI 950
SIRQEIREIE EGLQPKDNNL LVNAPHPQKD IASEKWDRPY TRERAVYPVP 1000
LLKERKFWPS VARLDDAYGD KNLFCTCSPV V 1031
Length:1,031
Mass (Da):114,233
Last modified:March 21, 2012 - v2
Checksum:i1AAB78E5A0D88F7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA91099.2.
PIRiS62435.
RefSeqiNP_592832.2. NM_001018233.2.

Genome annotation databases

EnsemblFungiiSPAC13G6.06c.1; SPAC13G6.06c.1:pep; SPAC13G6.06c.
GeneIDi2542828.
KEGGispo:SPAC13G6.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA91099.2 .
PIRi S62435.
RefSeqi NP_592832.2. NM_001018233.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4695084.
STRINGi 4896.SPAC13G6.06c-1.

Proteomic databases

MaxQBi Q09785.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC13G6.06c.1 ; SPAC13G6.06c.1:pep ; SPAC13G6.06c .
GeneIDi 2542828.
KEGGi spo:SPAC13G6.06c.

Organism-specific databases

PomBasei SPAC13G6.06c.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OrthoDBi EOG7KWSS4.

Miscellaneous databases

NextBioi 20803870.
PROi Q09785.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGCSP_SCHPO
AccessioniPrimary (citable) accession number: Q09785
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 21, 2012
Last modified: May 14, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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