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Q09785

- GCSP_SCHPO

UniProt

Q09785 - GCSP_SCHPO

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Protein

Putative glycine dehydrogenase (decarboxylating), mitochondrial

Gene

gcv2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

Cofactori

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcv2
ORF Names:SPAC13G6.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC13G6.06c.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. glycine cleavage complex Source: PomBase
  2. mitochondrion Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4949MitochondrionSequence AnalysisAdd
BLAST
Chaini50 – 1031982Putative glycine dehydrogenase (decarboxylating), mitochondrialPRO_0000010751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei783 – 7831N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

MaxQBiQ09785.

Interactioni

Protein-protein interaction databases

MINTiMINT-4695084.
STRINGi4896.SPAC13G6.06c-1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
InParanoidiQ09785.
KOiK00281.
OrthoDBiEOG7KWSS4.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09785-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFDSFMKRNQ LALIMFRACS KLQYHGVNTS LSRHLFLAKR NLSISSACLE
60 70 80 90 100
AKNSQKFPAL DTFEPRHIGP SKTDQQYQLE SLGYKDFDSF LKDVIPDSVR
110 120 130 140 150
TPESQLMAFG SVNPNEKNPP VNYSESEFTT LANNVANQNK LIKSFIGMGY
160 170 180 190 200
YNVKLPAAIQ RNVLENPEWY TQYTPYQAEI SQGRLESMMN YQTMIADLTG
210 220 230 240 250
LSISNASLLD EGTAAGEAMV MLMANDKKKR KTFLVDKNIY PNTLSVLRTR
260 270 280 290 300
ASGFGIKIEL DNITPELITK SAKHVFGIFV QYPAADGSIF DYGHLAATAR
310 320 330 340 350
SFNMHVVAAT DLLALTILKS PGEWGADVAV GSTQRFGLPM GYGGPHAGFF
360 370 380 390 400
ACSEEFKRKI PGRLIGLSKD RLENPAYRLA LQTREQHIRR EKATSNICTA
410 420 430 440 450
QALLANMSAF YAIYHGPNGL QEIANRIYAS TSFLKSALES SGYKIVNKSH
460 470 480 490 500
FFDTLTIEVE SADKVLAKAL DHGYNLRKVD DSHVGLSLDE TVCDKDIQAL
510 520 530 540 550
FSIFNINKSV DQYYMEIATS EPNGNSASTV DNLSICSLPE NFRRTTLYLQ
560 570 580 590 600
HPVFNRYHSE TELMRYIHHL QSKDLSLAHA MTPLGSCTMK LNAVTEMMPI
610 620 630 640 650
TNPLFANIHP YVPEEQAKGY RHVIEDLQLM LTTITGFDAA CFQPNSGAAG
660 670 680 690 700
EYTGLSVIRA YQRSIGQGHR NICLIPVSAH GTNPASAAMA GFTVIPVKCL
710 720 730 740 750
NNGYLDMQDL KEKASKHADK LAAFMVTYPS TFGIFEPDVK EALEVIHEHG
760 770 780 790 800
GQVYFDGANM NAMVGLCKAG DIGADVCHLN LHKTFCIPHG GGGPGVGPIC
810 820 830 840 850
VKKHLADFLP SHPVVSCGGK NGITSVSSSP FGSAGILPIS WAYMRMMGLA
860 870 880 890 900
GLRDASKAAL LNANYMAKRL SSHYKLVYTN KNNLCAHEFI LDAREFKATA
910 920 930 940 950
GVDATDIAKR LQDYSFHAPT LSWPIANTLM IEPTESESMY EMDRFCDALI
960 970 980 990 1000
SIRQEIREIE EGLQPKDNNL LVNAPHPQKD IASEKWDRPY TRERAVYPVP
1010 1020 1030
LLKERKFWPS VARLDDAYGD KNLFCTCSPV V
Length:1,031
Mass (Da):114,233
Last modified:March 21, 2012 - v2
Checksum:i1AAB78E5A0D88F7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91099.2.
PIRiS62435.
RefSeqiNP_592832.2. NM_001018233.2.

Genome annotation databases

EnsemblFungiiSPAC13G6.06c.1; SPAC13G6.06c.1:pep; SPAC13G6.06c.
GeneIDi2542828.
KEGGispo:SPAC13G6.06c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91099.2 .
PIRi S62435.
RefSeqi NP_592832.2. NM_001018233.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4695084.
STRINGi 4896.SPAC13G6.06c-1.

Proteomic databases

MaxQBi Q09785.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC13G6.06c.1 ; SPAC13G6.06c.1:pep ; SPAC13G6.06c .
GeneIDi 2542828.
KEGGi spo:SPAC13G6.06c.

Organism-specific databases

PomBasei SPAC13G6.06c.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
InParanoidi Q09785.
KOi K00281.
OrthoDBi EOG7KWSS4.

Miscellaneous databases

NextBioi 20803870.
PROi Q09785.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "Comparative functional genomics of the fission yeasts."
    Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K.
    , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
    Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVISION OF GENE MODEL.
  3. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGCSP_SCHPO
AccessioniPrimary (citable) accession number: Q09785
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 21, 2012
Last modified: November 26, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3