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Q09785 (GCSP_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative glycine dehydrogenase (decarboxylating), mitochondrial

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcv2
ORF Names:SPAC13G6.06c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length1031 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

Cofactor

Pyridoxal phosphate By similarity.

Subcellular location

Mitochondrion Ref.3.

Sequence similarities

Belongs to the GcvP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4949Mitochondrion Potential
Chain50 – 1031982Putative glycine dehydrogenase (decarboxylating), mitochondrial
PRO_0000010751

Amino acid modifications

Modified residue7831N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09785 [UniParc].

Last modified March 21, 2012. Version 2.
Checksum: 1AAB78E5A0D88F7B

FASTA1,031114,233
        10         20         30         40         50         60 
MFDSFMKRNQ LALIMFRACS KLQYHGVNTS LSRHLFLAKR NLSISSACLE AKNSQKFPAL 

        70         80         90        100        110        120 
DTFEPRHIGP SKTDQQYQLE SLGYKDFDSF LKDVIPDSVR TPESQLMAFG SVNPNEKNPP 

       130        140        150        160        170        180 
VNYSESEFTT LANNVANQNK LIKSFIGMGY YNVKLPAAIQ RNVLENPEWY TQYTPYQAEI 

       190        200        210        220        230        240 
SQGRLESMMN YQTMIADLTG LSISNASLLD EGTAAGEAMV MLMANDKKKR KTFLVDKNIY 

       250        260        270        280        290        300 
PNTLSVLRTR ASGFGIKIEL DNITPELITK SAKHVFGIFV QYPAADGSIF DYGHLAATAR 

       310        320        330        340        350        360 
SFNMHVVAAT DLLALTILKS PGEWGADVAV GSTQRFGLPM GYGGPHAGFF ACSEEFKRKI 

       370        380        390        400        410        420 
PGRLIGLSKD RLENPAYRLA LQTREQHIRR EKATSNICTA QALLANMSAF YAIYHGPNGL 

       430        440        450        460        470        480 
QEIANRIYAS TSFLKSALES SGYKIVNKSH FFDTLTIEVE SADKVLAKAL DHGYNLRKVD 

       490        500        510        520        530        540 
DSHVGLSLDE TVCDKDIQAL FSIFNINKSV DQYYMEIATS EPNGNSASTV DNLSICSLPE 

       550        560        570        580        590        600 
NFRRTTLYLQ HPVFNRYHSE TELMRYIHHL QSKDLSLAHA MTPLGSCTMK LNAVTEMMPI 

       610        620        630        640        650        660 
TNPLFANIHP YVPEEQAKGY RHVIEDLQLM LTTITGFDAA CFQPNSGAAG EYTGLSVIRA 

       670        680        690        700        710        720 
YQRSIGQGHR NICLIPVSAH GTNPASAAMA GFTVIPVKCL NNGYLDMQDL KEKASKHADK 

       730        740        750        760        770        780 
LAAFMVTYPS TFGIFEPDVK EALEVIHEHG GQVYFDGANM NAMVGLCKAG DIGADVCHLN 

       790        800        810        820        830        840 
LHKTFCIPHG GGGPGVGPIC VKKHLADFLP SHPVVSCGGK NGITSVSSSP FGSAGILPIS 

       850        860        870        880        890        900 
WAYMRMMGLA GLRDASKAAL LNANYMAKRL SSHYKLVYTN KNNLCAHEFI LDAREFKATA 

       910        920        930        940        950        960 
GVDATDIAKR LQDYSFHAPT LSWPIANTLM IEPTESESMY EMDRFCDALI SIRQEIREIE 

       970        980        990       1000       1010       1020 
EGLQPKDNNL LVNAPHPQKD IASEKWDRPY TRERAVYPVP LLKERKFWPS VARLDDAYGD 

      1030 
KNLFCTCSPV V 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
[2]"Comparative functional genomics of the fission yeasts."
Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N., Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y., Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K. expand/collapse author list , Bayne E.H., Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G., French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A., Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P., Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R., Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J., Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W., Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.
Science 332:930-936(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: REVISION OF GENE MODEL.
[3]"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CU329670 Genomic DNA. Translation: CAA91099.2.
PIRS62435.
RefSeqNP_592832.2. NM_001018233.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4695084.
STRING4896.SPAC13G6.06c-1.

Proteomic databases

MaxQBQ09785.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC13G6.06c.1; SPAC13G6.06c.1:pep; SPAC13G6.06c.
GeneID2542828.
KEGGspo:SPAC13G6.06c.

Organism-specific databases

PomBaseSPAC13G6.06c.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OrthoDBEOG7KWSS4.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Other

NextBio20803870.
PROQ09785.

Entry information

Entry nameGCSP_SCHPO
AccessionPrimary (citable) accession number: Q09785
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 21, 2012
Last modified: May 14, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names