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Protein

Putative glycine dehydrogenase (decarboxylating), mitochondrial

Gene

gcv2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-SPO-6783984 Glycine degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcv2
ORF Names:SPAC13G6.06c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC13G6.06c
PomBaseiSPAC13G6.06c gcv2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 49MitochondrionSequence analysisAdd BLAST49
ChainiPRO_000001075150 – 1031Putative glycine dehydrogenase (decarboxylating), mitochondrialAdd BLAST982

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei783N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

MaxQBiQ09785
PaxDbiQ09785
PRIDEiQ09785

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC13G6.06c.1

Structurei

3D structure databases

SMRiQ09785
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOGENOMiHOG000239369
InParanoidiQ09785
KOiK00281
OMAiQTMVCDL
OrthoDBiEOG092C0IRH

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.102 hits
3.90.1150.101 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09785-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDSFMKRNQ LALIMFRACS KLQYHGVNTS LSRHLFLAKR NLSISSACLE
60 70 80 90 100
AKNSQKFPAL DTFEPRHIGP SKTDQQYQLE SLGYKDFDSF LKDVIPDSVR
110 120 130 140 150
TPESQLMAFG SVNPNEKNPP VNYSESEFTT LANNVANQNK LIKSFIGMGY
160 170 180 190 200
YNVKLPAAIQ RNVLENPEWY TQYTPYQAEI SQGRLESMMN YQTMIADLTG
210 220 230 240 250
LSISNASLLD EGTAAGEAMV MLMANDKKKR KTFLVDKNIY PNTLSVLRTR
260 270 280 290 300
ASGFGIKIEL DNITPELITK SAKHVFGIFV QYPAADGSIF DYGHLAATAR
310 320 330 340 350
SFNMHVVAAT DLLALTILKS PGEWGADVAV GSTQRFGLPM GYGGPHAGFF
360 370 380 390 400
ACSEEFKRKI PGRLIGLSKD RLENPAYRLA LQTREQHIRR EKATSNICTA
410 420 430 440 450
QALLANMSAF YAIYHGPNGL QEIANRIYAS TSFLKSALES SGYKIVNKSH
460 470 480 490 500
FFDTLTIEVE SADKVLAKAL DHGYNLRKVD DSHVGLSLDE TVCDKDIQAL
510 520 530 540 550
FSIFNINKSV DQYYMEIATS EPNGNSASTV DNLSICSLPE NFRRTTLYLQ
560 570 580 590 600
HPVFNRYHSE TELMRYIHHL QSKDLSLAHA MTPLGSCTMK LNAVTEMMPI
610 620 630 640 650
TNPLFANIHP YVPEEQAKGY RHVIEDLQLM LTTITGFDAA CFQPNSGAAG
660 670 680 690 700
EYTGLSVIRA YQRSIGQGHR NICLIPVSAH GTNPASAAMA GFTVIPVKCL
710 720 730 740 750
NNGYLDMQDL KEKASKHADK LAAFMVTYPS TFGIFEPDVK EALEVIHEHG
760 770 780 790 800
GQVYFDGANM NAMVGLCKAG DIGADVCHLN LHKTFCIPHG GGGPGVGPIC
810 820 830 840 850
VKKHLADFLP SHPVVSCGGK NGITSVSSSP FGSAGILPIS WAYMRMMGLA
860 870 880 890 900
GLRDASKAAL LNANYMAKRL SSHYKLVYTN KNNLCAHEFI LDAREFKATA
910 920 930 940 950
GVDATDIAKR LQDYSFHAPT LSWPIANTLM IEPTESESMY EMDRFCDALI
960 970 980 990 1000
SIRQEIREIE EGLQPKDNNL LVNAPHPQKD IASEKWDRPY TRERAVYPVP
1010 1020 1030
LLKERKFWPS VARLDDAYGD KNLFCTCSPV V
Length:1,031
Mass (Da):114,233
Last modified:March 21, 2012 - v2
Checksum:i1AAB78E5A0D88F7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA91099.2
PIRiS62435
RefSeqiNP_592832.2, NM_001018233.2

Genome annotation databases

EnsemblFungiiSPAC13G6.06c.1; SPAC13G6.06c.1:pep; SPAC13G6.06c
GeneIDi2542828
KEGGispo:SPAC13G6.06c

Similar proteinsi

Entry informationi

Entry nameiGCSP_SCHPO
AccessioniPrimary (citable) accession number: Q09785
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 21, 2012
Last modified: February 28, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome