Reviewed, UniProtKB/Swiss-Prot Q09780 (KIME_SCHPO)

Names and origin

Protein names

Recommended name:
    Putative mevalonate kinase
      Short name=MK
    EC=2.7.1.36

Gene names

ORF Names:

SPAC13G6.11c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro phosphorylation Inferred from electronic annotation. Source: InterPro sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_SPombe nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW mevalonate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Putative mevalonate kinase		PRO_0000156661
Regions
	Nucleotide binding	133 – 143	11	ATP By similarity
Sites
	Binding site	130	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q09780-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: AE8B6D1646247710	FASTA	404	43,407
	10 20 30 40 50 60 MSKSLIVSSP GKTILFGEHA VVYGATALAA AVSLRSYCKL QTTNNNEIVI VMSDIGTERR 70 80 90 100 110 120 WNLQSLPWQH VTVENVQHPA SSPNLDLLQG LGELLKNEEN GLIHSAMLCT LYLFTSLSSP 130 140 150 160 170 180 SQGCTLTISS QVPLGAGLGS SATISVVVAT SLLLAFGNIE PPSSNSLQNN KALALIEAWS 190 200 210 220 230 240 FLGECCIHGT PSGIDNAVAT NGGLIAFRKA TAHQSAMKEF LKPKDTLSVM ITDTKQPKST 250 260 270 280 290 300 KKLVQGVFEL KERLPTVIDS IIDAIDGISK SAVLALTSES DKNSSAKKLG EFIVLNQKLL 310 320 330 340 350 360 ECLGVSHYSI DRVLQATKSI GWTKLTGAGG GGCTITLLTP ECKEEEFKLC KESLLAHKNS 370 380 390 400 IYDVQLGGPG VSVVTDSDSF FPQYESDFDF KKLNLLSKFN KYYI

References

[1]

"Identification of open reading frames in Schizosaccharomyces pombe cDNAs." Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H. DNA Res. 4:363-369(1997) [PubMed: 9501991] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: PR745.

[2]

"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB000541 mRNA. Translation: BAA25169.1. CU329670 Genomic DNA. Translation: CAA91104.1.
PIR	S62440.
RefSeq	NP_592837.1.
3D structure databases
HSSP	HSSP built from PDB template 1KVK based on UniProtKB P17256.
ModBase	Search...
Genome annotation databases
GeneID	2542818.
KEGG	spo:SPAC13G6.11c.
NMPDR	fig|4896.1.peg.2807.
Organism-specific databases
GeneDB_Spombe	SPAC13G6.11c.
Phylogenomic databases
OMA	Q09780. ELMEMNQ.
Enzyme and pathway databases
BioCyc	SPOM-XXX-01:SPOM-XXX-01-000581-MON.
BRENDA	2.7.1.36. 653.
Gene expression databases
ArrayExpress	Q09780.
Family and domain databases
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR006205. Mev_gal_kin. IPR006206. Mev_galkinase. IPR014721. Ribosomal_S5_D2-type_fold. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
PANTHER	PTHR10457:SF4. Mev_gal_kin. 1 hit.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PRINTS	PR00959. MEVGALKINASE.
TIGRFAMs	TIGR00549. mevalon_kin. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KIME_SCHPO

Accession

Primary (citable) accession number: Q09780

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)