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Protein

Putative mevalonate kinase

Gene

erg12

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.By similarity

Catalytic activityi

ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12ATPBy similarity1
Binding sitei130ATPBy similarity1
Metal bindingi141MagnesiumBy similarity1
Metal bindingi184MagnesiumBy similarity1
Active sitei195Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi135 – 141ATPBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-191273 Cholesterol biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Putative mevalonate kinaseCurated (EC:2.7.1.36By similarity)
Short name:
MK
Gene namesi
Name:erg12
ORF Names:SPAC13G6.11c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC13G6.11c
PomBaseiSPAC13G6.11c erg12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001566611 – 404Putative mevalonate kinaseAdd BLAST404

Proteomic databases

MaxQBiQ09780
PaxDbiQ09780
PRIDEiQ09780

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC13G6.11c.1

Structurei

3D structure databases

ProteinModelPortaliQ09780
SMRiQ09780
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000188934
InParanoidiQ09780
KOiK00869
OMAiEGWKFWR
OrthoDBiEOG092C5126
PhylomeDBiQ09780

Family and domain databases

Gene3Di3.30.230.10, 2 hits
3.30.70.890, 1 hit
InterProiView protein in InterPro
IPR013750 GHMP_kinase_C_dom
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR006203 GHMP_knse_ATP-bd_CS
IPR006205 Mev_gal_kin
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PfamiView protein in Pfam
PF08544 GHMP_kinases_C, 1 hit
PF00288 GHMP_kinases_N, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR00549 mevalon_kin, 1 hit
PROSITEiView protein in PROSITE
PS00627 GHMP_KINASES_ATP, 1 hit

Sequencei

Sequence statusi: Complete.

Q09780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSLIVSSP GKTILFGEHA VVYGATALAA AVSLRSYCKL QTTNNNEIVI
60 70 80 90 100
VMSDIGTERR WNLQSLPWQH VTVENVQHPA SSPNLDLLQG LGELLKNEEN
110 120 130 140 150
GLIHSAMLCT LYLFTSLSSP SQGCTLTISS QVPLGAGLGS SATISVVVAT
160 170 180 190 200
SLLLAFGNIE PPSSNSLQNN KALALIEAWS FLGECCIHGT PSGIDNAVAT
210 220 230 240 250
NGGLIAFRKA TAHQSAMKEF LKPKDTLSVM ITDTKQPKST KKLVQGVFEL
260 270 280 290 300
KERLPTVIDS IIDAIDGISK SAVLALTSES DKNSSAKKLG EFIVLNQKLL
310 320 330 340 350
ECLGVSHYSI DRVLQATKSI GWTKLTGAGG GGCTITLLTP ECKEEEFKLC
360 370 380 390 400
KESLLAHKNS IYDVQLGGPG VSVVTDSDSF FPQYESDFDF KKLNLLSKFN

KYYI
Length:404
Mass (Da):43,407
Last modified:November 1, 1995 - v1
Checksum:iAE8B6D1646247710
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000541 mRNA Translation: BAA25169.1
CU329670 Genomic DNA Translation: CAA91104.1
PIRiS62440
RefSeqiNP_592837.1, NM_001018238.2

Genome annotation databases

EnsemblFungiiSPAC13G6.11c.1; SPAC13G6.11c.1:pep; SPAC13G6.11c
GeneIDi2542818
KEGGispo:SPAC13G6.11c

Similar proteinsi

Entry informationi

Entry nameiKIME_SCHPO
AccessioniPrimary (citable) accession number: Q09780
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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