Reviewed,
UniProtKB/Swiss-Prot Q09780 (KIME_SCHPO)
Last modified
June 16, 2009.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Putative mevalonate kinase Short name=MK EC=2.7.1.36 | ||
| Gene names |
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| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||
| Taxonomic identifier | 4896 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 404 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate. |
| Subcellular location | Cytoplasm Potential. |
| Sequence similarities | Belongs to the GHMP kinase family. Mevalonate kinase subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis Sterol biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro phosphorylationInferred from electronic annotation. Source: InterPro sterol biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytosol Inferred from direct assay. Source: GeneDB_SPombe nucleusInferred from direct assay. Source: GeneDB_SPombe |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW mevalonate kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Identification of open reading frames in Schizosaccharomyces pombe cDNAs." Yoshioka S., Kato K., Nakai K., Okayama H., Nojima H. DNA Res. 4:363-369(1997) [PubMed: 9501991] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: PR745. |
| [2] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
Cross-references
Sequence databases | |
|---|---|
| AB000541 mRNA. Translation: BAA25169.1. CU329670 Genomic DNA. Translation: CAA91104.1. | |
| PIR | S62440. |
| RefSeq | NP_592837.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1KVK based on UniProtKB P17256. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2542818. |
| KEGG | spo:SPAC13G6.11c. |
| NMPDR | fig|4896.1.peg.2807. |
Organism-specific databases | |
| GeneDB_Spombe | SPAC13G6.11c. |
Phylogenomic databases | |
| OMA | Q09780. ELMEMNQ. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-000581-MON. |
| BRENDA | 2.7.1.36. 653. |
Gene expression databases | |
| ArrayExpress | Q09780. |
Family and domain databases | |
| InterPro | IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR006205. Mev_gal_kin. IPR006206. Mev_galkinase. IPR014721. Ribosomal_S5_D2-type_fold. [Graphical view] |
| Gene3D | G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. |
| PANTHER | PTHR10457:SF4. Mev_gal_kin. 1 hit. |
| Pfam | PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view] |
| PRINTS | PR00959. MEVGALKINASE. |
| TIGRFAMs | TIGR00549. mevalon_kin. 1 hit. |
| PROSITE | PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KIME_SCHPO | ||||||||
| Accession | Primary (citable) accession number: Q09780 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


