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Protein

Tuberous sclerosis 1 protein homolog

Gene

tsc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Together with tsc2, required for uptake of various amino acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1.3 Publications

GO - Molecular functioni

GO - Biological processi

  • methionine import into cell Source: PomBase
  • negative regulation of G1/S transition of mitotic cell cycle Source: PomBase
  • negative regulation of insulin receptor signaling pathway Source: GO_Central
  • negative regulation of TOR signaling Source: GO_Central
  • regulation of actin cytoskeleton organization Source: GO_Central
  • regulation of amino acid transmembrane transport Source: PomBase
  • regulation of GTPase activity Source: GO_Central
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tuberous sclerosis 1 protein homolog
Gene namesi
Name:tsc1
ORF Names:SPAC22F3.13
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC22F3.13.
PomBaseiSPAC22F3.13. tsc1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • TSC1-TSC2 complex Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000656531 – 899Tuberous sclerosis 1 protein homologAdd BLAST899

Proteomic databases

MaxQBiQ09778.
PRIDEiQ09778.

Interactioni

Subunit structurei

Interacts with tsc2.1 Publication

Protein-protein interaction databases

BioGridi278359. 83 interactors.
IntActiQ09778. 1 interactor.
MINTiMINT-4695004.

Structurei

Secondary structure

1899
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 14Combined sources13
Helixi26 – 38Combined sources13
Helixi44 – 60Combined sources17
Beta strandi63 – 65Combined sources3
Helixi66 – 79Combined sources14
Helixi80 – 82Combined sources3
Helixi87 – 96Combined sources10
Helixi98 – 103Combined sources6
Helixi109 – 123Combined sources15
Turni128 – 131Combined sources4
Helixi135 – 154Combined sources20
Helixi165 – 185Combined sources21
Helixi187 – 198Combined sources12
Helixi201 – 203Combined sources3
Helixi204 – 216Combined sources13
Helixi222 – 228Combined sources7
Helixi230 – 240Combined sources11
Helixi244 – 258Combined sources15
Turni259 – 261Combined sources3
Turni264 – 268Combined sources5
Helixi269 – 280Combined sources12
Turni284 – 286Combined sources3
Helixi332 – 334Combined sources3
Helixi339 – 349Combined sources11
Helixi351 – 357Combined sources7
Helixi361 – 366Combined sources6
Turni367 – 369Combined sources3
Helixi378 – 389Combined sources12
Helixi396 – 399Combined sources4
Helixi403 – 407Combined sources5
Helixi412 – 427Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KK0X-ray2.90A/B/C/D/E/F/G/H/I/J1-431[»]
4KK1X-ray3.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T1-431[»]
ProteinModelPortaliQ09778.
SMRiQ09778.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili540 – 706Sequence analysisAdd BLAST167
Coiled coili737 – 847Sequence analysisAdd BLAST111

Keywords - Domaini

Coiled coil

Phylogenomic databases

InParanoidiQ09778.
OMAiLANIMEI.
OrthoDBiEOG092C0K4M.
PhylomeDBiQ09778.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007483. Hamartin.
[Graphical view]
PANTHERiPTHR15154. PTHR15154. 3 hits.
PfamiPF04388. Hamartin. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLQSLVKAL WNVLHEEESE GYPDLTELIA EVESYQQRYP KQNPTNSQKI
60 70 80 90 100
RHILDEIYEK TPFNNTRRRI LWLAVLKTVI PLLILDRQAV GEWWDQIFFP
110 120 130 140 150
FLNSPTQLKP VFSDLKSILF YILIFHDEDE WGGDLRRECA EETITRLVDL
160 170 180 190 200
YVSKAIENLG DVESQEQRNQ TIECLVNVLV HYGIQRPKEL SSCFCHHFLN
210 220 230 240 250
PPTRIPILSV MVEVIRRQGP RLYEIPQTGF YDLVLKCAEF DTSPILLSYA
260 270 280 290 300
LSFILMILSH ICNSLDDSLY RLFCIYLRFS MIDPTSGFPS STASGNWEVF
310 320 330 340 350
HDFMSTYAST TTSQTDSSYN DVHDIVGSSQ PDYLESLDYS QLFSILYALY
360 370 380 390 400
PINFLEFLRD PKLYASKHNF QIRYSFNQEL LSTKSDGLLG RHLAHSNFLK
410 420 430 440 450
YTAETELTDK SRWTRLDSIA VVALCNSLNA VGIAESVMDP FGGKLPTTYE
460 470 480 490 500
ETSSATGLLA YPNESHDIAS EPFSISWPQN PSISGSVHSA TTFDKAQLSN
510 520 530 540 550
TEDSYDNISH GTSYSEGVSS IHMVKGERGS NNLELTSESL SSTNDTIRRL
560 570 580 590 600
QRDLLFLQNE LRFEKFVRQQ HLQNIGKLHR EHILDMAVES ERQKLLLTNK
610 620 630 640 650
RYKAQIELLN SEIDKHRSES QAALNRRVKW ENDFNNKIKA LREEKKAWKS
660 670 680 690 700
EESELKSSIE SLISQLESIR NSQIDIAFSK NQLELKLQLY ETKLKEYEQH
710 720 730 740 750
LSCVNISKKQ VSSSSDTSFG NTKMDSSMIL SNSEAVSDEQ ERELIESEKH
760 770 780 790 800
RMKLESENLH LQANIELLKK DLEAINVVYE AKIFDLEKRL SSEANAPELH
810 820 830 840 850
NPVNLNYDAQ LSKISEIKEN YDELLTRYRE LEGKFLESQA EVEELKNFQK
860 870 880 890
PLVDTGSSIH SSPGLQQSKF IIRNDSLHPK VGPPRRQSTD TSRSTFRQY
Length:899
Mass (Da):103,435
Last modified:November 1, 1995 - v1
Checksum:i03D7E9CC8866ECAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91078.1.
PIRiS62428.
RefSeqiNP_593028.1. NM_001018427.2.

Genome annotation databases

EnsemblFungiiSPAC22F3.13.1; SPAC22F3.13.1:pep; SPAC22F3.13.
GeneIDi2541869.
KEGGispo:SPAC22F3.13.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91078.1.
PIRiS62428.
RefSeqiNP_593028.1. NM_001018427.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KK0X-ray2.90A/B/C/D/E/F/G/H/I/J1-431[»]
4KK1X-ray3.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T1-431[»]
ProteinModelPortaliQ09778.
SMRiQ09778.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278359. 83 interactors.
IntActiQ09778. 1 interactor.
MINTiMINT-4695004.

Proteomic databases

MaxQBiQ09778.
PRIDEiQ09778.

Protocols and materials databases

DNASUi2541869.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC22F3.13.1; SPAC22F3.13.1:pep; SPAC22F3.13.
GeneIDi2541869.
KEGGispo:SPAC22F3.13.

Organism-specific databases

EuPathDBiFungiDB:SPAC22F3.13.
PomBaseiSPAC22F3.13. tsc1.

Phylogenomic databases

InParanoidiQ09778.
OMAiLANIMEI.
OrthoDBiEOG092C0K4M.
PhylomeDBiQ09778.

Miscellaneous databases

PROiQ09778.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR007483. Hamartin.
[Graphical view]
PANTHERiPTHR15154. PTHR15154. 3 hits.
PfamiPF04388. Hamartin. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTSC1_SCHPO
AccessioniPrimary (citable) accession number: Q09778
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.