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Q09770

- AGM2_SCHPO

UniProt

Q09770 - AGM2_SCHPO

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Protein

Phosphoacetylglucosamine mutase 2

Gene

SPAC1296.01c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.By similarity

Catalytic activityi

N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei77 – 771Phosphoserine intermediateBy similarity
Metal bindingi77 – 771Magnesium; via phosphate groupBy similarity
Metal bindingi292 – 2921MagnesiumBy similarity
Metal bindingi294 – 2941MagnesiumBy similarity
Metal bindingi296 – 2961MagnesiumBy similarity
Binding sitei519 – 5191SubstrateBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoacetylglucosamine mutase activity Source: PomBase

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. UDP-N-acetylglucosamine biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Cell wall biogenesis/degradation

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_188592. Synthesis of UDP-N-acetyl-glucosamine.
UniPathwayiUPA00113; UER00530.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoacetylglucosamine mutase 2By similarity (EC:5.4.2.3By similarity)
Short name:
PAGM
Alternative name(s):
Acetylglucosamine phosphomutaseBy similarity
N-acetylglucosamine-phosphate mutaseBy similarity
Gene namesi
ORF Names:SPAC1296.01cImported, SPAC22F3.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC1296.01c.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. mannosyltransferase complex Source: PomBase
  3. nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Phosphoacetylglucosamine mutase 2PRO_0000148018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei77 – 771Phosphoserine1 Publication
Modified residuei82 – 821Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09770.

Interactioni

Protein-protein interaction databases

BioGridi280512. 27 interactions.
MINTiMINT-4694906.
STRINGi4896.SPAC1296.01c-1.

Structurei

3D structure databases

ProteinModelPortaliQ09770.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni385 – 3873Substrate bindingBy similarity
Regioni510 – 5145Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiCOG1109.
HOGENOMiHOG000210027.
InParanoidiQ09770.
KOiK01836.
OMAiVANERCA.
OrthoDBiEOG7V1G0D.
PhylomeDBiQ09770.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 1 hit.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005843. A-D-PHexomutase_C.
IPR016657. PAGM.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PIRSFiPIRSF016408. PAGM. 1 hit.
SUPFAMiSSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09770-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDAEDSDSI VNEFVTAIVR ESDKFAKVHS YPMQYGTGGY RADAELLSSV
60 70 80 90 100
AFRTGVIASF LSAKLHGQPV GLMVTASHNA SSENGLKIVN ILSSLDSSKW
110 120 130 140 150
EAYLDQVVNA DSADELTVCL TSILKKAKII PGSEARVFVG YDSRSTSEIL
160 170 180 190 200
AQAVIDGIVV CKAKYENFGL LTTPQLHYMV KASQTYGTPD AIGEPTERGY
210 220 230 240 250
FEKLSKAYQS LMTGKKIKGT VLIDAANGVG AAKIKELAKY IDPKLFPIEI
260 270 280 290 300
VNDNIDNPEL LNNSCGADFV RTQQKPPNGI SAPKHARCAS FDGDADRIVY
310 320 330 340 350
FAFGSHSFHL LDGDKICALF AQFLIDLIRS TGLDLQVGIV QTAYANGAST
360 370 380 390 400
AFFQKTLKVP VLCVSPGLKH LYHAAQAYDV GVFFEANGHG TILVSHAALS
410 420 430 440 450
KIISHEVLSP AQFNALKTLK TVFELINQTD GDAITNLLLV EVILAHKNCT
460 470 480 490 500
LKEWNQLYSE IPSRLIRCEV EDRSIYTTTD AEQKLVTPEG LQEKIDALVA
510 520 530 540
KYTGGRAFVR SSGTEDAVRV YAEASSRGES EDLALRIVEL LH
Length:542
Mass (Da):58,916
Last modified:August 29, 2001 - v2
Checksum:i131871396737609E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91066.1.
PIRiT37562.
T38190. S62416.
RefSeqiNP_593040.2. NM_001018439.3.

Genome annotation databases

EnsemblFungiiSPAC1296.01c.1; SPAC1296.01c.1:pep; SPAC1296.01c.
GeneIDi3361436.
KEGGispo:SPAC1296.01c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA91066.1 .
PIRi T37562.
T38190. S62416.
RefSeqi NP_593040.2. NM_001018439.3.

3D structure databases

ProteinModelPortali Q09770.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 280512. 27 interactions.
MINTi MINT-4694906.
STRINGi 4896.SPAC1296.01c-1.

Proteomic databases

MaxQBi Q09770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC1296.01c.1 ; SPAC1296.01c.1:pep ; SPAC1296.01c .
GeneIDi 3361436.
KEGGi spo:SPAC1296.01c.

Organism-specific databases

PomBasei SPAC1296.01c.

Phylogenomic databases

eggNOGi COG1109.
HOGENOMi HOG000210027.
InParanoidi Q09770.
KOi K01836.
OMAi VANERCA.
OrthoDBi EOG7V1G0D.
PhylomeDBi Q09770.

Enzyme and pathway databases

UniPathwayi UPA00113 ; UER00530 .
Reactomei REACT_188592. Synthesis of UDP-N-acetyl-glucosamine.

Miscellaneous databases

NextBioi 20811483.
PROi Q09770.

Family and domain databases

Gene3Di 3.30.310.50. 1 hit.
3.40.120.10. 1 hit.
InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005843. A-D-PHexomutase_C.
IPR016657. PAGM.
[Graphical view ]
Pfami PF02878. PGM_PMM_I. 1 hit.
PF02879. PGM_PMM_II. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view ]
PIRSFi PIRSF016408. PAGM. 1 hit.
SUPFAMi SSF53738. SSF53738. 3 hits.
SSF55957. SSF55957. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.
  2. "ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe."
    Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.
    Nat. Biotechnol. 24:841-847(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77 AND SER-82, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiAGM2_SCHPO
AccessioniPrimary (citable) accession number: Q09770
Secondary accession number(s): O94610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 29, 2001
Last modified: November 26, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3