Reviewed, UniProtKB/Swiss-Prot Q09767 (ARL_SCHPO)

Names and origin

Protein names

Recommended name:
    ADP-ribosylation factor-like protein alp41
Alternative name(s):
    Altered polarity protein 41

Gene names

Name:	alp41
ORF Names:	SPAC22F3.05c

Organism

Schizosaccharomyces pombe (Fission yeast) [Complete proteome]

Taxonomic identifier

4896 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Has a role in the cofactor-dependent pathway of microtubule biogenesis. Required for growth polarity control. Ref.1
Subcellular location	Cytoplasm › cytoskeleton.
Sequence similarities	Belongs to the small GTPase superfamily. Arf family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Myristate
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	establishment or maintenance of cytoskeleton polarity Ref.1 Inferred from mutant phenotype. Source: GeneDB_SPombe regulation of microtubule polymerization or depolymerization Ref.1 Inferred from mutant phenotype. Source: GeneDB_SPombe small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from direct assay. Source: GeneDB_SPombe microtubule Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from direct assay. Source: GeneDB_SPombe
Molecular function	GTP binding Ref.1 Traceable author statement. Source: GeneDB_SPombe
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Potential
	Chain	2 – 186	185	ADP-ribosylation factor-like protein alp41		PRO_0000207423
Regions
	Nucleotide binding	23 – 30	8	GTP Potential
	Nucleotide binding	66 – 70	5	GTP Potential
	Nucleotide binding	125 – 128	4	GTP Potential
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine Potential

Sequences

	Sequence		Length	Mass (Da)
	Q09767-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 18845CF6D0500C21	FASTA	186	21,236
	10 20 30 40 50 60 MGLLTILRQQ KLKEREVRVL LLGLDNAGKT TILKCLLNED VNEVSPTFGF QIRTLEVEGL 70 80 90 100 110 120 RFTIWDIGGQ KTLRNFWKNY FESTEAIIWV VDSLDDLRLE ECRNTLQELL VEEKLLFTSI 130 140 150 160 170 180 LVLANKSDVS GALSSEEISK ILNISKYKSS HWRIFSVSAL TGLNIKDAIS WLANDLKEIK LGTIDY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A conserved small GTP-binding protein Alp41 is essential for the cofactor-dependent biogenesis of microtubules in fission yeast." Radcliffe P.A., Vardy L., Toda T. FEBS Lett. 468:84-88(2000) [PubMed: 10683446] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: ATCC 38366 / 972.
[2]	"The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P. Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB031326 Genomic DNA. Translation: BAA83522.1. CU329670 Genomic DNA. Translation: CAA91070.1.
PIR	S62420. T38186.
RefSeq	NP_593036.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2541769.
GenomeReviews	Gene locus alp41 in contig CU329670_GR.
KEGG	spo:SPAC22F3.05c.
NMPDR	fig|4896.1.peg.3006.
Organism-specific databases
GeneDB_Spombe	SPAC22F3.05c.
Phylogenomic databases
OMA	ISSRIFT
OrthoDB	EOG90CK07
Gene expression databases
ArrayExpress	Q09767.
Family and domain databases
InterPro	IPR006688. ARF. IPR006689. ARF/SAR. IPR005225. Small_GTP_bd. [Graphical view]
PANTHER	PTHR11711. ARF/SAR. 1 hit.
Pfam	PF00025. Arf. 1 hit. [Graphical view]
PRINTS	PR00328. SAR1GTPBP.
SMART	SM00177. ARF. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51417. ARF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARL_SCHPO

Accession

Primary (citable) accession number: Q09767

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)