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Protein

Hexokinase-1

Gene

hxk1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Has low affinity for glucose and some of its analogs.

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei115 – 1151ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: PomBase
  3. glucokinase activity Source: PomBase
  4. hexokinase activity Source: PomBase
  5. mannokinase activity Source: PomBase

GO - Biological processi

  1. canonical glycolysis Source: PomBase
  2. carbohydrate phosphorylation Source: GOC
  3. cellular glucose homeostasis Source: GO_Central
  4. fructose 6-phosphate metabolic process Source: PomBase
  5. fructose metabolic process Source: PomBase
  6. glucose 6-phosphate metabolic process Source: PomBase
  7. glucose metabolic process Source: PomBase
  8. glycolytic process Source: GO_Central
  9. mannose metabolic process Source: PomBase
  10. pentose-phosphate shunt, oxidative branch Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.1. 5613.
ReactomeiREACT_288992. Regulation of gene expression in beta cells.
REACT_325482. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_341094. Glucose transport.
SABIO-RKQ09756.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-1 (EC:2.7.1.1)
Gene namesi
Name:hxk1
ORF Names:SPAC24H6.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485 Componenti: Chromosome I

Organism-specific databases

PomBaseiSPAC24H6.04.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Hexokinase-1PRO_0000197609Add
BLAST

Proteomic databases

MaxQBiQ09756.
PaxDbiQ09756.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi279088. 7 interactions.
MINTiMINT-4694731.
STRINGi4896.SPAC24H6.04-1.

Structurei

3D structure databases

ProteinModelPortaliQ09756.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 465441HexokinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni79 – 212134Hexokinase small subdomainPROSITE-ProRule annotationAdd
BLAST
Regioni154 – 18027Glucose-bindingSequence AnalysisAdd
BLAST
Regioni213 – 454242Hexokinase large subdomainPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated
Contains 1 hexokinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ09756.
KOiK00844.
OMAiEAKMGLI.
OrthoDBiEOG79SF68.
PhylomeDBiQ09756.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLHDAYHWP SRTPSRKGSN IKLNKTLQDH LDELEEQFTI PTELLHRVTD
60 70 80 90 100
RFVSELYKGL TTNPGDVPMV PTWIIGTPDG NEHGSYLALD LGGTNLRVCA
110 120 130 140 150
VEVQGNGKFD ITQSKYRLPQ ELKVGTREAL FDYIADCIKK FVEEVHPGKS
160 170 180 190 200
QNLEIGFTFS YPCVQRSIND ASLVAWTKGF DIDGVEGESV GPLLSAALKR
210 220 230 240 250
VGCNNVRLNA ILSDTTGTLV ASNYASPGTE IGVIFGTGCN ACYIEKFSEI
260 270 280 290 300
PKLHKYDFPE DMNMIINCEW CDFDNQHVVL PRTKYDVAID EESPRPGLQT
310 320 330 340 350
YEKMIAGCYL GDILRRILLD LYEQGALFNG QDVTKIRDPL AMDTSVLSAI
360 370 380 390 400
EVDPFENLDE TQTLFEETYG LKTTEEERQF IRRACELIGT RSARLSACGV
410 420 430 440 450
CALVRKMNKP SMIVGTDGSV YNLYPRFKDR LAQAFKDILG EEIGSKVVTI
460 470 480
PAEDGSGVGA ALVSALEAKG KALTSDILAE HLKN
Length:484
Mass (Da):53,598
Last modified:October 31, 1995 - v1
Checksum:i165500F19E6BBB0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92894 mRNA. Translation: CAA63487.1.
CU329670 Genomic DNA. Translation: CAA90848.1.
PIRiS68694.
RefSeqiNP_592948.1. NM_001018349.2.

Genome annotation databases

EnsemblFungiiSPAC24H6.04.1; SPAC24H6.04.1:pep; SPAC24H6.04.
GeneIDi2542634.
KEGGispo:SPAC24H6.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92894 mRNA. Translation: CAA63487.1.
CU329670 Genomic DNA. Translation: CAA90848.1.
PIRiS68694.
RefSeqiNP_592948.1. NM_001018349.2.

3D structure databases

ProteinModelPortaliQ09756.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279088. 7 interactions.
MINTiMINT-4694731.
STRINGi4896.SPAC24H6.04-1.

Proteomic databases

MaxQBiQ09756.
PaxDbiQ09756.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC24H6.04.1; SPAC24H6.04.1:pep; SPAC24H6.04.
GeneIDi2542634.
KEGGispo:SPAC24H6.04.

Organism-specific databases

PomBaseiSPAC24H6.04.

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ09756.
KOiK00844.
OMAiEAKMGLI.
OrthoDBiEOG79SF68.
PhylomeDBiQ09756.

Enzyme and pathway databases

UniPathwayiUPA00242.
BRENDAi2.7.1.1. 5613.
ReactomeiREACT_288992. Regulation of gene expression in beta cells.
REACT_325482. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_341094. Glucose transport.
SABIO-RKQ09756.

Miscellaneous databases

NextBioi20803683.
PROiQ09756.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Schizosaccharomyces pombe possesses an unusual and a conventional hexokinase: biochemical and molecular characterization of both hexokinases."
    Petit T., Blazquez M.A., Gancedo C.
    FEBS Lett. 378:185-189(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiHXK1_SCHPO
AccessioniPrimary (citable) accession number: Q09756
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1995
Last sequence update: October 31, 1995
Last modified: March 31, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.