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Q09756

- HXK1_SCHPO

UniProt

Q09756 - HXK1_SCHPO

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Protein

Hexokinase-1

Gene

hxk1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Has low affinity for glucose and some of its analogs.

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei115 – 1151ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. fructokinase activity Source: PomBase
  3. glucokinase activity Source: PomBase
  4. hexokinase activity Source: PomBase
  5. mannokinase activity Source: PomBase

GO - Biological processi

  1. canonical glycolysis Source: PomBase
  2. carbohydrate phosphorylation Source: GOC
  3. fructose 6-phosphate metabolic process Source: PomBase
  4. fructose metabolic process Source: PomBase
  5. glucose 6-phosphate metabolic process Source: PomBase
  6. glucose metabolic process Source: PomBase
  7. mannose metabolic process Source: PomBase
  8. pentose-phosphate shunt, oxidative branch Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.1. 5615.
SABIO-RKQ09756.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-1 (EC:2.7.1.1)
Gene namesi
Name:hxk1
ORF Names:SPAC24H6.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC24H6.04.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Hexokinase-1PRO_0000197609Add
BLAST

Proteomic databases

MaxQBiQ09756.
PaxDbiQ09756.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi279088. 8 interactions.
MINTiMINT-4694731.
STRINGi4896.SPAC24H6.04-1.

Structurei

3D structure databases

ProteinModelPortaliQ09756.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 225200Hexokinase type-1Add
BLAST
Domaini229 – 469241Hexokinase type-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni154 – 18027Glucose-bindingSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.Curated
Contains 1 hexokinase type-1 domain.Curated
Contains 1 hexokinase type-2 domain.Curated

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ09756.
KOiK00844.
OMAiRITTHHA.
OrthoDBiEOG79SF68.
PhylomeDBiQ09756.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09756-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLHDAYHWP SRTPSRKGSN IKLNKTLQDH LDELEEQFTI PTELLHRVTD
60 70 80 90 100
RFVSELYKGL TTNPGDVPMV PTWIIGTPDG NEHGSYLALD LGGTNLRVCA
110 120 130 140 150
VEVQGNGKFD ITQSKYRLPQ ELKVGTREAL FDYIADCIKK FVEEVHPGKS
160 170 180 190 200
QNLEIGFTFS YPCVQRSIND ASLVAWTKGF DIDGVEGESV GPLLSAALKR
210 220 230 240 250
VGCNNVRLNA ILSDTTGTLV ASNYASPGTE IGVIFGTGCN ACYIEKFSEI
260 270 280 290 300
PKLHKYDFPE DMNMIINCEW CDFDNQHVVL PRTKYDVAID EESPRPGLQT
310 320 330 340 350
YEKMIAGCYL GDILRRILLD LYEQGALFNG QDVTKIRDPL AMDTSVLSAI
360 370 380 390 400
EVDPFENLDE TQTLFEETYG LKTTEEERQF IRRACELIGT RSARLSACGV
410 420 430 440 450
CALVRKMNKP SMIVGTDGSV YNLYPRFKDR LAQAFKDILG EEIGSKVVTI
460 470 480
PAEDGSGVGA ALVSALEAKG KALTSDILAE HLKN
Length:484
Mass (Da):53,598
Last modified:November 1, 1995 - v1
Checksum:i165500F19E6BBB0F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92894 mRNA. Translation: CAA63487.1.
CU329670 Genomic DNA. Translation: CAA90848.1.
PIRiS68694.
RefSeqiNP_592948.1. NM_001018349.2.

Genome annotation databases

EnsemblFungiiSPAC24H6.04.1; SPAC24H6.04.1:pep; SPAC24H6.04.
GeneIDi2542634.
KEGGispo:SPAC24H6.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X92894 mRNA. Translation: CAA63487.1 .
CU329670 Genomic DNA. Translation: CAA90848.1 .
PIRi S68694.
RefSeqi NP_592948.1. NM_001018349.2.

3D structure databases

ProteinModelPortali Q09756.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 279088. 8 interactions.
MINTi MINT-4694731.
STRINGi 4896.SPAC24H6.04-1.

Proteomic databases

MaxQBi Q09756.
PaxDbi Q09756.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC24H6.04.1 ; SPAC24H6.04.1:pep ; SPAC24H6.04 .
GeneIDi 2542634.
KEGGi spo:SPAC24H6.04.

Organism-specific databases

PomBasei SPAC24H6.04.

Phylogenomic databases

eggNOGi COG5026.
HOGENOMi HOG000162670.
InParanoidi Q09756.
KOi K00844.
OMAi RITTHHA.
OrthoDBi EOG79SF68.
PhylomeDBi Q09756.

Enzyme and pathway databases

UniPathwayi UPA00242 .
BRENDAi 2.7.1.1. 5615.
SABIO-RK Q09756.

Miscellaneous databases

NextBioi 20803683.
PROi Q09756.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
PROSITEi PS00378. HEXOKINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Schizosaccharomyces pombe possesses an unusual and a conventional hexokinase: biochemical and molecular characterization of both hexokinases."
    Petit T., Blazquez M.A., Gancedo C.
    FEBS Lett. 378:185-189(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiHXK1_SCHPO
AccessioniPrimary (citable) accession number: Q09756
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3