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Protein

Hexokinase-1

Gene

hxk1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Has low affinity for glucose and some of its analogs.

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathwayi: hexose metabolism

This protein is involved in the pathway hexose metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway hexose metabolism and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei115ATPBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • fructokinase activity Source: PomBase
  • glucokinase activity Source: PomBase
  • glucose binding Source: InterPro
  • hexokinase activity Source: PomBase
  • mannokinase activity Source: PomBase

GO - Biological processi

  • canonical glycolysis Source: PomBase
  • cellular glucose homeostasis Source: GO_Central
  • fructose 6-phosphate metabolic process Source: PomBase
  • fructose metabolic process Source: PomBase
  • glucose 6-phosphate metabolic process Source: PomBase
  • glucose metabolic process Source: PomBase
  • glycolytic process Source: GO_Central
  • mannose metabolic process Source: PomBase
  • pentose-phosphate shunt, oxidative branch Source: PomBase

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.1. 5613.
ReactomeiR-SPO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-SPO-6798695. Neutrophil degranulation.
R-SPO-70153. Glucose transport.
R-SPO-70171. Glycolysis.
SABIO-RKiQ09756.
UniPathwayiUPA00242.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-1 (EC:2.7.1.1)
Gene namesi
Name:hxk1
ORF Names:SPAC24H6.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC24H6.04.
PomBaseiSPAC24H6.04. hxk1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: PomBase
  • nucleus Source: PomBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001976091 – 484Hexokinase-1Add BLAST484

Proteomic databases

MaxQBiQ09756.
PRIDEiQ09756.

PTM databases

SwissPalmiQ09756.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi279088. 7 interactors.
MINTiMINT-4694731.

Structurei

3D structure databases

ProteinModelPortaliQ09756.
SMRiQ09756.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 465HexokinasePROSITE-ProRule annotationAdd BLAST441

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 212Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST134
Regioni154 – 180Glucose-bindingSequence analysisAdd BLAST27
Regioni213 – 454Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST242

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Phylogenomic databases

HOGENOMiHOG000162670.
InParanoidiQ09756.
KOiK00844.
OMAiAIAIDGC.
OrthoDBiEOG092C2JW4.
PhylomeDBiQ09756.

Family and domain databases

InterProiView protein in InterPro
IPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiView protein in Pfam
PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
PROSITEiView protein in PROSITE
PS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLHDAYHWP SRTPSRKGSN IKLNKTLQDH LDELEEQFTI PTELLHRVTD
60 70 80 90 100
RFVSELYKGL TTNPGDVPMV PTWIIGTPDG NEHGSYLALD LGGTNLRVCA
110 120 130 140 150
VEVQGNGKFD ITQSKYRLPQ ELKVGTREAL FDYIADCIKK FVEEVHPGKS
160 170 180 190 200
QNLEIGFTFS YPCVQRSIND ASLVAWTKGF DIDGVEGESV GPLLSAALKR
210 220 230 240 250
VGCNNVRLNA ILSDTTGTLV ASNYASPGTE IGVIFGTGCN ACYIEKFSEI
260 270 280 290 300
PKLHKYDFPE DMNMIINCEW CDFDNQHVVL PRTKYDVAID EESPRPGLQT
310 320 330 340 350
YEKMIAGCYL GDILRRILLD LYEQGALFNG QDVTKIRDPL AMDTSVLSAI
360 370 380 390 400
EVDPFENLDE TQTLFEETYG LKTTEEERQF IRRACELIGT RSARLSACGV
410 420 430 440 450
CALVRKMNKP SMIVGTDGSV YNLYPRFKDR LAQAFKDILG EEIGSKVVTI
460 470 480
PAEDGSGVGA ALVSALEAKG KALTSDILAE HLKN
Length:484
Mass (Da):53,598
Last modified:November 1, 1995 - v1
Checksum:i165500F19E6BBB0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92894 mRNA. Translation: CAA63487.1.
CU329670 Genomic DNA. Translation: CAA90848.1.
PIRiS68694.
RefSeqiNP_592948.1. NM_001018349.2.

Genome annotation databases

EnsemblFungiiSPAC24H6.04.1; SPAC24H6.04.1:pep; SPAC24H6.04.
GeneIDi2542634.
KEGGispo:SPAC24H6.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92894 mRNA. Translation: CAA63487.1.
CU329670 Genomic DNA. Translation: CAA90848.1.
PIRiS68694.
RefSeqiNP_592948.1. NM_001018349.2.

3D structure databases

ProteinModelPortaliQ09756.
SMRiQ09756.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279088. 7 interactors.
MINTiMINT-4694731.

PTM databases

SwissPalmiQ09756.

Proteomic databases

MaxQBiQ09756.
PRIDEiQ09756.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC24H6.04.1; SPAC24H6.04.1:pep; SPAC24H6.04.
GeneIDi2542634.
KEGGispo:SPAC24H6.04.

Organism-specific databases

EuPathDBiFungiDB:SPAC24H6.04.
PomBaseiSPAC24H6.04. hxk1.

Phylogenomic databases

HOGENOMiHOG000162670.
InParanoidiQ09756.
KOiK00844.
OMAiAIAIDGC.
OrthoDBiEOG092C2JW4.
PhylomeDBiQ09756.

Enzyme and pathway databases

UniPathwayiUPA00242.
BRENDAi2.7.1.1. 5613.
ReactomeiR-SPO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-SPO-6798695. Neutrophil degranulation.
R-SPO-70153. Glucose transport.
R-SPO-70171. Glycolysis.
SABIO-RKiQ09756.

Miscellaneous databases

PROiPR:Q09756.

Family and domain databases

InterProiView protein in InterPro
IPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiView protein in Pfam
PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
PROSITEiView protein in PROSITE
PS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHXK1_SCHPO
AccessioniPrimary (citable) accession number: Q09756
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 15, 2017
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.