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Q09756

- HXK1_SCHPO

UniProt

Q09756 - HXK1_SCHPO

Protein

Hexokinase-1

Gene

hxk1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Has low affinity for glucose and some of its analogs.

    Catalytic activityi

    ATP + D-hexose = ADP + D-hexose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei115 – 1151ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. fructokinase activity Source: PomBase
    3. glucokinase activity Source: PomBase
    4. hexokinase activity Source: PomBase
    5. mannokinase activity Source: PomBase

    GO - Biological processi

    1. carbohydrate phosphorylation Source: GOC
    2. fructose 6-phosphate metabolic process Source: PomBase
    3. fructose metabolic process Source: PomBase
    4. glucose 6-phosphate metabolic process Source: PomBase
    5. glucose metabolic process Source: PomBase
    6. glycolytic process Source: UniProtKB-KW
    7. mannose metabolic process Source: PomBase
    8. pentose-phosphate shunt, oxidative branch Source: PomBase

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.1.1. 5615.
    SABIO-RKQ09756.
    UniPathwayiUPA00242.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hexokinase-1 (EC:2.7.1.1)
    Gene namesi
    Name:hxk1
    ORF Names:SPAC24H6.04
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC24H6.04.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: PomBase
    2. nucleus Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Hexokinase-1PRO_0000197609Add
    BLAST

    Proteomic databases

    MaxQBiQ09756.
    PaxDbiQ09756.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    BioGridi279088. 8 interactions.
    MINTiMINT-4694731.
    STRINGi4896.SPAC24H6.04-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09756.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 225200Hexokinase type-1Add
    BLAST
    Domaini229 – 469241Hexokinase type-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni154 – 18027Glucose-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated
    Contains 1 hexokinase type-1 domain.Curated
    Contains 1 hexokinase type-2 domain.Curated

    Phylogenomic databases

    eggNOGiCOG5026.
    HOGENOMiHOG000162670.
    KOiK00844.
    OMAiRITTHHA.
    OrthoDBiEOG79SF68.
    PhylomeDBiQ09756.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.
    PROSITEiPS00378. HEXOKINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09756-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLHDAYHWP SRTPSRKGSN IKLNKTLQDH LDELEEQFTI PTELLHRVTD    50
    RFVSELYKGL TTNPGDVPMV PTWIIGTPDG NEHGSYLALD LGGTNLRVCA 100
    VEVQGNGKFD ITQSKYRLPQ ELKVGTREAL FDYIADCIKK FVEEVHPGKS 150
    QNLEIGFTFS YPCVQRSIND ASLVAWTKGF DIDGVEGESV GPLLSAALKR 200
    VGCNNVRLNA ILSDTTGTLV ASNYASPGTE IGVIFGTGCN ACYIEKFSEI 250
    PKLHKYDFPE DMNMIINCEW CDFDNQHVVL PRTKYDVAID EESPRPGLQT 300
    YEKMIAGCYL GDILRRILLD LYEQGALFNG QDVTKIRDPL AMDTSVLSAI 350
    EVDPFENLDE TQTLFEETYG LKTTEEERQF IRRACELIGT RSARLSACGV 400
    CALVRKMNKP SMIVGTDGSV YNLYPRFKDR LAQAFKDILG EEIGSKVVTI 450
    PAEDGSGVGA ALVSALEAKG KALTSDILAE HLKN 484
    Length:484
    Mass (Da):53,598
    Last modified:November 1, 1995 - v1
    Checksum:i165500F19E6BBB0F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92894 mRNA. Translation: CAA63487.1.
    CU329670 Genomic DNA. Translation: CAA90848.1.
    PIRiS68694.
    RefSeqiNP_592948.1. NM_001018349.2.

    Genome annotation databases

    EnsemblFungiiSPAC24H6.04.1; SPAC24H6.04.1:pep; SPAC24H6.04.
    GeneIDi2542634.
    KEGGispo:SPAC24H6.04.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X92894 mRNA. Translation: CAA63487.1 .
    CU329670 Genomic DNA. Translation: CAA90848.1 .
    PIRi S68694.
    RefSeqi NP_592948.1. NM_001018349.2.

    3D structure databases

    ProteinModelPortali Q09756.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 279088. 8 interactions.
    MINTi MINT-4694731.
    STRINGi 4896.SPAC24H6.04-1.

    Proteomic databases

    MaxQBi Q09756.
    PaxDbi Q09756.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC24H6.04.1 ; SPAC24H6.04.1:pep ; SPAC24H6.04 .
    GeneIDi 2542634.
    KEGGi spo:SPAC24H6.04.

    Organism-specific databases

    PomBasei SPAC24H6.04.

    Phylogenomic databases

    eggNOGi COG5026.
    HOGENOMi HOG000162670.
    KOi K00844.
    OMAi RITTHHA.
    OrthoDBi EOG79SF68.
    PhylomeDBi Q09756.

    Enzyme and pathway databases

    UniPathwayi UPA00242 .
    BRENDAi 2.7.1.1. 5615.
    SABIO-RK Q09756.

    Miscellaneous databases

    NextBioi 20803683.
    PROi Q09756.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    PROSITEi PS00378. HEXOKINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Schizosaccharomyces pombe possesses an unusual and a conventional hexokinase: biochemical and molecular characterization of both hexokinases."
      Petit T., Blazquez M.A., Gancedo C.
      FEBS Lett. 378:185-189(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiHXK1_SCHPO
    AccessioniPrimary (citable) accession number: Q09756
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3