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Q09756 (HXK1_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has low affinity for glucose and some of its analogs.

Catalytic activity

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Pathway

Carbohydrate metabolism; hexose metabolism.

Subunit structure

Monomer.

Sequence similarities

Belongs to the hexokinase family.

Contains 1 hexokinase type-1 domain.

Contains 1 hexokinase type-2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 484484Hexokinase-1
PRO_0000197609

Regions

Domain26 – 225200Hexokinase type-1
Domain229 – 469241Hexokinase type-2
Region154 – 18027Glucose-binding Potential

Sites

Binding site1151ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09756 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 165500F19E6BBB0F

FASTA48453,598
        10         20         30         40         50         60 
MSLHDAYHWP SRTPSRKGSN IKLNKTLQDH LDELEEQFTI PTELLHRVTD RFVSELYKGL 

        70         80         90        100        110        120 
TTNPGDVPMV PTWIIGTPDG NEHGSYLALD LGGTNLRVCA VEVQGNGKFD ITQSKYRLPQ 

       130        140        150        160        170        180 
ELKVGTREAL FDYIADCIKK FVEEVHPGKS QNLEIGFTFS YPCVQRSIND ASLVAWTKGF 

       190        200        210        220        230        240 
DIDGVEGESV GPLLSAALKR VGCNNVRLNA ILSDTTGTLV ASNYASPGTE IGVIFGTGCN 

       250        260        270        280        290        300 
ACYIEKFSEI PKLHKYDFPE DMNMIINCEW CDFDNQHVVL PRTKYDVAID EESPRPGLQT 

       310        320        330        340        350        360 
YEKMIAGCYL GDILRRILLD LYEQGALFNG QDVTKIRDPL AMDTSVLSAI EVDPFENLDE 

       370        380        390        400        410        420 
TQTLFEETYG LKTTEEERQF IRRACELIGT RSARLSACGV CALVRKMNKP SMIVGTDGSV 

       430        440        450        460        470        480 
YNLYPRFKDR LAQAFKDILG EEIGSKVVTI PAEDGSGVGA ALVSALEAKG KALTSDILAE 


HLKN 

« Hide

References

« Hide 'large scale' references
[1]"Schizosaccharomyces pombe possesses an unusual and a conventional hexokinase: biochemical and molecular characterization of both hexokinases."
Petit T., Blazquez M.A., Gancedo C.
FEBS Lett. 378:185-189(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X92894 mRNA. Translation: CAA63487.1.
CU329670 Genomic DNA. Translation: CAA90848.1.
PIRS68694.
RefSeqNP_592948.1. NM_001018349.2.

3D structure databases

ProteinModelPortalQ09756.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid279088. 8 interactions.
MINTMINT-4694731.
STRING4896.SPAC24H6.04-1.

Proteomic databases

PaxDbQ09756.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC24H6.04.1; SPAC24H6.04.1:pep; SPAC24H6.04.
GeneID2542634.
KEGGspo:SPAC24H6.04.

Organism-specific databases

PomBaseSPAC24H6.04.

Phylogenomic databases

eggNOGCOG5026.
HOGENOMHOG000162670.
KOK00844.
OMAFIRRACE.
OrthoDBEOG79SF68.

Enzyme and pathway databases

BRENDA2.7.1.1. 5615.
SABIO-RKQ09756.
UniPathwayUPA00242.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERPTHR19443. PTHR19443. 1 hit.
PfamPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
PROSITEPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20803683.
PROQ09756.

Entry information

Entry nameHXK1_SCHPO
AccessionPrimary (citable) accession number: Q09756
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways