Reviewed,
UniProtKB/Swiss-Prot Q09751 (LGUL_SCHPO)
Last modified
November 3, 2009.
Version 68.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Lactoylglutathione lyase EC=4.4.1.5 Alternative name(s): Methylglyoxalase Aldoketomutase Glyoxalase I Short name=Glx I Ketone-aldehyde mutase S-D-lactoylglutathione methylglyoxal lyase | ||||
| Gene names |
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| Organism | Schizosaccharomyces pombe (Fission yeast) [Complete proteome] | ||||
| Taxonomic identifier | 4896 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces |
Protein attributes
| Sequence length | 302 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Ref.2 |
| Catalytic activity | (R)-S-lactoylglutathione = glutathione + methylglyoxal. |
| Cofactor | Binds 1 zinc ion per subunit. Cobalt, nickel and manganese ions can also function as cofactors. Ref.2 |
| Pathway | |
| Subunit structure | Monomer. Ref.2 |
| Sequence similarities | Belongs to the glyoxalase I family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The genome sequence of Schizosaccharomyces pombe." Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. Nurse P.Nature 415:871-880(2002) [PubMed: 11859360] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 38366 / 972. |
| [2] | "Identification of thermostable glyoxalase I in the fission yeast Schizosaccharomyces pombe." Takatsume Y., Izawa S., Inoue Y. Arch. Microbiol. 181:371-377(2004) [PubMed: 15042280] [Abstract] Cited for: FUNCTION, COFACTOR, SUBUNIT. |
Cross-references
Sequence databases | |
|---|---|
| CU329671 Genomic DNA. Translation: CAA20759.1. | |
| PIR | T11675. |
| RefSeq | NP_596010.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1QIP based on UniProtKB Q04760. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q09751. |
Genome annotation databases | |
| GeneID | 2539736. |
| GenomeReviews | Gene locus glo1 in contig CU329671_GR. |
| KEGG | spo:SPBC12C2.12c. |
| NMPDR | fig|4896.1.peg.1876. |
Organism-specific databases | |
| GeneDB_Spombe | SPBC12C2.12c. |
Phylogenomic databases | |
| OMA | PHRGFGH. |
Enzyme and pathway databases | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-003750-MON. |
| BRENDA | 4.4.1.5. 653. |
Gene expression databases | |
| ArrayExpress | Q09751. |
Family and domain databases | |
| InterPro | IPR004360. Glyas_bleo-R_dOase. IPR004361. Glyoxalase_1. IPR018146. Glyoxalase_1_CS. [Graphical view] |
| Pfam | PF00903. Glyoxalase. 2 hits. [Graphical view] |
| ProDom | PD002334. Gly_diox. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00068. glyox_I. 2 hits. |
| PROSITE | PS00934. GLYOXALASE_I_1. 2 hits. PS00935. GLYOXALASE_I_2. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LGUL_SCHPO | ||||||||
| Accession | Primary (citable) accession number: Q09751 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Schizosaccharomyces pombe Schizosaccharomyces pombe: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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