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Protein

Protein BZZ1

Gene

bzz1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri397 – 44751Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BZZ1
Gene namesi
Name:bzz1
ORF Names:SPBC12C2.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC12C2.05c.
PomBaseiSPBC12C2.05c. bzz1.

Subcellular locationi

GO - Cellular componenti

  • actin cortical patch Source: PomBase
  • cell division site Source: PomBase
  • cell septum Source: UniProtKB-SubCell
  • cell tip Source: PomBase
  • cytoplasm Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Protein BZZ1PRO_0000116505Add
BLAST

Proteomic databases

MaxQBiQ09746.

Interactioni

Protein-protein interaction databases

BioGridi276234. 49 interactions.
MINTiMINT-4694652.

Structurei

3D structure databases

ProteinModelPortaliQ09746.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 272267F-BARPROSITE-ProRule annotationAdd
BLAST
Domaini521 – 57555SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini584 – 64259SH3 2PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili113 – 19078Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the BZZ1 family.Curated
Contains 1 F-BAR domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri397 – 44751Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Repeat, SH3 domain, Zinc-finger

Phylogenomic databases

HOGENOMiHOG000185865.
InParanoidiQ09746.
OMAiCHARCEL.
OrthoDBiEOG092C3MIC.
PhylomeDBiQ09746.

Family and domain databases

InterProiIPR020454. DAG/PE-bd.
IPR031160. F_BAR.
IPR001060. FCH_dom.
IPR002219. PE/DAG-bd.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00055. FCH. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLETYKFSD ELHDDFKVVD SWINNGAKWL EDIQLYYKER SSIEKEYAQK
60 70 80 90 100
LASLSNKYGE KKSRKSSALS VGDTPAMSAG SLECASLTTW SKILDELTRS
110 120 130 140 150
SKTHQKLSDD YSLDIAEKLK KLESHIEALR KVYDDLYKKF SSEKETLLNS
160 170 180 190 200
VKRAKVSYHE ACDDLESARQ KNDKYREQKT QRNLKLSESD MLDKKNKYLL
210 220 230 240 250
RMLVYNAHKQ KFYNETLPTL LNHMQVLNEY RVSNLNEIWC NSFSIEKSLH
260 270 280 290 300
DTLSQRTVEI QSEIAKNEPV LDSAMFGRHN SKNWALPADL HFEPSPIWHD
310 320 330 340 350
TDALVVDGSC KNYLRNLLVH SKNDLGKQKG ELVSLDSQLE GLRVDDPNSA
360 370 380 390 400
NQSFESKKAS INLEGKELMV KARIEDLEVR INKITSVANN LEEGGRFHDF
410 420 430 440 450
KHVSFKLPTS CSYCREIIWG LSKRGCVCKN CGFKCHARCE LLVPANCKNG
460 470 480 490 500
EPEVADDDAV DTSVTATDDF DASASSSNAY ESYRNTYTDD MDSSSIYQTS
510 520 530 540 550
LSNVKTEETT PAEPASKVDG VVLYDFTGEH EGVITASEGQ EFTLLEPDDG
560 570 580 590 600
SGWVRVKIDG TDGLIPASYV KLNDELNTSV TLDGDSSYVK ALYAYTAQSD
610 620 630 640
MELSIQEGDI IQVTNRNAGN GWSEGILNGV TGQFPANYVT DV
Length:642
Mass (Da):72,216
Last modified:November 1, 1995 - v1
Checksum:iE6770ED15BD73D3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA90818.1.
PIRiT39376.
RefSeqiNP_596017.1. NM_001021925.2.

Genome annotation databases

EnsemblFungiiSPBC12C2.05c.1; SPBC12C2.05c.1:pep; SPBC12C2.05c.
GeneIDi2539679.
KEGGispo:SPBC12C2.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA90818.1.
PIRiT39376.
RefSeqiNP_596017.1. NM_001021925.2.

3D structure databases

ProteinModelPortaliQ09746.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276234. 49 interactions.
MINTiMINT-4694652.

Proteomic databases

MaxQBiQ09746.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC12C2.05c.1; SPBC12C2.05c.1:pep; SPBC12C2.05c.
GeneIDi2539679.
KEGGispo:SPBC12C2.05c.

Organism-specific databases

EuPathDBiFungiDB:SPBC12C2.05c.
PomBaseiSPBC12C2.05c. bzz1.

Phylogenomic databases

HOGENOMiHOG000185865.
InParanoidiQ09746.
OMAiCHARCEL.
OrthoDBiEOG092C3MIC.
PhylomeDBiQ09746.

Miscellaneous databases

PROiQ09746.

Family and domain databases

InterProiIPR020454. DAG/PE-bd.
IPR031160. F_BAR.
IPR001060. FCH_dom.
IPR002219. PE/DAG-bd.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF00611. FCH. 1 hit.
PF00018. SH3_1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00008. DAGPEDOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00109. C1. 1 hit.
SM00055. FCH. 1 hit.
SM00326. SH3. 2 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51741. F_BAR. 1 hit.
PS50002. SH3. 2 hits.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBZZ1_SCHPO
AccessioniPrimary (citable) accession number: Q09746
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.