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Protein

Spermidine synthase

Gene

SPBC12C2.07c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.

Pathwayi: spermidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes spermidine from putrescine.
Proteins known to be involved in this subpathway in this organism are:
  1. Spermidine synthase (SPBC12C2.07c)
This subpathway is part of the pathway spermidine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes spermidine from putrescine, the pathway spermidine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44S-adenosylmethioninamineBy similarity1
Binding sitei74PutrescineBy similarity1
Binding sitei75S-adenosylmethioninamineBy similarity1
Binding sitei99S-adenosylmethioninamineBy similarity1
Binding sitei119S-adenosylmethioninamineBy similarity1
Active sitei168Proton acceptorBy similarity1
Binding sitei168S-adenosylmethioninamineBy similarity1
Binding sitei236PutrescineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPolyamine biosynthesis, Spermidine biosynthesis

Enzyme and pathway databases

ReactomeiR-SPO-351202. Metabolism of polyamines.
UniPathwayiUPA00248; UER00314.

Names & Taxonomyi

Protein namesi
Recommended name:
Spermidine synthase (EC:2.5.1.16)
Short name:
SPDSY
Alternative name(s):
Putrescine aminopropyltransferase
Gene namesi
ORF Names:SPBC12C2.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC12C2.07c.
PomBaseiSPBC12C2.07c.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001564611 – 298Spermidine synthaseAdd BLAST298

Proteomic databases

MaxQBiQ09741.
PRIDEiQ09741.

PTM databases

iPTMnetiQ09741.

Interactioni

Protein-protein interaction databases

BioGridi276463. 1 interactor.
MINTiMINT-4694602.
STRINGi4896.SPBC12C2.07c.1.

Structurei

3D structure databases

ProteinModelPortaliQ09741.
SMRiQ09741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 248PABSAdd BLAST236

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni150 – 151S-adenosylmethioninamine bindingBy similarity2
Regioni168 – 171Putrescine bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000256147.
InParanoidiQ09741.
KOiK00797.
OMAiYPCGHIG.
OrthoDBiEOG092C2J3O.
PhylomeDBiQ09741.

Family and domain databases

Gene3Di2.30.140.10. 1 hit.
HAMAPiMF_00198. Spermidine_synth. 1 hit.
InterProiView protein in InterPro
IPR030374. PABS.
IPR030373. PABS_CS.
IPR029063. SAM-dependent_MTases.
IPR001045. Spermi_synthase.
IPR030668. Spermi_synthase_euk.
IPR035246. Spermidine_synt_N.
IPR037163. Spermidine_synt_N_sf.
PfamiView protein in Pfam
PF17284. Spermine_synt_N. 1 hit.
PIRSFiPIRSF000502. Spermidine_synth. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00417. speE. 1 hit.
PROSITEiView protein in PROSITE
PS01330. PABS_1. 1 hit.
PS51006. PABS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q09741-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQELSHPL IKDGWFREIN NMWPGQAMTL KVKKVLYAGK SKYQDVLVFE
60 70 80 90 100
SETYGHVLVL DGAIQATERD EFSYQEMIAH LALNSHPNPK KVLVIGGGDG
110 120 130 140 150
GVLREVVKHE CVEEAILCDI DEDVIKVSKQ YLPEMSAGFN HPKVKVHIGD
160 170 180 190 200
GFKFLQDYQN TFDVIITDSS DPDGPAEALF QKPYFQLLSD ALRGGGVITT
210 220 230 240 250
QAECMWIHLG VISNVLTAVK TVFPNVRYAY TTIPTYPSGS IGFVVASKDA
260 270 280 290
SIDLSKPLRK WSPEEENKLC KYYNSEIHAA SFVLPTFARD VVDKATSS
Length:298
Mass (Da):33,150
Last modified:November 1, 1995 - v1
Checksum:iF7063EFBBB087875
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA90820.1.
PIRiT39374.
RefSeqiNP_596015.1. NM_001021923.2.

Genome annotation databases

EnsemblFungiiSPBC12C2.07c.1; SPBC12C2.07c.1:pep; SPBC12C2.07c.
GeneIDi2539919.
KEGGispo:SPBC12C2.07c.

Entry informationi

Entry nameiSPEE_SCHPO
AccessioniPrimary (citable) accession number: Q09741
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 25, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families