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Protein

Spermidine synthase

Gene

SPBC12C2.07c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.

Pathwayi: spermidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes spermidine from putrescine.
Proteins known to be involved in this subpathway in this organism are:
  1. Spermidine synthase (SPBC12C2.07c)
This subpathway is part of the pathway spermidine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes spermidine from putrescine, the pathway spermidine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441S-adenosylmethioninamineBy similarity
Binding sitei74 – 741PutrescineBy similarity
Binding sitei75 – 751S-adenosylmethioninamineBy similarity
Binding sitei99 – 991S-adenosylmethioninamineBy similarity
Binding sitei119 – 1191S-adenosylmethioninamineBy similarity
Active sitei168 – 1681Proton acceptorBy similarity
Binding sitei168 – 1681S-adenosylmethioninamineBy similarity
Binding sitei236 – 2361PutrescineBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Enzyme and pathway databases

ReactomeiR-SPO-351202. Metabolism of polyamines.
UniPathwayiUPA00248; UER00314.

Names & Taxonomyi

Protein namesi
Recommended name:
Spermidine synthase (EC:2.5.1.16)
Short name:
SPDSY
Alternative name(s):
Putrescine aminopropyltransferase
Gene namesi
ORF Names:SPBC12C2.07c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC12C2.07c.
PomBaseiSPBC12C2.07c.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298Spermidine synthasePRO_0000156461Add
BLAST

Proteomic databases

MaxQBiQ09741.

Interactioni

Protein-protein interaction databases

BioGridi276463. 1 interaction.
MINTiMINT-4694602.

Structurei

3D structure databases

ProteinModelPortaliQ09741.
SMRiQ09741. Positions 11-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 248236PABSAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni150 – 1512S-adenosylmethioninamine bindingBy similarity
Regioni168 – 1714Putrescine bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000256147.
InParanoidiQ09741.
KOiK00797.
OMAiEIVANCR.
OrthoDBiEOG7FJH8S.
PhylomeDBiQ09741.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00198. Spermidine_synth.
InterProiIPR030374. PABS.
IPR030373. PABS_CS.
IPR029063. SAM-dependent_MTases.
IPR001045. Spermi_synthase.
IPR030668. Spermi_synthase_euk.
[Graphical view]
PIRSFiPIRSF000502. Spermidine_synth. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00417. speE. 1 hit.
PROSITEiPS01330. PABS_1. 1 hit.
PS51006. PABS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09741-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQELSHPL IKDGWFREIN NMWPGQAMTL KVKKVLYAGK SKYQDVLVFE
60 70 80 90 100
SETYGHVLVL DGAIQATERD EFSYQEMIAH LALNSHPNPK KVLVIGGGDG
110 120 130 140 150
GVLREVVKHE CVEEAILCDI DEDVIKVSKQ YLPEMSAGFN HPKVKVHIGD
160 170 180 190 200
GFKFLQDYQN TFDVIITDSS DPDGPAEALF QKPYFQLLSD ALRGGGVITT
210 220 230 240 250
QAECMWIHLG VISNVLTAVK TVFPNVRYAY TTIPTYPSGS IGFVVASKDA
260 270 280 290
SIDLSKPLRK WSPEEENKLC KYYNSEIHAA SFVLPTFARD VVDKATSS
Length:298
Mass (Da):33,150
Last modified:November 1, 1995 - v1
Checksum:iF7063EFBBB087875
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA90820.1.
PIRiT39374.
RefSeqiNP_596015.1. NM_001021923.2.

Genome annotation databases

EnsemblFungiiSPBC12C2.07c.1; SPBC12C2.07c.1:pep; SPBC12C2.07c.
GeneIDi2539919.
KEGGispo:SPBC12C2.07c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA90820.1.
PIRiT39374.
RefSeqiNP_596015.1. NM_001021923.2.

3D structure databases

ProteinModelPortaliQ09741.
SMRiQ09741. Positions 11-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276463. 1 interaction.
MINTiMINT-4694602.

Proteomic databases

MaxQBiQ09741.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC12C2.07c.1; SPBC12C2.07c.1:pep; SPBC12C2.07c.
GeneIDi2539919.
KEGGispo:SPBC12C2.07c.

Organism-specific databases

EuPathDBiFungiDB:SPBC12C2.07c.
PomBaseiSPBC12C2.07c.

Phylogenomic databases

HOGENOMiHOG000256147.
InParanoidiQ09741.
KOiK00797.
OMAiEIVANCR.
OrthoDBiEOG7FJH8S.
PhylomeDBiQ09741.

Enzyme and pathway databases

UniPathwayiUPA00248; UER00314.
ReactomeiR-SPO-351202. Metabolism of polyamines.

Miscellaneous databases

PROiQ09741.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00198. Spermidine_synth.
InterProiIPR030374. PABS.
IPR030373. PABS_CS.
IPR029063. SAM-dependent_MTases.
IPR001045. Spermi_synthase.
IPR030668. Spermi_synthase_euk.
[Graphical view]
PIRSFiPIRSF000502. Spermidine_synth. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00417. speE. 1 hit.
PROSITEiPS01330. PABS_1. 1 hit.
PS51006. PABS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiSPEE_SCHPO
AccessioniPrimary (citable) accession number: Q09741
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.