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Q09740

- GFA1_SCHPO

UniProt

Q09740 - GFA1_SCHPO

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Protein

Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
SPBC12C2.11, SPBC21D10.02
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins) By similarity.

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21For GATase activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: PomBase

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. chitin biosynthetic process Source: PomBase
  3. external encapsulating structure organization Source: PomBase
  4. glutamine metabolic process Source: UniProtKB-KW
  5. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_188301. XBP1(S) activates chaperone genes.
REACT_188592. Synthesis of UDP-N-acetyl-glucosamine.
UniPathwayiUPA00113; UER00528.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Short name:
GFAT
Alternative name(s):
D-fructose-6-phosphate amidotransferase
Hexosephosphate aminotransferase
Gene namesi
ORF Names:SPBC12C2.11, SPBC21D10.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC12C2.11.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 696695Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135288Add
BLAST

Proteomic databases

MaxQBiQ09740.
PaxDbiQ09740.

Interactioni

Protein-protein interaction databases

BioGridi276179. 2 interactions.
MINTiMINT-4694590.
STRINGi4896.SPBC12C2.11-1.

Structurei

3D structure databases

ProteinModelPortaliQ09740.
SMRiQ09740. Positions 337-684.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 303302Glutamine amidotransferase type-2Add
BLAST
Domaini375 – 514140SIS 1Add
BLAST
Domaini547 – 686140SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiCRIPCEV.
OrthoDBiEOG7034RG.
PhylomeDBiQ09740.

Family and domain databases

Gene3Di3.60.20.10. 2 hits.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 2 hits.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 2 hits.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09740-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIFGYINY LVERDRGYIL KTLVKGLKRL EYRGYDSSGC AVDGDEGEDF    50
IMFKEVGNVS KLEASIKGSN VNKSTKFINH CAISHTRWAT HGIPSPINCH 100
PQRSDPHSEF IVVHNGILTN YRELRTVLES RGMVFESETD TECVAKLAKF 150
IYDTTPGVDF TSLAKLVFRE LEGAYALLIK SSHYPGEVVA TRRGSPLIVG 200
VKSEQKLKVD FVDVEFPEPA EGLPGTPKPT SLHPVFSNPA TNGMLRGDKP 250
DLLHRAQSRA FVSGEGVPGP IEYFFASDAT PIIEYTKRVM FLEDDDIAHV 300
RDGELHVHRL RREGGGSTTR TIETLEMEIA SVMKGNYDHY MIKEICEQPD 350
SLLNTMRGRV NFVNRLVTLG GLESYYDIIR KSRRLIFVAC GTSYHSCVAV 400
RPLFEELTNI PVVVELASDF VDRCPSVFRD DTFIFVSQSG ETADSLLALQ 450
YTLENGALAI GVVNCVGSSI SRKTHCGVHI NAGPEICVAS TKAYTSQYVA 500
LVLMALYLSR DSVSRLERRN EIIDGLAEIG EKVQETLHLN AAIKQTAIEQ 550
LINKDKMLII GRGYHYATAL EGALKVKEIS YTHAEGVLAG ELKHGVLALV 600
DNDMPIVMLL PDDYNFPKAW NAFEQVRARG GKPIIITDKK LDNLEGFTII 650
KVPKTVDCLQ GILNVIPFQL LSYWLAVKRG HNVDQPRNLA KSVTVE 696
Length:696
Mass (Da):77,322
Last modified:January 23, 2007 - v2
Checksum:i9C4867168FB3EBFA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA20758.1.
PIRiT11674.
RefSeqiNP_596011.1. NM_001021919.2.

Genome annotation databases

EnsemblFungiiSPBC12C2.11.1; SPBC12C2.11.1:pep; SPBC12C2.11.
GeneIDi2539622.
KEGGispo:SPBC12C2.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329671 Genomic DNA. Translation: CAA20758.1 .
PIRi T11674.
RefSeqi NP_596011.1. NM_001021919.2.

3D structure databases

ProteinModelPortali Q09740.
SMRi Q09740. Positions 337-684.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276179. 2 interactions.
MINTi MINT-4694590.
STRINGi 4896.SPBC12C2.11-1.

Proteomic databases

MaxQBi Q09740.
PaxDbi Q09740.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC12C2.11.1 ; SPBC12C2.11.1:pep ; SPBC12C2.11 .
GeneIDi 2539622.
KEGGi spo:SPBC12C2.11.

Organism-specific databases

PomBasei SPBC12C2.11.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi CRIPCEV.
OrthoDBi EOG7034RG.
PhylomeDBi Q09740.

Enzyme and pathway databases

UniPathwayi UPA00113 ; UER00528 .
Reactomei REACT_188301. XBP1(S) activates chaperone genes.
REACT_188592. Synthesis of UDP-N-acetyl-glucosamine.

Miscellaneous databases

NextBioi 20800778.
PROi Q09740.

Family and domain databases

Gene3Di 3.60.20.10. 2 hits.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 2 hits.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 2 hits.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiGFA1_SCHPO
AccessioniPrimary (citable) accession number: Q09740
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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