Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q09740

- GFA1_SCHPO

UniProt

Q09740 - GFA1_SCHPO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

SPBC12C2.11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).By similarity

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21For GATase activityBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: PomBase

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. chitin biosynthetic process Source: PomBase
  3. external encapsulating structure organization Source: PomBase
  4. glutamine metabolic process Source: UniProtKB-KW
  5. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_188301. XBP1(S) activates chaperone genes.
REACT_188592. Synthesis of UDP-N-acetyl-glucosamine.
UniPathwayiUPA00113; UER00528.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Short name:
GFAT
Alternative name(s):
D-fructose-6-phosphate amidotransferase
Hexosephosphate aminotransferase
Gene namesi
ORF Names:SPBC12C2.11, SPBC21D10.02
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome II

Organism-specific databases

PomBaseiSPBC12C2.11.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 696695Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135288Add
BLAST

Proteomic databases

MaxQBiQ09740.
PaxDbiQ09740.

Interactioni

Protein-protein interaction databases

BioGridi276179. 2 interactions.
MINTiMINT-4694590.
STRINGi4896.SPBC12C2.11-1.

Structurei

3D structure databases

ProteinModelPortaliQ09740.
SMRiQ09740. Positions 337-684.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 303302Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd
BLAST
Domaini375 – 514140SIS 1PROSITE-ProRule annotationAdd
BLAST
Domaini547 – 686140SIS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.PROSITE-ProRule annotation
Contains 2 SIS domains.PROSITE-ProRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
InParanoidiQ09740.
KOiK00820.
OMAiCRIPCEV.
OrthoDBiEOG7034RG.
PhylomeDBiQ09740.

Family and domain databases

Gene3Di3.60.20.10. 2 hits.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 2 hits.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 2 hits.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09740-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIFGYINY LVERDRGYIL KTLVKGLKRL EYRGYDSSGC AVDGDEGEDF
60 70 80 90 100
IMFKEVGNVS KLEASIKGSN VNKSTKFINH CAISHTRWAT HGIPSPINCH
110 120 130 140 150
PQRSDPHSEF IVVHNGILTN YRELRTVLES RGMVFESETD TECVAKLAKF
160 170 180 190 200
IYDTTPGVDF TSLAKLVFRE LEGAYALLIK SSHYPGEVVA TRRGSPLIVG
210 220 230 240 250
VKSEQKLKVD FVDVEFPEPA EGLPGTPKPT SLHPVFSNPA TNGMLRGDKP
260 270 280 290 300
DLLHRAQSRA FVSGEGVPGP IEYFFASDAT PIIEYTKRVM FLEDDDIAHV
310 320 330 340 350
RDGELHVHRL RREGGGSTTR TIETLEMEIA SVMKGNYDHY MIKEICEQPD
360 370 380 390 400
SLLNTMRGRV NFVNRLVTLG GLESYYDIIR KSRRLIFVAC GTSYHSCVAV
410 420 430 440 450
RPLFEELTNI PVVVELASDF VDRCPSVFRD DTFIFVSQSG ETADSLLALQ
460 470 480 490 500
YTLENGALAI GVVNCVGSSI SRKTHCGVHI NAGPEICVAS TKAYTSQYVA
510 520 530 540 550
LVLMALYLSR DSVSRLERRN EIIDGLAEIG EKVQETLHLN AAIKQTAIEQ
560 570 580 590 600
LINKDKMLII GRGYHYATAL EGALKVKEIS YTHAEGVLAG ELKHGVLALV
610 620 630 640 650
DNDMPIVMLL PDDYNFPKAW NAFEQVRARG GKPIIITDKK LDNLEGFTII
660 670 680 690
KVPKTVDCLQ GILNVIPFQL LSYWLAVKRG HNVDQPRNLA KSVTVE
Length:696
Mass (Da):77,322
Last modified:January 23, 2007 - v2
Checksum:i9C4867168FB3EBFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20758.1.
PIRiT11674.
RefSeqiNP_596011.1. NM_001021919.2.

Genome annotation databases

EnsemblFungiiSPBC12C2.11.1; SPBC12C2.11.1:pep; SPBC12C2.11.
GeneIDi2539622.
KEGGispo:SPBC12C2.11.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329671 Genomic DNA. Translation: CAA20758.1 .
PIRi T11674.
RefSeqi NP_596011.1. NM_001021919.2.

3D structure databases

ProteinModelPortali Q09740.
SMRi Q09740. Positions 337-684.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 276179. 2 interactions.
MINTi MINT-4694590.
STRINGi 4896.SPBC12C2.11-1.

Proteomic databases

MaxQBi Q09740.
PaxDbi Q09740.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPBC12C2.11.1 ; SPBC12C2.11.1:pep ; SPBC12C2.11 .
GeneIDi 2539622.
KEGGi spo:SPBC12C2.11.

Organism-specific databases

PomBasei SPBC12C2.11.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
InParanoidi Q09740.
KOi K00820.
OMAi CRIPCEV.
OrthoDBi EOG7034RG.
PhylomeDBi Q09740.

Enzyme and pathway databases

UniPathwayi UPA00113 ; UER00528 .
Reactomei REACT_188301. XBP1(S) activates chaperone genes.
REACT_188592. Synthesis of UDP-N-acetyl-glucosamine.

Miscellaneous databases

NextBioi 20800778.
PROi Q09740.

Family and domain databases

Gene3Di 3.60.20.10. 2 hits.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 2 hits.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 2 hits.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiGFA1_SCHPO
AccessioniPrimary (citable) accession number: Q09740
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3