Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q09738

- UBP8_SCHPO

UniProt

Q09738 - UBP8_SCHPO

Protein

Probable ubiquitin carboxyl-terminal hydrolase 8

Gene

ubp8

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei154 – 1541NucleophilePROSITE-ProRule annotation
    Active sitei395 – 3951Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri36 – 9661UBP-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: PomBase
    2. ubiquitin thiolesterase activity Source: PomBase
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. chromatin remodeling Source: PomBase
    2. histone acetylation Source: PomBase
    3. histone H2B conserved C-terminal lysine deubiquitination Source: PomBase
    4. protein deubiquitination Source: PomBase
    5. regulation of transcription from RNA polymerase II promoter Source: PomBase
    6. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiC19.A61.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ubiquitin carboxyl-terminal hydrolase 8 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 8
    Ubiquitin thioesterase 8
    Ubiquitin-specific-processing protease 8
    Gene namesi
    Name:ubp8
    ORF Names:SPAC13A11.04c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome I

    Organism-specific databases

    PomBaseiSPAC13A11.04c.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: PomBase
    2. nucleus Source: PomBase
    3. SAGA complex Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Probable ubiquitin carboxyl-terminal hydrolase 8PRO_0000080609Add
    BLAST

    Proteomic databases

    MaxQBiQ09738.

    Interactioni

    Protein-protein interaction databases

    BioGridi278611. 104 interactions.
    IntActiQ09738. 2 interactions.
    MINTiMINT-8210504.
    STRINGi4896.SPAC13A11.04c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ09738.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini145 – 435291USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. UBP8 subfamily.Curated
    Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri36 – 9661UBP-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5077.
    KOiK11366.
    OMAiVENWKQN.
    OrthoDBiEOG7R2BSX.
    PhylomeDBiQ09738.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view]
    SMARTiSM00290. ZnF_UBP. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q09738-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPGDVEGCQH LKLKPADVEN YQKICTQIFS CHFVPRRCST CKRINKRSIR    50
    CLSCHSVGCL WGHHGEEHAM EHTHMIGVDV KNGHTYCFGC QDYVYQTELE 100
    TLRFKIKNIK AWQSDHKRLP EKYNQMVCLE AYRKYPPVCA TAGLRGIQNL 150
    GATCFMSVIL QSILHNPLVR NLFFSGFHTS TDCKRPTCMT CAIDDMFSSI 200
    YNSKNKSTFY GPTAVLNLMW KLSKSLCGYS QQDGHEFFVY LLDQMHTESG 250
    GGTSMPCTCP IHRIFSGSLK NVVTCLDCKK ERVAVDPLMD ISLDINEPTL 300
    QGCLERFVSK EKVQYSCHSC GSKNAIKQLV FDKLPPTICM QLKRFEQNNF 350
    AMSTKIDKQV SYPAFLRMRY NFNQDDVDYQ LYSVVCHKGT LDTGHYIAYT 400
    YYQNQWFLLD DTTIVEVKES EVLNSQAYLL FYHERQILYS DEMTVKTEN 449
    Length:449
    Mass (Da):51,720
    Last modified:November 1, 1995 - v1
    Checksum:i281D265D064CB3FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA90805.1.
    PIRiT37611.
    RefSeqiNP_592992.1. NM_001018391.2.

    Genome annotation databases

    EnsemblFungiiSPAC13A11.04c.1; SPAC13A11.04c.1:pep; SPAC13A11.04c.
    GeneIDi2542135.
    KEGGispo:SPAC13A11.04c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CU329670 Genomic DNA. Translation: CAA90805.1 .
    PIRi T37611.
    RefSeqi NP_592992.1. NM_001018391.2.

    3D structure databases

    ProteinModelPortali Q09738.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 278611. 104 interactions.
    IntActi Q09738. 2 interactions.
    MINTi MINT-8210504.
    STRINGi 4896.SPAC13A11.04c-1.

    Protein family/group databases

    MEROPSi C19.A61.

    Proteomic databases

    MaxQBi Q09738.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPAC13A11.04c.1 ; SPAC13A11.04c.1:pep ; SPAC13A11.04c .
    GeneIDi 2542135.
    KEGGi spo:SPAC13A11.04c.

    Organism-specific databases

    PomBasei SPAC13A11.04c.

    Phylogenomic databases

    eggNOGi COG5077.
    KOi K11366.
    OMAi VENWKQN.
    OrthoDBi EOG7R2BSX.
    PhylomeDBi Q09738.

    Miscellaneous databases

    NextBioi 20803207.
    PROi Q09738.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view ]
    SMARTi SM00290. ZnF_UBP. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiUBP8_SCHPO
    AccessioniPrimary (citable) accession number: Q09738
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3