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Q09738 (UBP8_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable ubiquitin carboxyl-terminal hydrolase 8
EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 8
Ubiquitin thioesterase 8
Ubiquitin-specific-processing protease 8
Gene names
Name:ubp8
ORF Names:SPAC13A11.04c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces ›

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C19 family. UBP8 subfamily.

Contains 1 UBP-type zinc finger.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Probable ubiquitin carboxyl-terminal hydrolase 8
PRO_0000080609

Regions

Zinc finger36 – 9661UBP-type

Sites

Active site1541Nucleophile By similarity
Active site3951Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q09738 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 281D265D064CB3FC

FASTA44951,720
        10         20         30         40         50         60 
MPGDVEGCQH LKLKPADVEN YQKICTQIFS CHFVPRRCST CKRINKRSIR CLSCHSVGCL 

        70         80         90        100        110        120 
WGHHGEEHAM EHTHMIGVDV KNGHTYCFGC QDYVYQTELE TLRFKIKNIK AWQSDHKRLP 

       130        140        150        160        170        180 
EKYNQMVCLE AYRKYPPVCA TAGLRGIQNL GATCFMSVIL QSILHNPLVR NLFFSGFHTS 

       190        200        210        220        230        240 
TDCKRPTCMT CAIDDMFSSI YNSKNKSTFY GPTAVLNLMW KLSKSLCGYS QQDGHEFFVY 

       250        260        270        280        290        300 
LLDQMHTESG GGTSMPCTCP IHRIFSGSLK NVVTCLDCKK ERVAVDPLMD ISLDINEPTL 

       310        320        330        340        350        360 
QGCLERFVSK EKVQYSCHSC GSKNAIKQLV FDKLPPTICM QLKRFEQNNF AMSTKIDKQV 

       370        380        390        400        410        420 
SYPAFLRMRY NFNQDDVDYQ LYSVVCHKGT LDTGHYIAYT YYQNQWFLLD DTTIVEVKES 

       430        440 
EVLNSQAYLL FYHERQILYS DEMTVKTEN

« Hide

References

[1]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CU329670 Genomic DNA. Translation: CAA90805.1.
PIRT37611.
RefSeqNP_592992.1. NM_001018391.2.

3D structure databases

ProteinModelPortalQ09738.
ModBaseSearch...

Protein-protein interaction databases

STRING4896.SPAC13A11.04c-1.

Protein family/group databases

MEROPSC19.A61.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPAC13A11.04c.1; SPAC13A11.04c.1:pep; SPAC13A11.04c.
GeneID2542135.
KEGGspo:SPAC13A11.04c.

Organism-specific databases

PomBaseSPAC13A11.04c.

Phylogenomic databases

eggNOGCOG5077.
KOK11366.
OMAIHEHAKA.
OrthoDBEOG4X3M8J.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
SMARTSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEPS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20803207.

Entry information

Entry nameUBP8_SCHPO
AccessionPrimary (citable) accession number: Q09738
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

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