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Q09738

- UBP8_SCHPO

UniProt

Q09738 - UBP8_SCHPO

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Protein

Probable ubiquitin carboxyl-terminal hydrolase 8

Gene
ubp8, SPAC13A11.04c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei154 – 1541Nucleophile By similarity
Active sitei395 – 3951Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri36 – 9661UBP-typeAdd
BLAST

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: PomBase
  2. ubiquitin thiolesterase activity Source: PomBase
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. chromatin remodeling Source: PomBase
  2. histone acetylation Source: PomBase
  3. histone H2B conserved C-terminal lysine deubiquitination Source: PomBase
  4. protein deubiquitination Source: PomBase
  5. regulation of transcription from RNA polymerase II promoter Source: PomBase
  6. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC19.A61.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 8 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 8
Ubiquitin thioesterase 8
Ubiquitin-specific-processing protease 8
Gene namesi
Name:ubp8
ORF Names:SPAC13A11.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome I

Organism-specific databases

PomBaseiSPAC13A11.04c.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: PomBase
  2. nucleus Source: PomBase
  3. SAGA complex Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Probable ubiquitin carboxyl-terminal hydrolase 8PRO_0000080609Add
BLAST

Proteomic databases

MaxQBiQ09738.

Interactioni

Protein-protein interaction databases

BioGridi278611. 104 interactions.
IntActiQ09738. 2 interactions.
MINTiMINT-8210504.
STRINGi4896.SPAC13A11.04c-1.

Structurei

3D structure databases

ProteinModelPortaliQ09738.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini145 – 435291USPAdd
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5077.
KOiK11366.
OMAiVENWKQN.
OrthoDBiEOG7R2BSX.
PhylomeDBiQ09738.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09738-1 [UniParc]FASTAAdd to Basket

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MPGDVEGCQH LKLKPADVEN YQKICTQIFS CHFVPRRCST CKRINKRSIR    50
CLSCHSVGCL WGHHGEEHAM EHTHMIGVDV KNGHTYCFGC QDYVYQTELE 100
TLRFKIKNIK AWQSDHKRLP EKYNQMVCLE AYRKYPPVCA TAGLRGIQNL 150
GATCFMSVIL QSILHNPLVR NLFFSGFHTS TDCKRPTCMT CAIDDMFSSI 200
YNSKNKSTFY GPTAVLNLMW KLSKSLCGYS QQDGHEFFVY LLDQMHTESG 250
GGTSMPCTCP IHRIFSGSLK NVVTCLDCKK ERVAVDPLMD ISLDINEPTL 300
QGCLERFVSK EKVQYSCHSC GSKNAIKQLV FDKLPPTICM QLKRFEQNNF 350
AMSTKIDKQV SYPAFLRMRY NFNQDDVDYQ LYSVVCHKGT LDTGHYIAYT 400
YYQNQWFLLD DTTIVEVKES EVLNSQAYLL FYHERQILYS DEMTVKTEN 449
Length:449
Mass (Da):51,720
Last modified:November 1, 1995 - v1
Checksum:i281D265D064CB3FC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA90805.1.
PIRiT37611.
RefSeqiNP_592992.1. NM_001018391.2.

Genome annotation databases

EnsemblFungiiSPAC13A11.04c.1; SPAC13A11.04c.1:pep; SPAC13A11.04c.
GeneIDi2542135.
KEGGispo:SPAC13A11.04c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CU329670 Genomic DNA. Translation: CAA90805.1 .
PIRi T37611.
RefSeqi NP_592992.1. NM_001018391.2.

3D structure databases

ProteinModelPortali Q09738.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 278611. 104 interactions.
IntActi Q09738. 2 interactions.
MINTi MINT-8210504.
STRINGi 4896.SPAC13A11.04c-1.

Protein family/group databases

MEROPSi C19.A61.

Proteomic databases

MaxQBi Q09738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPAC13A11.04c.1 ; SPAC13A11.04c.1:pep ; SPAC13A11.04c .
GeneIDi 2542135.
KEGGi spo:SPAC13A11.04c.

Organism-specific databases

PomBasei SPAC13A11.04c.

Phylogenomic databases

eggNOGi COG5077.
KOi K11366.
OMAi VENWKQN.
OrthoDBi EOG7R2BSX.
PhylomeDBi Q09738.

Miscellaneous databases

NextBioi 20803207.
PROi Q09738.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
SMARTi SM00290. ZnF_UBP. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiUBP8_SCHPO
AccessioniPrimary (citable) accession number: Q09738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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