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Protein

Probable ubiquitin carboxyl-terminal hydrolase 8

Gene

ubp8

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei154NucleophilePROSITE-ProRule annotation1
Active sitei395Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri36 – 96UBP-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiC19.A61

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ubiquitin carboxyl-terminal hydrolase 8 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 8
Ubiquitin thioesterase 8
Ubiquitin-specific-processing protease 8
Gene namesi
Name:ubp8
ORF Names:SPAC13A11.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC13A11.04c
PomBaseiSPAC13A11.04c ubp8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806091 – 449Probable ubiquitin carboxyl-terminal hydrolase 8Add BLAST449

Proteomic databases

MaxQBiQ09738
PaxDbiQ09738
PRIDEiQ09738

Interactioni

Protein-protein interaction databases

BioGridi278611, 109 interactors
IntActiQ09738, 2 interactors
MINTiQ09738
STRINGi4896.SPAC13A11.04c.1

Structurei

3D structure databases

ProteinModelPortaliQ09738
SMRiQ09738
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 435USPAdd BLAST291

Sequence similaritiesi

Belongs to the peptidase C19 family. UBP8 subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri36 – 96UBP-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiQ09738
KOiK11366
OMAiCDDHLIT
OrthoDBiEOG092C5R71
PhylomeDBiQ09738

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001394 Peptidase_C19_UCH
IPR037798 UBP8
IPR018200 USP_CS
IPR028889 USP_dom
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PANTHERiPTHR43961:SF2 PTHR43961:SF2, 1 hit
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF02148 zf-UBP, 1 hit
SMARTiView protein in SMART
SM00290 ZnF_UBP, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS50271 ZF_UBP, 1 hit

Sequencei

Sequence statusi: Complete.

Q09738-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGDVEGCQH LKLKPADVEN YQKICTQIFS CHFVPRRCST CKRINKRSIR
60 70 80 90 100
CLSCHSVGCL WGHHGEEHAM EHTHMIGVDV KNGHTYCFGC QDYVYQTELE
110 120 130 140 150
TLRFKIKNIK AWQSDHKRLP EKYNQMVCLE AYRKYPPVCA TAGLRGIQNL
160 170 180 190 200
GATCFMSVIL QSILHNPLVR NLFFSGFHTS TDCKRPTCMT CAIDDMFSSI
210 220 230 240 250
YNSKNKSTFY GPTAVLNLMW KLSKSLCGYS QQDGHEFFVY LLDQMHTESG
260 270 280 290 300
GGTSMPCTCP IHRIFSGSLK NVVTCLDCKK ERVAVDPLMD ISLDINEPTL
310 320 330 340 350
QGCLERFVSK EKVQYSCHSC GSKNAIKQLV FDKLPPTICM QLKRFEQNNF
360 370 380 390 400
AMSTKIDKQV SYPAFLRMRY NFNQDDVDYQ LYSVVCHKGT LDTGHYIAYT
410 420 430 440
YYQNQWFLLD DTTIVEVKES EVLNSQAYLL FYHERQILYS DEMTVKTEN
Length:449
Mass (Da):51,720
Last modified:November 1, 1995 - v1
Checksum:i281D265D064CB3FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA90805.1
PIRiT37611
RefSeqiNP_592992.1, NM_001018391.2

Genome annotation databases

EnsemblFungiiSPAC13A11.04c.1; SPAC13A11.04c.1:pep; SPAC13A11.04c
GeneIDi2542135
KEGGispo:SPAC13A11.04c

Similar proteinsi

Entry informationi

Entry nameiUBP8_SCHPO
AccessioniPrimary (citable) accession number: Q09738
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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