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Q09734

- MIP_TRYCR

UniProt

Q09734 - MIP_TRYCR

Protein

Macrophage infectivity potentiator

Gene

MIP

Organism
Trypanosoma cruzi
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Strongly inhibited by FK506 and L-685,818.

    GO - Molecular functioni

    1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. protein folding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Keywords - Biological processi

    Virulence

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Macrophage infectivity potentiator (EC:5.2.1.8)
    Alternative name(s):
    Peptidyl-prolyl cis-trans isomerase
    Short name:
    PPIase
    Rotamase
    Gene namesi
    Name:MIP
    OrganismiTrypanosoma cruzi
    Taxonomic identifieri5693 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 196167Macrophage infectivity potentiatorPRO_0000025535Add
    BLAST

    Structurei

    Secondary structure

    1
    196
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi36 – 5722
    Beta strandi61 – 633
    Beta strandi69 – 746
    Beta strandi88 – 958
    Beta strandi101 – 1044
    Helixi105 – 1084
    Beta strandi112 – 1143
    Helixi116 – 1183
    Helixi121 – 1277
    Beta strandi135 – 1406
    Helixi142 – 1443
    Turni145 – 1495
    Beta strandi151 – 1555
    Beta strandi161 – 17010
    Helixi171 – 1733
    Helixi179 – 19113

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JVWX-ray1.70A30-196[»]
    ProteinModelPortaliQ09734.
    SMRiQ09734. Positions 33-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ09734.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini85 – 17187PPIase FKBP-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family.Curated
    Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q09734-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHRENYFSKI AFCLLGVLFL SCITSVQTVS GDAASHEERM NNYRKRVGRL    50
    FMEQKAAQPD AVKLPSGLVF QRIARGSGKR APAIDDKCEV HYTGRLRDGT 100
    VFDSSRERGK PTTFRPNEVI KGWTEALQLM REGDRWRLFI PYDLAYGVTG 150
    GGGMIPPYSP LEFDVELISI KDGGKGRTAE EVDEILRKAE EDREDM 196
    Length:196
    Mass (Da):22,136
    Last modified:November 1, 1995 - v1
    Checksum:i40ACD50B2ED4AFA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69655 Genomic DNA. Translation: CAA49346.1.
    PIRiS55332.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69655 Genomic DNA. Translation: CAA49346.1 .
    PIRi S55332.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JVW X-ray 1.70 A 30-196 [» ]
    ProteinModelPortali Q09734.
    SMRi Q09734. Positions 33-192.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q09734.

    Family and domain databases

    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection."
      Moro A., Ruiz-Cabello F., Fernandez-Cano A., Stock R.P., Gonzalez A.
      EMBO J. 14:2483-2490(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Y.

    Entry informationi

    Entry nameiMIP_TRYCR
    AccessioniPrimary (citable) accession number: Q09734
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3