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Q09734 (MIP_TRYCR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Macrophage infectivity potentiator

EC=5.2.1.8
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name=PPIase
Rotamase
Gene names
Name:MIP
OrganismTrypanosoma cruzi
Taxonomic identifier5693 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Strongly inhibited by FK506 and L-685,818.

Subcellular location

Secretedextracellular space.

Sequence similarities

Belongs to the FKBP-type PPIase family.

Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentSecreted
   DomainSignal
   Molecular functionIsomerase
Rotamase
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

protein folding

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptidyl-prolyl cis-trans isomerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 196167Macrophage infectivity potentiator
PRO_0000025535

Regions

Domain85 – 17187PPIase FKBP-type

Secondary structure

.............................. 196
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q09734 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 40ACD50B2ED4AFA3

FASTA19622,136
        10         20         30         40         50         60 
MHRENYFSKI AFCLLGVLFL SCITSVQTVS GDAASHEERM NNYRKRVGRL FMEQKAAQPD 

        70         80         90        100        110        120 
AVKLPSGLVF QRIARGSGKR APAIDDKCEV HYTGRLRDGT VFDSSRERGK PTTFRPNEVI 

       130        140        150        160        170        180 
KGWTEALQLM REGDRWRLFI PYDLAYGVTG GGGMIPPYSP LEFDVELISI KDGGKGRTAE 

       190 
EVDEILRKAE EDREDM 

« Hide

References

[1]"Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection."
Moro A., Ruiz-Cabello F., Fernandez-Cano A., Stock R.P., Gonzalez A.
EMBO J. 14:2483-2490(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Y.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69655 Genomic DNA. Translation: CAA49346.1.
PIRS55332.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JVWX-ray1.70A30-196[»]
ProteinModelPortalQ09734.
SMRQ09734. Positions 33-192.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ09734.

Entry information

Entry nameMIP_TRYCR
AccessionPrimary (citable) accession number: Q09734
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references