Q09734 (MIP_TRYCR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Macrophage infectivity potentiator
EC=5.2.1.8

Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name=PPIase
Rotamase

Gene names

Name:

MIP

Organism

Trypanosoma cruzi

Taxonomic identifier

5693 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Schizotrypanum

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Strongly inhibited by FK506 and L-685,818.
Subcellular location	Secreted › extracellular space.
Sequence similarities	Belongs to the FKBP-type PPIase family. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Secreted
Domain	Signal
Molecular function	Isomerase Rotamase
Technical term	3D-structure
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW protein folding Inferred from electronic annotation. Source: UniProtKB-KW protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

29

Potential

Chain

30 – 196

167

Macrophage infectivity potentiator

PRO_0000025535

Regions

Domain

85 – 171

87

PPIase FKBP-type

Secondary structure

1

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196

Helix Strand Turn

Details...

Helix

36 – 57

22

Beta strand

61 – 63

3

Beta strand

69 – 74

6

Beta strand

88 – 95

8

Beta strand

101 – 104

4

Helix

105 – 108

4

Beta strand

112 – 114

3

Helix

116 – 118

3

Helix

121 – 127

7

Beta strand

135 – 140

6

Helix

142 – 144

3

Turn

145 – 149

5

Beta strand

151 – 155

5

Beta strand

161 – 170

10

Helix

171 – 173

3

Helix

179 – 191

13

Sequences

	Sequence		Length	Mass (Da)
	Q09734 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 40ACD50B2ED4AFA3	FASTA	196	22,136
	10 20 30 40 50 60 MHRENYFSKI AFCLLGVLFL SCITSVQTVS GDAASHEERM NNYRKRVGRL FMEQKAAQPD 70 80 90 100 110 120 AVKLPSGLVF QRIARGSGKR APAIDDKCEV HYTGRLRDGT VFDSSRERGK PTTFRPNEVI 130 140 150 160 170 180 KGWTEALQLM REGDRWRLFI PYDLAYGVTG GGGMIPPYSP LEFDVELISI KDGGKGRTAE 190 EVDEILRKAE EDREDM

References

[1]	"Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection." Moro A., Ruiz-Cabello F., Fernandez-Cano A., Stock R.P., Gonzalez A. EMBO J. 14:2483-2490(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Y.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X69655 Genomic DNA. Translation: CAA49346.1.

PIR

S55332.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JVW	X-ray	1.70	A	30-196	[»]

ProteinModelPortal

Q09734.

SMR

Q09734. Positions 33-192.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]

PANTHER

PTHR10516. PTHR10516. 1 hit.

Pfam

PF00254. FKBP_C. 1 hit.
[Graphical view]

PROSITE

PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q09734.

Entry information

Entry name

MIP_TRYCR

Accession

Primary (citable) accession number: Q09734

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)