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Q09734

- MIP_TRYCR

UniProt

Q09734 - MIP_TRYCR

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Protein
Macrophage infectivity potentiator
Gene
MIP
Organism
Trypanosoma cruzi
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Strongly inhibited by FK506 and L-685,818.

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage infectivity potentiator (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
Gene namesi
Name:MIP
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Chaini30 – 196167Macrophage infectivity potentiator
PRO_0000025535Add
BLAST

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi36 – 5722
Beta strandi61 – 633
Beta strandi69 – 746
Beta strandi88 – 958
Beta strandi101 – 1044
Helixi105 – 1084
Beta strandi112 – 1143
Helixi116 – 1183
Helixi121 – 1277
Beta strandi135 – 1406
Helixi142 – 1443
Turni145 – 1495
Beta strandi151 – 1555
Beta strandi161 – 17010
Helixi171 – 1733
Helixi179 – 19113

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JVWX-ray1.70A30-196[»]
ProteinModelPortaliQ09734.
SMRiQ09734. Positions 33-192.

Miscellaneous databases

EvolutionaryTraceiQ09734.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 17187PPIase FKBP-type
Add
BLAST

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09734-1 [UniParc]FASTAAdd to Basket

« Hide

MHRENYFSKI AFCLLGVLFL SCITSVQTVS GDAASHEERM NNYRKRVGRL    50
FMEQKAAQPD AVKLPSGLVF QRIARGSGKR APAIDDKCEV HYTGRLRDGT 100
VFDSSRERGK PTTFRPNEVI KGWTEALQLM REGDRWRLFI PYDLAYGVTG 150
GGGMIPPYSP LEFDVELISI KDGGKGRTAE EVDEILRKAE EDREDM 196
Length:196
Mass (Da):22,136
Last modified:November 1, 1995 - v1
Checksum:i40ACD50B2ED4AFA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69655 Genomic DNA. Translation: CAA49346.1.
PIRiS55332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69655 Genomic DNA. Translation: CAA49346.1 .
PIRi S55332.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JVW X-ray 1.70 A 30-196 [» ]
ProteinModelPortali Q09734.
SMRi Q09734. Positions 33-192.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q09734.

Family and domain databases

InterProi IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection."
    Moro A., Ruiz-Cabello F., Fernandez-Cano A., Stock R.P., Gonzalez A.
    EMBO J. 14:2483-2490(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Y.

Entry informationi

Entry nameiMIP_TRYCR
AccessioniPrimary (citable) accession number: Q09734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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