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Q09734

- MIP_TRYCR

UniProt

Q09734 - MIP_TRYCR

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Protein

Macrophage infectivity potentiator

Gene

MIP

Organism
Trypanosoma cruzi
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Strongly inhibited by FK506 and L-685,818.

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage infectivity potentiator (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
Gene namesi
Name:MIP
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 196167Macrophage infectivity potentiatorPRO_0000025535Add
BLAST

Structurei

Secondary structure

1
196
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi36 – 5722Combined sources
Beta strandi61 – 633Combined sources
Beta strandi69 – 746Combined sources
Beta strandi88 – 958Combined sources
Beta strandi101 – 1044Combined sources
Helixi105 – 1084Combined sources
Beta strandi112 – 1143Combined sources
Helixi116 – 1183Combined sources
Helixi121 – 1277Combined sources
Beta strandi135 – 1406Combined sources
Helixi142 – 1443Combined sources
Turni145 – 1495Combined sources
Beta strandi151 – 1555Combined sources
Beta strandi161 – 17010Combined sources
Helixi171 – 1733Combined sources
Helixi179 – 19113Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JVWX-ray1.70A30-196[»]
ProteinModelPortaliQ09734.
SMRiQ09734. Positions 33-192.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ09734.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 17187PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09734-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHRENYFSKI AFCLLGVLFL SCITSVQTVS GDAASHEERM NNYRKRVGRL
60 70 80 90 100
FMEQKAAQPD AVKLPSGLVF QRIARGSGKR APAIDDKCEV HYTGRLRDGT
110 120 130 140 150
VFDSSRERGK PTTFRPNEVI KGWTEALQLM REGDRWRLFI PYDLAYGVTG
160 170 180 190
GGGMIPPYSP LEFDVELISI KDGGKGRTAE EVDEILRKAE EDREDM
Length:196
Mass (Da):22,136
Last modified:November 1, 1995 - v1
Checksum:i40ACD50B2ED4AFA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69655 Genomic DNA. Translation: CAA49346.1.
PIRiS55332.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69655 Genomic DNA. Translation: CAA49346.1 .
PIRi S55332.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JVW X-ray 1.70 A 30-196 [» ]
ProteinModelPortali Q09734.
SMRi Q09734. Positions 33-192.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q09734.

Family and domain databases

InterProi IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infection."
    Moro A., Ruiz-Cabello F., Fernandez-Cano A., Stock R.P., Gonzalez A.
    EMBO J. 14:2483-2490(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Y.

Entry informationi

Entry nameiMIP_TRYCR
AccessioniPrimary (citable) accession number: Q09734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3