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Protein

Macrophage infectivity potentiator

Gene

MIP

Organism
Trypanosoma cruzi
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Strongly inhibited by FK506 and L-685,818.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Macrophage infectivity potentiator (EC:5.2.1.8)
Alternative name(s):
Peptidyl-prolyl cis-trans isomerase
Short name:
PPIase
Rotamase
Gene namesi
Name:MIP
OrganismiTrypanosoma cruzi
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002553530 – 196Macrophage infectivity potentiatorAdd BLAST167

Proteomic databases

PaxDbiQ09734.

Interactioni

Protein-protein interaction databases

STRINGi353153.XP_810893.1.

Structurei

Secondary structure

1196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi36 – 57Combined sources22
Beta strandi61 – 63Combined sources3
Beta strandi69 – 74Combined sources6
Beta strandi88 – 95Combined sources8
Beta strandi101 – 104Combined sources4
Helixi105 – 108Combined sources4
Beta strandi112 – 114Combined sources3
Helixi116 – 118Combined sources3
Helixi121 – 127Combined sources7
Beta strandi135 – 140Combined sources6
Helixi142 – 144Combined sources3
Turni145 – 149Combined sources5
Beta strandi151 – 155Combined sources5
Beta strandi161 – 170Combined sources10
Helixi171 – 173Combined sources3
Helixi179 – 191Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JVWX-ray1.70A30-196[»]
ProteinModelPortaliQ09734.
SMRiQ09734.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ09734.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 171PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST87

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0544. Eukaryota.
COG0545. LUCA.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q09734-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRENYFSKI AFCLLGVLFL SCITSVQTVS GDAASHEERM NNYRKRVGRL
60 70 80 90 100
FMEQKAAQPD AVKLPSGLVF QRIARGSGKR APAIDDKCEV HYTGRLRDGT
110 120 130 140 150
VFDSSRERGK PTTFRPNEVI KGWTEALQLM REGDRWRLFI PYDLAYGVTG
160 170 180 190
GGGMIPPYSP LEFDVELISI KDGGKGRTAE EVDEILRKAE EDREDM
Length:196
Mass (Da):22,136
Last modified:November 1, 1995 - v1
Checksum:i40ACD50B2ED4AFA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69655 Genomic DNA. Translation: CAA49346.1.
PIRiS55332.

Genome annotation databases

GeneDBiTcCLB.508897.110:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69655 Genomic DNA. Translation: CAA49346.1.
PIRiS55332.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JVWX-ray1.70A30-196[»]
ProteinModelPortaliQ09734.
SMRiQ09734.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi353153.XP_810893.1.

Proteomic databases

PaxDbiQ09734.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiTcCLB.508897.110:pep.

Phylogenomic databases

eggNOGiKOG0544. Eukaryota.
COG0545. LUCA.

Miscellaneous databases

EvolutionaryTraceiQ09734.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIP_TRYCR
AccessioniPrimary (citable) accession number: Q09734
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.