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Protein

Probable proteasome subunit beta type-4

Gene

SPAC31A2.04c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-SPO-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-SPO-174113 SCF-beta-TrCP mediated degradation of Emi1
R-SPO-382556 ABC-family proteins mediated transport
R-SPO-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-SPO-5689603 UCH proteinases
R-SPO-5689880 Ub-specific processing proteases
R-SPO-68949 Orc1 removal from chromatin
R-SPO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-SPO-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.984

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit beta type-4 (EC:3.4.25.1)
Gene namesi
ORF Names:SPAC31A2.04c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC31A2.04c
PomBaseiSPAC31A2.04c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001480541 – 194Probable proteasome subunit beta type-4Add BLAST194

Proteomic databases

MaxQBiQ09720
PaxDbiQ09720
PRIDEiQ09720

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

BioGridi279554, 2 interactors
STRINGi4896.SPAC31A2.04c.1

Structurei

3D structure databases

ProteinModelPortaliQ09720
SMRiQ09720
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000188743
InParanoidiQ09720
KOiK02734
OMAiQLYSMRN
OrthoDBiEOG092C3ZSC
PhylomeDBiQ09720

Family and domain databases

CDDicd03758 proteasome_beta_type_2, 1 hit
Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR035206 Proteasome_beta2
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF6 PTHR11599:SF6, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q09720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLLAVQGQ DFVLTASSSS AVRGITVLKP DDDKSQILNS HNLMLYCGEA
60 70 80 90 100
GDTTNFAEYI AANISLYTLR HNLNLSPEAT ASFTRKQLAT SLRSRKPYQV
110 120 130 140 150
NILLAGYETN LGKPELFWLD YLATCVRVPY ACQGYSSFYC LSIFDRYYKP
160 170 180 190
DLTIDEAVRI MKLCFDELKK RMPIDFKGFI CKVVDKDGIR EINI
Length:194
Mass (Da):21,967
Last modified:November 1, 1995 - v1
Checksum:i323495DC73053A82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA90462.1
PIRiS58101
RefSeqiNP_592916.1, NM_001018317.2

Genome annotation databases

EnsemblFungiiSPAC31A2.04c.1; SPAC31A2.04c.1:pep; SPAC31A2.04c
GeneIDi2543122
KEGGispo:SPAC31A2.04c

Similar proteinsi

Entry informationi

Entry nameiPSB4_SCHPO
AccessioniPrimary (citable) accession number: Q09720
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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