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Protein

AP-2 complex subunit mu

Gene

apm4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor (Potential).Curated

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Endocytosis, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit mu
Alternative name(s):
Clathrin assembly protein complex 2 mu medium chain
Clathrin coat-associated protein AP50
Mu2-adaptin
Plasma membrane adaptor AP-2 50 kDa protein
Probable clathrin coat assembly protein AP50
Gene namesi
Name:apm4
ORF Names:SPAC31A2.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC31A2.09c.
PomBaseiSPAC31A2.09c. apm4.

Subcellular locationi

GO - Cellular componenti

  • AP-2 adaptor complex Source: PomBase
  • cell division site Source: PomBase
  • cytosol Source: PomBase
  • mitotic spindle Source: PomBase
  • mitotic spindle pole body Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937791 – 446AP-2 complex subunit muAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei145Phosphoserine1 Publication1
Modified residuei151Phosphoserine1 Publication1
Modified residuei152Phosphoserine1 Publication1
Modified residuei157Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09718.
PRIDEiQ09718.

PTM databases

iPTMnetiQ09718.

Interactioni

Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit apl3 and beta-type subunit apl1), a medium chain (mu-type subunit apm4) and a small adaptin (sigma-type subunit aps2).By similarity

Protein-protein interaction databases

BioGridi278027. 39 interactors.
MINTiMINT-4694368.

Structurei

3D structure databases

ProteinModelPortaliQ09718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini177 – 445MHDPROSITE-ProRule annotationAdd BLAST269

Sequence similaritiesi

Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000173246.
InParanoidiQ09718.
KOiK11826.
OMAiPPLSMNF.
OrthoDBiEOG092C2NDI.
PhylomeDBiQ09718.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q09718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISGLFIFNL KGDTLICKTF RHDLKKSVTE IFRVAILTNT DYRHPIVSIG
60 70 80 90 100
SSTYIYTKHE DLYVVAITKG NPNVMIVLEF LESLIQDLTH YFGKLNENTV
110 120 130 140 150
KDNVSFIFEL LDEMIDYGII QTTEPDALAR SVSITAVKKK GNALSLKRSH
160 170 180 190 200
SSQLAHTTSS EIPGSVPWRR AGIKYRKNSI YIDIVERMNL LISSTGNVLR
210 220 230 240 250
SDVSGVVKMR AMLSGMPECQ FGLNDKLDFK LKQSESKSKS NNSRNPSSVN
260 270 280 290 300
GGFVILEDCQ FHQCVRLPEF ENEHRITFIP PDGEVELMSY RSHENINIPF
310 320 330 340 350
RIVPIVEQLS KQKIIYRISI RADYPHKLSS SLNFRIPVPT NVVKANPRVN
360 370 380 390 400
RGKAGYEPSE NIINWKIPRF LGETELIFYA EVELSNTTNQ QIWAKPPISL
410 420 430 440
DFNILMFTSS GLHVQYLRVS EPSNSKYKSI KWVRYSTRAG TCEIRI
Length:446
Mass (Da):50,821
Last modified:November 1, 1995 - v1
Checksum:i95AA8F8A8CFFA680
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA90467.1.
PIRiS59646.
RefSeqiNP_592921.1. NM_001018322.2.

Genome annotation databases

EnsemblFungiiSPAC31A2.09c.1; SPAC31A2.09c.1:pep; SPAC31A2.09c.
GeneIDi2541527.
KEGGispo:SPAC31A2.09c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA. Translation: CAA90467.1.
PIRiS59646.
RefSeqiNP_592921.1. NM_001018322.2.

3D structure databases

ProteinModelPortaliQ09718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278027. 39 interactors.
MINTiMINT-4694368.

PTM databases

iPTMnetiQ09718.

Proteomic databases

MaxQBiQ09718.
PRIDEiQ09718.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC31A2.09c.1; SPAC31A2.09c.1:pep; SPAC31A2.09c.
GeneIDi2541527.
KEGGispo:SPAC31A2.09c.

Organism-specific databases

EuPathDBiFungiDB:SPAC31A2.09c.
PomBaseiSPAC31A2.09c. apm4.

Phylogenomic databases

HOGENOMiHOG000173246.
InParanoidiQ09718.
KOiK11826.
OMAiPPLSMNF.
OrthoDBiEOG092C2NDI.
PhylomeDBiQ09718.

Miscellaneous databases

PROiQ09718.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP2M_SCHPO
AccessioniPrimary (citable) accession number: Q09718
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.