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Protein

AP-2 complex subunit mu

Gene

apm4

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor (Potential).Curated

GO - Biological processi

Keywordsi

Biological processEndocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-SPO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-SPO-8866427 VLDLR internalisation and degradation
R-SPO-8964038 LDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
AP-2 complex subunit mu
Alternative name(s):
Clathrin assembly protein complex 2 mu medium chain
Clathrin coat-associated protein AP50
Mu2-adaptin
Plasma membrane adaptor AP-2 50 kDa protein
Probable clathrin coat assembly protein AP50
Gene namesi
Name:apm4
ORF Names:SPAC31A2.09c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC31A2.09c
PomBaseiSPAC31A2.09c apm4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Coated pit, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937791 – 446AP-2 complex subunit muAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei145Phosphoserine1 Publication1
Modified residuei151Phosphoserine1 Publication1
Modified residuei152Phosphoserine1 Publication1
Modified residuei157Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ09718
PaxDbiQ09718
PRIDEiQ09718

PTM databases

iPTMnetiQ09718

Interactioni

Subunit structurei

Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit apl3 and beta-type subunit apl1), a medium chain (mu-type subunit apm4) and a small adaptin (sigma-type subunit aps2).By similarity

Protein-protein interaction databases

BioGridi278027, 39 interactors
STRINGi4896.SPAC31A2.09c.1

Structurei

3D structure databases

ProteinModelPortaliQ09718
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini177 – 445MHDPROSITE-ProRule annotationAdd BLAST269

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000173246
InParanoidiQ09718
KOiK11826
OMAiSWRKADV
OrthoDBiEOG092C2NDI
PhylomeDBiQ09718

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR001392 Clathrin_mu
IPR018240 Clathrin_mu_CS
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992 Clathrin_mu, 1 hit
PRINTSiPR00314 CLATHRINADPT
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit

Sequencei

Sequence statusi: Complete.

Q09718-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISGLFIFNL KGDTLICKTF RHDLKKSVTE IFRVAILTNT DYRHPIVSIG
60 70 80 90 100
SSTYIYTKHE DLYVVAITKG NPNVMIVLEF LESLIQDLTH YFGKLNENTV
110 120 130 140 150
KDNVSFIFEL LDEMIDYGII QTTEPDALAR SVSITAVKKK GNALSLKRSH
160 170 180 190 200
SSQLAHTTSS EIPGSVPWRR AGIKYRKNSI YIDIVERMNL LISSTGNVLR
210 220 230 240 250
SDVSGVVKMR AMLSGMPECQ FGLNDKLDFK LKQSESKSKS NNSRNPSSVN
260 270 280 290 300
GGFVILEDCQ FHQCVRLPEF ENEHRITFIP PDGEVELMSY RSHENINIPF
310 320 330 340 350
RIVPIVEQLS KQKIIYRISI RADYPHKLSS SLNFRIPVPT NVVKANPRVN
360 370 380 390 400
RGKAGYEPSE NIINWKIPRF LGETELIFYA EVELSNTTNQ QIWAKPPISL
410 420 430 440
DFNILMFTSS GLHVQYLRVS EPSNSKYKSI KWVRYSTRAG TCEIRI
Length:446
Mass (Da):50,821
Last modified:November 1, 1995 - v1
Checksum:i95AA8F8A8CFFA680
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA90467.1
PIRiS59646
RefSeqiNP_592921.1, NM_001018322.2

Genome annotation databases

EnsemblFungiiSPAC31A2.09c.1; SPAC31A2.09c.1:pep; SPAC31A2.09c
GeneIDi2541527
KEGGispo:SPAC31A2.09c

Similar proteinsi

Entry informationi

Entry nameiAP2M_SCHPO
AccessioniPrimary (citable) accession number: Q09718
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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