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Protein

Transcriptional repressor tup11

Gene

tup11

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor.

GO - Molecular functioni

  • histone binding Source: PomBase

GO - Biological processi

  • carbon catabolite repression of transcription by glucose Source: PomBase
  • chromatin silencing Source: PomBase
  • negative regulation of transcription by RNA polymerase II Source: PomBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor tup11
Gene namesi
Name:tup11
ORF Names:SPAC18B11.10
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC18B11.10
PomBaseiSPAC18B11.10 tup11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi362Y → C: No interaction with fep1. 1 Publication1
Mutagenesisi542L → S: No interaction with fep1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513101 – 614Transcriptional repressor tup11Add BLAST614

Proteomic databases

MaxQBiQ09715
PaxDbiQ09715
PRIDEiQ09715

PTM databases

iPTMnetiQ09715

Interactioni

Subunit structurei

Interacts with fep1. Binds to histones H3 and H4.1 Publication

GO - Molecular functioni

  • histone binding Source: PomBase

Protein-protein interaction databases

BioGridi278766, 31 interactors
STRINGi4896.SPAC18B11.10.1

Structurei

3D structure databases

ProteinModelPortaliQ09715
SMRiQ09715
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati311 – 340WD 1Add BLAST30
Repeati358 – 388WD 2Add BLAST31
Repeati400 – 430WD 3Add BLAST31
Repeati441 – 471WD 4Add BLAST31
Repeati482 – 512WD 5Add BLAST31
Repeati536 – 566WD 6Add BLAST31
Repeati578 – 608WD 7Add BLAST31

Sequence similaritiesi

Belongs to the WD repeat TUP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOGENOMiHOG000200558
InParanoidiQ09715
KOiK06666
OrthoDBiEOG092C21A7
PhylomeDBiQ09715

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR013890 Tscrpt_rep_Tup1_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08581 Tup_N, 1 hit
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010558 Transcrip_repressor_Tup1_N, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q09715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVEDATKV QEMLDALKAE YNALAHHSFA SKARGNDYES SMIQSQIQEI
60 70 80 90 100
EAFRKTVDDM YEKQKSIRET YEKDINKLKR ELEELGVEAN TASYRNRGER
110 120 130 140 150
SELAASNNQV THIDQEHPSQ TKSTSQPPSN HLPAFQQIPP IHQSAYPQNN
160 170 180 190 200
VAEVLMPPIP PSVEASSGQN FNQGIASQNP AISTSNLPST TPLYIPPVNY
210 220 230 240 250
GANQVSQQPN PQLPGVSNYY NPSATSKPAV NVQPPRIPTK ATPSAEPSMT
260 270 280 290 300
ASANAGSISQ AGPDGEYQGR EQIAPVSDTE AARKTTSQSW YVTYNPACKR
310 320 330 340 350
VFNINLVHTL EHPSVVCCVK FSNNGKYLAT GCNQAANVFD VQTGKKLFTL
360 370 380 390 400
HEESPDPSRD LYVRTIAFSP DGKYLVTGTE DRQIKLWDLS TQKVRYVFSG
410 420 430 440 450
HEQDIYSLDF SHNGRFIVSG SGDRTARLWD VETGQCILKL EIENGVTAIA
460 470 480 490 500
ISPNDQFIAV GSLDQIIRVW SVSGTLVERL EGHKESVYSI AFSPDSSILL
510 520 530 540 550
SGSLDKTIKV WELQATRSVG LSAIKPEGIC KATYTGHTDF VLSVAVSPDS
560 570 580 590 600
RWGLSGSKDR SMQFWDLQTG QSYLTCQGHK NSVISVCFSP DGRQFASGSG
610
DLRARIWSID PASP
Length:614
Mass (Da):67,331
Last modified:November 1, 1995 - v1
Checksum:iB02289556DE2C1B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA90594.1
AB027768 Genomic DNA Translation: BAA87072.1
PIRiS58306
RefSeqiNP_592873.1, NM_001018273.2

Genome annotation databases

EnsemblFungiiSPAC18B11.10.1; SPAC18B11.10.1:pep; SPAC18B11.10
GeneIDi2542299
KEGGispo:SPAC18B11.10

Similar proteinsi

Entry informationi

Entry nameiTUP11_SCHPO
AccessioniPrimary (citable) accession number: Q09715
Secondary accession number(s): Q9USG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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